David Meaney

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi request reprint The separate roles of calcium and mechanical forces in mediating cell death in mechanically injured neurons
    Theresa A Lusardi
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104 6392, USA
    Biorheology 40:401-9. 2003
  2. pmc Computational investigation of the changing patterns of subtype specific NMDA receptor activation during physiological glutamatergic neurotransmission
    Pallab Singh
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Comput Biol 7:e1002106. 2011
  3. pmc Antagonism of purinergic signalling improves recovery from traumatic brain injury
    Anthony M Choo
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA
    Brain 136:65-80. 2013
  4. doi request reprint Biomechanics of concussion
    David F Meaney
    Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104 6392, USA
    Clin Sports Med 30:19-31, vii. 2011
  5. ncbi request reprint Relationship between structural modeling and hyperelastic material behavior: application to CNS white matter
    D F Meaney
    Department of Bioengineering, University of Pennsylvania, 3320 Smith Walk, Philadelphia, PA 19104 6392, USA
    Biomech Model Mechanobiol 1:279-93. 2003
  6. pmc Calcium-permeable AMPA receptors appear in cortical neurons after traumatic mechanical injury and contribute to neuronal fate
    Jennifer M Spaethling
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6321, USA
    J Neurotrauma 25:1207-16. 2008
  7. ncbi request reprint Traumatic axonal injury induces proteolytic cleavage of the voltage-gated sodium channels modulated by tetrodotoxin and protease inhibitors
    Akira Iwata
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6316, USA
    J Neurosci 24:4605-13. 2004
  8. ncbi request reprint Effect of acute calcium influx after mechanical stretch injury in vitro on the viability of hippocampal neurons
    Theresa A Lusardi
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 21:61-72. 2004
  9. pmc Enhanced astrocytic Ca2+ signals contribute to neuronal excitotoxicity after status epilepticus
    Shinghua Ding
    Silvio Conte Center for Integration at the Tripartite Synapse, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:10674-84. 2007
  10. ncbi request reprint Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit composition
    Michael N DeRidder
    Department of Bioengineering, University of Pennsylvania, 3320 Smith Walk, Room 105E, Hayden Hall, Philadelphia, PA 19104, USA
    Neurobiol Dis 22:165-76. 2006

Collaborators

Detail Information

Publications34

  1. ncbi request reprint The separate roles of calcium and mechanical forces in mediating cell death in mechanically injured neurons
    Theresa A Lusardi
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104 6392, USA
    Biorheology 40:401-9. 2003
    ..Finally, at the highest levels of stretch, the cell survivability decreases at 24 hrs following the stretch injury. These data show the association between loss in calcium regulation and early signs of neuronal cell death...
  2. pmc Computational investigation of the changing patterns of subtype specific NMDA receptor activation during physiological glutamatergic neurotransmission
    Pallab Singh
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America
    PLoS Comput Biol 7:e1002106. 2011
    ....
  3. pmc Antagonism of purinergic signalling improves recovery from traumatic brain injury
    Anthony M Choo
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, USA
    Brain 136:65-80. 2013
    ..This work shows the potential of studying astrocyte signalling after trauma to yield new and effective therapeutic targets for treating traumatic brain injury...
  4. doi request reprint Biomechanics of concussion
    David F Meaney
    Department of Bioengineering, University of Pennsylvania, 240 Skirkanich Hall, 210 South 33rd Street, Philadelphia, PA 19104 6392, USA
    Clin Sports Med 30:19-31, vii. 2011
    ..Studies of how these mechanical conditions contribute to the cellular mechanisms of damage in mild traumatic brain injury are reviewed. Finally, future directions for improving understanding concussion biomechanics are discussed...
  5. ncbi request reprint Relationship between structural modeling and hyperelastic material behavior: application to CNS white matter
    D F Meaney
    Department of Bioengineering, University of Pennsylvania, 3320 Smith Walk, Philadelphia, PA 19104 6392, USA
    Biomech Model Mechanobiol 1:279-93. 2003
    ....
  6. pmc Calcium-permeable AMPA receptors appear in cortical neurons after traumatic mechanical injury and contribute to neuronal fate
    Jennifer M Spaethling
    Department of Pharmacology, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6321, USA
    J Neurotrauma 25:1207-16. 2008
    ..These data point to a potentially new and more targeted therapeutic approach for treating TBI...
  7. ncbi request reprint Traumatic axonal injury induces proteolytic cleavage of the voltage-gated sodium channels modulated by tetrodotoxin and protease inhibitors
    Akira Iwata
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104 6316, USA
    J Neurosci 24:4605-13. 2004
    ..In turn, degradation of the alpha-subunit promotes persistent elevations in [Ca2+]i, fueling additional pathologic changes. These observations may have important implications for developing therapeutic strategies for axonal trauma...
  8. ncbi request reprint Effect of acute calcium influx after mechanical stretch injury in vitro on the viability of hippocampal neurons
    Theresa A Lusardi
    Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 21:61-72. 2004
    ....
  9. pmc Enhanced astrocytic Ca2+ signals contribute to neuronal excitotoxicity after status epilepticus
    Shinghua Ding
    Silvio Conte Center for Integration at the Tripartite Synapse, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 27:10674-84. 2007
    ..These observations support neurotoxic roles for astrocytic gliotransmission in pathological conditions and identify this process as a novel therapeutic target...
  10. ncbi request reprint Traumatic mechanical injury to the hippocampus in vitro causes regional caspase-3 and calpain activation that is influenced by NMDA receptor subunit composition
    Michael N DeRidder
    Department of Bioengineering, University of Pennsylvania, 3320 Smith Walk, Room 105E, Hayden Hall, Philadelphia, PA 19104, USA
    Neurobiol Dis 22:165-76. 2006
    ....
  11. pmc Combination therapies for traumatic brain injury: prospective considerations
    Susan Margulies
    School of Engineering and Applied Science, Department of Bioengineering, University of Pennsylvania, 210 S 33rd Street, Philadelphia, PA 19104 6321, USA
    J Neurotrauma 26:925-39. 2009
    ..Overall there was great enthusiasm for working collaboratively to act on these recommendations...
  12. pmc Immediate short-duration hypothermia provides long-term protection in an in vivo model of traumatic axonal injury
    Marek Ma
    Department of Emergency Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Neurol 215:119-27. 2009
    ..027). There was no differential protection based on axon size. These results support further clinical investigation of temporally optimized therapeutic hypothermia after traumatic brain injury...
  13. ncbi request reprint Pharmacologically induced calcium oscillations protect neurons from increases in cytosolic calcium after trauma
    Donna M Geddes-Klein
    Department of Bioengineering, University of Pennsylvania, Philadelphia, 19104, USA
    J Neurochem 97:462-74. 2006
    ..These results provide novel insights into how the [Ca(2+)](i) response to stretch is initiated, and how reduced inhibition - a feature of the developing brain - may affect the sensitivity of the immature brain to trauma...
  14. ncbi request reprint Mechanisms and consequences of neuronal stretch injury in vitro differ with the model of trauma
    Donna M Geddes-Klein
    Department of Bioengineering University of Pennsylvania, Philadelphia, Pennsylvania 19104 6392, USA
    J Neurotrauma 23:193-204. 2006
    ....
  15. ncbi request reprint Roller coasters, g forces, and brain trauma: on the wrong track?
    Douglas H Smith
    Department of Neurosurgery, University of Pennsylvania, Philadelphia 19104, USA
    J Neurotrauma 19:1117-20. 2002
    ..Accordingly, our findings do not support the contention that current roller coaster rides produce high enough forces to mechanically deform and injure the brain...
  16. ncbi request reprint Diffuse axonal injury in head trauma
    Douglas H Smith
    Department of Neurosurgery, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA 19104, USA
    J Head Trauma Rehabil 18:307-16. 2003
    ..DAI may largely account for the clinical manifestations of brain trauma. However, DAI is extremely difficult to detect noninvasively and is poorly defined as clinical syndrome...
  17. ncbi request reprint Traumatic axonal injury results in biphasic calpain activation and retrograde transport impairment in mice
    Kathryn E Saatman
    Department of Neurosurgery, University of Pennsylvania, Philadelphia 19104, USA
    J Cereb Blood Flow Metab 23:34-42. 2003
    ..These data suggest that early calpain activation may contribute to progressive intraaxonal structural damage, whereas delayed calpain activation may be associated with axonal degeneration...
  18. pmc Transcriptome transfer produces a predictable cellular phenotype
    Jai Yoon Sul
    Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 106:7624-9. 2009
    ..The host-cell phenotypic changes develop over many weeks and are persistent. We call this process of RNA-induced phenotype changes, transcriptome-induced phenotype remodeling...
  19. pmc In-vitro approaches for studying blast-induced traumatic brain injury
    Yung Chia Chen
    Departments of Bioengineering, University of Pennsylvania, 210 S 33rd Street, Philadelphia, PA 19104, USA
    J Neurotrauma 26:861-76. 2009
    ..These in-vitro models, viewed in combination with in-vivo models and clinical studies, can be used to assess both the mechanisms and possible treatments for this type of trauma...
  20. pmc Long-term accumulation of amyloid-beta, beta-secretase, presenilin-1, and caspase-3 in damaged axons following brain trauma
    Xiao Han Chen
    Department of Neurosurgery, University of Pennsylvania, 105C Hayden Hall, 3320 SmithWalk, Philadelphia, PA 19104 6316, USA
    Am J Pathol 165:357-71. 2004
    ..The abnormal concentration of these factors may lead to APP proteolysis and Abeta formation within the axonal membrane compartment...
  21. doi request reprint Hemostatic and neuroprotective effects of human recombinant activated factor VII therapy after traumatic brain injury in pigs
    Jun Zhang
    Department of Neurosurgery and Penn Center for Brain Injury and Repair, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Exp Neurol 210:645-55. 2008
    ..Finally, rFVIIa treatment provided a surprising neuroprotective effect by reducing hippocampal neuron degeneration as well as the extent of DAI...
  22. ncbi request reprint Extreme stretch growth of integrated axons
    Bryan J Pfister
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurosci 24:7978-83. 2004
    ..These data provide the first evidence that mechanical stimuli can induce extreme "stretch growth" of integrated axon tracts, far exceeding any previously observed limits of axon growth...
  23. ncbi request reprint Development of transplantable nervous tissue constructs comprised of stretch-grown axons
    Bryan J Pfister
    Department of Neurosurgery, Center for Brain Injury Repair, University of Pennsylvania, 3320 Smith Walk, 105 Hayden Hall, Philadelphia, PA 19104, USA
    J Neurosci Methods 153:95-103. 2006
    ..Ideally, bridging nerve damage with living axon tracts may serve to establish or promote new functional connections...
  24. ncbi request reprint A device to study the initiation and propagation of calcium transients in cultured neurons after mechanical stretch
    Theresa A Lusardi
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104 6392, USA
    Ann Biomed Eng 32:1546-58. 2004
    ....
  25. pmc mGluR5 stimulates gliotransmission in the nucleus accumbens
    Marcello D'Ascenzo
    Silvio Conte Center for Integration at the Tripartite Synapse, Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 104:1995-2000. 2007
    ....
  26. ncbi request reprint Modeling of microstructural kinematics during simple elongation of central nervous system tissue
    Allison C Bain
    Department of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104 6392, USA
    J Biomech Eng 125:798-804. 2003
    ..Ultimately, these results can be used in conjunction with computational simulations of traumatic brain injury to aid in establishing the relative risk of cellular structures in the CNS white matter to mechanical injury...
  27. ncbi request reprint Expression profiling following traumatic brain injury: a review
    Paolo G Marciano
    Department of Neuroscience, University of Pennsylvania, Philadelphia, USA
    Neurochem Res 27:1147-55. 2002
    ..The elucidation of the complex alterations in gene expression underlying the pathological sequelae following TBI is of central importance in the design of future therapeutic agents...
  28. pmc Calpain mediates proteolysis of the voltage-gated sodium channel alpha-subunit
    Catherine R von Reyn
    Departments of Bioengineering, Pharmacology, Neurosurgery, Emergency Medicine, and Neuroscience, University of Pennsylvania, Philadelphia, PA 19104 6321, USA
    J Neurosci 29:10350-6. 2009
    ....
  29. pmc Cytoplasmic BK(Ca) channel intron-containing mRNAs contribute to the intrinsic excitability of hippocampal neurons
    Thomas J Bell
    Department of Pharmacology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 105:1901-6. 2008
    ..These data suggest a new regulatory mechanism for modulating the membrane properties and ion channel gradients of hippocampal neurons...
  30. ncbi request reprint Linking impact to cellular and molecular sequelae of CNS injury: modeling in vivo complexity with in vitro simplicity
    Jennifer M Spaethling
    Department of Bioengineering, University of Pennsylvania, 3320 Smith Walk, Philadelphia, PA 19104 6392, USA
    Prog Brain Res 161:27-39. 2007
    ..Finally, we synthesize the current knowledge and point out possible future directions for this group of models, especially in the effort toward developing new therapies for the traumatically brain injured patient...
  31. pmc Mechanically induced reactive gliosis causes ATP-mediated alterations in astrocyte stiffness
    William J Miller
    Departments of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 26:789-97. 2009
    ....
  32. ncbi request reprint Methodological considerations regarding single-cell gene expression profiling for brain injury
    Jason E Davis
    The Head Injury Center, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Neurochem Res 29:1113-21. 2004
    ..In this review, we will discuss the application of these techniques to experimental, clinically relevant models of traumatic brain injury...
  33. pmc Matrices with compliance comparable to that of brain tissue select neuronal over glial growth in mixed cortical cultures
    Penelope C Georges
    Institute for Medicine and Engineering, Sea Run Holdings Inc, Freeport, Maine, USA
    Biophys J 90:3012-8. 2006
    ....
  34. ncbi request reprint A quasi-linear, viscoelastic, structural model of the plantar soft tissue with frequency-sensitive damping properties
    William R Ledoux
    Department of Veterans Affairs, RR and D Center of Excellence for Limb Loss Prevention and Prosthetic Engineering, VA Puget Sound Health Care System, Seattle WA, 98108, USA
    J Biomech Eng 126:831-7. 2004
    ..Thus, the data demonstrate that the structural properties of the foot can vary across regions, but careful consideration must be given to the applied loads and the manner in which the loads were applied...

Research Grants22

  1. BIOMECHANICAL ANALYSIS OF TRAUMATIC BRAIN INJURY MODELS
    David F Meaney; Fiscal Year: 2010
    ..Using the information of receptor activation, the investigators will develop and test treatment strategies to reduce neuronal death following traumatic brain injury. ..
  2. Force Transmission in the Central Nervous System
    David Meaney; Fiscal Year: 2005
    ....
  3. BIOMECHANICAL ANALYSIS OF TRAUMATIC BRAIN INJURY MODELS
    David Meaney; Fiscal Year: 2007
    ..Using the information of receptor activation, the investigators will develop and test treatment strategies to reduce neuronal death following traumatic brain injury. ..
  4. BRP: Molecular Expression of Force Transmission in the Central Nervous System
    David Meaney; Fiscal Year: 2007
    ..Both treatment approaches are tested for their effectiveness if given either immediately or several hours after injury, which is critical to know if these will be used clinically in the future. ..
  5. BIOMECHANICAL ANALYSIS OF TRAUMATIC BRAIN INJURY MODELS
    David Meaney; Fiscal Year: 2009
    ..Using the information of receptor activation, the investigators will develop and test treatment strategies to reduce neuronal death following traumatic brain injury. ..
  6. A new technology for engineering axonal growth
    David Meaney; Fiscal Year: 2005
    ..Once developed, we use this to propose a series of studies on how a specific cytoskeletal component (neurofilaments) may be a key limiting factor in controlling the growth rate with this technique. ..
  7. BIOMECHANICAL ANALYSIS OF TRAUMATIC BRAIN INJURY MODELS
    David Meaney; Fiscal Year: 2000
    ..Once accomplished, the research will significantly enhance existing models to understand the sequelae and treatment of human closed head injury. ..
  8. BIOMECHANICAL ANALYSIS OF TRAUMATIC BRAIN INJURY MODELS
    David Meaney; Fiscal Year: 2004
    ..Once accomplished, the research will significantly enhance the interpretation of existing models to understand a portion of the molecular sequelae and, in turn, treatment strategies for closed head injury. ..
  9. BRP: Molecular Expression of Force Transmission in the Central Nervous System
    David F Meaney; Fiscal Year: 2010
    ..Both treatment approaches are tested for their effectiveness if given either immediately or several hours after injury, which is critical to know if these will be used clinically in the future. ..