G U Meduri

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. ncbi Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial
    G Umberto Meduri
    Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, 956 Court Ave, Room H316, Memphis, TN 38163, USA
    Chest 131:954-63. 2007
  2. pmc Effects of methylprednisolone on intracellular bacterial growth
    G U Meduri
    Pulmonary and Critical Care Medicine Memphis Lung Research Program, Department of Medicine, University of Tennessee, Memphis, Tennessee 38163, USA
    Clin Diagn Lab Immunol 8:1156-63. 2001
  3. ncbi Prolonged methylprednisolone treatment suppresses systemic inflammation in patients with unresolving acute respiratory distress syndrome: evidence for inadequate endogenous glucocorticoid secretion and inflammation-induced immune cell resistance to glucoc
    G Umberto Meduri
    Memphis Lung Research Program, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Tennessee, Memphis, Tennessee, USA
    Am J Respir Crit Care Med 165:983-91. 2002
  4. pmc Rapid induction of autoantibodies during ARDS and septic shock
    Peter D Burbelo
    Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Transl Med 8:97. 2010
  5. ncbi Evidence of biological efficacy for prolonged glucocorticoid treatment in patients with unresolving ARDS
    G U Meduri
    Memphis Lung Research Program, Dept of Medicine, Pulmonary and Critical Care Division, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Eur Respir J Suppl 42:57s-64s. 2003
  6. pmc Clinical review: a paradigm shift: the bidirectional effect of inflammation on bacterial growth. Clinical implications for patients with acute respiratory distress syndrome
    G Umberto Meduri
    Divisions of Pulmonary and Critical Care Medicine and Infectious Disease, Department of Medicine, University of Tennessee, Memphis, Tennessee, USA
    Crit Care 6:24-9. 2002
  7. ncbi Nuclear factor-kappaB- and glucocorticoid receptor alpha- mediated mechanisms in the regulation of systemic and pulmonary inflammation during sepsis and acute respiratory distress syndrome. Evidence for inflammation-induced target tissue resistance to glu
    G Umberto Meduri
    Memphis Lung Research Program, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Tennessee Health Science Center, USA
    Neuroimmunomodulation 12:321-38. 2005
  8. ncbi Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature
    G Umberto Meduri
    University of Tennessee Health Science Center and Memphis VA Medical Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Room H316, 956 Court Avenue, TN 38163, Memphis, USA
    Intensive Care Med 34:61-9. 2008
  9. doi Activation and regulation of systemic inflammation in ARDS: rationale for prolonged glucocorticoid therapy
    G Umberto Meduri
    Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Chest 136:1631-43. 2009
  10. ncbi Systemic inflammation-associated glucocorticoid resistance and outcome of ARDS
    G Umberto Meduri
    Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Ann N Y Acad Sci 1024:24-53. 2004

Collaborators

Detail Information

Publications26

  1. ncbi Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial
    G Umberto Meduri
    Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, 956 Court Ave, Room H316, Memphis, TN 38163, USA
    Chest 131:954-63. 2007
    ..To determine the effects of low-dose prolonged methylprednisolone infusion on lung function in patients with early severe ARDS...
  2. pmc Effects of methylprednisolone on intracellular bacterial growth
    G U Meduri
    Pulmonary and Critical Care Medicine Memphis Lung Research Program, Department of Medicine, University of Tennessee, Memphis, Tennessee 38163, USA
    Clin Diagn Lab Immunol 8:1156-63. 2001
    ....
  3. ncbi Prolonged methylprednisolone treatment suppresses systemic inflammation in patients with unresolving acute respiratory distress syndrome: evidence for inadequate endogenous glucocorticoid secretion and inflammation-induced immune cell resistance to glucoc
    G Umberto Meduri
    Memphis Lung Research Program, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Tennessee, Memphis, Tennessee, USA
    Am J Respir Crit Care Med 165:983-91. 2002
    ..Prolonged methylprednisolone administration accelerated the resolution of both systemic inflammation and peripheral acquired glucocorticoid resistance in ARDS...
  4. pmc Rapid induction of autoantibodies during ARDS and septic shock
    Peter D Burbelo
    Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Transl Med 8:97. 2010
    ....
  5. ncbi Evidence of biological efficacy for prolonged glucocorticoid treatment in patients with unresolving ARDS
    G U Meduri
    Memphis Lung Research Program, Dept of Medicine, Pulmonary and Critical Care Division, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Eur Respir J Suppl 42:57s-64s. 2003
    ....
  6. pmc Clinical review: a paradigm shift: the bidirectional effect of inflammation on bacterial growth. Clinical implications for patients with acute respiratory distress syndrome
    G Umberto Meduri
    Divisions of Pulmonary and Critical Care Medicine and Infectious Disease, Department of Medicine, University of Tennessee, Memphis, Tennessee, USA
    Crit Care 6:24-9. 2002
    ..The bidirectional effects of proinflammatory cytokines on bacterial growth may help to explain the frequent occurrence of nosocomial infections in patients with unresolving acute respiratory distress syndrome...
  7. ncbi Nuclear factor-kappaB- and glucocorticoid receptor alpha- mediated mechanisms in the regulation of systemic and pulmonary inflammation during sepsis and acute respiratory distress syndrome. Evidence for inflammation-induced target tissue resistance to glu
    G Umberto Meduri
    Memphis Lung Research Program, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Tennessee Health Science Center, USA
    Neuroimmunomodulation 12:321-38. 2005
    ..The findings provide a rationale for the use of prolonged GC treatment in early ARDS...
  8. ncbi Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literature
    G Umberto Meduri
    University of Tennessee Health Science Center and Memphis VA Medical Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Room H316, 956 Court Avenue, TN 38163, Memphis, USA
    Intensive Care Med 34:61-9. 2008
    ....
  9. doi Activation and regulation of systemic inflammation in ARDS: rationale for prolonged glucocorticoid therapy
    G Umberto Meduri
    Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Chest 136:1631-43. 2009
    ..75; 95% CI, 0.63 to 0.89; p < 0.001; I(2), 43%) and for those treated before day 14 (RR, 0.71; 95% CI, 0.59 to 0.85; p < 0.001; I(2), 40%)...
  10. ncbi Systemic inflammation-associated glucocorticoid resistance and outcome of ARDS
    G Umberto Meduri
    Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Ann N Y Acad Sci 1024:24-53. 2004
    ..In the third part, we review factors affecting cellular response to GC and potential mechanisms involved in inflammation-associated GC resistance...
  11. ncbi Cytokines IL-1beta, IL-6, and TNF-alpha enhance in vitro growth of bacteria
    G U Meduri
    Memphis Lung Research Program, Department of Medicine, Division of Pulmonary, Department of Preventive Medicine, University of Tennessee, USA
    Am J Respir Crit Care Med 160:961-7. 1999
    ..In this study we provide additional evidence for a newly described pathogenetic mechanism for bacterial proliferation in the presence of exaggerated and protracted inflammation...
  12. ncbi Procollagen types I and III aminoterminal propeptide levels during acute respiratory distress syndrome and in response to methylprednisolone treatment
    G U Meduri
    Departments of Medicine and Preventive Medicine, and Memphis Lung Research Program, University of Tennessee, Baptist Memorial Hospitals, and Veterans Affairs Medical Center, Memphis, Tennessee, USA
    Am J Respir Crit Care Med 158:1432-41. 1998
    ..These findings provide additional evidence of an association between biological efficacy and physiologic response during prolonged methylprednisolone treatment of unresolving ARDS...
  13. ncbi Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trial
    G U Meduri
    Baptist Memorial Hospitals, Veterans Affairs Medical Center, University of Tennessee, Memphis, USA
    JAMA 280:159-65. 1998
    ..No pharmacological therapeutic protocol has been found effective in modifying the clinical course of acute respiratory distress syndrome (ARDS) and mortality remains greater than 50%...
  14. ncbi Enhanced extracellular growth of Staphylococcus aureus in the presence of selected linear peptide fragments of human interleukin (IL)-1beta and IL-1 receptor antagonist
    S Kanangat
    Memphis Lung Research Program, Department of Medicine, Divisions of Pulmonary and Critical Care Medicine, University of Tennessee, Memphis, Tennessee, USA
    J Infect Dis 183:65-69. 2001
    ..These results build on the newly evolved concept of direct interactions between the soluble mediators of inflammation and infectious agents...
  15. ncbi Pneumonia in acute respiratory distress syndrome. A prospective evaluation of bilateral bronchoscopic sampling
    G U Meduri
    Pulmonary and Critical Care Division, University of Tennessee and Veterans Administration Medical Center, Memphis, Tennessee, USA
    Am J Respir Crit Care Med 158:870-5. 1998
    ..In patients with ARDS and suspected VAP, bilateral BAL quantitative bacterial cultures had significant growth on one side only in 19% and in both sides in 13%...
  16. ncbi New rationale for glucocorticoid treatment in septic shock
    G U Meduri
    Division of Pulmonary and Critical Care Medicine, The University of Tennessee and Veterans Affairs Medical Center, Memphis 38163, USA
    J Chemother 11:541-50. 1999
    ..This hypothesis is supported by the laboratory findings of a recent randomized study of patients with unresolving acute respiratory disease...
  17. ncbi Time-variant increase in methylprednisolone clearance in patients with acute respiratory distress syndrome: a population pharmacokinetic study
    C R Yates
    University of Tennessee, Memphis, USA
    J Clin Pharmacol 41:415-24. 2001
    ..Means (+/- SD) of plasma protein binding differed between healthy individuals (72% +/- 4%) and ARDS patients (46% +/- 11%) (p < 0.001). The pharmacokinetics of MP in ARDS patients has not been described previously...
  18. doi Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care Medicine
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
    Crit Care Med 36:1937-49. 2008
    ..To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients...
  19. doi Prolonged glucocorticoid treatment and secondary prevention in acute respiratory distress syndrome
    G Umberto Meduri
    Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center and Memphis Veterans Affairs Medical Center 111, 1030 Jefferson Avenue, Suite Room CW444, Memphis, TN 38104, USA
    Expert Rev Respir Med 4:201-10. 2010
    ....
  20. ncbi Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized study
    Marco Confalonieri
    Azienda Ospedaliero Universitaria di Trieste, Strada di Fiume 447, 34100 Trieste, Italy
    Am J Respir Crit Care Med 171:242-8. 2005
    ..01), MODS score (p = 0.003), and delayed septic shock (p = 0.001). Hydrocortisone treatment was associated with a significant reduction in length of hospital stay (p = 0.03) and mortality (p = 0.009)...
  21. ncbi Effectiveness of prolonged glucocorticoid treatment in acute respiratory distress syndrome: the right drug, the right way?
    G Umberto Meduri
    Crit Care Med 34:236-8. 2006
  22. ncbi Acute lung injury and acute respiratory distress syndrome
    G Umberto Meduri
    Lancet 370:384; author reply 384-5. 2007
  23. doi Critical illness-related corticosteroid insufficiency and community-acquired pneumonia: back to the future!
    D Annane
    Eur Respir J 31:1150-2. 2008
  24. ncbi Corticosteroids in ARDS: a counterpoint
    G Umberto Meduri
    Chest 132:1093-4; author reply 1094. 2007
  25. ncbi Proteomic analysis of inflammatory biomarkers in bronchoalveolar lavage
    Carlos de Torre
    Critical Care Medicine Department, Clinical Center, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Proteomics 6:3949-57. 2006
    ..This pattern was also found in ARDS BAL after immunoblot analysis. These approaches will be useful to improve current methods of monitoring lung inflammation and to identify new therapeutic targets...
  26. ncbi Noninvasive ventilation for treating acute respiratory failure in AIDS patients with Pneumocystis carinii pneumonia
    Marco Confalonieri
    Struttura Complessa Pneumologia, Azienda Ospedaliera di Trieste, U O Pneumologia, via Bonomea 265, 34100 Trieste, Italy
    Intensive Care Med 28:1233-8. 2002
    ..To compare noninvasive positive pressure ventilation (NPPV) vs. invasive mechanical ventilation in AIDS patients with Pneumocystis carinii pneumonia (PCP)-related acute respiratory failure (ARF)...