Mandeep R Mehra

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Fish oils produce anti-inflammatory effects and improve body weight in severe heart failure
    Mandeep R Mehra
    Division of Cardiology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Heart Lung Transplant 25:834-8. 2006
  2. ncbi request reprint The emergence of genomic and proteomic biomarkers in heart transplantation
    Mandeep R Mehra
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Heart Lung Transplant 24:S213-8. 2005
  3. doi request reprint Gene-based bio-signature patterns and cardiac allograft rejection
    Mandeep R Mehra
    Division of Cardiology, University of Maryland School of Medicine, 22 South Greene Street S3B06, Baltimore, MD 21201, USA
    Heart Fail Clin 6:87-92. 2010
  4. doi request reprint Clinical implications and longitudinal alteration of peripheral blood transcriptional signals indicative of future cardiac allograft rejection
    Mandeep R Mehra
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Heart Lung Transplant 27:297-301. 2008
  5. doi request reprint High-density lipoprotein cholesterol levels and prognosis in advanced heart failure
    Mandeep R Mehra
    Division of Cardiology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Heart Lung Transplant 28:876-80. 2009
  6. doi request reprint Cardiomyopathy and the dilemma of geometric mitral regurgitation
    Mandeep R Mehra
    Division of Cardiology, University of Maryland School of Medicine, University Medical Center, 22 South Greene Street, Baltimore, MD 21201, USA
    Curr Opin Cardiol 24:179-83. 2009
  7. ncbi request reprint Gene expression profiling and cardiac allograft rejection monitoring: is IMAGE just a mirage?
    Mandeep R Mehra
    University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Heart Lung Transplant 29:599-602. 2010
  8. ncbi request reprint Transcriptional signals of T-cell and corticosteroid-sensitive genes are associated with future acute cellular rejection in cardiac allografts
    Mandeep R Mehra
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Heart Lung Transplant 26:1255-63. 2007
  9. ncbi request reprint The promise of protein-based and gene-based clinical markers in heart transplantation: from bench to bedside
    Mandeep R Mehra
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Nat Clin Pract Cardiovasc Med 3:136-43. 2006
  10. ncbi request reprint Optimizing outcomes in the patient with acute decompensated heart failure
    Mandeep R Mehra
    Division of Cardiology, Department of Medicine, University of Maryland, Baltimore, MD, USA
    Am Heart J 151:571-9. 2006

Collaborators

Detail Information

Publications92

  1. ncbi request reprint Fish oils produce anti-inflammatory effects and improve body weight in severe heart failure
    Mandeep R Mehra
    Division of Cardiology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Heart Lung Transplant 25:834-8. 2006
    ..We sought to evaluate the effects of fish oils on pro-inflammatory cytokines and body weight in patients with advanced heart failure...
  2. ncbi request reprint The emergence of genomic and proteomic biomarkers in heart transplantation
    Mandeep R Mehra
    Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Heart Lung Transplant 24:S213-8. 2005
  3. doi request reprint Gene-based bio-signature patterns and cardiac allograft rejection
    Mandeep R Mehra
    Division of Cardiology, University of Maryland School of Medicine, 22 South Greene Street S3B06, Baltimore, MD 21201, USA
    Heart Fail Clin 6:87-92. 2010
    ..Despite these advances, clinical entrenchment of gene-based pharmacotherapy in cardiac transplantation will require independent replication and validation of investigational findings...
  4. doi request reprint Clinical implications and longitudinal alteration of peripheral blood transcriptional signals indicative of future cardiac allograft rejection
    Mandeep R Mehra
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Heart Lung Transplant 27:297-301. 2008
    ..We have previously demonstrated that a peripheral blood transcriptional profile using 11 distinct genes predicts onset of cardiac allograft rejection weeks to months prior to the actual event...
  5. doi request reprint High-density lipoprotein cholesterol levels and prognosis in advanced heart failure
    Mandeep R Mehra
    Division of Cardiology, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Heart Lung Transplant 28:876-80. 2009
    ..Prostaglandins represent an important compensatory pathway in advanced heart failure (HF). Whether HDL levels discriminate prognosis in HF remains unknown...
  6. doi request reprint Cardiomyopathy and the dilemma of geometric mitral regurgitation
    Mandeep R Mehra
    Division of Cardiology, University of Maryland School of Medicine, University Medical Center, 22 South Greene Street, Baltimore, MD 21201, USA
    Curr Opin Cardiol 24:179-83. 2009
    ..In this review, we discuss contemporary directions in the knowledge base for managing geometric mitral regurgitation...
  7. ncbi request reprint Gene expression profiling and cardiac allograft rejection monitoring: is IMAGE just a mirage?
    Mandeep R Mehra
    University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Heart Lung Transplant 29:599-602. 2010
    ..Furthermore, we contend that it may not be necessary to replace an invasive cardiac biopsy strategy with anything other than better standardized clinical and functional allograft vigilance in low-risk survivors...
  8. ncbi request reprint Transcriptional signals of T-cell and corticosteroid-sensitive genes are associated with future acute cellular rejection in cardiac allografts
    Mandeep R Mehra
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Heart Lung Transplant 26:1255-63. 2007
    ..Profiling mRNA levels of 11 informative genes expressed by circulating immune effector cells identifies cardiac allograft recipients at low risk for current moderate-severe acute cellular rejection (ACR)...
  9. ncbi request reprint The promise of protein-based and gene-based clinical markers in heart transplantation: from bench to bedside
    Mandeep R Mehra
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Nat Clin Pract Cardiovasc Med 3:136-43. 2006
    ..We discuss here the main findings for the more-successful protein markers identified so far, and the genomic molecular approaches being used to improve heart transplant outcomes...
  10. ncbi request reprint Optimizing outcomes in the patient with acute decompensated heart failure
    Mandeep R Mehra
    Division of Cardiology, Department of Medicine, University of Maryland, Baltimore, MD, USA
    Am Heart J 151:571-9. 2006
    ....
  11. pmc Death messengers
    Mandeep R Mehra
    Department of Medicine, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
    BMJ 335:1296-7. 2007
  12. doi request reprint Highlights of the 2007 Scientific Meeting of the Heart Failure Society of America: Washington, DC, September 16-19, 2007
    Mandeep R Mehra
    Cardiology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Am Coll Cardiol 51:320-7. 2008
  13. doi request reprint Evidence of clinical practice heterogeneity in the use of implantable cardioverter-defibrillators in heart failure and post-myocardial infarction left ventricular dysfunction: Findings from IMPROVE HF
    Mandeep R Mehra
    University of Maryland School of Medicine, Baltimore, Maryland, USA
    Heart Rhythm 6:1727-34. 2009
    ....
  14. ncbi request reprint Genomic biomarkers and heart transplantation
    Mandeep R Mehra
    University of Maryland, Baltimore, MD 21201, USA
    Heart Fail Clin 3:83-6. 2007
    ..These advances, if continually validated in practice, could usher in an era of decreased immunosuppression complications, lesser need for invasive surveillance, and more clinical confidence in immunosuppressive strategies...
  15. ncbi request reprint Rationale, design, and methods for the Transplant-Eligible MAnagement of Congestive Heart Failure (TMAC) trial: a multicenter clinical outcomes trial using nesiritide for TMAC
    Mandeep R Mehra
    University of Maryland School of Medicine, Baltimore, MD 21201 1595, USA
    Am Heart J 153:932-40. 2007
    ....
  16. doi request reprint International Society for Heart and Lung Transplantation working formulation of a standardized nomenclature for cardiac allograft vasculopathy-2010
    Mandeep R Mehra
    ISHLT Working Group on Classification of Cardiac Allograft Vasculopathy commissioned by the Education Committee and Board of Directors of the Society
    J Heart Lung Transplant 29:717-27. 2010
    ..This document represents a working formulation for an international nomenclature of cardiac allograft vasculopathy, similar to the development of the system for adjudication of cardiac allograft rejection by histology...
  17. ncbi request reprint Gene expression profiles and B-type natriuretic peptide elevation in heart transplantation: more than a hemodynamic marker
    Mandeep R Mehra
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Circulation 114:I21-6. 2006
    ..This investigation studied peripheral gene expression signatures of elevated BNP concentrations in clinically quiescent heart transplant recipients in an effort to elucidate molecular correlates beyond hemodynamic perturbations...
  18. doi request reprint Comparison of medical therapy dosing in outpatients cared for in cardiology practices with heart failure and reduced ejection fraction with and without device therapy: report from IMPROVE HF
    J Thomas Heywood
    Division of Cardiology, Scripps Clinic Torrey Pines, La Jolla, Calif 92037, USA
    Circ Heart Fail 3:596-605. 2010
    ..Few data exist to characterize the delivery of evidence-based medical therapy for outpatients with heart failure who have received implantable cardioverter-defibrillators or cardiac resynchronization therapy (CRT) for systolic dysfunction...
  19. doi request reprint Factors associated with improvement in guideline-based use of ICDs in eligible heart failure patients
    Mandeep R Mehra
    University of Maryland School of Medicine, Baltimore, Maryland, USA
    Pacing Clin Electrophysiol 35:135-45. 2012
    ..We investigated patient, physician, and practice factors associated with improvements in ICD use...
  20. doi request reprint Improving evidence-based care for heart failure in outpatient cardiology practices: primary results of the Registry to Improve the Use of Evidence-Based Heart Failure Therapies in the Outpatient Setting (IMPROVE HF)
    Gregg C Fonarow
    Department of Medicine, Ahmanson UCLA Cardiomyopathy Center, UCLA Medical Center, Los Angeles, CA 90095 1679, USA
    Circulation 122:585-96. 2010
    ....
  21. doi request reprint B-type natriuretic peptide assessment in ambulatory heart failure patients: insights from IMPROVE HF
    Andrew P Ambrosy
    Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    J Cardiovasc Med (Hagerstown) 13:360-7. 2012
    ....
  22. doi request reprint Factors associated with improvement in ejection fraction in clinical practice among patients with heart failure: findings from IMPROVE HF
    Jane E Wilcox
    Division of Cardiology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
    Am Heart J 163:49-56.e2. 2012
    ..This study evaluated changes in LVEF and associated factors in outpatients with systolic HF or post-myocardial infarction with reduced LVEF during 24 months of follow-up...
  23. doi request reprint Lack of diagnostic and prognostic utility of circulating plasma myeloperoxidase concentrations in patients presenting with dyspnea
    Keyur B Shah
    The University of Maryland School of Medicine, Department of Medicine, Baltimore, MD, USA
    Clin Chem 55:59-67. 2009
    ..We sought to assess the diagnostic accuracy of MPO for acute decompensated heart failure (ADHF) and its prognostic value for patients with acute dyspnea...
  24. doi request reprint Tobacco smoke exposure in either the donor or recipient before transplantation accelerates cardiac allograft rejection, vascular inflammation, and graft loss
    Ashwani K Khanna
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Circulation 120:1814-21. 2009
    ..In this experimental study, we investigated early consequences of tobacco smoke exposure in cardiac transplant donors and recipients with an emphasis on alloinflammatory mediators of graft outcome...
  25. doi request reprint Evidence for early right ventricular and septal mechanical activation (interventricular dyssynchrony) in pulmonary hypertension
    Daniel J Schwartz
    Department of Internal Medicine, Division of Cardiology, University of Maryland Medical Systems, Baltimore, Maryland, USA
    Am J Cardiol 102:1273-7. 2008
    ..In conclusion, PAH is associated with interventricular dyssynchrony manifested by accelerated RV free wall and septal activation times. Whether such dyssynchrony should serve as a therapeutic target remains to be determined...
  26. doi request reprint Heart failure care in the outpatient cardiology practice setting: findings from IMPROVE HF
    Gregg C Fonarow
    Department of Medicine, Ahmanson UCLA Cardiomyopathy Center, UCLA Medical Center, Los Angeles, CA 90095 1679, USA
    Circ Heart Fail 1:98-106. 2008
    ..IMPROVE HF is a prospective cohort study designed to characterize current management of patients with chronic HF and ejection fraction < or =35% in a national registry of 167 US outpatient cardiology practices...
  27. ncbi request reprint Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure
    Larry A Allen
    Division of Cardiology, University of Colorado Denver, Aurora, CO, USA
    J Card Fail 16:230-8. 2010
    ..Our study sought to validate the prognostic value of RDW in heart failure and to explore the potential mechanisms underlying this association...
  28. doi request reprint Antioxidant N-acetyl cysteine reverses cigarette smoke-induced myocardial infarction by inhibiting inflammation and oxidative stress in a rat model
    Ashwani K Khanna
    Department of Pathology, University of Maryland, Baltimore, MD 21201, USA
    Lab Invest 92:224-35. 2012
    ....
  29. doi request reprint Associations between outpatient heart failure process-of-care measures and mortality
    Gregg C Fonarow
    Department of Medicine, Ahmanson UCLA Cardiomyopathy Center, Los Angeles, CA 90095 1679, USA
    Circulation 123:1601-10. 2011
    ..However, this association has not been evaluated for current and emerging outpatient HF measures...
  30. pmc Chronic heart failure: contemporary diagnosis and management
    Gautam V Ramani
    University of Maryland School of Medicine, Baltimore, USA
    Mayo Clin Proc 85:180-95. 2010
    ....
  31. pmc Prospective, observational study of antiplatelet and coagulation biomarkers as predictors of thromboembolic events after implantation of ventricular assist devices
    Farhan Majeed
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD, USA
    Nat Clin Pract Cardiovasc Med 6:147-57. 2009
    ..We evaluated the predictive value of aspirin hyporesponsiveness and markers of coagulation and fibrinolysis...
  32. ncbi request reprint Imaging markers of adverse remodeling: from organ to organelle
    Eric M Thorn
    University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Heart Fail Clin 2:117-27. 2006
  33. doi request reprint Surgery for severe mitral regurgitation and left ventricular failure: what do we really know?
    Mandeep R Mehra
    Division of Cardiology, Department of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Card Fail 14:145-50. 2008
    ..It is unclear if surgery is associated with improved survival in this setting. There is a pressing need for well-conducted prospective randomized clinical trials to quantify the benefits of surgical repair of functional geometric MR...
  34. pmc New York Heart Association functional class predicts exercise parameters in the current era
    Stuart D Russell
    Department of Medicine, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Am Heart J 158:S24-30. 2009
    ..Using baseline data from the HF-ACTION (Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing) study, we examined this relationship...
  35. doi request reprint Immune reconstitution inflammatory syndrome and human immunodeficiency virus-associated myocarditis
    Jonathan S Rogers
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mayo Clin Proc 83:1275-9. 2008
    ..The case underscores the importance of recognizing this potential complication of AIDS treatment and calls for renewed vigilance concerning cardiac manifestations of HIV, especially during the immune reconstitution phase...
  36. doi request reprint Acute heart failure syndromes in patients with coronary artery disease early assessment and treatment
    James D Flaherty
    Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
    J Am Coll Cardiol 53:254-63. 2009
    ..Prospective studies of the assessment and treatment of CAD in patients with AHFS are urgently needed...
  37. ncbi request reprint Statin use and risks of death or fatal rejection in the Heart Transplant Lipid Registry
    Audrey H Wu
    Division of Cardiology, Department of Medicine, University of Washington, Seattle, Washington, USA
    Am J Cardiol 95:367-72. 2005
    ..Statin therapy was significantly associated with lower risk of death and fatal rejection, benefits that were independent of lipid values...
  38. pmc Simultaneous "hybrid" percutaneous coronary intervention and minimally invasive surgical bypass grafting: feasibility, safety, and clinical outcomes
    Barry Reicher
    Division of Cardiology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    Am Heart J 155:661-7. 2008
    ....
  39. doi request reprint Current and future challenges in therapy for antibody-mediated rejection
    Nandini Nair
    Division of Cardiology, Scott and White Hospital, Temple, Texas 76508, USA
    J Heart Lung Transplant 30:612-7. 2011
    ..This review discusses the challenges in treating AMR and provides a critical analysis of current and possible future therapies...
  40. doi request reprint Test-retest reliability of assessment for intraventricular dyssynchrony by tissue Doppler imaging echocardiography
    Mark R Vesely
    Division of Cardiology, Department of Medicine, University of Maryland Hospital and School of Medicine, Baltimore, MD, USA
    Am J Cardiol 101:645-50. 2008
    ..35). Bland-Altman analysis demonstrated wide confidence intervals, exceeding the diagnostic cutoff values for the respective criteria. In conclusion, the accurate assessment of IVD by TDI may be limited by poor test-retest reliability...
  41. ncbi request reprint Comparison of characteristics and outcomes of asymptomatic versus symptomatic left ventricular dysfunction in subjects 65 years old or older (from the Cardiovascular Health Study)
    Jay Pandhi
    Division of Cardiology, University of Maryland Medical Center, Baltimore, MD, USA
    Am J Cardiol 107:1667-74. 2011
    ..However, the prevalence is lower than in those with SLVSD. Patients with ALVSD are at an increased risk of HF and mortality, particularly those with greater severity of LV impairment...
  42. ncbi request reprint Durable mechanical circulatory support in advanced heart failure: a critical care cardiology perspective
    Anuradha Lala
    Department of Medicine, Division of Cardiology, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, A3, Boston, MA 02115, USA
    Cardiol Clin 31:581-93, viii-ix. 2013
    ..The "Holy Grail" for MCS will be a focus on clinical recovery and explantation of devices rather than the currently more narrowly defined indications of bridge to transplantation or lifetime device therapy. ..
  43. ncbi request reprint Brain injury and ventricular dysfunction: insights into reversible heart failure
    Radha Goel
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, MD, USA
    Congest Heart Fail 11:99-101. 2005
    ..The mechanisms leading to reversible cardiac dysfunction are discussed in this review, with concentration on the implications of such injury in determining outcomes following transplantation...
  44. pmc Targeted in vitro and in vivo gene transfer into T lymphocytes: potential of direct inhibition of allo-immune activation
    Ashwani K Khanna
    Department of Medicine, Division of Cardiology, University of Maryland, Baltimore, MD 21201, USA
    BMC Immunol 7:26. 2006
    ..Lymphocyte proliferation was quantified by 3H-thymidine uptake assay; IL-2 mRNA expression was studied by RT-PCR and using Real Time PCR assay, we monitored the CD3, p21, TNF-alpha and IFN-gamma mRNA expression...
  45. ncbi request reprint The characteristics and prognostic importance of NT-ProBNP concentrations in critically ill patients
    Keyur B Shah
    University of Maryland School of Medicine, Baltimore, USA
    Am J Med 120:1071-7. 2007
    ..We evaluate amino-terminal brain natriuretic peptide (NT-proBNP) in the medical ICU, specifically its correlation with noncardiac admission diagnosis and prognosis of critically ill patients...
  46. doi request reprint Adverse effects of nicotine and immunosuppression on proximal tubular epithelial cell viability, tissue repair and oxidative stress gene expression
    Ashwani K Khanna
    Tobacco Research Laboratory, Division of Cardiology, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
    J Heart Lung Transplant 28:612-20. 2009
    ..Tobacco recidivism is an important modifiable risk marker for cardiac allograft loss, but its effects on renal dysfunction remain poorly studied...
  47. ncbi request reprint Sexual activity and chronic heart failure
    Stacy A Mandras
    Division of Cardiology, Washington University in Saint Louis, St Louis, MO, USA
    Mayo Clin Proc 82:1203-10. 2007
    ..Fear of a cardiac event during intercourse can interfere with patients' ability to perform and enjoy sex, and so it is important that the physician be able to counsel patients with CHF about sexual activity...
  48. ncbi request reprint Amyloidosis and the heart: a comprehensive review
    Keyur B Shah
    Division of Cardiology, University of Maryland School of Medicine, Baltimore, USA
    Arch Intern Med 166:1805-13. 2006
    ..Heart transplantation is controversial and is generally performed only at isolated centers...
  49. ncbi request reprint Is all intimal proliferation created equal in cardiac allograft vasculopathy? The quantity-quality paradox
    Mandeep R Mehra
    Ochsner Cardiomyopathy and Heart Transplantation Center, Ochsner Clinic Foundation, New Orleans, Louisiana, USA
    J Heart Lung Transplant 22:118-23. 2003
    ..We sought to contrast clinical characteristics of heart transplant recipients who have prognostically relevant, severe intimal proliferation and who experience cardiac events with those who remain event free...
  50. ncbi request reprint Relationship among epicardial coronary disease, tissue myocardial perfusion, and survival in heart transplantation
    Srinivasa P Potluri
    Division of Cardiomyopathy and Cardiac Transplantation, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    J Heart Lung Transplant 24:1019-25. 2005
    ..We studied the correlation of epicardial coronary anatomy with microvascular flow as determined by TMPG and correlated it with patient outcome...
  51. ncbi request reprint Molecular testing in the management of cardiac transplant recipients: initial clinical experience
    Randall C Starling
    Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA
    J Heart Lung Transplant 25:1389-95. 2006
  52. ncbi request reprint Anything but a biopsy: noninvasive monitoring for cardiac allograft rejection
    Mandeep R Mehra
    Ochsner Cardiomyopathy and Heart Transplantation Center, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Curr Opin Cardiol 17:131-6. 2002
    ..Until well-constructed studies not only define the predictive values of noninvasive techniques but also appropriately evaluate the clinical safety of any such approach, invasive endomyocardial biopsy will remain the gold standard...
  53. ncbi request reprint Usefulness of an elevated B-type natriuretic peptide to predict allograft failure, cardiac allograft vasculopathy, and survival after heart transplantation
    Mandeep R Mehra
    Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, Louisiana 70121, USA
    Am J Cardiol 94:454-8. 2004
    ..002). Higher BNP levels in patients long after heart transplantation are associated with allograft dysfunction and cardiac allograft vasculopathy and are strongly and independently predictive of cardiovascular death...
  54. ncbi request reprint Cardiac troponin levels in heart failure
    Srinivasa Potluri
    Department of Cardiology, Ochsner Clinic Foundation, New Orleans, Louisiana, USA
    Cardiol Rev 12:21-5. 2004
    ..Furthermore, large-scale trials are necessary to establish them as noninvasive monitoring markers of heart failure and effectiveness of treatment...
  55. ncbi request reprint Surrogate markers for late cardiac allograft survival
    Mandeep R Mehra
    Ochsner Clinic Foundation, New Orleans, LA, USA
    Am J Transplant 4:1184-91. 2004
    ....
  56. ncbi request reprint Obesity and suppressed B-type natriuretic peptide levels in heart failure
    Mandeep R Mehra
    Department of Cardiovascular Medicine, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    J Am Coll Cardiol 43:1590-5. 2004
    ..This investigation evaluated the relationship between obesity and B-type natriuretic peptide (BNP) in heart failure...
  57. ncbi request reprint The impact of mode of donor brain death on cardiac allograft vasculopathy: an intravascular ultrasound study
    Mandeep R Mehra
    Ochsner Cardiomyopathy and Heart Transplantation Center, Ochsner Medical Institutions, New Orleans, Louisiana 70121, USA
    J Am Coll Cardiol 43:806-10. 2004
    ..We evaluated the association of mode of brain death with cardiac allograft vasculopathy...
  58. ncbi request reprint B-type natriuretic peptide in heart transplantation: an important marker of allograft performance
    Myung H Park
    Cardiomyopathy and Heart Transplant Center, Ochsner Clinic Foundation, New Orleans, LA, USA
    Heart Fail Rev 8:359-63. 2003
    ..Further studies are needed to further assess the utility of BNP as surrogate marker for cardiac function and adaptation...
  59. ncbi request reprint C-Reactive protein and cardiac allograft vasculopathy. is inflammation the critical link?
    Hector O Ventura
    J Am Coll Cardiol 42:483-5. 2003
  60. ncbi request reprint Body composition and prognosis in chronic systolic heart failure: the obesity paradox
    Carl J Lavie
    Ochsner Heart and Vascular Institute, New Orleans, Lousiana 70121, USA
    Am J Cardiol 91:891-4. 2003
  61. ncbi request reprint Is heart failure with preserved systolic function an overlooked enigma?
    Mandeep R Mehra
    The Ochsner Cardiomyopathy and Heart Transplantation Center, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Curr Cardiol Rep 4:187-93. 2002
    ..Outcomes-based placebo-controlled clinical trials are currently underway to define appropriate therapeutic strategies in diastolic heart failure...
  62. ncbi request reprint Ethnic disparity in clinical outcome after heart transplantation is abrogated using tacrolimus and mycophenolate mofetil-based immunosuppression
    Mandeep R Mehra
    The Ochsner Cardiomyopathy and Heart Transplantation Center, Ochsner Clinic Foundation, New Orleans, LA, USA
    Transplantation 74:1568-73. 2002
    ..We examined the hypothesis that a combination of tacrolimus and mycophenolate mofetil "resurrects" clinical outcome of black Americans to those seen in white heart transplant recipients...
  63. ncbi request reprint Usefulness of B-type natriuretic peptide levels in predicting hemodynamic perturbations after heart transplantation despite preserved left ventricular systolic function
    Myung H Park
    The Cardiomyopathy and Heart Transplantation Center, The Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Am J Cardiol 90:1326-9. 2002
    ..Rapid bedside BNP analysis may provide a noninvasive surrogate method for the comprehensive assessment of cardiac allograft function and hemodynamics in heart transplantation...
  64. ncbi request reprint Effect of immunosuppressive regimen on novel markers of atherothrombosis in heart transplantation: homocysteine, c-reactive protein, and mean platelet volume
    Mandeep R Mehra
    The Ochsner Cardiomyopathy and Heart Transplantation Center, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Transplant Proc 34:1866-8. 2002
  65. ncbi request reprint Bedside b-type natriuretic peptide and acute non-cellular cardiac allograft rejection
    Myung H Park
    J Heart Lung Transplant 21:613-4. 2002
  66. ncbi request reprint Efficacy and safety of sildenafil in the evaluation of pulmonary hypertension in severe heart failure
    Jamshid Alaeddini
    Cardiomyopathy and Heart Transplantation Center, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Am J Cardiol 94:1475-7. 2004
    ..Compared with sildenafil 25 mg, sildenafil 50 mg demonstrated greater reductions of pulmonary pressures. Oral sildenafil is safe and effective for the evaluation of PH reactivity in heart failure...
  67. ncbi request reprint Recrudescent tobacco exposure following heart transplantation: clinical profiles and relationship with athero-thrombosis risk markers
    Mandeep R Mehra
    The Cardiomyopathy and Heart Transplantation Center, Ochsner Clinic Foundation, New Orleans, LA, USA
    Am J Transplant 5:1137-40. 2005
    ..The adverse effects of tobacco do not appear to be directly modulated by an effect on athero-thrombotic risk markers...
  68. ncbi request reprint Listing criteria for heart transplantation: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates--2006
    Mandeep R Mehra
    International Society for Heart and Lung Transplantation, Addison, Texas 75001, USA
    J Heart Lung Transplant 25:1024-42. 2006
  69. ncbi request reprint A multicenter, prospective, randomized, double-blind trial of basiliximab in heart transplantation
    Mandeep R Mehra
    Cardiomyopathy and Heart Transplant Center, Ochsner Clinic Foundation, New Orleans, Louisiana, USA
    J Heart Lung Transplant 24:1297-304. 2005
    ....
  70. ncbi request reprint Utility of impedance cardiography for the identification of short-term risk of clinical decompensation in stable patients with chronic heart failure
    Milton Packer
    University of Texas Southwestern Medical Center, Dallas, Texas 75390 8822, USA
    J Am Coll Cardiol 47:2245-52. 2006
    ..This study sought to assess the potential utility of impedance cardiography (ICG) in predicting clinical deterioration in ambulatory patients with heart failure (HF)...
  71. ncbi request reprint Steroid weaning in heart transplantation is associated with decreased B-type natriuretic peptide: surrogate evidence for cardiac adaptation
    P A Uber
    Ochsner Cardiomyopathy and Heart Transplantation Center, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Transplant Proc 34:1843-4. 2002
  72. ncbi request reprint It is time to stop ignoring malignancy in heart transplantation: a call to arms
    Paul J Hauptman
    St Louis University Health Sciences Center, MO 63110, USA
    J Heart Lung Transplant 24:1111-3. 2005
    ..Recommendations on malignancy screening are provided as well as an outline of areas of ongoing uncertainty...
  73. ncbi request reprint Multicenter retrospective analysis of cardiovascular risk factors affecting long-term outcome of de novo cardiac transplant recipients
    Jon A Kobashigawa
    University of California at Los Angeles, Los Angeles, California 90095, USA
    J Heart Lung Transplant 25:1063-9. 2006
    ..This study is the first in-depth multicenter assessment of ongoing post-transplant risk factors in heart transplant patients and their impact on 5-year outcomes...
  74. ncbi request reprint Understanding B-type natriuretic peptide and its role in diagnosing and monitoring congestive heart failure
    Alan Maisel
    Coronary Care Unit, La Jolla VA Medical Center, San Diego, CA, USA
    Clin Cornerstone 7:S7-17. 2005
    ..Emerging clinical data will help further refine biomarker-guided therapeutic and monitoring strategies involving BNP...
  75. ncbi request reprint The economic implications of noninvasive molecular testing for cardiac allograft rejection
    Roger W Evans
    Am J Transplant 5:1553-8. 2005
    ....
  76. ncbi request reprint Multicenter intravascular ultrasound validation study among heart transplant recipients: outcomes after five years
    Jon A Kobashigawa
    University of California at Los Angeles, Los Angeles, California, USA
    J Am Coll Cardiol 45:1532-7. 2005
    ..We sought to assess the validity of first-year intravascular ultrasound (IVUS) data as a surrogate marker for long-term outcome after heart transplantation...
  77. ncbi request reprint Comparison of cardiac and peripheral arterial stiffening and ventriculovascular uncoupling in patients with uncomplicated hypertension versus patients with hypertension after heart transplantation
    Richard V Milani
    Department of Cardiology, Ochsner Clinic Foundation, New Orleans, Louisiana, USA
    Am J Cardiol 98:789-92. 2006
    ..These aberrations, which determine cardiovascular performance in the setting of HT, are not simply explained by vascular age or post-transplantation hypertension but may adversely affect functional capacity...
  78. ncbi request reprint Patient selection for cardiac resynchronization therapy: from the Council on Clinical Cardiology Subcommittee on Electrocardiography and Arrhythmias and the Quality of Care and Outcomes Research Interdisciplinary Working Group, in collaboration with the H
    S Adam Strickberger
    Circulation 111:2146-50. 2005
    ..This advisory identifies appropriate candidates for CRT on the basis of the inclusion criteria and results from the published clinical trials...
  79. ncbi request reprint Left ventricular geometry and survival in patients with normal left ventricular ejection fraction
    Richard V Milani
    Department of Cardiology Ochsner Clinic Foundation, New Orleans, Louisiana, USA
    Am J Cardiol 97:959-63. 2006
    ..Normalization of CR is associated with better survival, whereas transition to LV hypertrophy increases mortality...
  80. ncbi request reprint Peak oxygen consumption and heart failure prognosis in women
    Carl J Lavie
    J Am Coll Cardiol 49:375; author reply 375-6. 2007
  81. ncbi request reprint Calcineurin-inhibitor withdrawal in heart transplantation recipients (the case against)
    Mandeep R Mehra
    Ochsner Cardiomyopathy and Heart Transplantation Center, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Transplant Proc 34:1825-7. 2002
  82. ncbi request reprint Emergence of Laplace therapeutics: declaring an end to end-stage heart failure
    Mandeep R Mehra
    Ochsner Cardiomyopathy and Heart Transplantation Center, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Congest Heart Fail 8:228-31, 234. 2002
    ..We are at a new crossroad in our quest to tackle chronic heart failure. It is our contention that the use of antiremodeling strategies, including device approaches, will soon signal the end of end-stage heart failure...
  83. ncbi request reprint Induction therapy in heart transplantation: is there a role?
    Patricia A Uber
    J Heart Lung Transplant 26:205-9. 2007
  84. ncbi request reprint BNP Consensus Panel 2004: A clinical approach for the diagnostic, prognostic, screening, treatment monitoring, and therapeutic roles of natriuretic peptides in cardiovascular diseases
    Marc A Silver
    Department of Medicine and Heart Failure Institute, Advocate Christ Medical Center, Oak Lawn, IL 60453 2600, USA
    Congest Heart Fail 10:1-30. 2004
    ..An expert Consensus Panel with basic, methodological, and clinical expertise was convened to summarize current knowledge in these areas and the findings and consensus statements are contained herein...
  85. ncbi request reprint Comparative beneficial effects of simvastatin and pravastatin on cardiac allograft rejection and survival
    Mandeep R Mehra
    Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121 2483, USA
    J Am Coll Cardiol 40:1609-14. 2002
    ..We further examined the relative efficacy and safety of these two drugs on lipid-lowering in heart transplantation...
  86. ncbi request reprint Rationale and process: International Society for Heart and Lung Transplantation guidelines for the care of cardiac transplant candidates--2006
    Mandeep R Mehra
    International Society for Heart and Lung Transplantation, Addison, Texas 75001, USA
    J Heart Lung Transplant 25:1001-2. 2006
  87. ncbi request reprint Treatment of hypertension for patients with diastolic dysfunction
    Prakash Krishnan
    Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Curr Opin Cardiol 18:272-7. 2003
    ..One of the major causes of diastolic dysfunction is hypertension. Advances in diagnosis and treatment strategies may improve the clinical outcome for patients with diastolic dysfunction...
  88. ncbi request reprint An update on clinical outcomes in heart and lung transplantation
    Edward R Garrity
    Lung Transplantation Program, Loyola University Hospital, Maywood, IL, USA
    Transplantation 77:S68-74. 2004
    ..Tacrolimus therapy has contributed much to the success rates of both heart and lung transplantation, and by 2001, it had become the preeminent immunosuppressant agent used in lung transplantation...
  89. ncbi request reprint Mitral regurgitation in chronic heart failure: more questions than answers?
    Mandeep R Mehra
    Department of Cardiovascular Medicine, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Curr Cardiol Rep 6:96-9. 2004
    ..Even in highly experienced hands, intermediate outcomes appear to be inferior to those of cardiac transplantation. Percutaneous mitral valve repair remains an investigational procedure that warrants further clinical research...
  90. ncbi request reprint Ventricular assist devices: destination therapy or just another stop on the road?
    Mandeep R Mehra
    Ochsner Cardiomyopathy and Heart Transplantation Center, Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Curr Heart Fail Rep 1:36-40. 2004
    ....
  91. ncbi request reprint Usefulness of B-type natriuretic peptide as a predictor of treatment outcome in pulmonary arterial hypertension
    Myung H Park
    Cardiomyopathy and Pulmonary Vascular Disease Center, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Congest Heart Fail 10:221-5. 2004
    ..003). This investigation establishes the utility of BNP for predicting response to epoprostenol therapy in pulmonary arterial hypertension...
  92. pmc Gallstone disease in heart transplant recipients
    William S Richardson
    Ochsner Clinic Foundation, 1514 Jefferson Highway, New Orleans, LA 70121, USA
    Ann Surg 237:273-6. 2003
    ..To review the outcome of cholecystectomy after heart transplant...