Research Topics
| Herwig Ulf Meier-KriescheSummaryAffiliation: University of Florida Country: USA Publications
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Detail Information
Publications
Mycophenolate mofetil initiation in renal transplant patients at different times posttransplantation: the TranCept Switch studyHerwig Ulf Meier-Kriesche
Division of Nephrology, University of Florida College of Medicine, Gainesville, FL 32610 0224, USA
Transplantation 91:984-90. 2011..Despite evidence of favorable long-term effects of mycophenolate mofetil (MMF) in renal transplantation, its introduction at different times posttransplant has not been studied in large cohorts...
Mycophenolate mofetil versus azathioprine therapy is associated with a significant protection against long-term renal allograft function deteriorationHerwig Ulf Meier-Kriesche
Department of Internal Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0224, USA
Transplantation 75:1341-6. 2003....
Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent eraHerwig Ulf Meier-Kriesche
University of Florida, College of Medicine, Division of Nephrology, Gainesville, FL, USA
Am J Transplant 4:378-83. 2004..However, the etiology of this concerning trend for worse death censored graft survival in recent years will warrant further investigation...
Long-term renal allograft survival: have we made significant progress or is it time to rethink our analytic and therapeutic strategies?Herwig Ulf Meier-Kriesche
Department of Medicine, University of Florida, Gainesville, FL, USA
Am J Transplant 4:1289-95. 2004..Redirection of attention from early endpoints towards the process of long-term graft loss may be necessary to sustain early gains in the long term...
Kidney transplantation halts cardiovascular disease progression in patients with end-stage renal diseaseHerwig Ulf Meier-Kriesche
Kidney Transplant Program, Division of Nephrology, University of Florida College of Medicine, 1600 SW Archer Rd, Rm CG 98, Gainesville, FL, USA
Am J Transplant 4:1662-8. 2004..The data presented in this paper thus suggest that the development or progression of these lesions could be ameliorated by restoring renal function with a transplant...
Mycophenolate mofetil vs azathioprine in a large population of elderly renal transplant patientsHerwig Ulf Meier-Kriesche
Division of Internal Medicine, University of Florida College of Medicine, Gainesville, FL, USA
Nephrol Dial Transplant 19:2864-9. 2004..Previous studies reported a higher risk of death due to infection in elderly recipients treated with MMF-based immunosuppression...
Sirolimus with neoral versus mycophenolate mofetil with neoral is associated with decreased renal allograft survivalHerwig Ulf Meier-Kriesche
Department of Internal Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
Am J Transplant 4:2058-66. 2004..Outcomes regarding alternative strategies of Rapa utilization with reduced CsA, with alternative agents or with no calcineurin inhibitor cannot be extrapolated from these data...
Kidneys from deceased donors: maximizing the value of a scarce resourceHerwig Ulf Meier-Kriesche
Department of Medicine, University of Florida, Gainesville, FL, USA
Am J Transplant 5:1725-30. 2005..5 billion dollars...
Sirolimus in combination with tacrolimus is associated with worse renal allograft survival compared to mycophenolate mofetil combined with tacrolimusHerwig Ulf Meier-Kriesche
Department of Medicine, University of Florida College of Medicine, Florida, USA
Am J Transplant 5:2273-80. 2005..These results have to be interpreted in the context of the inherent limitations of any retrospective database analysis and evaluated in context with data from prospective clinical trials...
Switching immunosuppression medications after renal transplantation--a common practiceHerwig Ulf Meier-Kriesche
Division of Nephrology, University of Florida College of Medicine, 1600 SW Archer Road, Box 100224, Gainesville, FL 32610 0224, USA
Nephrol Dial Transplant 21:2256-62. 2006..The rate of change to immunosuppression discharge regimens over time is unknown. We examined the frequency of changes to initial drug treatment regimens and factors associated with a drug change following renal transplantation...
Immunosuppression: evolution in practice and trends, 1994-2004H U Meier-Kriesche
University of Florida, Gainesville, FL, USA
Am J Transplant 6:1111-31. 2006..The percentage of patients treated for acute rejection during the first year following transplantation has continued to decline, reaching 13% for those who received a kidney in 2003, 48% of which cases were treated with antibodies...
A lifetime versus a graft life approach redefines the importance of HLA matching in kidney transplant patientsHerwig Ulf Meier-Kriesche
Department of Medicine, University of Florida, Gainesville, FL 32610, USA
Transplantation 88:23-9. 2009..An unforeseen consequence of poorer matching could be increased sensitization for candidates pursuing retransplantation...
Decreased renal function is a strong risk factor for cardiovascular death after renal transplantationHerwig Ulf Meier-Kriesche
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224
Transplantation 75:1291-5. 2003..The purpose of this study was to investigate if renal function has a significant role in determining the risk for cardiovascular death in renal-allograft recipients...
Waiting time on dialysis as the strongest modifiable risk factor for renal transplant outcomes: a paired donor kidney analysisHerwig Ulf Meier-Kriesche
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, USA
Transplantation 74:1377-81. 2002....
Long-term use of mycophenolate mofetil is associated with a reduction in the incidence and risk of late rejectionHerwig Ulf Meier-Kriesche
Department of Internal Medicine, University of Florida, USA
Am J Transplant 3:68-73. 2003..30, p < 0.001). Further study is indicated to determine the optimal duration of MMF therapy after renal allograft transplantation...
The impact of body mass index on renal transplant outcomes: a significant independent risk factor for graft failure and patient deathHerwig Ulf Meier-Kriesche
Division of Nephrology, University of Florida, Shands Hospital, 1600 SW Archer Rd, Rm CG 98, Gainesville FL 32610 0224, USA
Transplantation 73:70-4. 2002..To investigate this hypothesis we retrospectively analyzed 51,927 primary, adult renal transplants registered in the USRDS...
Low dendritic cell count after allogeneic hematopoietic stem cell transplantation predicts relapse, death, and acute graft-versus-host diseaseVijay Reddy
Division of Hematology Oncology, University of Florida College of Medicine, 1600 SW Archer Rd, Gainesville, FL 32610, USA
Blood 103:4330-5. 2004..Low numbers of circulating DCs significantly increase the risk for relapse and acute GVHD and predict death after allogeneic SCT...
Are we frozen in time? Analysis of the utilization and efficacy of pulsatile perfusion in renal transplantationJesse D Schold
Department of Medicine, University of Florida, Gainesville, FL, USA
Am J Transplant 5:1681-8. 2005..Additional evidence of improvement in graft survival, particularly in more recent years, provides further encouraging evidence for the use of PP...
Access to quality: evaluation of the allocation of deceased donor kidneys for transplantationJesse D Schold
Department of Medicine, University of Florida, Gainesville, Florida 32610 0224, USA
J Am Soc Nephrol 16:3121-7. 2005..The extent to which these disparities are in line with broad policies of equity and potentially modifiable will have to be examined in the context of allocation policy...
Effect of sirolimus withdrawal in patients with deteriorating renal functionBruce Kaplan
University of Florida, Gainesville, FL 32610 0224, USA
Am J Transplant 4:1709-12. 2004..This strategy may be particularly useful in those patients where CNI withdrawal is considered to be of high immunologic or metabolic risk...
Long-term graft survival with neoral and tacrolimus: a paired kidney analysisBruce Kaplan
Department of Medicine, University of Florida, Gainesville, Florida 32610, USA
J Am Soc Nephrol 14:2980-4. 2003..Renal function was superior in the patients receiving initial tacrolimus therapy; however, slope of 1/Cr did not differ between the agents...
Half of kidney transplant candidates who are older than 60 years now placed on the waiting list will die before receiving a deceased-donor transplantJesse Schold
Department of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
Clin J Am Soc Nephrol 4:1239-45. 2009..Waiting times to deceased-donor transplantation (DDTx) have significantly increased in the past decade. This trend particularly affects older candidates given a high mortality rate on dialysis...
The broad spectrum of quality in deceased donor kidneysJesse D Schold
University of Florida, Gainesville, FL, USA
Am J Transplant 5:757-65. 2005....
Poor predictive value of serum creatinine for renal allograft lossBruce Kaplan
University of Florida College of Medicine, Gainesville, FL, USA
Am J Transplant 3:1560-5. 2003..While renal function is a strong risk factor and highly correlated with graft failure, the utility of renal function as a predictive tool for graft loss is limited...
Factors associated with long-term renal allograft survivalBruce Kaplan
Division of Nephrology, Shands University Hospital, University of Florida, Gainesville, Florida 32610 0224, USA
Ther Drug Monit 24:36-9. 2002....
The association of candidate mortality rates with kidney transplant outcomes and center performance evaluationsJesse D Schold
Department of Medicine, University of Florida, Gainesville, FL, USA
Transplantation 85:1-6. 2008..Pressures to enhance outcomes may lead centers to exclude high-risk but otherwise viable transplant candidates...
Treatment for BK virus: incidence, risk factors and outcomes for kidney transplant recipients in the United StatesJesse D Schold
Department of Medicine, University of Florida, Gainesville, FL 32610, USA
Transpl Int 22:626-34. 2009..Careful monitoring and further understanding of disease etiology and treatment strategies are needed...
Assessment of efficacy and safety of FK778 in comparison with standard care in renal transplant recipients with untreated BK nephropathyAntonio Guasch
Department of Medicine, Emory University, Atlanta, GA, USA
Transplantation 90:891-7. 2010..A safe and effective immunosuppressive agent that does not predispose to viral infection is needed in transplantation...
Interleukin 12 is associated with reduced relapse without increased incidence of graft-versus-host disease after allogeneic hematopoietic stem cell transplantationVijay Reddy
Division of Hematology Oncology, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
Biol Blood Marrow Transplant 11:1014-21. 2005..Patients with high pretransplantation IL-12 levels have an increased likelihood of higher posttransplantation IL-12 levels, possibly because of a host-graft interaction, and this may predispose to better clinical outcomes...
Increased levels of tumor necrosis factor alpha are associated with an increased risk of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantationVijay Reddy
University of Florida College of Medicine, Gainesville, FL 32610, USA
Biol Blood Marrow Transplant 11:698-705. 2005..017). In conclusion, a high posttransplantation TNF level is significantly associated with the risk for developing CMV infection. Early detection of high levels of TNF may be used to identify patients at high risk for developing CMV-Ag...
Renal function with cyclosporine C2 monitoring, enteric-coated mycophenolate sodium and basiliximab: a 12-month randomized trial in renal transplant recipientsDiane Cibrik
Department of Internal Medicine, Division of Nephrology, University of Michigan, Ann Arbor, MI 48109, USA
Clin Transplant 21:192-201. 2007....
Randomized calcineurin inhibitor cross over study to measure the pharmacokinetics of co-administered enteric-coated mycophenolate sodiumBruce Kaplan
Division of Nephrology, Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0224, USA
Clin Transplant 19:551-8. 2005..These observations should be taken into consideration when switching from one calcineurin inhibitor to another, but the final dosage should be based on both this pharmacokinetic data and the clinical situation...
Deceased donor kidney and liver transplantation to nonresident aliens in the United StatesJesse D Schold
Department of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
Transplantation 84:1548-56. 2007..The aim of the present study is to examine characteristics and allocation patterns for NRAs compared to U.S. citizens in the context of the two most common forms of solid organ transplantation...
Calcineurin inhibitors in kidney transplantation: friend or foe?Michael Jin Casey
Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida 32610 0224, USA
Curr Opin Nephrol Hypertens 20:610-5. 2011..In this review, we assess CNI efficacy as well as the latest strategies employed to limit long-term CNI nephrotoxicity...
Which renal transplant candidates should accept marginal kidneys in exchange for a shorter waiting time on dialysis?Jesse D Schold
Division of Nephrology, Hypertension, and Transplantation, Department of Medicine, College of Medicine, University of Florida, PO Box 100224, Gainesville, FL, USA
Clin J Am Soc Nephrol 1:532-8. 2006..These findings are important for transplant candidates and advocates decision-making and for potential further implementation in allocation policy...
The effects of renal transplantation on peripheral blood dendritic cellsKarl L Womer
Department of Medicine, University of Florida College of Medicine, Gainesville, FL, USA
Clin Transplant 19:659-67. 2005..Furthermore, PBDC monitoring may represent a novel strategy to predict important outcomes such as acute rejection, long-term graft loss and infectious complications...
The pivotal impact of center characteristics on survival of candidates listed for deceased donor kidney transplantationJesse D Schold
Department of Medicine, Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, Florida, USA
Med Care 47:146-53. 2009....
Improvement in hypercalcemia with cinacalcet after kidney transplantationTitte R Srinivas
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, FL 32610 0224, USA
Clin J Am Soc Nephrol 1:323-6. 2006..10). Graft function remained stable. Cinacalcet lowers SCa and raises SP in the short term in patients with persistent post-Tx hyperparathyroidism; long-term bone effects and persistent hyperparathyroidism merit further study...
Overview of large database analysis in renal transplantationBruce Kaplan
Department of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA
Am J Transplant 3:1052-6. 2003..We hope to present both a guide to investigators who are first embarking on large-scale database analysis and also to present a fair view of the utility and limitations of a potentially very useful research tool in renal transplantation...
Mycophenolate mofetil in solid-organ transplantationTitte R Srinivas
Division of Nephrology, Hypertension and Transplantation, University of Florida, 1600 SW Archer Road, Box 100224, Gainesville, FL 32610-0224, USA
Expert Opin Pharmacother 4:2325-45. 2003....
Effects of blood transfusions given after renal transplantationJuan C Scornik
Department of Pathology, University of Florida College of Medicine, Gainesville, FL 32610, USA
Transplantation 87:1381-6. 2009..However, antibodies can be induced by posttransplant blood transfusions rather than by the graft, casting doubts about the possible role of antibodies in a patient with graft dysfunction...
Minimizing immunosuppression, an alternative approach to reducing side effects: objectives and interim resultTitte R Srinivas
Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, Florida, USA
Clin J Am Soc Nephrol 3:S101-16. 2008..The long-term safety and efficacy of CNI and steroid minimization strategies needs to be further validated in controlled clinical trials with adequate long-term follow-up...
Uric acid levels have no significant effect on renal function in adult renal transplant recipients: evidence from the symphony studyHerwig Ulf Meier-Kriesche
Department of Medicine, University of Florida, Gainesville, Florida, USA
Clin J Am Soc Nephrol 4:1655-60. 2009..Renal transplantation is no exception, and limited information is available concerning the independent role of UA on progression of renal function in transplant recipients. DESIGN, SETTING, PARTICIPANTS, and..
Mycophenolate mofetil: long-term outcomes in solid organ transplantationTitte R Srinivas
University of Florida, 1600 SW Archer Road, Box 100224, Gainesville FL 32610 0224, USA
Expert Rev Clin Immunol 2:495-518. 2006....
The relationship between circulating natural killer cells after reduced intensity conditioning hematopoietic stem cell transplantation and relapse-free survival and graft-versus-host diseaseErin M Dunbar
Division of Hematology Oncology, Department of Medicine, University of Florida, Gainesville, Florida, USA
Haematologica 93:1852-8. 2008..We hypothesized that reconstituted circulating natural killer cells may be associated with improved relapse-free survival after HLA-matched hematopoietic stem cell transplantation...
Calcineurin inhibitor-free immunosuppression in kidney transplantationGiselle Guerra
Division of Nephrology, Hypertension and Transplantation, College of Medicine, University of Florida, Gainesville, FL 32610 0224, USA
Transpl Int 20:813-27. 2007..The long-term safety and efficacy of CNI withdrawal and avoidance strategies need to be further validated in controlled clinical trials...
Association between admission hyperglycemia and length of stay after renal transplantationSusmeeta Tewari
Department of Internal Medicine, University of Florida, Gainesville, Florida 32610 0226, USA
Endocr Pract 16:805-9. 2010..To compare length of stay, readmissions, infections, and mortality in patients with end-stage renal disease who have been admitted to receive renal transplant, stratified according to diabetes status and admission glucose concentration...
Effect of IVIG administration on complement activation and HLA antibody levelsTakafumi Machimoto
Department of Pathology, University of Florida College of Medicine, Gainesville, FL, USA
Transpl Int 23:1015-22. 2010..These results may explain the inconsistent results of IVIG to achieve desensitization...
Immunosuppressive strategies to improve outcomes of kidney transplantationIgnatius Y Tang
Transplantation Medicine, Section of Nephrology, Department of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
Semin Nephrol 27:377-92. 2007..We discuss the impact of various immunosuppressive regimens on the outcome measures of kidney transplantation: acute rejection episodes, allograft survival, and renal function...
Kidney-transplant rejection and anti-MICA antibodiesDuska Dragun
N Engl J Med 358:196; author reply 196. 2008
Renal transplantations performed using non-heart-beating organ donors: going back to the future?Steven M Rudich
Division of Transplant Surgery, University of Michigan Medical Center, Ann Arbor, MI, USA
Transplantation 74:1715-20. 2002..Donor age, recipient transplant number, female recipient, mechanism of injury, and DGF were the most pertinent variables leading to poor outcomes...
Interaction between donor and recipient age in determining the risk of chronic renal allograft failureHerwig-Ulf Meier-Kriesche
Department of Medicine, The University of Michigan, Ann Arbor, Michigan, USA
J Am Geriatr Soc 50:14-7. 2002..An overall additive and, in the long term (beyond 36 months posttransplant), synergistic deleterious effect on renal allograft survival was observed for the interaction of donor and recipient age...
Death after graft loss: an important late study endpoint in kidney transplantationBruce Kaplan
University of Florida, College of Medicine, Division of Nephrology, 1600 SW Archer Road, Gainesville, FL 32610-0224, USA
Am J Transplant 2:970-4. 2002....
Renal allograft survival in patients with oxalosisDiane M Cibrik
Department of Medicine, University of Michigan Health System, Ann Arbor, USA
Transplantation 74:707-10. 2002....
Should we be performing pancreas transplants?Herwig-Ulf Meier-Kriesche
Am J Transplant 4:1935-6. 2004
Renal transplantation: a half century of success and the long road aheadBruce Kaplan
J Am Soc Nephrol 15:3270-1. 2004
Pharmacokinetic principles of immunosuppressive drugsTitte R Srinivas
Department of Medicine, University of Florida, Gainesville, Florida, USA
Am J Transplant 5:207-17. 2005..In addition, we hope this review will help in understanding some of the basic drug interactions encountered in transplant practice...
Mycophenolate sodium does not reduce the incidence of GI adverse events compared with mycophenolate mofetilHerwig-Ulf Meier-Kriesche
Am J Transplant 5:1164; author reply 1165-6. 2005
Cyclosporine microemulsion and tacrolimus are associated with decreased chronic allograft failure and improved long-term graft survival as compared with sandimmuneHerwig-Ulf Meier-Kriesche
University of Michigan Health System, Department of Internal Medicine, Nephrology, Ann Arbor 48109-0364, USA
Am J Transplant 2:100-4. 2002..This association is independent of the use of MMF or changes in era...
The impact of mycophenolate mofetil on long-term outcomes in kidney transplantationTitte R Srinivas
Division of Nephrology, Hypertension, and Renal Transplantation, University of Florida, Gainesville, FL 32610, USA
Transplantation 80:S211-20. 2005..In coming years, these benefits will require reevaluation in the context of the growing use of novel protocols combining MMF with tacrolimus or sirolimus...
The impact of pretransplant dialysis on outcomes in renal transplantationHerwig-Ulf Meier-Kriesche
Department of Medicine, University of Florida, Gainesville, Florida 32610-0224, USA
Semin Dial 18:499-504. 2005..In fact, it is better to transplant patients preemptively than to wait until they reach ESRD and start dialysis...
Association of antibody induction with short- and long-term cause-specific mortality in renal transplant recipientsHerwig-Ulf Meier-Kriesche
Division of Nephrology, University of Florida, Gainesville, Florida 32610-0224, USA
J Am Soc Nephrol 13:769-72. 2002..In addition, ABI was associated with a significant risk for long-term malignancy-related death. The risk of ABI should be taken in context with potential benefits of this therapy...
The relationship between diabetes and infectious hospitalizations in renal transplant recipientsM Cecilia Lansang
Division of Endocrinology, University of Florida, Gainesville, USA
Diabetes Care 29:1659-60. 2006
No robust conclusions to be drawn from clinical trials in the absence of an adequate control groupHenrik Ekberg
Lund University, Malmo, Sweden
Transpl Int 20:25-6. 2007
Gastrointestinal side effects of mycophenolic acid in renal transplant patients: a reappraisalNeal M Davies
Nephrol Dial Transplant 22:2440-8. 2007..Thus, in order to reduce the risk of rejection and subsequent damage to the graft, it is important to consider other causes of GI events in renal transplant patients before altering immunosuppressive regimens...
Renal allograft survival in transplant recipients with focal segmental glomerulosclerosisDiane M Cibrik
Department of Medicine, University of Michigan, Ann Arbor, MI, USA
Am J Transplant 3:64-7. 2003..Zero mismatch LRD kidney transplants are not a risk factor for graft loss in FSGS patients but are associated with significantly better death-censored graft survival as compared to CAD 6-antigen match or mismatched donations...
Gender imbalance in living donor renal transplantationLiise K Kayler
Department of Surgery, University of Michigan Health System, Ann Arbor, MI 48109, USA
Transplantation 73:248-52. 2002..Strategies should be devised to ensure access for women to renal transplantation and to encourage and facilitate donation by men...
Response to "Sustained improvement of renal graft function for two years in hypertensive renal transplant recipients treated with nifedipine as compared with lisinopril"Titte R Srinivas
Transplantation 74:139; author reply 139-40. 2002
Obesity and kidney transplantationTitte R Srinivas
University of Florida, Gainesville, FL 32610-0224, USA
Contrib Nephrol 151:19-41. 2006..An approach to obesity in renal transplantation, based on the evidence to date, is presented...
