D Mehta

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc Modulatory role of focal adhesion kinase in regulating human pulmonary arterial endothelial barrier function
    Dolly Mehta
    Department of Pharmacology, College of Medicine, The University of Illinois, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    J Physiol 539:779-89. 2002
  2. ncbi Galphaq-TRPC6-mediated Ca2+ entry induces RhoA activation and resultant endothelial cell shape change in response to thrombin
    Itender Singh
    Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 282:7833-43. 2007
  3. pmc The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin
    Nebojsa Knezevic
    Center for Lung and Vascular Biology, Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
    J Exp Med 206:2761-77. 2009
  4. pmc TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation
    Mohammad Tauseef
    Department of Pharmacology, 2 Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 61605, USA
    J Exp Med 209:1953-68. 2012
  5. pmc Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities
    Tracy Thennes Schmidt
    Dept of Pharmacology, The Univ of Illinois, College of Medicine, 835 S Wolcott Ave, Chicago, IL 60612
    Am J Physiol Lung Cell Mol Physiol 305:L291-300. 2013
  6. ncbi Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates rac activation and adherens junction assembly in endothelial cells
    Dolly Mehta
    Department of Pharmacology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 280:17320-8. 2005
  7. ncbi RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability
    Dolly Mehta
    Department of Pharmacology, College of Medicine, The University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 278:33492-500. 2003
  8. ncbi Integrated control of lung fluid balance
    Dolly Mehta
    Department of Pharmacology, University of Illinois Chicago Medical Center, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1081-90. 2004
  9. ncbi Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function
    D Mehta
    Department of Pharmacology, The University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 276:22614-20. 2001
  10. ncbi Requirement for Ca2+ signaling in the mechanism of thrombin-induced increase in endothelial permeability
    R Sandoval
    Department of Pharmacology, College of Medicine, The University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Am J Physiol Lung Cell Mol Physiol 280:L239-47. 2001

Collaborators

Detail Information

Publications34

  1. pmc Modulatory role of focal adhesion kinase in regulating human pulmonary arterial endothelial barrier function
    Dolly Mehta
    Department of Pharmacology, College of Medicine, The University of Illinois, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    J Physiol 539:779-89. 2002
    ....
  2. ncbi Galphaq-TRPC6-mediated Ca2+ entry induces RhoA activation and resultant endothelial cell shape change in response to thrombin
    Itender Singh
    Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 282:7833-43. 2007
    ..Our results demonstrate that Galphaq activation of TRPC6 signals the activation of PKCalpha, and thereby induces RhoA activity and endothelial cell contraction...
  3. pmc The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombin
    Nebojsa Knezevic
    Center for Lung and Vascular Biology, Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
    J Exp Med 206:2761-77. 2009
    ..Rescuing FAK activation in fyn(-/-) mice attenuated the rise in lung vascular permeability. Our results demonstrate that Gbeta1-mediated Fyn activation integrates FAK with AJ, preventing persistent endothelial barrier leakiness...
  4. pmc TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation
    Mohammad Tauseef
    Department of Pharmacology, 2 Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 61605, USA
    J Exp Med 209:1953-68. 2012
    ..Our findings suggest that TRPC6-dependent Ca(2+) entry into ECs, secondary to TLR4-induced DAG generation, participates in mediating both lung vascular barrier disruption and inflammation induced by endotoxin...
  5. pmc Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities
    Tracy Thennes Schmidt
    Dept of Pharmacology, The Univ of Illinois, College of Medicine, 835 S Wolcott Ave, Chicago, IL 60612
    Am J Physiol Lung Cell Mol Physiol 305:L291-300. 2013
    ..Our findings demonstrate that EC-FAK plays an essential role in maintaining AJs and thereby lung vascular barrier function by establishing the normal balance between RhoA and Rac1 activities...
  6. ncbi Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates rac activation and adherens junction assembly in endothelial cells
    Dolly Mehta
    Department of Pharmacology, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 280:17320-8. 2005
    ..Thus, our results demonstrate that S1P promotes endothelial junctional integrity by activating the release of endoplasmic reticulum-Ca2+, which induces Rac activation and promotes AJ annealing...
  7. ncbi RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeability
    Dolly Mehta
    Department of Pharmacology, College of Medicine, The University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 278:33492-500. 2003
    ..In summary, Rho activation signals interaction of IP3R with TRPC1 at the plasma membrane of endothelial cells, and triggers Ca2+ entry following store depletion and the resultant increase in endothelial permeability...
  8. ncbi Integrated control of lung fluid balance
    Dolly Mehta
    Department of Pharmacology, University of Illinois Chicago Medical Center, Chicago, IL 60612, USA
    Am J Physiol Lung Cell Mol Physiol 287:L1081-90. 2004
    ..Development of mouse models in which the function of regulatory proteins (identified in cell culture studies) can be systematically analyzed will provide a better and more integrated picture of lung fluid balance. In vivo veritas!..
  9. ncbi Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier function
    D Mehta
    Department of Pharmacology, The University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 276:22614-20. 2001
    ..Taken together, these results indicate that PKC-alpha is critical in regulating GDI phosphorylation, Rho activation, and in signaling Rho-dependent endothelial barrier dysfunction...
  10. ncbi Requirement for Ca2+ signaling in the mechanism of thrombin-induced increase in endothelial permeability
    R Sandoval
    Department of Pharmacology, College of Medicine, The University of Illinois at Chicago, Chicago, Illinois 60612, USA
    Am J Physiol Lung Cell Mol Physiol 280:L239-47. 2001
    ..These results indicate that Ca2+ influx and activation of Ca2+-dependent signaling pathways are important determinants of the thrombin-induced increase in endothelial permeability...
  11. ncbi Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeability
    Michael Holinstat
    Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, The University of Illinois, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    J Biol Chem 281:2296-305. 2006
    ..Our studies demonstrate that FAK-induced down-modulation of RhoA activity via p190RhoGAP is a crucial step in signaling endothelial barrier restoration after increased endothelial permeability...
  12. pmc Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells
    Mohammad Tauseef
    Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
    Circ Res 103:1164-72. 2008
    ..Our results suggest the crucial role of activation of the SPHK1-->S1P-->S1P1 signaling pathway in response to inflammatory mediators in endothelial cells in regulating endothelial barrier homeostasis...
  13. ncbi Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement
    Michael Holinstat
    Department of Pharmacology and Anesthesiology, University of Illinois, College of Medicine, Chicago, Illinois 60612, USA
    J Biol Chem 278:28793-8. 2003
    ..Thus, Rho activation in endothelial cells and the subsequent actin cytoskeletal re-arrangement require the cooperative interaction of both G12/13 and PKCalpha pathways that converge at p115RhoGEF...
  14. ncbi Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cells
    Gias U Ahmmed
    Department of Pharmacology, College of Medicine, University of Illinois, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    J Biol Chem 279:20941-9. 2004
    ..These results demonstrate that PKCalpha phosphorylation of TRPC1 is an important determinant of Ca2+ entry in human endothelial cells...
  15. ncbi Synergistic effects of tumor necrosis factor-alpha and thrombin in increasing endothelial permeability
    C Tiruppathi
    Department of Pharmacology, College of Medicine, University of Illinois at Chicago, 60612, USA
    Am J Physiol Lung Cell Mol Physiol 281:L958-68. 2001
    ..These results suggest that TNF-alpha stimulation of endothelial cells results in amplification of the thrombin-induced Ca(2+) influx by an Src-dependent mechanism, thereby promoting loss of endothelial barrier function...
  16. ncbi Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeability
    Chinnaswamy Tiruppathi
    Department of Pharmacology, College of Medicine, The University of Illinois, Chicago, Ill 60612, USA
    Circ Res 91:70-6. 2002
    ..These results show that TRPC4-dependent Ca2+ entry in mouse LECs is a key determinant of increased microvascular permeability...
  17. pmc GDI-1 phosphorylation switch at serine 96 induces RhoA activation and increased endothelial permeability
    Nebojsa Knezevic
    Department of Pharmacology, College of Medicine, The University of Illinois, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    Mol Cell Biol 27:6323-33. 2007
    ..Inhibiting GDI-1 phosphorylation at S96 is a potential therapeutic target for modulating RhoA activity and thus preventing the increase in endothelial permeability associated with vascular inflammation...
  18. ncbi Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout mice
    S M Vogel
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Physiol Genomics 4:137-145. 2000
    ..The results indicate that the PAR-1 receptor is critical in mediating the permeability-increasing and vasoconstrictor effects of thrombin in pulmonary microvessels...
  19. ncbi Differential role of CD18 integrins in mediating lung neutrophil sequestration and increased microvascular permeability induced by Escherichia coli in mice
    X Gao
    Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    J Immunol 167:2895-901. 2001
    ..The increased pulmonary microvascular permeability induced by E. coli is solely the result of engagement of CD18 integrins even when PMN accumulation and migration responses are significantly CD18 independent...
  20. pmc Critical role of Cdc42 in mediating endothelial barrier protection in vivo
    Ramaswamy Ramchandran
    Department of Pharmacology and the Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
    Am J Physiol Lung Cell Mol Physiol 295:L363-9. 2008
    ..Therefore, Cdc42 activity of microvessel endothelial cells is a critical determinant of junctional barrier restrictiveness and may represent a means of therapeutically modulating increased lung vascular permeability and edema formation...
  21. doi Regulation of endothelial junctional permeability
    Emily Vandenbroucke
    Department of Pharmacology and Center for Lung and Vascular Biology, The University of Illonois College of Medicine, Chicago, IL 60612, USA
    Ann N Y Acad Sci 1123:134-45. 2008
    ..This review provides an overview of the mechanisms that regulate paracellular permeability...
  22. ncbi RhoGDI-1 modulation of the activity of monomeric RhoGTPase RhoA regulates endothelial barrier function in mouse lungs
    Matvey Gorovoy
    University of Illinois College of Medicine, Department of Pharmacology, 835 S Wolcott Ave, Chicago, IL 60612, USA
    Circ Res 101:50-8. 2007
    ..In this regard, therapies augmenting endothelial RhoGDI-1 function may be beneficial in reestablishing the endothelial barrier and lung fluid balance in lung inflammatory diseases such as acute respiratory distress syndrome...
  23. ncbi Angiopoietin-1 opposes VEGF-induced increase in endothelial permeability by inhibiting TRPC1-dependent Ca2 influx
    David Jho
    Department of Pharmacology and The Center of Lung and Vascular Biology, The University of Illinois, Chicago, IL 60612, USA
    Circ Res 96:1282-90. 2005
    ..These results demonstrate that Ang1 blocks the TRPC1-dependent Ca2+ influx induced by VEGF by interfering with the interaction of IP3R with TRPC1, and thereby abrogates the increase in endothelial permeability...
  24. pmc A new role for PTEN in regulating transient receptor potential canonical channel 6-mediated Ca2+ entry, endothelial permeability, and angiogenesis
    Vidisha Kini
    Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
    J Biol Chem 285:33082-91. 2010
    ..Ca(2+) entry through TRPC6 induces an increase in endothelial permeability and directly promotes angiogenesis. Thus, PTEN is indicated to play a role beyond suppressing PI3K signaling...
  25. pmc Role of protein kinase Czeta in thrombin-induced RhoA activation and inter-endothelial gap formation of human dermal microvessel endothelial cell monolayers
    Richard D Minshall
    Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA
    Microvasc Res 80:240-9. 2010
    ..The results raise the possibility that inhibition of PKCzeta may be a novel drug target for thrombin-induced inflammatory hyperpermeability...
  26. doi Expression of TREM-1 is inhibited by PGD2 and PGJ2 in macrophages
    Mansoor Ali Syed
    Department of Veterans Affairs, Jesse Brown VA Hospital, University of Illinois at Chicago, Chicago, IL, USA
    Exp Cell Res 316:3140-9. 2010
    ..Our data suggest a novel mechanism by which these prostaglandins exhibit anti-inflammatory effects and a new therapeutic approach to inhibition of TREM-1...
  27. ncbi A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration
    Fei Huang
    Department of Pharmacology, Rush University Medical Center, Chicago, Illinois 60612, USA
    Endothelium 14:25-34. 2007
    ..The findings indicate that the proinflammatory and atherogenic LPC stimulated endothelial GPR4, which promoted monocyte transmigration through a RhoA-dependent pathway...
  28. ncbi Signaling mechanisms regulating endothelial permeability
    Dolly Mehta
    Center of Lung and Vascular Biology, Dept of Pharmacology M C 868, University of Illinois, 835 S Wolcott Avenue, Chicago, IL 60612, USA
    Physiol Rev 86:279-367. 2006
    ....
  29. ncbi Dual regulation of endothelial junctional permeability
    Yulia A Komarova
    Department of Pharmacology and Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA
    Sci STKE 2007:re8. 2007
    ..This Review provides a working model for molecular mechanisms for the dual regulation of endothelial barrier function...
  30. pmc Role of protein tyrosine phosphatase 1B in vascular endothelial growth factor signaling and cell-cell adhesions in endothelial cells
    Yoshimasa Nakamura
    Department of Pharmacology, Center for Lung and Vascular Biology, University of Illinois at Chicago, Chicago, IL 60612, USA
    Circ Res 102:1182-91. 2008
    ..Induction of PTP1B by hindlimb ischemia may represent an important counterregulatory mechanism that blunts overactivation of VEGFR2 during angiogenesis in vivo...
  31. doi MYD88-dependent and -independent activation of TREM-1 via specific TLR ligands
    Heng Zheng
    Department of Veterans Affairs, Jesse Brown VA Hospital, and Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
    Eur J Immunol 40:162-71. 2010
    ..However, the downstream signaling required for the expression of TREM-1 is dependent on the stimulus and the surface receptor through which the signaling is initiated...
  32. ncbi Forskolin induces myosin light chain dephosphorylation in bovine trabecular meshwork cells
    Charanya Ramachandran
    School of Optometry, Indiana University, Bloomington, Indiana 47405, USA
    Curr Eye Res 33:169-76. 2008
    ..In this study, we have investigated effects of forskolin, which is known to elevate cAMP and also enhance aqueous humor outflow, on myosin light chain (MLC) phosphorylation, a biochemical marker of actin contractility...
  33. ncbi Lysophosphatidylcholine: an enigmatic lysolipid
    Dolly Mehta
    Am J Physiol Lung Cell Mol Physiol 289:L174-5. 2005
  34. ncbi p120: the guardian of endothelial junctional integrity
    Dolly Mehta
    Am J Physiol Lung Cell Mol Physiol 286:L1140-2. 2004

Research Grants12

  1. Rho Regulation of Pulmonary Vascular Permeability
    Dolly Mehta; Fiscal Year: 2003
    ..With the information gained, it is hoped that new lines of therapy could be developed against inflammatory diseases that are characterized by "leaky" pulmonary vessel. ..
  2. Rho Regulation of Pulmonary Vascular Permeability
    Dolly Mehta; Fiscal Year: 2009
    ..We believe that characterization of an important calcium channel in endothelial cells, TRPC6 will provide valuable insights to help us develop therapeutic strategies to reverse the vascular leakiness and thereby lung injury. ..
  3. Focal Adhesion Kinase Regulation of Lung Vascular Permeability and Edemagenesis
    Dolly Mehta; Fiscal Year: 2010
    ..These studies will be critical for defining the mechanism of restoration of endothelial barrier function and identifying potential new molecular targets in the pharmacotherapy of ARDS. ..
  4. Rho Regulation of Pulmonary Vascular Permeability
    Dolly Mehta; Fiscal Year: 2010
    ..We believe that characterization of an important calcium channel in endothelial cells, TRPC6 will provide valuable insights to help us develop therapeutic strategies to reverse the vascular leakiness and thereby lung injury. ..
  5. Rho Regulation of Pulmonary Vascular Permeability
    Dolly Mehta; Fiscal Year: 2009
    ..We believe that characterization of an important calcium channel in endothelial cells, TRPC6 will provide valuable insights to help us develop therapeutic strategies to reverse the vascular leakiness and thereby lung injury. ..
  6. Focal Adhesion Kinase Regulation of Lung Vascular Permeability and Edemagenesis
    Dolly Mehta; Fiscal Year: 2009
    ..These studies will be critical for defining the mechanism of restoration of endothelial barrier function and identifying potential new molecular targets in the pharmacotherapy of ARDS. ..
  7. Focal Adhesion Kinase Regulation of Lung Vascular Permeability and Edemagenesis
    Dolly Mehta; Fiscal Year: 2007
    ..These studies will be critical for defining the mechanism of restoration of endothelial barrier function and identifying potential new molecular targets in the pharmacotherapy of ARDS. ..
  8. Rho Regulation of Pulmonary Vascular Permeability
    Dolly Mehta; Fiscal Year: 2006
    ..With the information gained, it is hoped that new lines of therapy could be developed against inflammatory diseases that are characterized by "leaky" pulmonary vessel. ..
  9. Rho Regulation of Pulmonary Vascular Permeability
    Dolly Mehta; Fiscal Year: 2005
    ..With the information gained, it is hoped that new lines of therapy could be developed against inflammatory diseases that are characterized by "leaky" pulmonary vessel. ..
  10. Rho Regulation of Pulmonary Vascular Permeability
    Dolly Mehta; Fiscal Year: 2004
    ..With the information gained, it is hoped that new lines of therapy could be developed against inflammatory diseases that are characterized by "leaky" pulmonary vessel. ..
  11. Rho Regulation of Pulmonary Vascular Permeability
    Dolly Mehta; Fiscal Year: 2011
    ..We believe that characterization of an important calcium channel in endothelial cells, TRPC6 will provide valuable insights to help us develop therapeutic strategies to reverse the vascular leakiness and thereby lung injury. ..