Research Topics
| G U MeduriSummaryAffiliation: University of Tennessee Country: USA Publications
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Detail Information
Publications
Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trialG Umberto Meduri
Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, 956 Court Ave, Room H316, Memphis, TN 38163, USA
Chest 131:954-63. 2007..To determine the effects of low-dose prolonged methylprednisolone infusion on lung function in patients with early severe ARDS...
Effects of methylprednisolone on intracellular bacterial growthG U Meduri
Pulmonary and Critical Care Medicine Memphis Lung Research Program, Department of Medicine, University of Tennessee, Memphis, Tennessee 38163, USA
Clin Diagn Lab Immunol 8:1156-63. 2001....- Prolonged methylprednisolone treatment suppresses systemic inflammation in patients with unresolving acute respiratory distress syndrome: evidence for inadequate endogenous glucocorticoid secretion and inflammation-induced immune cell resistance to glucocG Umberto Meduri
Memphis Lung Research Program, Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Tennessee, Memphis, Tennessee, USA
Am J Respir Crit Care Med 165:983-91. 2002..Prolonged methylprednisolone administration accelerated the resolution of both systemic inflammation and peripheral acquired glucocorticoid resistance in ARDS... - Rapid induction of autoantibodies during ARDS and septic shockPeter D Burbelo
Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892, USA
J Transl Med 8:97. 2010.... - Evidence of biological efficacy for prolonged glucocorticoid treatment in patients with unresolving ARDSG U Meduri
Memphis Lung Research Program, Dept of Medicine, Pulmonary and Critical Care Division, The University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
Eur Respir J Suppl 42:57s-64s. 2003.... - Clinical review: a paradigm shift: the bidirectional effect of inflammation on bacterial growth. Clinical implications for patients with acute respiratory distress syndromeG Umberto Meduri
Divisions of Pulmonary and Critical Care Medicine and Infectious Disease, Department of Medicine, University of Tennessee, Memphis, Tennessee, USA
Crit Care 6:24-9. 2002..The bidirectional effects of proinflammatory cytokines on bacterial growth may help to explain the frequent occurrence of nosocomial infections in patients with unresolving acute respiratory distress syndrome... - Nuclear factor-kappaB- and glucocorticoid receptor alpha- mediated mechanisms in the regulation of systemic and pulmonary inflammation during sepsis and acute respiratory distress syndrome. Evidence for inflammation-induced target tissue resistance to gluG Umberto Meduri
Memphis Lung Research Program, Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, University of Tennessee Health Science Center, USA
Neuroimmunomodulation 12:321-38. 2005..The findings provide a rationale for the use of prolonged GC treatment in early ARDS... - Steroid treatment in ARDS: a critical appraisal of the ARDS network trial and the recent literatureG Umberto Meduri
University of Tennessee Health Science Center and Memphis VA Medical Center, Division of Pulmonary, Critical Care, and Sleep Medicine, Room H316, 956 Court Avenue, TN 38163, Memphis, USA
Intensive Care Med 34:61-9. 2008.... 
Activation and regulation of systemic inflammation in ARDS: rationale for prolonged glucocorticoid therapyG Umberto Meduri
Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Chest 136:1631-43. 2009..75; 95% CI, 0.63 to 0.89; p < 0.001; I(2), 43%) and for those treated before day 14 (RR, 0.71; 95% CI, 0.59 to 0.85; p < 0.001; I(2), 40%)...- Systemic inflammation-associated glucocorticoid resistance and outcome of ARDSG Umberto Meduri
Department of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Ann N Y Acad Sci 1024:24-53. 2004..In the third part, we review factors affecting cellular response to GC and potential mechanisms involved in inflammation-associated GC resistance... - Cytokines IL-1beta, IL-6, and TNF-alpha enhance in vitro growth of bacteriaG U Meduri
Memphis Lung Research Program, Department of Medicine, Division of Pulmonary, Department of Preventive Medicine, University of Tennessee, USA
Am J Respir Crit Care Med 160:961-7. 1999..In this study we provide additional evidence for a newly described pathogenetic mechanism for bacterial proliferation in the presence of exaggerated and protracted inflammation... - Procollagen types I and III aminoterminal propeptide levels during acute respiratory distress syndrome and in response to methylprednisolone treatmentG U Meduri
Departments of Medicine and Preventive Medicine, and Memphis Lung Research Program, University of Tennessee, Baptist Memorial Hospitals, and Veterans Affairs Medical Center, Memphis, Tennessee, USA
Am J Respir Crit Care Med 158:1432-41. 1998..These findings provide additional evidence of an association between biological efficacy and physiologic response during prolonged methylprednisolone treatment of unresolving ARDS... - Effect of prolonged methylprednisolone therapy in unresolving acute respiratory distress syndrome: a randomized controlled trialG U Meduri
Baptist Memorial Hospitals, Veterans Affairs Medical Center, University of Tennessee, Memphis, USA
JAMA 280:159-65. 1998..No pharmacological therapeutic protocol has been found effective in modifying the clinical course of acute respiratory distress syndrome (ARDS) and mortality remains greater than 50%... - Enhanced extracellular growth of Staphylococcus aureus in the presence of selected linear peptide fragments of human interleukin (IL)-1beta and IL-1 receptor antagonistS Kanangat
Memphis Lung Research Program, Department of Medicine, Divisions of Pulmonary and Critical Care Medicine, University of Tennessee, Memphis, Tennessee, USA
J Infect Dis 183:65-69. 2001..These results build on the newly evolved concept of direct interactions between the soluble mediators of inflammation and infectious agents... - Pneumonia in acute respiratory distress syndrome. A prospective evaluation of bilateral bronchoscopic samplingG U Meduri
Pulmonary and Critical Care Division, University of Tennessee and Veterans Administration Medical Center, Memphis, Tennessee, USA
Am J Respir Crit Care Med 158:870-5. 1998..In patients with ARDS and suspected VAP, bilateral BAL quantitative bacterial cultures had significant growth on one side only in 19% and in both sides in 13%... - New rationale for glucocorticoid treatment in septic shockG U Meduri
Division of Pulmonary and Critical Care Medicine, The University of Tennessee and Veterans Affairs Medical Center, Memphis 38163, USA
J Chemother 11:541-50. 1999..This hypothesis is supported by the laboratory findings of a recent randomized study of patients with unresolving acute respiratory disease... - Time-variant increase in methylprednisolone clearance in patients with acute respiratory distress syndrome: a population pharmacokinetic studyC R Yates
University of Tennessee, Memphis, USA
J Clin Pharmacol 41:415-24. 2001..Means (+/- SD) of plasma protein binding differed between healthy individuals (72% +/- 4%) and ARDS patients (46% +/- 11%) (p < 0.001). The pharmacokinetics of MP in ARDS patients has not been described previously... - Recommendations for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients: consensus statements from an international task force by the American College of Critical Care MedicinePaul E Marik
Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA, USA
Crit Care Med 36:1937-49. 2008..To develop consensus statements for the diagnosis and management of corticosteroid insufficiency in critically ill adult patients... - Prolonged glucocorticoid treatment and secondary prevention in acute respiratory distress syndromeG Umberto Meduri
Department of Medicine, Division of Pulmonary, Critical Care, and Sleep Medicine, University of Tennessee Health Science Center and Memphis Veterans Affairs Medical Center 111, 1030 Jefferson Avenue, Suite Room CW444, Memphis, TN 38104, USA
Expert Rev Respir Med 4:201-10. 2010.... - Hydrocortisone infusion for severe community-acquired pneumonia: a preliminary randomized studyMarco Confalonieri
Azienda Ospedaliero Universitaria di Trieste, Strada di Fiume 447, 34100 Trieste, Italy
Am J Respir Crit Care Med 171:242-8. 2005..01), MODS score (p = 0.003), and delayed septic shock (p = 0.001). Hydrocortisone treatment was associated with a significant reduction in length of hospital stay (p = 0.03) and mortality (p = 0.009)... - Effectiveness of prolonged glucocorticoid treatment in acute respiratory distress syndrome: the right drug, the right way?G Umberto Meduri
Crit Care Med 34:236-8. 2006 - Acute lung injury and acute respiratory distress syndromeG Umberto Meduri
Lancet 370:384; author reply 384-5. 2007 - Critical illness-related corticosteroid insufficiency and community-acquired pneumonia: back to the future!D Annane
Eur Respir J 31:1150-2. 2008 - Corticosteroids in ARDS: a counterpointG Umberto Meduri
Chest 132:1093-4; author reply 1094. 2007 - Proteomic analysis of inflammatory biomarkers in bronchoalveolar lavageCarlos de Torre
Critical Care Medicine Department, Clinical Center, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
Proteomics 6:3949-57. 2006..This pattern was also found in ARDS BAL after immunoblot analysis. These approaches will be useful to improve current methods of monitoring lung inflammation and to identify new therapeutic targets... - Noninvasive ventilation for treating acute respiratory failure in AIDS patients with Pneumocystis carinii pneumoniaMarco Confalonieri
Struttura Complessa Pneumologia, Azienda Ospedaliera di Trieste, U O Pneumologia, via Bonomea 265, 34100 Trieste, Italy
Intensive Care Med 28:1233-8. 2002..To compare noninvasive positive pressure ventilation (NPPV) vs. invasive mechanical ventilation in AIDS patients with Pneumocystis carinii pneumonia (PCP)-related acute respiratory failure (ARF)...