Nehal N Mehta

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc A human model of inflammatory cardio-metabolic dysfunction; a double blind placebo-controlled crossover trial
    Nehal N Mehta
    Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    J Transl Med 10:124. 2012
  2. pmc Abnormal lipoprotein particles and cholesterol efflux capacity in patients with psoriasis
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania School of Medicine, USA
    Atherosclerosis 224:218-21. 2012
  3. pmc Attributable risk estimate of severe psoriasis on major cardiovascular events
    Nehal N Mehta
    Preventive Cardiology, Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Med 124:775.e1-6. 2011
  4. pmc Usefulness of insulin resistance estimation and the metabolic syndrome in predicting coronary atherosclerosis in type 2 diabetes mellitus
    Nehal N Mehta
    Cardiovascular Institute, Philadelphia, Pennsylvania, USA
    Am J Cardiol 107:406-11. 2011
  5. pmc The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels
    Nehal N Mehta
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Penn Tower, 6th Floor, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA
    Eur Heart J 32:963-71. 2011
  6. pmc Systemic and vascular inflammation in patients with moderate to severe psoriasis as measured by [18F]-fluorodeoxyglucose positron emission tomography-computed tomography (FDG-PET/CT): a pilot study
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania School of Medicine, 6 Penn Tower, Philadelphia, PA 19104, USA
    Arch Dermatol 147:1031-9. 2011
  7. pmc Experimental endotoxemia induces adipose inflammation and insulin resistance in humans
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 59:172-81. 2010
  8. pmc Relation of plasma fatty acid binding proteins 4 and 5 with the metabolic syndrome, inflammation and coronary calcium in patients with type-2 diabetes mellitus
    Roshanak Bagheri
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Cardiol 106:1118-23. 2010
  9. pmc Race and gender variation in response to evoked inflammation
    Jane F Ferguson
    Cardiovascular Institute, Perelman School of Medicine, at the University of Pennsylvania, 11 136 Smilow Center for Translational Research, Building 421, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Transl Med 11:63. 2013
  10. doi request reprint Measurement of waist circumference predicts coronary atherosclerosis beyond plasma adipokines
    Subhasish Bose
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 21:E118-23. 2013

Detail Information

Publications39

  1. pmc A human model of inflammatory cardio-metabolic dysfunction; a double blind placebo-controlled crossover trial
    Nehal N Mehta
    Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA
    J Transl Med 10:124. 2012
    ....
  2. pmc Abnormal lipoprotein particles and cholesterol efflux capacity in patients with psoriasis
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania School of Medicine, USA
    Atherosclerosis 224:218-21. 2012
    ..We sought to study how chronic in vivo inflammation modulates lipoprotein particle composition using nuclear magnetic resonance spectroscopy (NMR) and HDL efflux in psoriasis...
  3. pmc Attributable risk estimate of severe psoriasis on major cardiovascular events
    Nehal N Mehta
    Preventive Cardiology, Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, USA
    Am J Med 124:775.e1-6. 2011
    ..We compared the risk of major adverse cardiac events between patients with psoriasis and the general population and estimated the attributable risk of severe psoriasis...
  4. pmc Usefulness of insulin resistance estimation and the metabolic syndrome in predicting coronary atherosclerosis in type 2 diabetes mellitus
    Nehal N Mehta
    Cardiovascular Institute, Philadelphia, Pennsylvania, USA
    Am J Cardiol 107:406-11. 2011
    ....
  5. pmc The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels
    Nehal N Mehta
    Penn Cardiovascular Institute, University of Pennsylvania School of Medicine, Penn Tower, 6th Floor, 3400 Civic Center Blvd, Philadelphia, PA 19104, USA
    Eur Heart J 32:963-71. 2011
    ..Therefore, we examined the relationship between these two SNPs and plasma CXCL12 levels...
  6. pmc Systemic and vascular inflammation in patients with moderate to severe psoriasis as measured by [18F]-fluorodeoxyglucose positron emission tomography-computed tomography (FDG-PET/CT): a pilot study
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania School of Medicine, 6 Penn Tower, Philadelphia, PA 19104, USA
    Arch Dermatol 147:1031-9. 2011
    ..To evaluate the feasibility of using [18F]-fluorodeoxyglucose positron emission tomography-computed tomography (FDG-PET/CT) to detect and quantify systemic inflammation in patients with psoriasis...
  7. pmc Experimental endotoxemia induces adipose inflammation and insulin resistance in humans
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 59:172-81. 2010
    ..This study sought to explore potential mechanisms of inflammatory-induced IR in humans with a focus on adipose tissue...
  8. pmc Relation of plasma fatty acid binding proteins 4 and 5 with the metabolic syndrome, inflammation and coronary calcium in patients with type-2 diabetes mellitus
    Roshanak Bagheri
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Am J Cardiol 106:1118-23. 2010
    ..These findings suggest that FABP4 and FABP5 may represent mediators of and biomarkers for metabolic and cardiovascular disease in type 2 diabetes mellitus...
  9. pmc Race and gender variation in response to evoked inflammation
    Jane F Ferguson
    Cardiovascular Institute, Perelman School of Medicine, at the University of Pennsylvania, 11 136 Smilow Center for Translational Research, Building 421, 3400 Civic Center Boulevard, Philadelphia, PA 19104, USA
    J Transl Med 11:63. 2013
    ..Our objective was to examine race and gender influence on the response to experimental endotoxemia...
  10. doi request reprint Measurement of waist circumference predicts coronary atherosclerosis beyond plasma adipokines
    Subhasish Bose
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Obesity (Silver Spring) 21:E118-23. 2013
    ..The association of plasma adipokines beyond waist circumference (WC) with coronary artery calcification (CAC), a measure of subclinical atherosclerosis, is unknown...
  11. pmc Fractalkine is a novel human adipochemokine associated with type 2 diabetes
    Rachana Shah
    Division of Pediatric Endocrinology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 60:1512-8. 2011
    ..Fractalkine (CX3CL1) and its receptor (CX3CR1) comprise a chemokine system involved in leukocyte recruitment and adhesion in atherosclerosis, but its role in adipose inflammation and type 2 diabetes is unknown...
  12. pmc Lipoprotein(a) is strongly associated with coronary artery calcification in type-2 diabetic women
    Atif N Qasim
    Department of Medicine, Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States
    Int J Cardiol 150:17-21. 2011
    ..The purpose of this study was to investigate whether type-2 diabetic subjects, relative to non-diabetics, might benefit more from Lp(a) measurement in the prediction of CHD risk, as measured by coronary artery calcium (CAC)...
  13. pmc Apolipoprotein B but not LDL cholesterol is associated with coronary artery calcification in type 2 diabetic whites
    Seth S Martin
    Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes 58:1887-92. 2009
    ..We investigated the hypothesis that apoB is a superior marker of CAC relative to LDL cholesterol...
  14. pmc Comparison of high-density lipoprotein cholesterol to apolipoprotein A-I and A-II to predict coronary calcium and the effect of insulin resistance
    Seth S Martin
    Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, USA
    Am J Cardiol 107:393-8. 2011
    ..In conclusion, HDL cholesterol outperformed apoA-I and apoA-II in CAC prediction, but its association with CAC was attenuated by measures of insulin resistance...
  15. pmc Adipose genes down-regulated during experimental endotoxemia are also suppressed in obesity
    Rachana Shah
    Division of Endocrinology and Diabetes at the Children s Hospital of Philadelphia, 11NW Tower, 34th and Civic Center Boulevard, Philadelphia, Pennsylvania 19104, USA
    J Clin Endocrinol Metab 97:E2152-9. 2012
    ..Adipose inflammation is a crucial link between obesity and its metabolic complications. Human experimental endotoxemia is a controlled model for the study of inflammatory cardiometabolic responses in vivo...
  16. pmc Association of lower plasma fetuin-a levels with peripheral arterial disease in type 2 diabetes
    Luis H Eraso
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Diabetes Care 33:408-10. 2010
    ..Fetuin-A is an inhibitor of vascular calcification and a mediator of insulin resistance. This study evaluated the association of plasma fetuin-A and peripheral arterial disease (PAD)...
  17. pmc Prevalence of metabolic syndrome in patients with psoriasis: a population-based study in the United Kingdom
    Sinead M Langan
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK
    J Invest Dermatol 132:556-62. 2012
    ..These findings suggest that screening for metabolic disease should be considered for psoriasis, especially when it is severe...
  18. pmc Type 2 diabetes does not attenuate racial differences in coronary calcification
    Alisha N Wade
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6160, United States
    Diabetes Res Clin Pract 91:101-7. 2011
    ..We investigated the relationship of race and CAC in a sample of patients with type 2 diabetes without clinical CVD...
  19. pmc Inflammation modulates human HDL composition and function in vivo
    Margarita de la Llera Moya
    Division of Gastroenterology, Hepatology and Nutrition, Children s Hospital of Philadelphia, Philadelphia, PA, USA
    Atherosclerosis 222:390-4. 2012
    ..Inflammation may directly impair HDL functions, in particular reverse cholesterol transport (RCT), but limited data support this concept in humans...
  20. pmc Translational studies of lipoprotein-associated phospholipase A₂ in inflammation and atherosclerosis
    Jane F Ferguson
    Cardiovascular Institute, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6160, USA
    J Am Coll Cardiol 59:764-72. 2012
    ..This study sought to examine the role of lipoprotein-associated phospholipase A₂ (Lp-PLA₂/PLA2G7) in human inflammation and coronary atherosclerosis...
  21. pmc Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the General Practice Research Database
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Eur Heart J 31:1000-6. 2010
    ..We conducted a cohort study using the General Practice Research Database to determine if severe psoriasis patients have an increased risk of cardiovascular (CV) mortality...
  22. pmc Gender differences in the association of C-reactive protein with coronary artery calcium in type-2 diabetes
    Atif N Qasim
    The Cardiovascular Institute, University of Pennsylvania School of Medicine, Philadelphia, USA
    Clin Endocrinol (Oxf) 74:44-50. 2011
    ..Whether CRP has value as a CVD risk marker in type-2 diabetes (T2DM) is unclear. We examined whether CRP has gender differences in association with coronary artery calcium (CAC) in diabetic and nondiabetic samples without clinical CVD...
  23. pmc Adipokines, insulin resistance, and coronary artery calcification
    Atif Qasim
    Cardiovascular Institute and Institute for Translational Medicine and Therapeutics, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    J Am Coll Cardiol 52:231-6. 2008
    ..In addition, we assessed which biomarkers of adiposity and insulin resistance are the strongest predictors of CAC beyond traditional risk factors, metabolic syndrome, and plasma C-reactive protein (CRP)...
  24. doi request reprint Delayed time-point 18F-FDG PET CT imaging enhances assessment of atherosclerotic plaque inflammation
    Björn A Blomberg
    Perelman School of Medicine at the University of Pennsylvania, USA
    Nucl Med Commun 34:860-7. 2013
    ..The aim of this study was to determine the ideal circulation time of fluorine-18 fluorodeoxyglucose (F-FDG) in order to detect and quantify atherosclerotic plaque inflammation with PET computed tomography (CT) imaging...
  25. doi request reprint Candidate gene association study of coronary artery calcification in chronic kidney disease: findings from the CRIC study (Chronic Renal Insufficiency Cohort)
    Jane F Ferguson
    Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania
    J Am Coll Cardiol 62:789-98. 2013
    ..This study sought to identify loci for coronary artery calcification (CAC) in patients with chronic kidney disease (CKD)...
  26. pmc Aortic vascular inflammation in psoriasis is associated with HDL particle size and concentration: a pilot study
    Yiding Yu
    Cardiovascular Institute, University of Pennsylvania 6 Penn Tower, Philadelphia, Pennsylvania, USA
    Am J Cardiovasc Dis 2:285-92. 2012
    ..These findings suggest that HDL particle characteristics may play an important role in psoriatic vascular inflammation and CVD...
  27. pmc Psoriasis and cardiovascular risk: strength in numbers, part II
    Joel M Gelfand
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 131:1007-10. 2011
    ....
  28. pmc Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies
    Muredach P Reilly
    Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Lancet 377:383-92. 2011
    ..We tested whether genetic factors distinctly contribute to either development of coronary atherosclerosis or, specifically, to myocardial infarction in existing coronary atherosclerosis...
  29. pmc Prevalence and treatment patterns of psoriatic arthritis in the UK
    Alexis Ogdie
    Division of Rheumatology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 8 Penn Tower, 1 Convention Ave, Philadelphia, PA 19104, USA
    Rheumatology (Oxford) 52:568-75. 2013
    ....
  30. doi request reprint Vitamin D, metabolic dyslipidemia, and metabolic syndrome in rheumatoid arthritis
    Joshua F Baker
    Department of Medicine, Division of Rheumatology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Am J Med 125:1036.e9-1036.e15. 2012
    ..We investigated the associations between vitamin D and dyslipidemia and the metabolic syndrome in patients with rheumatoid arthritis, a group at high risk for cardiovascular disease...
  31. pmc Gene profiling of human adipose tissue during evoked inflammation in vivo
    Rachana Shah
    Division of Pediatric Endocrinology, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Diabetes 58:2211-9. 2009
    ..However, few human adipose-secreted proteins are known to mediate these processes. We hypothesized that microarray mRNA profiling of human adipose during evoked inflammation could identify novel adipocytokines...
  32. ncbi request reprint Images in cardiovascular medicine. Pulmonary venous aneurysms in hereditary hemorrhagic telangiectasia detected by 3-dimensional magnetic resonance angiography
    Victor A Ferrari
    Adult Congenital Heart Disease Program, Division of Cardiovascular Medicine, Department of Medicine, Hospital of the University of Pennsylvania, 3400 Spruce St, 9014 E Gates Pavilion, Philadelphia, PA 19104, USA
    Circulation 108:e122-3. 2003
  33. pmc Peroxisome Proliferator-Activated Receptor-α Agonism With Fenofibrate Does Not Suppress Inflammatory Responses to Evoked Endotoxemia
    Claire K Mulvey
    Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA C K M, J F F, J T M, S K, R Y S, P N P, M H U U, N N M, M P R
    J Am Heart Assoc 1:e002923. 2012
    ....
  34. pmc CXCL12: a new player in coronary disease identified through human genetics
    Samira S Farouk
    Cardiovascular Institute, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Trends Cardiovasc Med 20:204-9. 2010
    ..These GWAS demonstrate that CXCL12 may emerge as a potential therapeutic target for atherosclerosis and thrombosis...
  35. pmc Psoriasis and cardiovascular risk: strength in numbers
    Joel M Gelfand
    Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Invest Dermatol 130:919-22. 2010
    ..This negative result should be interpreted in light of the study's limitations, the complex relationship among levels of psoriasis severity, patient age, and cardiovascular (CV) risk, and the context of the rapidly growing literature...
  36. pmc Selective PKC beta inhibition with ruboxistaurin and endothelial function in type-2 diabetes mellitus
    Nehal N Mehta
    Cardiovascular Institute, University of Pennsylvania Medical Center, 909 BRB 2 3, 421 Curie Blvd, Philadelphia, PA 19104 6160, USA
    Cardiovasc Drugs Ther 23:17-24. 2009
    ..Prior studies demonstrate beneficial effects of PKC beta inhibition on microvascular parameters, but, to date, no study has examined the effect on macrovascular atherosclerotic readouts...
  37. pmc Dysglycemia but not lipids is associated with abnormal urinary albumin excretion in diabetic kidney disease: a report from the Kidney Early Evaluation Program (KEEP)
    Subhasish Bose
    Department of Nephrology, Temple University Hospital, Philadelphia, PA, USA
    BMC Nephrol 13:104. 2012
    ..We sought to investigate the association of dyslipidemia and glycemic control with levels of albuminuria in the National Kidney Foundation (NKF) Kidney Early Evaluation Program (KEEP) participants with DM and CKD stage 3 or higher...
  38. ncbi request reprint Innate immunity modulates adipokines in humans
    Paul D Anderson
    Cardiovascular Institute, University of Pennsylvania Medical Center, Philadelphia, PA 19104 6160, USA
    J Clin Endocrinol Metab 92:2272-9. 2007
    ..Chronic inflammation converges in type 2 diabetes and atherosclerosis. Modulation of adipokine signaling by innate immunity in humans is of considerable interest given the role of adipokines in insulin resistance and atherosclerosis...
  39. pmc Fluorescent green plaques: light at the end of the catheter?
    Nehal N Mehta
    Institute for Translational Medicine and Therapeutics, Cardiovascular Institute, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA
    Cell Metab 14:7-8. 2011
    ..Fluorescence imaging with indocyanine green specifically identifies lipid-rich plaques in rabbits and in humans and represents a promising, though invasive, approach...