G U Meduri

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. ncbi Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial
    G U Meduri
    Baptist Memorial Hospitals, Veterans Affairs Medical Center, University of Tennessee, Memphis, USA
    JAMA 280:159-65. 1998
  2. ncbi Pneumonia in acute respiratory distress syndrome. A prospective evaluation of bilateral bronchoscopic sampling
    G U Meduri
    Pulmonary and Critical Care Division, University of Tennessee and Veterans Administration Medical Center, Memphis, Tennessee, USA
    Am J Respir Crit Care Med 158:870-5. 1998
  3. ncbi Procollagen types I and III aminoterminal propeptide levels during acute respiratory distress syndrome and in response to methylprednisolone treatment
    G U Meduri
    Departments of Medicine and Preventive Medicine, and Memphis Lung Research Program, University of Tennessee, Baptist Memorial Hospitals, and Veterans Affairs Medical Center, Memphis, Tennessee, USA
    Am J Respir Crit Care Med 158:1432-41. 1998
  4. ncbi Cytokines IL-1beta, IL-6, and TNF-alpha enhance in vitro growth of bacteria
    G U Meduri
    Memphis Lung Research Program, Department of Medicine, Division of Pulmonary, Department of Preventive Medicine, University of Tennessee, USA
    Am J Respir Crit Care Med 160:961-7. 1999
  5. ncbi Effects of methylprednisolone on intracellular bacterial growth
    G U Meduri
    Pulmonary and Critical Care Medicine Memphis Lung Research Program, Department of Medicine, University of Tennessee, Memphis, Tennessee 38163, USA
    Clin Diagn Lab Immunol 8:1156-63. 2001
  6. ncbi Enhanced extracellular growth of Staphylococcus aureus in the presence of selected linear peptide fragments of human interleukin (IL)-1beta and IL-1 receptor antagonist
    S Kanangat
    Memphis Lung Research Program, Department of Medicine, Divisions of Pulmonary and Critical Care Medicine, University of Tennessee, Memphis, Tennessee, USA
    J Infect Dis 183:65-69. 2001
  7. ncbi Time-variant increase in methylprednisolone clearance in patients with acute respiratory distress syndrome: a population pharmacokinetic study
    C R Yates
    University of Tennessee, Memphis, USA
    J Clin Pharmacol 41:415-24. 2001
  8. ncbi Evidence of biological efficacy for prolonged glucocorticoid treatment in patients with unresolving ARDS
    G U Meduri
    Memphis Lung Research Program, Dept of Medicine, Pulmonary and Critical Care Division, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Eur Respir J Suppl 42:57s-64s. 2003

Collaborators

  • J T Dalton
  • A Mukherjee
  • S Kanangat
  • C R Yates
  • E Tolley
  • T M Ludden
  • F Stentz
  • A Vysokanov
  • A Postlethwaite
  • D Schaberg
  • M S Bronze

Detail Information

Publications8

  1. ncbi Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial
    G U Meduri
    Baptist Memorial Hospitals, Veterans Affairs Medical Center, University of Tennessee, Memphis, USA
    JAMA 280:159-65. 1998
    ..No pharmacological therapeutic protocol has been found effective in modifying the clinical course of acute respiratory distress syndrome (ARDS) and mortality remains greater than 50%...
  2. ncbi Pneumonia in acute respiratory distress syndrome. A prospective evaluation of bilateral bronchoscopic sampling
    G U Meduri
    Pulmonary and Critical Care Division, University of Tennessee and Veterans Administration Medical Center, Memphis, Tennessee, USA
    Am J Respir Crit Care Med 158:870-5. 1998
    ..In patients with ARDS and suspected VAP, bilateral BAL quantitative bacterial cultures had significant growth on one side only in 19% and in both sides in 13%...
  3. ncbi Procollagen types I and III aminoterminal propeptide levels during acute respiratory distress syndrome and in response to methylprednisolone treatment
    G U Meduri
    Departments of Medicine and Preventive Medicine, and Memphis Lung Research Program, University of Tennessee, Baptist Memorial Hospitals, and Veterans Affairs Medical Center, Memphis, Tennessee, USA
    Am J Respir Crit Care Med 158:1432-41. 1998
    ..These findings provide additional evidence of an association between biological efficacy and physiologic response during prolonged methylprednisolone treatment of unresolving ARDS...
  4. ncbi Cytokines IL-1beta, IL-6, and TNF-alpha enhance in vitro growth of bacteria
    G U Meduri
    Memphis Lung Research Program, Department of Medicine, Division of Pulmonary, Department of Preventive Medicine, University of Tennessee, USA
    Am J Respir Crit Care Med 160:961-7. 1999
    ..In this study we provide additional evidence for a newly described pathogenetic mechanism for bacterial proliferation in the presence of exaggerated and protracted inflammation...
  5. ncbi Effects of methylprednisolone on intracellular bacterial growth
    G U Meduri
    Pulmonary and Critical Care Medicine Memphis Lung Research Program, Department of Medicine, University of Tennessee, Memphis, Tennessee 38163, USA
    Clin Diagn Lab Immunol 8:1156-63. 2001
    ....
  6. ncbi Enhanced extracellular growth of Staphylococcus aureus in the presence of selected linear peptide fragments of human interleukin (IL)-1beta and IL-1 receptor antagonist
    S Kanangat
    Memphis Lung Research Program, Department of Medicine, Divisions of Pulmonary and Critical Care Medicine, University of Tennessee, Memphis, Tennessee, USA
    J Infect Dis 183:65-69. 2001
    ..These results build on the newly evolved concept of direct interactions between the soluble mediators of inflammation and infectious agents...
  7. ncbi Time-variant increase in methylprednisolone clearance in patients with acute respiratory distress syndrome: a population pharmacokinetic study
    C R Yates
    University of Tennessee, Memphis, USA
    J Clin Pharmacol 41:415-24. 2001
    ..Means (+/- SD) of plasma protein binding differed between healthy individuals (72% +/- 4%) and ARDS patients (46% +/- 11%) (p < 0.001). The pharmacokinetics of MP in ARDS patients has not been described previously...
  8. ncbi Evidence of biological efficacy for prolonged glucocorticoid treatment in patients with unresolving ARDS
    G U Meduri
    Memphis Lung Research Program, Dept of Medicine, Pulmonary and Critical Care Division, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Eur Respir J Suppl 42:57s-64s. 2003
    ....