Borna Mehrad

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi Differential effects of oral versus transdermal estrogen replacement therapy on C-reactive protein in postmenopausal women
    Wanpen Vongpatanasin
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75390, USA
    J Am Coll Cardiol 41:1358-63. 2003
  2. ncbi Conditional transgenic models to study chemokine biology
    Sergio A Lira
    Immunobiology Center, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Biol 239:105-22. 2004
  3. pmc Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis
    Brad E Morrison
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9034, USA
    J Clin Invest 112:1862-70. 2003
  4. ncbi Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease
    Borna Mehrad
    Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA, USA
    Biochem Biophys Res Commun 353:104-8. 2007
  5. ncbi Transient lung-specific expression of the chemokine KC improves outcome in invasive aspergillosis
    Borna Mehrad
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Am J Respir Crit Care Med 166:1263-8. 2002
  6. ncbi The lupus-susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections
    Borna Mehrad
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 176:3233-9. 2006
  7. pmc The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis
    Robert M Strieter
    Department of Medicine, Division of Pulmonary Critical Care, Box 800466, Charlottesville, VA 22908 0466, USA
    J Leukoc Biol 86:1111-8. 2009
  8. pmc The role of circulating mesenchymal progenitor cells, fibrocytes, in promoting pulmonary fibrosis
    Robert M Strieter
    University of Virginia, Department of Medicine, Division of Pulmonary Critical Care, Box 800466, Charlottesville, Virginia 22908 0466, USA
    Trans Am Clin Climatol Assoc 120:49-59. 2009
  9. pmc The role of CC chemokine receptor 6 in host defense in a model of invasive pulmonary aspergillosis
    Anagha P Phadke
    Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Respir Crit Care Med 175:1165-72. 2007
  10. pmc Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection
    Matthew A Crawford
    Department of Medicine, University of Virginia, Charlottesville, VA, USA
    PLoS Pathog 6:e1001199. 2010

Collaborators

Detail Information

Publications25

  1. ncbi Differential effects of oral versus transdermal estrogen replacement therapy on C-reactive protein in postmenopausal women
    Wanpen Vongpatanasin
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75390, USA
    J Am Coll Cardiol 41:1358-63. 2003
    ..We investigated whether the route of estrogen replacement therapy (ET) is the major determinant of C-reactive protein (CRP) in postmenopausal women...
  2. ncbi Conditional transgenic models to study chemokine biology
    Sergio A Lira
    Immunobiology Center, Mount Sinai School of Medicine, New York, NY, USA
    Methods Mol Biol 239:105-22. 2004
  3. pmc Chemokine-mediated recruitment of NK cells is a critical host defense mechanism in invasive aspergillosis
    Brad E Morrison
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9034, USA
    J Clin Invest 112:1862-70. 2003
    ....
  4. ncbi Circulating peripheral blood fibrocytes in human fibrotic interstitial lung disease
    Borna Mehrad
    Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA, USA
    Biochem Biophys Res Commun 353:104-8. 2007
    ..Taken together, these data suggest that fibrocytes are involved in the pathogenesis of human lung fibrosis...
  5. ncbi Transient lung-specific expression of the chemokine KC improves outcome in invasive aspergillosis
    Borna Mehrad
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Am J Respir Crit Care Med 166:1263-8. 2002
    ..Taken together, these data suggest that overexpression of KC in the lung in the setting of established invasive aspergillosis results in improved host defense and outcome of disease...
  6. ncbi The lupus-susceptibility locus, Sle3, mediates enhanced resistance to bacterial infections
    Borna Mehrad
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Immunol 176:3233-9. 2006
    ..These observations support the concept that some of the genetic loci that mediate autoimmunity may also confer augmented antimicrobial innate immunity...
  7. pmc The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of pulmonary fibrosis
    Robert M Strieter
    Department of Medicine, Division of Pulmonary Critical Care, Box 800466, Charlottesville, VA 22908 0466, USA
    J Leukoc Biol 86:1111-8. 2009
    ..In this review, we present data supporting the critical role these cells play in the pathogenesis of pulmonary fibrosis...
  8. pmc The role of circulating mesenchymal progenitor cells, fibrocytes, in promoting pulmonary fibrosis
    Robert M Strieter
    University of Virginia, Department of Medicine, Division of Pulmonary Critical Care, Box 800466, Charlottesville, Virginia 22908 0466, USA
    Trans Am Clin Climatol Assoc 120:49-59. 2009
    ..In this review, we present data supporting the critical role these cells play in the pathogenesis of pulmonary fibrosis...
  9. pmc The role of CC chemokine receptor 6 in host defense in a model of invasive pulmonary aspergillosis
    Anagha P Phadke
    Division of Pulmonary and Critical Care Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Respir Crit Care Med 175:1165-72. 2007
    ..CCR6, a beta-chemokine receptor, mediates migration of dendritic cells (DCs) and several lymphocyte subsets to sites of epithelial inflammation, but its role in infections has not been examined extensively...
  10. pmc Interferon-inducible CXC chemokines directly contribute to host defense against inhalational anthrax in a murine model of infection
    Matthew A Crawford
    Department of Medicine, University of Virginia, Charlottesville, VA, USA
    PLoS Pathog 6:e1001199. 2010
    ..anthracis infection, as well as infections caused by pathogenic and potentially, multi-drug resistant bacteria including other spore-forming organisms...
  11. pmc Fibrocyte CXCR4 regulation as a therapeutic target in pulmonary fibrosis
    Borna Mehrad
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA 22908, United States
    Int J Biochem Cell Biol 41:1708-18. 2009
    ..This approach may hold promise in human fibrotic lung diseases...
  12. pmc Neutrophils mediate maturation and efflux of lung dendritic cells in response to Aspergillus fumigatus germ tubes
    Stacy J Park
    Department of Microbiology, Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, Virginia, USA
    Infect Immun 80:1759-65. 2012
    ..Taken together, our data support an immunomodulatory cross talk between neutrophils and dendritic cells in the context of host response to Aspergillus that promotes the maturation and efflux of lung dendritic cells...
  13. pmc The role of circulating mesenchymal progenitor cells (fibrocytes) in the pathogenesis of fibrotic disorders
    Ellen C Keeley
    Divisions of Cardiology, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    Thromb Haemost 101:613-8. 2009
    ..In this review we will present data supporting the critical role they play in the pathogenesis of chronic inflammatory fibrotic diseases of the lungs, heart and vasculature...
  14. ncbi Neutrophils regulate airway responses in a model of fungal allergic airways disease
    Stacy J Park
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    J Immunol 176:2538-45. 2006
    ..Taken together, these data implicate neutrophils in the pathogenesis of fungal allergic airway disease...
  15. pmc New mechanisms of pulmonary fibrosis
    Robert M Strieter
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908 0466, USA
    Chest 136:1364-70. 2009
    ..In this review, we will discuss these evolving conceptual mechanisms for the pathogenesis of pulmonary fibrosis relevant to idiopathic pulmonary fibrosis...
  16. pmc Identification of the bacterial protein FtsX as a unique target of chemokine-mediated antimicrobial activity against Bacillus anthracis
    Matthew A Crawford
    Department of Medicine, Division of Infectious Diseases, University of Virginia, Charlottesville, VA 22908, USA
    Proc Natl Acad Sci U S A 108:17159-64. 2011
    ....
  17. pmc Antimicrobial effects of interferon-inducible CXC chemokines against Bacillus anthracis spores and bacilli
    Matthew A Crawford
    Department of Medicine, Division of Infectious Diseases, University of Virginia Health Sciences System, Charlottesville, VA 22908, USA
    Infect Immun 77:1664-78. 2009
    ..anthracis infection as well as infections caused by other spore-forming organisms...
  18. pmc Plasma CXCL12 levels as a predictor of future stroke
    Robert C Schutt
    Department of Medicine, University of Virginia, Division of Cardiology, PO Box 800158, Charlottesville, VA 22908 0158, USA
    Stroke 43:3382-6. 2012
    ..The aim of this study was to test the hypothesis that elevated circulating baseline CXCL12 levels are associated with subsequent stroke...
  19. pmc Chemokines as mediators of angiogenesis
    Borna Mehrad
    Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, VA, USA
    Thromb Haemost 97:755-62. 2007
    ..In this review, we summarize the key literature in this growing field...
  20. pmc Chemokines as mediators of neovascularization
    Ellen C Keeley
    Department of Medicine, Division of Cardiology, University of Virginia, Charlottesville, VA 22908 0466, USA
    Arterioscler Thromb Vasc Biol 28:1928-36. 2008
    ..In addition, CCL2, a CC chemokine ligand, has been implicated in arteriogenesis. In this article, we review the current literature on the role of chemokines as mediators of neovascularization...
  21. pmc Chemokines as mediators of tumor angiogenesis and neovascularization
    Ellen C Keeley
    Department of Medicine, Division of Cardiology, University of Virginia, Charlottesville, VA, USA
    Exp Cell Res 317:685-90. 2011
    ..In this paper, we review the current literature regarding the role of chemokines as mediators of tumor angiogenesis and neovascularization...
  22. pmc CXC chemokines in cancer angiogenesis and metastases
    Ellen C Keeley
    Division of Cardiology, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
    Adv Cancer Res 106:91-111. 2010
    ..In this chapter, we will discuss the disparate activity that CXC chemokines play in regulating cancer-associated angiogenesis and metastases...
  23. pmc The role of fibrocytes in fibrotic diseases of the lungs and heart
    Ellen C Keeley
    Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia, Lee Street, Charlottesville, Virginia 22908, USA
    Fibrogenesis Tissue Repair 4:2. 2011
    ..In this review, we focus on the contribution of fibrocytes to fibrotic diseases of the lungs and the heart, including interstitial lung diseases, asthma, pulmonary hypertension, atherosclerosis and ischemic cardiomyopathy...
  24. pmc Innate immunity to Aspergillus species
    Stacy J Park
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Virginia, P O Box 800546, Charlottesville, VA 22908, USA
    Clin Microbiol Rev 22:535-51. 2009
    ..In this review, we summarize the current literature on the multiple layers of innate defenses against Aspergillus species that dictate the outcome of this host-microbe interaction...
  25. pmc Circulating progenitor cells in chronic lung disease
    Borna Mehrad
    University of Virginia, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Box 800546, Charlottesville, VA 22908, USA
    Expert Rev Respir Med 1:157-65. 2007
    ..In this review, we summarize the current understanding of the biology of adult circulating progenitors as related to lung disease...