Research Topics
Genomes and Genes | D MehtaSummaryAffiliation: University of Illinois at Chicago Country: USA Publications
Research Grants
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Publications
Modulatory role of focal adhesion kinase in regulating human pulmonary arterial endothelial barrier functionDolly Mehta
Department of Pharmacology, College of Medicine, The University of Illinois, 835 S Wolcott Avenue, Chicago, IL 60612, USA
J Physiol 539:779-89. 2002....- Galphaq-TRPC6-mediated Ca2+ entry induces RhoA activation and resultant endothelial cell shape change in response to thrombinItender Singh
Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
J Biol Chem 282:7833-43. 2007..Our results demonstrate that Galphaq activation of TRPC6 signals the activation of PKCalpha, and thereby induces RhoA activity and endothelial cell contraction... - Integrated control of lung fluid balanceDolly Mehta
Department of Pharmacology, University of Illinois Chicago Medical Center, Chicago, IL 60612, USA
Am J Physiol Lung Cell Mol Physiol 287:L1081-90. 2004..Development of mouse models in which the function of regulatory proteins (identified in cell culture studies) can be systematically analyzed will provide a better and more integrated picture of lung fluid balance. In vivo veritas!.. - Protein kinase C-alpha signals rho-guanine nucleotide dissociation inhibitor phosphorylation and rho activation and regulates the endothelial cell barrier functionD Mehta
Department of Pharmacology, The University of Illinois College of Medicine, Chicago, Illinois 60612, USA
J Biol Chem 276:22614-20. 2001..Taken together, these results indicate that PKC-alpha is critical in regulating GDI phosphorylation, Rho activation, and in signaling Rho-dependent endothelial barrier dysfunction... - Sphingosine 1-phosphate-induced mobilization of intracellular Ca2+ mediates rac activation and adherens junction assembly in endothelial cellsDolly Mehta
Department of Pharmacology, University of Illinois, Chicago, Illinois 60612, USA
J Biol Chem 280:17320-8. 2005..Thus, our results demonstrate that S1P promotes endothelial junctional integrity by activating the release of endoplasmic reticulum-Ca2+, which induces Rac activation and promotes AJ annealing... - RhoA interaction with inositol 1,4,5-trisphosphate receptor and transient receptor potential channel-1 regulates Ca2+ entry. Role in signaling increased endothelial permeabilityDolly Mehta
Department of Pharmacology, College of Medicine, The University of Illinois, Chicago, Illinois 60612, USA
J Biol Chem 278:33492-500. 2003..In summary, Rho activation signals interaction of IP3R with TRPC1 at the plasma membrane of endothelial cells, and triggers Ca2+ entry following store depletion and the resultant increase in endothelial permeability... - Requirement for Ca2+ signaling in the mechanism of thrombin-induced increase in endothelial permeabilityR Sandoval
Department of Pharmacology, College of Medicine, The University of Illinois at Chicago, Chicago, Illinois 60612, USA
Am J Physiol Lung Cell Mol Physiol 280:L239-47. 2001..These results indicate that Ca2+ influx and activation of Ca2+-dependent signaling pathways are important determinants of the thrombin-induced increase in endothelial permeability... - Suppression of RhoA activity by focal adhesion kinase-induced activation of p190RhoGAP: role in regulation of endothelial permeabilityMichael Holinstat
Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, The University of Illinois, 835 S Wolcott Avenue, Chicago, IL 60612, USA
J Biol Chem 281:2296-305. 2006..Our studies demonstrate that FAK-induced down-modulation of RhoA activity via p190RhoGAP is a crucial step in signaling endothelial barrier restoration after increased endothelial permeability... - Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cellsMohammad Tauseef
Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, IL 60612, USA
Circ Res 103:1164-72. 2008..Our results suggest the crucial role of activation of the SPHK1-->S1P-->S1P1 signaling pathway in response to inflammatory mediators in endothelial cells in regulating endothelial barrier homeostasis... - Protein kinase Calpha-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangementMichael Holinstat
Department of Pharmacology and Anesthesiology, University of Illinois, College of Medicine, Chicago, Illinois 60612, USA
J Biol Chem 278:28793-8. 2003..Thus, Rho activation in endothelial cells and the subsequent actin cytoskeletal re-arrangement require the cooperative interaction of both G12/13 and PKCalpha pathways that converge at p115RhoGEF... - Protein kinase Calpha phosphorylates the TRPC1 channel and regulates store-operated Ca2+ entry in endothelial cellsGias U Ahmmed
Department of Pharmacology, College of Medicine, University of Illinois, 835 S Wolcott Avenue, Chicago, IL 60612, USA
J Biol Chem 279:20941-9. 2004..These results demonstrate that PKCalpha phosphorylation of TRPC1 is an important determinant of Ca2+ entry in human endothelial cells... - Synergistic effects of tumor necrosis factor-alpha and thrombin in increasing endothelial permeabilityC Tiruppathi
Department of Pharmacology, College of Medicine, University of Illinois at Chicago, 60612, USA
Am J Physiol Lung Cell Mol Physiol 281:L958-68. 2001..These results suggest that TNF-alpha stimulation of endothelial cells results in amplification of the thrombin-induced Ca(2+) influx by an Src-dependent mechanism, thereby promoting loss of endothelial barrier function... - Impairment of store-operated Ca2+ entry in TRPC4(-/-) mice interferes with increase in lung microvascular permeabilityChinnaswamy Tiruppathi
Department of Pharmacology, College of Medicine, The University of Illinois, Chicago, Ill 60612, USA
Circ Res 91:70-6. 2002..These results show that TRPC4-dependent Ca2+ entry in mouse LECs is a key determinant of increased microvascular permeability... - GDI-1 phosphorylation switch at serine 96 induces RhoA activation and increased endothelial permeabilityNebojsa Knezevic
Department of Pharmacology, College of Medicine, The University of Illinois, 835 S Wolcott Avenue, Chicago, IL 60612, USA
Mol Cell Biol 27:6323-33. 2007..Inhibiting GDI-1 phosphorylation at S96 is a potential therapeutic target for modulating RhoA activity and thus preventing the increase in endothelial permeability associated with vascular inflammation... - Abrogation of thrombin-induced increase in pulmonary microvascular permeability in PAR-1 knockout miceS M Vogel
Department of Pharmacology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
Physiol Genomics 4:137-145. 2000..The results indicate that the PAR-1 receptor is critical in mediating the permeability-increasing and vasoconstrictor effects of thrombin in pulmonary microvessels... - The G protein betagamma subunit mediates reannealing of adherens junctions to reverse endothelial permeability increase by thrombinNebojsa Knezevic
Center for Lung and Vascular Biology, Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
J Exp Med 206:2761-77. 2009..Rescuing FAK activation in fyn(-/-) mice attenuated the rise in lung vascular permeability. Our results demonstrate that Gbeta1-mediated Fyn activation integrates FAK with AJ, preventing persistent endothelial barrier leakiness... - Differential role of CD18 integrins in mediating lung neutrophil sequestration and increased microvascular permeability induced by Escherichia coli in miceX Gao
Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA
J Immunol 167:2895-901. 2001..The increased pulmonary microvascular permeability induced by E. coli is solely the result of engagement of CD18 integrins even when PMN accumulation and migration responses are significantly CD18 independent... - RhoGDI-1 modulation of the activity of monomeric RhoGTPase RhoA regulates endothelial barrier function in mouse lungsMatvey Gorovoy
University of Illinois College of Medicine, Department of Pharmacology, 835 S Wolcott Ave, Chicago, IL 60612, USA
Circ Res 101:50-8. 2007..In this regard, therapies augmenting endothelial RhoGDI-1 function may be beneficial in reestablishing the endothelial barrier and lung fluid balance in lung inflammatory diseases such as acute respiratory distress syndrome... - Critical role of Cdc42 in mediating endothelial barrier protection in vivoRamaswamy Ramchandran
Department of Pharmacology and the Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, Illinois 60612, USA
Am J Physiol Lung Cell Mol Physiol 295:L363-9. 2008..Therefore, Cdc42 activity of microvessel endothelial cells is a critical determinant of junctional barrier restrictiveness and may represent a means of therapeutically modulating increased lung vascular permeability and edema formation... - Regulation of endothelial junctional permeabilityEmily Vandenbroucke
Department of Pharmacology and Center for Lung and Vascular Biology, The University of Illonois College of Medicine, Chicago, IL 60612, USA
Ann N Y Acad Sci 1123:134-45. 2008..This review provides an overview of the mechanisms that regulate paracellular permeability... - Role of protein kinase Czeta in thrombin-induced RhoA activation and inter-endothelial gap formation of human dermal microvessel endothelial cell monolayersRichard D Minshall
Department of Pharmacology, University of Illinois at Chicago, Chicago, IL, USA
Microvasc Res 80:240-9. 2010..The results raise the possibility that inhibition of PKCzeta may be a novel drug target for thrombin-induced inflammatory hyperpermeability... - Angiopoietin-1 opposes VEGF-induced increase in endothelial permeability by inhibiting TRPC1-dependent Ca2 influxDavid Jho
Department of Pharmacology and The Center of Lung and Vascular Biology, The University of Illinois, Chicago, IL 60612, USA
Circ Res 96:1282-90. 2005..These results demonstrate that Ang1 blocks the TRPC1-dependent Ca2+ influx induced by VEGF by interfering with the interaction of IP3R with TRPC1, and thereby abrogates the increase in endothelial permeability... - A new role for PTEN in regulating transient receptor potential canonical channel 6-mediated Ca2+ entry, endothelial permeability, and angiogenesisVidisha Kini
Department of Pharmacology and Center for Lung and Vascular Biology, College of Medicine, University of Illinois, Chicago, Illinois 60612, USA
J Biol Chem 285:33082-91. 2010..Ca(2+) entry through TRPC6 induces an increase in endothelial permeability and directly promotes angiogenesis. Thus, PTEN is indicated to play a role beyond suppressing PI3K signaling... - A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigrationFei Huang
Department of Pharmacology, Rush University Medical Center, Chicago, Illinois 60612, USA
Endothelium 14:25-34. 2007..The findings indicate that the proinflammatory and atherogenic LPC stimulated endothelial GPR4, which promoted monocyte transmigration through a RhoA-dependent pathway... - Signaling mechanisms regulating endothelial permeabilityDolly Mehta
Center of Lung and Vascular Biology, Dept. of Pharmacology (M/C 868, University of Illinois, 835 S. Wolcott Avenue, Chicago, IL 60612, USA
Physiol Rev 86:279-367. 2006.... - Expression of TREM-1 is inhibited by PGD2 and PGJ2 in macrophagesMansoor Ali Syed
Department of Veterans Affairs, Jesse Brown VA Hospital, University of Illinois at Chicago, Chicago, IL, USA
Exp Cell Res 316:3140-9. 2010..Our data suggest a novel mechanism by which these prostaglandins exhibit anti-inflammatory effects and a new therapeutic approach to inhibition of TREM-1... - Role of protein tyrosine phosphatase 1B in vascular endothelial growth factor signaling and cell-cell adhesions in endothelial cellsYoshimasa Nakamura
Department of Pharmacology, Center for Lung and Vascular Biology, University of Illinois at Chicago, Chicago, IL 60612, USA
Circ Res 102:1182-91. 2008..Induction of PTP1B by hindlimb ischemia may represent an important counterregulatory mechanism that blunts overactivation of VEGFR2 during angiogenesis in vivo... - Dual regulation of endothelial junctional permeabilityYulia A Komarova
Department of Pharmacology and Center for Lung and Vascular Biology, University of Illinois College of Medicine, Chicago, IL 60612, USA
Sci STKE 2007:re8. 2007..This Review provides a working model for molecular mechanisms for the dual regulation of endothelial barrier function... - MYD88-dependent and -independent activation of TREM-1 via specific TLR ligandsHeng Zheng
Department of Veterans Affairs, Jesse Brown VA Hospital, and Department of Pharmacology, University of Illinois, Chicago, IL 60612, USA
Eur J Immunol 40:162-71. 2010..However, the downstream signaling required for the expression of TREM-1 is dependent on the stimulus and the surface receptor through which the signaling is initiated... - Forskolin induces myosin light chain dephosphorylation in bovine trabecular meshwork cellsCharanya Ramachandran
School of Optometry, Indiana University, Bloomington, Indiana 47405, USA
Curr Eye Res 33:169-76. 2008..In this study, we have investigated effects of forskolin, which is known to elevate cAMP and also enhance aqueous humor outflow, on myosin light chain (MLC) phosphorylation, a biochemical marker of actin contractility... - Lysophosphatidylcholine: an enigmatic lysolipidDolly Mehta
Am J Physiol Lung Cell Mol Physiol 289:L174-5. 2005 - p120: the guardian of endothelial junctional integrityDolly Mehta
Am J Physiol Lung Cell Mol Physiol 286:L1140-2. 2004
Research Grants
- Focal Adhesion Kinase Regulation of Lung Vascular Permeability and EdemagenesisDolly Mehta; Fiscal Year: 2010..These studies will be critical for defining the mechanism of restoration of endothelial barrier function and identifying potential new molecular targets in the pharmacotherapy of ARDS. ..
- Rho Regulation of Pulmonary Vascular PermeabilityDolly Mehta; Fiscal Year: 2010..We believe that characterization of an important calcium channel in endothelial cells, TRPC6 will provide valuable insights to help us develop therapeutic strategies to reverse the vascular leakiness and thereby lung injury. ..
- Focal Adhesion Kinase Regulation of Lung Vascular Permeability and EdemagenesisDolly Mehta; Fiscal Year: 2007..These studies will be critical for defining the mechanism of restoration of endothelial barrier function and identifying potential new molecular targets in the pharmacotherapy of ARDS. ..
- Rho Regulation of Pulmonary Vascular PermeabilityDolly Mehta; Fiscal Year: 2006..With the information gained, it is hoped that new lines of therapy could be developed against inflammatory diseases that are characterized by "leaky" pulmonary vessel. ..
- Rho Regulation of Pulmonary Vascular PermeabilityDolly Mehta; Fiscal Year: 2011..We believe that characterization of an important calcium channel in endothelial cells, TRPC6 will provide valuable insights to help us develop therapeutic strategies to reverse the vascular leakiness and thereby lung injury. ..