Ravindra Mehta

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Renal kallikrein excretion and epigenetics in human acute kidney injury: expression, mechanisms and consequences
    Sun Woo Kang
    Department of Nephrology, Inje University, Busan, South Korea
    BMC Nephrol 12:27. 2011
  2. ncbi Fluid accumulation, recognition and staging of acute kidney injury in critically-ill patients
    Etienne Macedo
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego San Diego, 200 West Arbor Drive, MC 8342, San Diego, CA 92103, USA
    Crit Care 14:R82. 2010
  3. ncbi Biomarker explorations in acute kidney injury: the journey continues
    Ravindra L Mehta
    Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, San Diego, California 92103, USA
    Kidney Int 80:332-4. 2011
  4. ncbi Acute renal failure definitions and classification: time for change?
    Ravindra L Mehta
    Divisions of Nephrology, Departments of Medicine, University of California San Diego for the PICARD Study Group, USA
    J Am Soc Nephrol 14:2178-87. 2003
  5. ncbi Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
    Ravindra L Mehta
    Department of Medicine, University of California San Diego Medical Center 8342, 200 W, Arbor Drive, San Diego, CA 92103, USA
    Crit Care 11:R31. 2007
  6. ncbi Continuous renal replacement therapy in the critically ill patient
    Ravindra L Mehta
    University of California, San Diego, San Diego, California, USA
    Kidney Int 67:781-95. 2005
  7. ncbi Urine IL-18 levels as a predictor of acute kidney injury in intensive care patients
    Ravindra L Mehta
    Division of Nephrology, Department of Medicine, University of California, San Diego, CA 92103, USA
    Nat Clin Pract Nephrol 2:252-3. 2006
  8. ncbi Acute kidney injury in critical care: time for a paradigm shift?
    Shamik H Shah
    Department of Medicine, University of California San Diego, San Diego, California, USA
    Curr Opin Nephrol Hypertens 15:561-5. 2006
  9. ncbi Controversies in acute kidney injury: effects of fluid overload on outcome
    Ravindra L Mehta
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA, USA
    Contrib Nephrol 174:200-11. 2011
  10. ncbi Glycemic control and critical illness: is the kidney involved?
    Ravindra L Mehta
    UCSD Medical Center 8342, 200 W Arbor Drive, San Diego, CA 92103, USA
    J Am Soc Nephrol 18:2623-7. 2007

Research Grants

  1. PREDICTING AND IMPROVING OUTCOMES IN ACUTE RENAL FAILURE
    Ravindra Mehta; Fiscal Year: 2001
  2. CLINICAL RESEARCH ENHANCEMENT FROM SUPPLEMENTAL TRAINING
    Ravindra Mehta; Fiscal Year: 2007

Collaborators

Detail Information

Publications61

  1. ncbi Renal kallikrein excretion and epigenetics in human acute kidney injury: expression, mechanisms and consequences
    Sun Woo Kang
    Department of Nephrology, Inje University, Busan, South Korea
    BMC Nephrol 12:27. 2011
    ..Therefore we first examined KLK1 renal excretion in human AKI, and then probed potential endocrine and epigenetic mechanisms for its alterations...
  2. ncbi Fluid accumulation, recognition and staging of acute kidney injury in critically-ill patients
    Etienne Macedo
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego San Diego, 200 West Arbor Drive, MC 8342, San Diego, CA 92103, USA
    Crit Care 14:R82. 2010
    ..We evaluated the effect of fluid accumulation on sCr to estimate severity of AKI...
  3. ncbi Biomarker explorations in acute kidney injury: the journey continues
    Ravindra L Mehta
    Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, San Diego, California 92103, USA
    Kidney Int 80:332-4. 2011
    ..Although these results are promising, several caveats need to be considered and applied for future confirmatory studies...
  4. ncbi Acute renal failure definitions and classification: time for change?
    Ravindra L Mehta
    Divisions of Nephrology, Departments of Medicine, University of California San Diego for the PICARD Study Group, USA
    J Am Soc Nephrol 14:2178-87. 2003
  5. ncbi Acute Kidney Injury Network: report of an initiative to improve outcomes in acute kidney injury
    Ravindra L Mehta
    Department of Medicine, University of California San Diego Medical Center 8342, 200 W, Arbor Drive, San Diego, CA 92103, USA
    Crit Care 11:R31. 2007
    ..We describe an initiative to develop uniform standards for defining and classifying AKI and to establish a forum for multidisciplinary interaction to improve care for patients with or at risk for AKI...
  6. ncbi Continuous renal replacement therapy in the critically ill patient
    Ravindra L Mehta
    University of California, San Diego, San Diego, California, USA
    Kidney Int 67:781-95. 2005
  7. ncbi Urine IL-18 levels as a predictor of acute kidney injury in intensive care patients
    Ravindra L Mehta
    Division of Nephrology, Department of Medicine, University of California, San Diego, CA 92103, USA
    Nat Clin Pract Nephrol 2:252-3. 2006
  8. ncbi Acute kidney injury in critical care: time for a paradigm shift?
    Shamik H Shah
    Department of Medicine, University of California San Diego, San Diego, California, USA
    Curr Opin Nephrol Hypertens 15:561-5. 2006
    ..This review summarizes the recent advances and provides an overview of emerging trends in this field...
  9. ncbi Controversies in acute kidney injury: effects of fluid overload on outcome
    Ravindra L Mehta
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA, USA
    Contrib Nephrol 174:200-11. 2011
    ..It is unclear whether fluid retention is simply a marker of the severity of organ failure or a mediator of events. In this article we review the evidence and provide a framework for future studies to refine these concepts further...
  10. ncbi Glycemic control and critical illness: is the kidney involved?
    Ravindra L Mehta
    UCSD Medical Center 8342, 200 W Arbor Drive, San Diego, CA 92103, USA
    J Am Soc Nephrol 18:2623-7. 2007
    ..The development of acute kidney injury is also a risk in this setting. This article discusses potential approaches for efficient and effective management of hyperglycemia...
  11. ncbi Pharmacologic approaches for volume excess in acute kidney injury (AKI)
    R L Mehta
    Division of Nephrology, University of California San Diego, San Diego, CA 92103, USA
    Int J Artif Organs 31:127-44. 2008
    ..This report details our current knowledge in this area, provides evidence-based clinical practice recommendations where appropriate, and formulates a research agenda to address unanswered questions...
  12. ncbi Timed and targeted therapy for acute kidney injury: a glimpse of the future
    Ravindra L Mehta
    Division of Nephrology and Hypertension, Department of Medicine, University of California, San Diego, California, USA
    Kidney Int 77:947-9. 2010
    ..Biomarkers are emerging to define the course of acute kidney injury and offer an opportunity to provide targeted interventions. The EARLYARF study by Endre et al. provides a glimpse of the challenges and opportunities that lie ahead...
  13. ncbi Effluent volume in continuous renal replacement therapy overestimates the delivered dose of dialysis
    Rolando Claure-Del Granado
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, California, USA
    Clin J Am Soc Nephrol 6:467-75. 2011
    ..Because filter fouling can reduce the efficacy of solute clearance, the actual delivered dose may be substantially lower than the observed effluent rate...
  14. ncbi Sepsis as a cause and consequence of acute kidney injury: Program to Improve Care in Acute Renal Disease
    Ravindra L Mehta
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, 200 W Arbor Drive, San Diego, CA 92103, USA
    Intensive Care Med 37:241-8. 2011
    ..This study examined the incidence of, and outcomes associated with, sepsis developing after AKI...
  15. ncbi Outcomes research in acute renal failure
    Ravindra L Mehta
    Department of Medicine, University of California, San Diego, CA, USA
    Semin Nephrol 23:283-94. 2003
    ..This article provides a critical appraisal of outcomes research in ARF and describes an approach for selecting appropriate endpoints for future clinical research in ARF...
  16. ncbi Current status of renal replacement therapy for acute renal failure. A survey of US nephrologists. The National Kidney Foundation Council on Dialysis
    R L Mehta
    University of California, San Diego, CA 92103, USA
    Am J Nephrol 19:377-82. 1999
    ..This article describes the results of this survey and provides a snapshot of the current management practices for ARF. It is our hope that this information will provide a baseline for further research in this area...
  17. ncbi A randomized clinical trial of continuous versus intermittent dialysis for acute renal failure
    R L Mehta
    Department of Medicine, University of California, San Diego, USA
    Kidney Int 60:1154-63. 2001
    ..Continuous hemodialysis and hemofiltration techniques have recently emerged as alternative modalities. These two therapies have not been directly compared...
  18. ncbi Techniques for assessing and achieving fluid balance in acute renal failure
    Ravindra L Mehta
    Department of Medicine, Division of Nephrology, University of California, San Diego, California, USA
    Curr Opin Crit Care 8:535-43. 2002
    ..This article provides an overview of the concept of fluid management in the critically ill patient with acute renal failure...
  19. ncbi Refining predictive models in critically ill patients with acute renal failure
    Ravindra L Mehta
    Division of Nephrology, University of California, San Diego Medical Center, San Diego, California 92103, USA
    J Am Soc Nephrol 13:1350-7. 2002
    ..Cross-validation of the model and additional bedside experience will be needed before it can be effectively applied across centers, particularly in the context of clinical trials...
  20. ncbi Nephrology consultation in acute renal failure: does timing matter?
    Ravindra L Mehta
    Division of Nephrology, Department of Medicine, University of California, San Diego, California, USA
    Am J Med 113:456-61. 2002
    ..The goals of this study were to identify correlates of the timing of nephrology consultation in acute renal failure, and to explore the relation between timing of consultation and outcomes...
  21. ncbi Randomized controlled study of extracorporeal albumin dialysis for hepatic encephalopathy in advanced cirrhosis
    Tarek I Hassanein
    Department of Medicine, University of California, San Diego, CA 92103 8707, USA
    Hepatology 46:1853-62. 2007
    ..Because this 5-day study was not designed to examine the impact of MARS on survival, a full assessment of the role of albumin dialysis awaits the results of additional controlled trials...
  22. ncbi Renal replacement therapy for acute renal failure
    E Macedo
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA, USA
    Minerva Urol Nefrol 61:189-204. 2009
    ..This review outlines current concepts in the use of dialysis techniques for AKI and suggests an approach for selecting the optimal method of renal replacement therapy...
  23. ncbi Acid-base disturbances in the intensive care unit: current issues and the use of continuous renal replacement therapy as a customized treatment tool
    J Bouchard
    Division of Nephrology, Department of Medicine, University of California San Diego, California USA
    Int J Artif Organs 31:6-14. 2008
    ..The use of CRRT as a customized therapy for acid-base disorders is discussed, allowing an integration of both physiological and technical concepts...
  24. ncbi Mortality after acute renal failure: models for prognostic stratification and risk adjustment
    G M Chertow
    Department of Medicine Research, Division of Nephrology, University of California San Francisco, San Francisco, California, USA
    Kidney Int 70:1120-6. 2006
    ..By incorporating exposures over time, the discriminatory power of predictive models in ARF can be significantly improved...
  25. ncbi Prerenal azotemia in congestive heart failure
    Etienne Macedo
    University of California San Diego, San Diego, Calif, USA
    Contrib Nephrol 164:79-87. 2010
    ..Achieving a consensus definition for prerenal syndrome will allow physicians to describe treatments and interventions as well as conduct and compare epidemiological studies in order to better describe the implications of this syndrome...
  26. ncbi The molecular adsorbents recycling system as a liver support system based on albumin dialysis: a summary of preclinical investigations, prospective, randomized, controlled clinical trial, and clinical experience from 19 centers
    Jan Stange
    Division of Gastroenterology, Hepatology, UCSD Medical Center, San Diego, California 92103 8413, USA
    Artif Organs 26:103-10. 2002
    ..MARS has been used in 26 patients with acute liver failure or primary graft dysfunction. Nineteen centers reporting on 103 patients have shown that MARS treatment is safe, easy to handle, feasible, and effective...
  27. ncbi Defining urine output criterion for acute kidney injury in critically ill patients
    Etienne Macedo
    Department of Medicine, University of California San Diego, San Diego, CA, USA
    Nephrol Dial Transplant 26:509-15. 2011
    ..Additionally, we assessed various definitions of oliguria to determine whether measurement of urine output using a fixed 6-h interval that matches nurses' shifts would be equivalent to the current standard for AKI diagnosis and staging...
  28. ncbi Clinical benefit and approach of ultrafiltration in acute heart failure
    A Sharma
    Division of Nephrology, University of California, San Diego, CA 92103, USA
    Cardiology 96:144-54. 2001
    ....
  29. ncbi Assessing fluid change in hemodialysis: whole body versus sum of segmental bioimpedance spectroscopy
    T Chanchairujira
    Nephrology Division, Department of Medicine, University of California San Diego Medical Center, San Diego, California 92103, USA
    Kidney Int 60:2337-42. 2001
    ..More studies are needed to evaluate the benefit of SBIS over WBIS in clinical practice...
  30. ncbi Comparison of methods for estimating glomerular filtration rate in critically ill patients with acute kidney injury
    Josee Bouchard
    Division of Nephrology and Hypertension, Department of Medicine, University of California San Diego, San Diego, CA, USA
    Nephrol Dial Transplant 25:102-7. 2010
    ....
  31. ncbi Mechanical ventilation and renal function: an area for concern?
    Neesh Pannu
    Department of Medicine, Division of Nephrology, University of California, San Diego, USA
    Am J Kidney Dis 39:616-24. 2002
    ..This review compiles the information in this area and provides a framework for future investigation in this field...
  32. ncbi Plasma cytokine levels predict mortality in patients with acute renal failure
    Edith M Simmons
    Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    Kidney Int 65:1357-65. 2004
    ..Strategies to modulate inflammation must take into account the complex cytokine biology in patients with established ARF...
  33. ncbi Timing of initiation of dialysis in critically ill patients with acute kidney injury
    Kathleen D Liu
    Division of Nephrology, Department of Medicine, University of California San Francisco, USA
    Clin J Am Soc Nephrol 1:915-9. 2006
    ..Although the results could reflect residual confounding by severity of illness, they provide a rationale for prospective testing of alternative dialysis initiation strategies in critically ill patients with severe AKI...
  34. ncbi Insulin resistance in critically ill patients with acute renal failure
    Seema Basi
    Department of Medicine, Division of Nephrology, Vanderbilt University Medical Center, Nashville, TN 37232-2372, USA
    Am J Physiol Renal Physiol 289:F259-64. 2005
    ..Insulin resistance as defined by hyperglycemia in the setting of higher insulin concentrations may be associated with mortality in critically ill patients with ARF. The IGF-IGFBP axis may play an important role in this process...
  35. ncbi Diuretics, mortality, and nonrecovery of renal function in acute renal failure
    Ravindra L Mehta
    Division of Nephrology, University of California, San Diego, Medical Center, USA
    JAMA 288:2547-53. 2002
    ..In the absence of compelling contradictory data from a randomized, blinded clinical trial, the widespread use of diuretics in critically ill patients with acute renal failure should be discouraged...
  36. ncbi Dialysis modalities in the intensive care unit
    Omaran Abdeen
    Division of Nephrology and Hypertension, University of California, San Diego Medical Center, 8342, 200 West Arbor Drive, San Diego, CA 92103, USA
    Crit Care Clin 18:223-47. 2002
    ..Newer therapies aimed at more optimal and more specific blood purification may prove promising in the management of complex critically ill patients with ARF and other comorbid conditions...
  37. ncbi Reasons for non-enrollment in a cohort study of ARF: the Program to Improve Care in Acute Renal Disease (PICARD) experience and implications for a clinical trials network
    Glenn M Chertow
    Department of Medicine Research, University of California San Francisco, San Francisco, CA 94118 1211, USA
    Am J Kidney Dis 42:507-12. 2003
    ..Previous clinical trials of ARF have been hampered by the heterogeneous population affected, difficulty defining ARF, delays in identification of ARF, and significant comorbid conditions, among other factors...
  38. ncbi Spectrum of acute renal failure in the intensive care unit: the PICARD experience
    Ravindra L Mehta
    Division of Nephrology, Department of Medicine, University of California San Diego, San Diego, California, USA
    Kidney Int 66:1613-21. 2004
    ..There is wide variation across institutions in patient characteristics and practice patterns. These differences highlight the need for additional multicenter observational and interventional studies in ARF...
  39. ncbi Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group
    Rinaldo Bellomo
    Department of Intensive Care and Medicine, Austin Health, Melbourne, Australia
    Crit Care 8:R204-12. 2004
    ..Accordingly, we sought to review the available evidence, make recommendations and delineate key questions for future studies...
  40. ncbi Improving outcomes from acute kidney injury
    Bruce A Molitoris
    J Am Soc Nephrol 18:1992-4. 2007
  41. ncbi The first international consensus conference on continuous renal replacement therapy
    John A Kellum
    Department of Critical Care Medicine and Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Kidney Int 62:1855-63. 2002
    ..We sought to review the available evidence, make evidence-based practice recommendations, and delineate key questions for future study...
  42. ncbi Effect of mechanical ventilation on the kidney
    Neesh Pannu
    Division of Nephrology, Department of Medicine, University of Alberta, 11 108B, 8440 112 Street Edmonton, Alta, Canada T6G 2G3
    Best Pract Res Clin Anaesthesiol 18:189-203. 2004
    ..This chapter reviews the information in these areas and provides a framework for future investigation in this field...
  43. ncbi Acute renal failure and cardiac surgery: marching in place or moving ahead?
    Ravindra L Mehta
    J Am Soc Nephrol 16:12-4. 2005
  44. ncbi Acid-base and electrolyte management in continuous renal replacement therapy
    Ravindra L Mehta
    Division of Nephrology, Department of Medicine, University of California San Diego Medical Center, San Diego, CA 92103 8342, USA
    Blood Purif 20:262-8. 2002
    ..This article provides an overview of the principles of acid-base and electrolyte management with continuous renal replacement therapy...
  45. ncbi Improving outcomes of acute kidney injury: report of an initiative
    Bruce A Molitoris
    Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Nat Clin Pract Nephrol 3:439-42. 2007
    ..These proposed standards will need to be validated in future studies, a process that will be facilitated by the Acute Kidney Injury Network, which offers a forum that encourages acquisition of knowledge to improve patient outcomes...
  46. ncbi Hemodialysis access assessment with intravascular ultrasound
    Armin Arbab-Zadeh
    University of California, San Diego; and the San Diego Veterans Affairs Health Care System, San Diego, CA 92161, USA
    Am J Kidney Dis 39:813-23. 2002
    ..IVUS detected more vascular abnormalities than angiography. IVUS may be a useful independent imaging and screening modality in the assessment of dialysis access complications, which may help increase graft patency and reduce cost...
  47. ncbi Emerging therapies for extracorporeal support
    Josee Bouchard
    University of California at San Diego, San Diego, CA 92103, USA
    Nephron Physiol 109:p85-91. 2008
    ..This article reviews the mechanisms, advantages and limitations of these techniques along with the current evidence available regarding their influence on major clinical outcomes...
  48. ncbi Renal replacement therapy in acute kidney injury: intermittent versus continuous? How much is enough?
    Josee Bouchard
    Department of Medicine, Division of Nephrology, University of California San Diego, San Diego, CA, USA
    Adv Chronic Kidney Dis 15:235-47. 2008
    ....
  49. ncbi Improving outcomes from acute kidney injury: report of an initiative
    Arvind Bagga
    Pediatr Nephrol 22:1655-8. 2007
    ..The vital role of multi-disciplinary conferences for disseminating knowledge and clarifying issues in clinical practice was recognized...
  50. ncbi Improving outcomes from acute kidney injury: report of an initiative
    Adeera Levin
    Am J Kidney Dis 50:1-4. 2007
  51. ncbi Comparing dialysis modalities for critically ill patients: are we barking up the wrong tree?
    Ravindra L Mehta
    Clin J Am Soc Nephrol 2:413-4. 2007
  52. ncbi Development of a clinical research agenda for acute kidney injury using an international, interdisciplinary, three-step modified Delphi process
    John A Kellum
    Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Scaife Hall, Room 608, 3550 Terrace Street, Pittsburgh, PA 15261, USA
    Clin J Am Soc Nephrol 3:887-94. 2008
    ..An international, consensus-based, prioritized research agenda was sought to guide clinical and translational research in acute kidney injury...
  53. ncbi Delivery of renal replacement therapy in acute kidney injury: what are the key issues?
    Andrew Davenport
    UCL Center for Nephrology, Royal Free and University College Medical School, Hampstead Campus, Rowland Hill Street, London NW3 2PF, UK
    Clin J Am Soc Nephrol 3:869-75. 2008
    ..Although several observational and interventional studies have addressed these topics, there are no consensus recommendations in this field...
  54. ncbi Survival by dialysis modality in critically ill patients with acute kidney injury
    Kerry C Cho
    Division of Nephrology, Department of Medicine, University of California San Francisco, San Francisco, CA 94118, USA
    J Am Soc Nephrol 17:3132-8. 2006
    ..Larger, prospective, randomized clinical trials to compare CRRT and IHD in severe AKI are needed...
  55. ncbi Economic and health consequences of selling a kidney in India
    Madhav Goyal
    Department of Internal Medicine, Geisinger Health System, 200 Scenery Dr, State College, PA 16801, USA
    JAMA 288:1589-93. 2002
    ..However, whether individuals who sell their kidneys actually benefit from the sale is controversial...
  56. ncbi Timing of initiation and discontinuation of renal replacement therapy in AKI: unanswered key questions
    Noel Gibney
    Division of Critical Care Medicine, 3C1 16 University of Alberta Hospital, 8440 112 Street, Edmonton, AB, Canada T6G 2B7
    Clin J Am Soc Nephrol 3:876-80. 2008
    ....
  57. ncbi Acute kidney injury: toward an integrated understanding through development of a research agenda
    Adeera Levin
    Division of Nephrology UBC, St. Pauls Hospital, Providence Wing, Room 6010A, 1160 Burrard Street, Vancouver BC, V6Z1Y8, Canada
    Clin J Am Soc Nephrol 3:862-3. 2008
  58. ncbi From acute renal failure to acute kidney injury: emerging concepts
    Ravindra L Mehta
    Crit Care Med 36:1641-2. 2008
  59. ncbi In critically ill patients with acute renal failure, outcomes, not dollars, should drive modality choice
    Ravindra L Mehta
    Crit Care Med 31:644-6. 2003
  60. ncbi Dialysis dosage in acute kidney injury: still a conundrum?
    Ravindra L Mehta
    J Am Soc Nephrol 19:1046-8. 2008

Research Grants7

  1. PREDICTING AND IMPROVING OUTCOMES IN ACUTE RENAL FAILURE
    Ravindra Mehta; Fiscal Year: 2001
    ..It is anticipated (by the applicants) that information gained from this study, being largely observational, will be used to rationally design intervention strategies in future years. ..
  2. CLINICAL RESEARCH ENHANCEMENT FROM SUPPLEMENTAL TRAINING
    Ravindra Mehta; Fiscal Year: 2007
    ..IOur goal is to ensure that scholars emerging from this program will have the fundamental skills Inecessary for independent clinical research. ..