M Mehta

Summary

Affiliation: University of Wisconsin
Country: USA

Publications

  1. ncbi request reprint Tomotherapy and other innovative IMRT delivery systems
    John D Fenwick
    Department of Medical Physics, Clatterbridge Centre for Oncology, Wirral, United Kingdom
    Semin Radiat Oncol 16:199-208. 2006
  2. ncbi request reprint Lead-in phase to randomized trial of motexafin gadolinium and whole-brain radiation for patients with brain metastases: centralized assessment of magnetic resonance imaging, neurocognitive, and neurologic end points
    Minesh P Mehta
    Department of Human Oncology, Medical School, University of Wisconsin Madison, K4 334 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
    J Clin Oncol 20:3445-53. 2002
  3. ncbi request reprint The contemporary role of radiation therapy in the management of lung cancer
    M P Mehta
    Department of Human Oncology, University of Wisconsin Madison Medical School, 53792, USA
    Surg Oncol Clin N Am 9:539-61, ix. 2000
  4. ncbi request reprint Radiotherapy for brain tumors
    M P Mehta
    Department of Human Oncology, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
    Curr Oncol Rep 2:438-44. 2000
  5. ncbi request reprint A new approach to dose escalation in non-small-cell lung cancer
    M Mehta
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 49:23-33. 2001
  6. ncbi request reprint Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases
    Minesh P Mehta
    University of Wisconsin Madison, Department Human Oncology Radiation Oncology, 53792, USA
    J Clin Oncol 21:2529-36. 2003
  7. ncbi request reprint Novel radiosensitizers for tumors of the central nervous system
    Minesh P Mehta
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    Curr Opin Investig Drugs 5:1284-91. 2004
  8. pmc Hippocampal-sparing whole-brain radiotherapy: a "how-to" technique using helical tomotherapy and linear accelerator-based intensity-modulated radiotherapy
    Vinai Gondi
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 78:1244-52. 2010
  9. doi request reprint Motexafin gadolinium combined with prompt whole brain radiotherapy prolongs time to neurologic progression in non-small-cell lung cancer patients with brain metastases: results of a phase III trial
    Minesh P Mehta
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 73:1069-76. 2009
  10. pmc Whole brain radiotherapy with hippocampal avoidance and simultaneously integrated brain metastases boost: a planning study
    Alonso N Gutierrez
    Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 69:589-97. 2007

Research Grants

Detail Information

Publications85

  1. ncbi request reprint Tomotherapy and other innovative IMRT delivery systems
    John D Fenwick
    Department of Medical Physics, Clatterbridge Centre for Oncology, Wirral, United Kingdom
    Semin Radiat Oncol 16:199-208. 2006
    ....
  2. ncbi request reprint Lead-in phase to randomized trial of motexafin gadolinium and whole-brain radiation for patients with brain metastases: centralized assessment of magnetic resonance imaging, neurocognitive, and neurologic end points
    Minesh P Mehta
    Department of Human Oncology, Medical School, University of Wisconsin Madison, K4 334 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
    J Clin Oncol 20:3445-53. 2002
    ....
  3. ncbi request reprint The contemporary role of radiation therapy in the management of lung cancer
    M P Mehta
    Department of Human Oncology, University of Wisconsin Madison Medical School, 53792, USA
    Surg Oncol Clin N Am 9:539-61, ix. 2000
    ..In a variety of different contexts, the specific indications, results, controversies, and emerging areas are highlighted, with an emphasis on the author's personal techniques and a review of the pertinent literature...
  4. ncbi request reprint Radiotherapy for brain tumors
    M P Mehta
    Department of Human Oncology, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
    Curr Oncol Rep 2:438-44. 2000
    ..The final "frontier" covered in this review is the newer categories of radiosensitizers, ranging from topoisomerase-I inhibitors, to expanded metalloporphyrins, to oxygen- dissociating agents...
  5. ncbi request reprint A new approach to dose escalation in non-small-cell lung cancer
    M Mehta
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 49:23-33. 2001
    ..To describe the radiobiological rationale for dose-per-fraction escalation in non-small-cell lung cancer (NSCLC) and to devise a novel Phase I scheme to implement this strategy using advanced radiotherapy delivery technologies...
  6. ncbi request reprint Survival and neurologic outcomes in a randomized trial of motexafin gadolinium and whole-brain radiation therapy in brain metastases
    Minesh P Mehta
    University of Wisconsin Madison, Department Human Oncology Radiation Oncology, 53792, USA
    J Clin Oncol 21:2529-36. 2003
    ....
  7. ncbi request reprint Novel radiosensitizers for tumors of the central nervous system
    Minesh P Mehta
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    Curr Opin Investig Drugs 5:1284-91. 2004
    ....
  8. pmc Hippocampal-sparing whole-brain radiotherapy: a "how-to" technique using helical tomotherapy and linear accelerator-based intensity-modulated radiotherapy
    Vinai Gondi
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 78:1244-52. 2010
    ..Herein we report our preliminary experience with whole-brain radiotherapy using hippocampal sparing for patients with brain metastases...
  9. doi request reprint Motexafin gadolinium combined with prompt whole brain radiotherapy prolongs time to neurologic progression in non-small-cell lung cancer patients with brain metastases: results of a phase III trial
    Minesh P Mehta
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 73:1069-76. 2009
    ..To determine the efficacy of motexafin gadolinium (MGd) in combination with whole brain radiotherapy (WBRT) for the treatment of brain metastases from non-small-cell lung cancer...
  10. pmc Whole brain radiotherapy with hippocampal avoidance and simultaneously integrated brain metastases boost: a planning study
    Alonso N Gutierrez
    Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 69:589-97. 2007
    ....
  11. ncbi request reprint Distribution of brain metastases in relation to the hippocampus: implications for neurocognitive functional preservation
    Amol Ghia
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 68:971-7. 2007
    ....
  12. ncbi request reprint Feasibility report of image guided stereotactic body radiotherapy (IG-SBRT) with tomotherapy for early stage medically inoperable lung cancer using extreme hypofractionation
    Wes Hodge
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Acta Oncol 45:890-6. 2006
    ..Daily pretreatment MVCT imaging allows for precise daily tumor targeting with the patient in the actual treatment position, and therefore provides for precise image guidance...
  13. doi request reprint Relationship between neurocognitive function and quality of life after whole-brain radiotherapy in patients with brain metastasis
    Jing Li
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 71:64-70. 2008
    ..To examine the relationship between neurocognitive function (NCF) and quality of life (QOL) in patients with brain metastases after whole-brain radiotherapy...
  14. ncbi request reprint Comparison of linac based fractionated stereotactic radiotherapy and tomotherapy treatment plans for skull-base tumors
    Emilie T Soisson
    Department of Medical Physics, University of Wisconsin Medical School, Madison, WI 53792, USA
    Radiother Oncol 78:313-21. 2006
    ..To compare and evaluate helical tomotherapy and linac based fractionated stereotactic radiotherapy (FSRT) techniques in the treatment of skull-base tumors...
  15. doi request reprint Motexafin gadolinium: a novel radiosensitizer for brain tumors
    Dave Francis
    University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, K4 B100 Madison, WI 53717, USA
    Expert Opin Pharmacother 10:2171-80. 2009
    ..In the following manuscript, we summarize motexafin gadolinium and its role in brain tumors...
  16. doi request reprint Current treatment strategies for brain metastasis and complications from therapeutic techniques: a review of current literature
    Christopher S Platta
    Department of Human Oncology and Paul P Carbone Comprehensive Cancer Center, University of Wisconsin, Madison, USA
    Am J Clin Oncol 33:398-407. 2010
    ..Finally, we will discuss current treatment strategies for possibly maintaining and improving cognitive function for these patients...
  17. ncbi request reprint Patterns of treatment failure in infants with primitive neuroectodermal tumors who were treated on CCG-921: a phase III combined modality study
    Theodore S Hong
    Department of Human Oncology, School of Medicine, University of Wisconsin, Madison, WI 53792, USA
    Pediatr Blood Cancer 45:676-82. 2005
    ..To analyze patterns of treatment failure in infants with primitive neuroectodermal tumors (PNETs) who were treated primarily with chemotherapy in a large multi-institutional study...
  18. ncbi request reprint Whole-brain radiotherapy in the management of brain metastasis
    Deepak Khuntia
    University of Wisconsin, Madison, WI 53792, USA
    J Clin Oncol 24:1295-304. 2006
    ..In this review article, we present the standard treatment approach of whole-brain radiotherapy and discuss new directions, including the role of chemical modifiers and the management and prevention of neurocognitive deficits...
  19. ncbi request reprint Tumor volume changes on serial imaging with megavoltage CT for non-small-cell lung cancer during intensity-modulated radiotherapy: how reliable, consistent, and meaningful is the effect?
    Malika L Siker
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 66:135-41. 2006
    ....
  20. ncbi request reprint Clinical implementation of adaptive helical tomotherapy: a unique approach to image-guided intensity modulated radiotherapy
    James S Welsh
    Department of Human Oncology, University of Wisconsin, Madison, Wisconsin, USA
    Technol Cancer Res Treat 5:465-79. 2006
    ....
  21. pmc A comprehensive assessment by tumor site of patient setup using daily MVCT imaging from more than 3,800 helical tomotherapy treatments
    Leah K Schubert
    Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA
    Int J Radiat Oncol Biol Phys 73:1260-9. 2009
    ..To assess patient setup corrections based on daily megavoltage CT (MVCT) imaging for four anatomic treatment sites treated on tomotherapy...
  22. pmc Phase 2 trial of radiation plus high-dose tamoxifen for glioblastoma multiforme: RTOG protocol BR-0021
    H Ian Robins
    Comprehensive Cancer Center, University of Wisconsin, Madison, WI 53792 6164, USA
    Neuro Oncol 8:47-52. 2006
    ..The lower-than-expected incidence seen here has also been observed in other high-dose TAM GBM studies. We speculate that TAM inhibited the PKC-mediated phosphorylation of coagulation factors...
  23. ncbi request reprint Motexafin-gadolinium taken up in vitro by at least 90% of glioblastoma cell nuclei
    Gelsomina De Stasio
    Department of Physics and Synchrotron Radiation Center, University of Wisconsin Madison, Stoughton, Winconsin 53589, USA
    Clin Cancer Res 12:206-13. 2006
    ....
  24. ncbi request reprint Linear accelerator radiosurgery for trigeminal neuralgia
    Gregory M Richards
    Department of Human Oncology, University of Wisconsin Medical School, K4 B29 Clinical Sciences Center, Madison, Wisconsin 53792, USA
    Neurosurgery 57:1193-200; discussion 1193-200. 2005
    ..To report the clinical outcomes following treatment of trigeminal neuralgia with linear accelerator-based radiosurgery...
  25. doi request reprint Novel insights into the management of brain metastases
    Vinai Gondi
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, Wisconsin 53792, USA
    Curr Opin Neurol 23:556-62. 2010
    ..This review provides available clinical evidence regarding current therapies, discusses ongoing controversies, and introduces investigational approaches in the management of brain metastases...
  26. ncbi request reprint Targeted therapy for brain metastases: improving the therapeutic ratio
    Rakesh R Patel
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    Clin Cancer Res 13:1675-83. 2007
    ..In this review article, we discuss new directions in the management of brain metastases, including the role of chemical modifiers, novel systemic agents, and the management and prevention of neurocognitive deficits...
  27. doi request reprint Fractionated radiotherapy for intracranial meningiomas
    Vinai Gondi
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
    J Neurooncol 99:349-56. 2010
    ..EBRT planning is highly individualized and requires a detailed understanding of tumor grade, adjacent radiosensitive structures such as the anterior optic apparatus, and radiographic characteristics of the tumor such as hyperostosis...
  28. pmc Estimated risk of perihippocampal disease progression after hippocampal avoidance during whole-brain radiotherapy: safety profile for RTOG 0933
    Vinai Gondi
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
    Radiother Oncol 95:327-31. 2010
    ..By quantifying baseline incidence of perihippocampal or hippocampal metastasis, we sought to estimate the risk of developing metastases in the hippocampal avoidance region (the hippocampus plus 5mm margin)...
  29. pmc On the estimation of the location of the hippocampus in the context of hippocampal avoidance whole brain radiotherapy treatment planning
    Edward T Bender
    Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Technol Cancer Res Treat 8:425-32. 2009
    ..62 (range .40-.76) for methods utilizing deformation. Comparable results were achieved in auto-contouring CT images when deformable registration was used, demonstrating that the methodology is robust with respect to imaging modality...
  30. doi request reprint Radiation techniques in neuro-oncology
    Deepak Khuntia
    Department of Human Oncology, University of Wisconsin Madison, Madison, Wisconsin 53792
    Neurotherapeutics 6:487-99. 2009
    ..Included is a discussion of standard two- and three-dimensional radiation, as well as intensity-modulated radiotherapy, image-guided radiation therapy, stereotactic radiosurgery, and heavy particles...
  31. doi request reprint Dose coverage beyond the gross tumor volume for various stereotactic body radiotherapy planning techniques reporting similar control rates for stage I non-small-cell lung cancer
    Noah B Arvidson
    Department of Medical Physics, University of Wisconsin, Madison, WI, USA
    Int J Radiat Oncol Biol Phys 72:1597-603. 2008
    ..To investigate the dose falloff region for various stereotactic body radiotherapy (SBRT) planning techniques used in the treatment of Stage I non-small-cell lung cancer reporting similar control rates...
  32. pmc Motexafin gadolinium and involved field radiation therapy for intrinsic pontine glioma of childhood: a Children's Oncology Group phase I study
    Kristin A Bradley
    University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Neuro Oncol 10:752-8. 2008
    ..The maximum tolerated dose of MGd and the recommended phase II dose was 4.4 mg/kg when administered as a daily intravenous bolus in conjunction with 6 weeks of involved field radiation therapy for pediatric intrinsic pontine gliomas...
  33. ncbi request reprint Radiotherapy and radiosensitizers in the treatment of glioblastoma multiforme
    Julie E Chang
    Department of Medicine, Section of Hematology and Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Clin Adv Hematol Oncol 5:894-902, 907-15. 2007
    ....
  34. pmc Proof of principle of ocular sparing in dogs with sinonasal tumors treated with intensity-modulated radiation therapy
    Jessica A Lawrence
    School of Veterinary Medicine, Department of Medical Sciences, 2015 Linden Drive, Madison, WI 53706, USA
    Vet Radiol Ultrasound 51:561-70. 2010
    ..These data provide proof-of-principle that conformal avoidance radiotherapy can be delivered through high conformity IMRT, resulting in decreased normal tissue toxicity as compared with historical controls treated with 2D-RT...
  35. ncbi request reprint Helical tomotherapy: image guidance and adaptive dose guidance
    Wolfgang A Tome
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Front Radiat Ther Oncol 40:162-78. 2007
    ....
  36. ncbi request reprint Motexafin gadolinium: a novel radiosensitizer for brain tumors
    Afshin Forouzannia
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Clinical Science Center, Madison, WI 53792, USA
    Expert Rev Anticancer Ther 7:785-94. 2007
    ..Motexafin gadolinium is very well tolerated with tumor specific uptake. The rationale for the use of this drug as well as its current and future role as a radiation enhancer in the management of brain tumors is reviewed...
  37. ncbi request reprint Current strategies in whole-brain radiation therapy for brain metastases
    Minesh P Mehta
    University of Wisconsin Hospital, Madison, Wisconsin 53792, USA
    Neurosurgery 57:S33-44; discusssion S1-4. 2005
    ....
  38. ncbi request reprint Fractionated stereotactic radiotherapy: a short review
    Wolfgang A Tome
    Department of Human Oncology, Medical School, University of Wisconsin, 600 Highland Ave, Madison, WI 53792, USA
    Technol Cancer Res Treat 1:153-72. 2002
    ....
  39. ncbi request reprint Management of brain metastases
    Kristin A Bradley
    Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA
    Semin Oncol 31:693-701. 2004
    ..In addition, current controversies in the management of brain metastases, such as the choice of surgery or radiosurgery for resectable lesions and the possible avoidance of (WBRT), are highlighted...
  40. ncbi request reprint A challenge to traditional radiation oncology
    Jack F Fowler
    Department of Human Oncology, Medical School of the University of Wisconsin, Madison, WI, USA
    Int J Radiat Oncol Biol Phys 60:1241-56. 2004
    ....
  41. ncbi request reprint The utility of megavoltage computed tomography images from a helical tomotherapy system for setup verification purposes
    Lisa J Forrest
    Department of Human Oncology, University of Wisconsin, Madison, WI, USA
    Int J Radiat Oncol Biol Phys 60:1639-44. 2004
    ..To evaluate the utility of relatively low-dose megavoltage computed tomography (MVCT) images from a clinical helical tomotherapy system for setup verification purposes...
  42. ncbi request reprint Combined modality treatment for central nervous system malignancies
    H Ian Robins
    Department of Medicine, University of Wisconsin, Madison, WI 53792, USA
    Semin Oncol 30:11-22. 2003
    ..Clearly, such promising innovations must be delineated in the context of continued preclinical studies and controlled clinical trials...
  43. ncbi request reprint Helical tomotherapy: an innovative technology and approach to radiation therapy
    James S Welsh
    Department of Human Oncology, University of Wisconsin, School of Medicine, 600 Highland Avenue, Madison, WI 53792, USA
    Technol Cancer Res Treat 1:311-6. 2002
    ..Based on radiobiological principles that exploit the physical advantages of helical tomotherapy, several dosimetric and clinical investigations are underway...
  44. ncbi request reprint Are gadolinium contrast agents suitable for gadolinium neutron capture therapy?
    Gelsomina De Stasio
    University of Wisconsin Madison, Department of Physics and Synchrotron Radiation Center, 3731 Schneider Drive, Stoughton, WI 53589, USA
    Neurol Res 27:387-98. 2005
    ..Here, we studied the nuclear uptake of Gd by glioblastoma (GBM) tumor cells after treatment with two Gd compounds commonly used for magnetic resonance imaging, to evaluate their potential as GdNCT agents...
  45. ncbi request reprint Megavoltage computed tomography imaging: a potential tool to guide and improve the delivery of thoracic radiation therapy
    James S Welsh
    Department of Human Oncology, University of Wisconsin School of Medicine, Madison, USA
    Clin Lung Cancer 5:303-6. 2004
    ..Further studies are ongoing to optimize MVCT imaging and better define its utility in patients with NSCLC...
  46. ncbi request reprint Therapeutic advances in the treatment of brain metastases
    Julie E Chang
    Hematology and Oncology Fellow, University of Wisconsin Hospital and Clinics, Madison, WI 53792, USA
    Clin Adv Hematol Oncol 5:54-64. 2007
    ..Systemic agents showing activity in brain metastases including temozolomide, RSR13, motexafin gadolinium, and lapatinib are being explored...
  47. ncbi request reprint Patterns of failure in supratentorial primitive neuroectodermal tumors treated in Children's Cancer Group Study 921, a phase III combined modality study
    Theodore S Hong
    Department of Human Oncology, University of Wisconsin School of Medicine, Madison, WI, USA
    Int J Radiat Oncol Biol Phys 60:204-13. 2004
    ..To analyze the patterns of failure in patients with supratentorial primitive neuroectodermal tumors (ST-PNETs) treated with combined modality therapy in a large, randomized, multi-institutional study...
  48. ncbi request reprint Combined chemoradiotherapy advances
    Gordon Wong
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, USA
    Cancer Treat Res 139:281-305. 2008
  49. ncbi request reprint Chemoradiation for upper aerodigestive tract cancer: balancing evidence from clinical trials with individual patient recommendations
    Paul M Harari
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI, USA
    Curr Probl Cancer 28:7-40. 2004
  50. ncbi request reprint Motexafin gadolinium in the treatment of brain metastases
    Gregory M Richards
    University of Wisconsin School of Medicine and Public Health, Department of Human Oncology, Madison, WI 53792, USA
    Expert Opin Pharmacother 8:351-9. 2007
    ....
  51. ncbi request reprint The impact of daily setup variations on head-and-neck intensity-modulated radiation therapy
    Theodore S Hong
    Department of Human Oncology, University of Wisconsin Medical School, University Hospital and Clinics, 600 Highland Avenue K4 332, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 61:779-88. 2005
    ..This study provides a detailed analysis regarding the potential impact of daily setup variations on the overall integrity of H&N IMRT...
  52. ncbi request reprint Reduction in radiation dose to lung and other normal tissues using helical tomotherapy to treat lung cancer, in comparison to conventional field arrangements
    Rufus A Scrimger
    Department of Human Oncology, University of Wisconsin, Madison, Wisconsin 53792, USA
    Am J Clin Oncol 26:70-8. 2003
    ..This has important implications for dose escalation strategies in the future...
  53. ncbi request reprint Continuous 28-day iododeoxyuridine infusion and hyperfractionated accelerated radiotherapy for malignant glioma: a phase I clinical study
    Craig A Schulz
    Department of Human Oncology, University of Wisconsin Medical School, 600 Highland Avenue, Madison, WI 53792, USA
    Int J Radiat Oncol Biol Phys 59:1107-15. 2004
    ....
  54. ncbi request reprint Should concomitant and adjuvant treatment with temozolomide be used as standard therapy in patients with anaplastic glioma?
    Malika L Siker
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, K4 3, Madison, WI 53792 8500, USA
    Crit Rev Oncol Hematol 60:99-111. 2006
    ..Further investigation is needed to better define the role of chemotherapy in patients with anaplastic gliomas. Trials evaluating chemoradiotherapy as well as targeted therapeutic agents are the subject of further research...
  55. ncbi request reprint Optically guided intensity modulated radiotherapy
    W A Tome
    Department of Human Oncology, University of Wisconsin, K4 B100 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
    Radiother Oncol 61:33-44. 2001
    ..In this paper we report on the extension of our system for stereotactic fractionated radiotherapy to include intensity modulated static ports...
  56. ncbi request reprint Phase I trial of intravenous thymidine and carboplatin in patients with advanced cancer
    H I Robins
    University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
    J Clin Oncol 17:2922-31. 1999
    ..To evaluate the biologic interactions and toxicities of carboplatin combined with a 24-hour infusion of thymidine 75 mg/m(2) in a phase I trial...
  57. ncbi request reprint Megavoltage computed tomography: an emerging tool for image-guided radiotherapy
    Theodore S Hong
    Department of Human Oncology, University of Wisconsin Medical School, Madison, WI, USA
    Am J Clin Oncol 30:617-23. 2007
    ..In this study, we assessed the image-quality, absorbed radiation doses, and clinical practicality of MVCT from our helical tomotherapy prototype unit...
  58. pmc A phase I study of topotecan as a radiosensitizer for brainstem glioma of childhood: first report of the Children's Cancer Group-0952
    Seema N Sanghavi
    Department of Human Oncology, Medical School, University of Wisconsin, 600 Highland Avenue, Madison, WI 53792, USA
    Neuro Oncol 5:8-13. 2003
    ..50 mg/m(2) x 33 (total dosage = 16.5 mg/m(2)); the recommended safe MTD of daily topotecan for further phase II testing is 0.40 mg/m(2) x 33 (total dosage = 13.2 mg/m(2))...
  59. ncbi request reprint The impact of hybrid PET-CT scan on overall oncologic management, with a focus on radiotherapy planning: a prospective, blinded study
    Tim J Kruser
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA edu
    Technol Cancer Res Treat 8:149-58. 2009
    ..Hybrid PET/CT imaging at the time of treatment planning may be highly informative and an economical manner in which to obtain PET imaging, with the dual goals of staging and treatment planning...
  60. ncbi request reprint Resection versus radiosurgery for patients with brain metastases
    Malika L Siker
    University of Wisconsin School of Medicine and Public Health, Department of Human Oncology, Madison, WI, USA
    Future Oncol 3:95-102. 2007
    ....
  61. ncbi request reprint Regression after whole-brain radiation therapy for brain metastases correlates with survival and improved neurocognitive function
    Jing Li
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center, Madison, WI 53792, USA
    J Clin Oncol 25:1260-6. 2007
    ..Whole-brain radiation therapy (WBRT) offers tumor shrinking and palliation in many cases, but it has been speculated that these benefits may be outweighed by adverse effects on neurocognitive function (NCF)...
  62. ncbi request reprint Therapeutic management of metastatic brain tumors
    Gregory M Richards
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA
    Crit Rev Oncol Hematol 61:70-8. 2007
    ..Efforts to incorporate these approaches to improve survival are currently under active investigation...
  63. ncbi request reprint Integral radiation dose to normal structures with conformal external beam radiation
    Hidefumi Aoyama
    Department of Human Oncology, University of Wisconsin, Madison, WI, USA
    Int J Radiat Oncol Biol Phys 64:962-7. 2006
    ..This study was designed to evaluate the integral dose (ID) received by normal tissue from intensity-modulated radiotherapy (IMRT) for prostate cancer...
  64. ncbi request reprint Neurocognitive and functional assessment of patients with brain metastases: a pilot study
    Mary A Herman
    Department of Human Oncology, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Am J Clin Oncol 26:273-9. 2003
    ..Despite high functional status, most patients demonstrated impairment in memory and fine motor domains. Neurocognitive test batteries can and should be used in patients with brain metastases enrolled in clinical trials...
  65. ncbi request reprint Clinical promise tempered by reality in the delivery of combined chemoradiation for common solid tumors
    Paul M Harari
    Department of Human Oncology, University of Wisconsin Comprehensive Cancer Center and School of Medicine, Madison, WI 53792, USA
    Semin Radiat Oncol 13:3-12. 2003
    ..However, we lack randomized trials that directly compare operative versus nonoperative treatment approaches and thus have consciously neglected review of the surgical series for purposes of this article...
  66. ncbi request reprint Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial
    David W Andrews
    Department of Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
    Lancet 363:1665-72. 2004
    ..We aimed to assess whether stereotactic radiosurgery provided any therapeutic benefit in a randomised multi-institutional trial directed by the Radiation Therapy Oncology Group (RTOG)...
  67. ncbi request reprint Models support prophylactic cranial irradiation
    Minesh P Mehta
    J Clin Oncol 24:3524-6. 2006
  68. ncbi request reprint Phase II study of fenretinide (NSC 374551) in adults with recurrent malignant gliomas: A North American Brain Tumor Consortium study
    Vinay K Puduvalli
    Department of Neuro Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 431, Houston TX 77030, USA
    J Clin Oncol 22:4282-9. 2004
    ..Fenretinide induces apoptosis in malignant gliomas in vitro. This two-stage phase II trial was conducted to determine the efficacy of fenretinide in adults with recurrent malignant gliomas...
  69. ncbi request reprint Treatment of malignant gliomas: radiotherapy, chemotherapy and integration of new targeted agents
    Carsten Nieder
    Department of Radiation Oncology, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str 22, 81675 Munich, Germany
    Expert Rev Neurother 4:691-703. 2004
    ..e., drugs, antibodies and antisense oligonucleotides) have now entered clinical trials, mainly for recurrent gliomas and a small number are being tested in combination with radiotherapy. Early results of such approaches are presented...
  70. ncbi request reprint The American Society for Therapeutic Radiology and Oncology (ASTRO) evidence-based review of the role of radiosurgery for brain metastases
    Minesh P Mehta
    The American Society for Therapeutic Radiology and Oncology, Fairfax, VA 22033, USA
    Int J Radiat Oncol Biol Phys 63:37-46. 2005
    ..To systematically review the evidence for the use of stereotactic radiosurgery in adult patients with brain metastases...
  71. ncbi request reprint A multi-institutional review of radiosurgery alone vs. radiosurgery with whole brain radiotherapy as the initial management of brain metastases
    Penny K Sneed
    Department of Radiation Oncology, University of California San Francisco, 505 Parnassus Avenue, San Francisco, CA 94143 0226, USA
    Int J Radiat Oncol Biol Phys 53:519-26. 2002
    ..Data collected from 10 institutions were reviewed to compare survival probabilities of patients with newly diagnosed brain metastases managed initially with radiosurgery (RS) alone vs. RS + whole brain radiotherapy (WBRT)...
  72. ncbi request reprint The American Society for Therapeutic Radiology and Oncology (ASTRO) evidence-based review of the role of radiosurgery for malignant glioma
    May N Tsao
    The American Society for Therapeutic Radiology and Oncology, Fairfax, VA 22033, USA
    Int J Radiat Oncol Biol Phys 63:47-55. 2005
    ..To systematically review the evidence for the use of stereotactic radiosurgery or stereotactic fractionated radiation therapy in adult patients with malignant glioma...
  73. ncbi request reprint Treatment of brain metastases: a short review of current therapies and the emerging role of temozolomide
    Lauren E Abrey
    Department of Neurology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Clin Adv Hematol Oncol 1:231-6. 2003
    ..We provide a brief review of current and novel therapies for brain metastases, including new data on the efficacy and safety of temozolomide, a second-generation alkylating agent...
  74. ncbi request reprint Gentlemen (and ladies), choose your weapons: Gamma knife vs. linear accelerator radiosurgery
    Volker W Stieber
    Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1030, USA
    Technol Cancer Res Treat 2:79-86. 2003
    ....
  75. ncbi request reprint Phase II Radiation Therapy Oncology Group trial of conventional radiation therapy followed by treatment with recombinant interferon-beta for supratentorial glioblastoma: results of RTOG 9710
    Howard Colman
    Department of Neuro Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 66:818-24. 2006
    ..The aim of this study was to determine whether recombinant human interferon beta-1a (rhIFN-beta), when given after radiation therapy, improves survival in glioblastoma...
  76. pmc Phase 2 study of BCNU and temozolomide for recurrent glioblastoma multiforme: North American Brain Tumor Consortium study
    Michael D Prados
    Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
    Neuro Oncol 6:33-7. 2004
    ..We conclude that BCNU plus temozolomide when used in these doses and schedule has only modest activity, with significant toxicity, and appears to be no more effective than single-agent temozolomide...
  77. ncbi request reprint Advances in radiation therapy for brain tumors
    Volker W Stieber
    Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1030, USA
    Neurol Clin 25:1005-33, ix. 2007
    ..In the dose range used when treating these tumors, the probability of causing serious late toxicity is relatively low and secondary malignancies are rare...
  78. pmc O6-benzylguanine suppression of O6-alkylguanine-DNA alkyltransferase in anaplastic gliomas
    S Clifford Schold
    University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA
    Neuro Oncol 6:28-32. 2004
    ..We conclude that a BG dose of 120 mg/m(2) given 6 h before an alkylating drug would be effective in suppressing AGT and possibly potentiating the cytotoxic effects of the drug...
  79. doi request reprint A phase III study of conventional radiation therapy plus thalidomide versus conventional radiation therapy for multiple brain metastases (RTOG 0118)
    Jonathan P S Knisely
    Department of Therapeutic Radiology, Yale University School of Medicine and Yale Cancer Center, New Haven, CT 06520 8040, USA
    Int J Radiat Oncol Biol Phys 71:79-86. 2008
    ..To compare whole-brain radiation therapy (WBRT) with WBRT combined with thalidomide for patients with brain metastases not amenable to resection or radiosurgery...
  80. ncbi request reprint Neurocognitive function and progression in patients with brain metastases treated with whole-brain radiation and motexafin gadolinium: results of a randomized phase III trial
    Christina A Meyers
    Department of Neuro Oncology, Unit 431, M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Clin Oncol 22:157-65. 2004
    ....
  81. ncbi request reprint Randomized comparison of stereotactic radiosurgery followed by conventional radiotherapy with carmustine to conventional radiotherapy with carmustine for patients with glioblastoma multiforme: report of Radiation Therapy Oncology Group 93-05 protocol
    Luis Souhami
    Department of Oncology, Division of Radiation Oncology, McGill University, Montreal, Quebec, Canada
    Int J Radiat Oncol Biol Phys 60:853-60. 2004
    ..We investigated the effect of stereotactic radiosurgery (SRS) added to conventional external beam radiation therapy (EBRT) with carmustine (BCNU) on the survival of patients with GBM...
  82. doi request reprint Improvement, clinical course, and quality of life after palliative radiotherapy for recurrent glioblastoma
    Carsten Nieder
    Department of Internal Medicine Oncology and Radiation Oncology Units, Nordlandssykehuset HF, Bodø, Norway
    Am J Clin Oncol 31:300-5. 2008
    ..Salvage chemotherapy or targeted agents should be prospectively tested against re-irradiation alone...
  83. ncbi request reprint Current management of brain metastases, with a focus on systemic options
    Corey J Langer
    Division of Thoracic Oncology, Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    J Clin Oncol 23:6207-19. 2005
    ..On the basis of these findings, it might be possible to identify new agents that may enhance the efficacy of WBRT...
  84. pmc The prognostic value of nestin expression in newly diagnosed glioblastoma: report from the Radiation Therapy Oncology Group
    Prakash Chinnaiyan
    Department of Radiation Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, USA
    Radiat Oncol 3:32. 2008
    ....
  85. doi request reprint Prospective evaluation of quality of life and neurocognitive effects in patients with multiple brain metastases receiving whole-brain radiotherapy with or without thalidomide on Radiation Therapy Oncology Group (RTOG) trial 0118
    Benjamin W Corn
    Department of Radiation Oncology, Tel Aviv Medical Center, Tel Aviv, Israel
    Int J Radiat Oncol Biol Phys 71:71-8. 2008
    ..This secondary analysis of 156 patients examined neurocognitive and quality of life (QOL) outcomes...

Research Grants3

  1. Improving Cancer Outcome--Adaptive Helical Tomotherapy
    Minesh Mehta; Fiscal Year: 2005
    ..Our Program Project will allow Tomotherapy to reach a level of scientific and technological maturity where, in the future, technological intercomparisons through Phase III trials may be undertaken. ..
  2. NABTC (UCSF PROJECT LEADER) U OF WISCONSIN
    Minesh Mehta; Fiscal Year: 2007
    ....