Parmender P Mehta

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. pmc MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells
    Pallavi Chaturvedi
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Cancer Res 68:2065-70. 2008
  2. ncbi request reprint Introduction: a tribute to cell-to-cell channels
    Parmender P Mehta
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Membr Biol 217:5-12. 2007
  3. pmc Phosphorylation on Ser-279 and Ser-282 of connexin43 regulates endocytosis and gap junction assembly in pancreatic cancer cells
    Kristen E Johnson
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Mol Biol Cell 24:715-33. 2013
  4. pmc Assembly of connexin43 into gap junctions is regulated differentially by E-cadherin and N-cadherin in rat liver epithelial cells
    Rajgopal Govindarajan
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Mol Biol Cell 21:4089-107. 2010
  5. pmc Retinoids regulate the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells
    Linda Kelsey
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e32846. 2012
  6. pmc E-cadherin differentially regulates the assembly of Connexin43 and Connexin32 into gap junctions in human squamous carcinoma cells
    Souvik Chakraborty
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Biol Chem 285:10761-76. 2010
  7. doi request reprint Improvement of cytotoxic effects induced by mitoxantrone on hormone-refractory metastatic prostate cancer cells by co-targeting epidermal growth factor receptor and hedgehog signaling cascades
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, College of Medicine, Eppley Institute of Cancer and Allied Diseases, 985870 University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Growth Factors 25:400-16. 2007
  8. pmc Functions of normal and malignant prostatic stem/progenitor cells in tissue regeneration and cancer progression and novel targeting therapies
    Murielle Mimeault
    and Surinder K Batra, Ph D, Department of Biochemistry and Molecular Biology, Eppley Institute for Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Endocr Rev 29:234-52. 2008
  9. pmc Androgen-regulated formation and degradation of gap junctions in androgen-responsive human prostate cancer cells
    Shalini Mitra
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Mol Biol Cell 17:5400-16. 2006
  10. ncbi request reprint Impaired trafficking of connexins in androgen-independent human prostate cancer cell lines and its mitigation by alpha-catenin
    Rajgopal Govindarajan
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Biol Chem 277:50087-97. 2002

Research Grants

Collaborators

Detail Information

Publications10

  1. pmc MUC4 mucin interacts with and stabilizes the HER2 oncoprotein in human pancreatic cancer cells
    Pallavi Chaturvedi
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Cancer Res 68:2065-70. 2008
    ..Our findings add a new dimension to MUC4 function as a modulator of cell signaling and provide mechanistic evidence for its role in pancreatic cancer progression...
  2. ncbi request reprint Introduction: a tribute to cell-to-cell channels
    Parmender P Mehta
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Membr Biol 217:5-12. 2007
  3. pmc Phosphorylation on Ser-279 and Ser-282 of connexin43 regulates endocytosis and gap junction assembly in pancreatic cancer cells
    Kristen E Johnson
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Mol Biol Cell 24:715-33. 2013
    ..Thus the differential phosphorylation of Cx43 on Ser-279 and Ser-282 is fine-tuned to control Cx43's endocytosis and assembly into gap junctions...
  4. pmc Assembly of connexin43 into gap junctions is regulated differentially by E-cadherin and N-cadherin in rat liver epithelial cells
    Rajgopal Govindarajan
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Mol Biol Cell 21:4089-107. 2010
    ....
  5. pmc Retinoids regulate the formation and degradation of gap junctions in androgen-responsive human prostate cancer cells
    Linda Kelsey
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 7:e32846. 2012
    ..Thus, the effects of retinoids and androgens on growth and the formation and degradation of gap junctions and their function might be related to their ability to modulate prostate growth and cancer...
  6. pmc E-cadherin differentially regulates the assembly of Connexin43 and Connexin32 into gap junctions in human squamous carcinoma cells
    Souvik Chakraborty
    Department of Biochemistry and Molecular Biology, Eppley Institute for Research in Cancer and Allied Diseases, Eppley Cancer Center, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Biol Chem 285:10761-76. 2010
    ....
  7. doi request reprint Improvement of cytotoxic effects induced by mitoxantrone on hormone-refractory metastatic prostate cancer cells by co-targeting epidermal growth factor receptor and hedgehog signaling cascades
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, College of Medicine, Eppley Institute of Cancer and Allied Diseases, 985870 University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Growth Factors 25:400-16. 2007
    ....
  8. pmc Functions of normal and malignant prostatic stem/progenitor cells in tissue regeneration and cancer progression and novel targeting therapies
    Murielle Mimeault
    and Surinder K Batra, Ph D, Department of Biochemistry and Molecular Biology, Eppley Institute for Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Endocr Rev 29:234-52. 2008
    ....
  9. pmc Androgen-regulated formation and degradation of gap junctions in androgen-responsive human prostate cancer cells
    Shalini Mitra
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Mol Biol Cell 17:5400-16. 2006
    ....
  10. ncbi request reprint Impaired trafficking of connexins in androgen-independent human prostate cancer cell lines and its mitigation by alpha-catenin
    Rajgopal Govindarajan
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Biol Chem 277:50087-97. 2002
    ..Our results suggest that impaired trafficking, and not the inability to form gap junctions, is the major cause of communication deficiency in human prostate cancer cell lines...

Research Grants7

  1. GAP JUNCTIONS AND CELL INTERACTIONS IN PROSTATE CANCER
    Parmender Mehta; Fiscal Year: 2002
    ..Such experiments should enhance our knowledge about the pathobiology of prostate cancer. ..
  2. Communication and Chemoprevention of Prostate Cancer
    Parmender Mehta; Fiscal Year: 2009
    ..abstract_text> ..