James H Meador-Woodruff

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi request reprint Dopamine receptor transcript expression in striatum and prefrontal and occipital cortex. Focal abnormalities in orbitofrontal cortex in schizophrenia
    J H Meador-Woodruff
    Department of Psychiatry, University of Michigan, Ann Arbor, USA
    Arch Gen Psychiatry 54:1089-95. 1997
  2. ncbi request reprint Effects of clozapine and haloperidol on 5-HT6 receptor mRNA levels in rat brain
    J A Frederick
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109 0720, USA
    Schizophr Res 38:7-12. 1999
  3. ncbi request reprint Glutamate receptor expression in schizophrenic brain
    J H Meador-Woodruff
    Mental Health Research Institute, Department of Psychiatry, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI, USA
    Brain Res Brain Res Rev 31:288-94. 2000
  4. ncbi request reprint Abnormal kainate receptor expression in prefrontal cortex in schizophrenia
    J H Meador-Woodruff
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Neuropsychopharmacology 24:545-52. 2001
  5. ncbi request reprint Striatal ionotropic glutamate receptor expression in schizophrenia, bipolar disorder, and major depressive disorder
    J H Meador-Woodruff
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Brain Res Bull 55:631-40. 2001
  6. ncbi request reprint Molecular abnormalities of the glutamate synapse in the thalamus in schizophrenia
    James H Meador-Woodruff
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    Ann N Y Acad Sci 1003:75-93. 2003
  7. ncbi request reprint Expression of the ionotropic glutamate receptor subunits and NMDA receptor-associated intracellular proteins in the substantia nigra in schizophrenia
    Helena T Mueller
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Medical School, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Brain Res Mol Brain Res 121:60-9. 2004
  8. ncbi request reprint Altered transcript expression of NMDA receptor-associated postsynaptic proteins in the thalamus of subjects with schizophrenia
    Sarah M Clinton
    Department of Psychiatry and Mental Health Research Institute, Universiyt of Michgan medical School, MI 48109 0720, USA
    Am J Psychiatry 160:1100-9. 2003
  9. ncbi request reprint Abnormalities of the NMDA Receptor and Associated Intracellular Molecules in the Thalamus in Schizophrenia and Bipolar Disorder
    Sarah M Clinton
    Department of Psychiatry, Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, MI 48109 0720, USA
    Neuropsychopharmacology 29:1353-62. 2004
  10. ncbi request reprint Abnormal striatal expression of transcripts encoding NMDA interacting PSD proteins in schizophrenia, bipolar disorder and major depression
    Lars V Kristiansen
    Department of Psychiatry and The Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Schizophr Res 78:87-93. 2005

Detail Information

Publications46

  1. ncbi request reprint Dopamine receptor transcript expression in striatum and prefrontal and occipital cortex. Focal abnormalities in orbitofrontal cortex in schizophrenia
    J H Meador-Woodruff
    Department of Psychiatry, University of Michigan, Ann Arbor, USA
    Arch Gen Psychiatry 54:1089-95. 1997
    ..We determined the expression of transcripts encoding the dopamine receptors in the brains of schizophrenic patients...
  2. ncbi request reprint Effects of clozapine and haloperidol on 5-HT6 receptor mRNA levels in rat brain
    J A Frederick
    Mental Health Research Institute, University of Michigan, Ann Arbor 48109 0720, USA
    Schizophr Res 38:7-12. 1999
    ..These results suggest that downregulation of this receptor in the hippocampus might be a characteristic of atypical antipsychotic drugs, although this hypothesis will require testing with other atypical antipsychotics...
  3. ncbi request reprint Glutamate receptor expression in schizophrenic brain
    J H Meador-Woodruff
    Mental Health Research Institute, Department of Psychiatry, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI, USA
    Brain Res Brain Res Rev 31:288-94. 2000
    ..These data support the hypothesis of abnormal glutamatergic neurotransmission involving the ionotropic glutamate receptors in schizophrenia...
  4. ncbi request reprint Abnormal kainate receptor expression in prefrontal cortex in schizophrenia
    J H Meador-Woodruff
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Neuropsychopharmacology 24:545-52. 2001
    ....
  5. ncbi request reprint Striatal ionotropic glutamate receptor expression in schizophrenia, bipolar disorder, and major depressive disorder
    J H Meador-Woodruff
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109 0720, USA
    Brain Res Bull 55:631-40. 2001
    ....
  6. ncbi request reprint Molecular abnormalities of the glutamate synapse in the thalamus in schizophrenia
    James H Meador-Woodruff
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109 0720, USA
    Ann N Y Acad Sci 1003:75-93. 2003
    ..Our data suggest that schizophrenia is associated with abnormal glutamate receptor-related intracellular signaling in the thalamus, and point to novel targets for innovative drug discovery...
  7. ncbi request reprint Expression of the ionotropic glutamate receptor subunits and NMDA receptor-associated intracellular proteins in the substantia nigra in schizophrenia
    Helena T Mueller
    Department of Psychiatry and Mental Health Research Institute, University of Michigan, Medical School, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Brain Res Mol Brain Res 121:60-9. 2004
    ..These data support the hypothesis that schizophrenia may involve alterations in dopamine-glutamate interactions...
  8. ncbi request reprint Altered transcript expression of NMDA receptor-associated postsynaptic proteins in the thalamus of subjects with schizophrenia
    Sarah M Clinton
    Department of Psychiatry and Mental Health Research Institute, Universiyt of Michgan medical School, MI 48109 0720, USA
    Am J Psychiatry 160:1100-9. 2003
    ..They hypothesized that this reduction is associated with specific NR(1) isoforms and that NMDA receptor-related postsynaptic density proteins are abnormally expressed...
  9. ncbi request reprint Abnormalities of the NMDA Receptor and Associated Intracellular Molecules in the Thalamus in Schizophrenia and Bipolar Disorder
    Sarah M Clinton
    Department of Psychiatry, Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, MI 48109 0720, USA
    Neuropsychopharmacology 29:1353-62. 2004
    ....
  10. ncbi request reprint Abnormal striatal expression of transcripts encoding NMDA interacting PSD proteins in schizophrenia, bipolar disorder and major depression
    Lars V Kristiansen
    Department of Psychiatry and The Molecular and Behavioral Neuroscience Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Schizophr Res 78:87-93. 2005
    ....
  11. ncbi request reprint Metabotropic glutamate receptor protein expression in the prefrontal cortex and striatum in schizophrenia
    Daya S Gupta
    Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109 0720, USA
    Synapse 57:123-31. 2005
    ....
  12. ncbi request reprint Expression of transcripts encoding AMPA receptor subunits and associated postsynaptic proteins in the macaque brain
    Monica Beneyto
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Comp Neurol 468:530-54. 2004
    ....
  13. ncbi request reprint Up-regulation of NMDA receptor subunit and post-synaptic density protein expression in the thalamus of elderly patients with schizophrenia
    Sarah M Clinton
    Department of Psychiatry, Molecular and Behavioral Neuroscience Institute, University of Michigan Medical School, Ann Arbor, 48109, USA
    J Neurochem 98:1114-25. 2006
    ..Further, these findings provide additional evidence of NMDA receptor alterations in schizophrenia, which may play an important role in the neurobiology of the illness...
  14. ncbi request reprint Expression of excitatory amino acid transporter interacting protein transcripts in the thalamus in schizophrenia
    Ibone Huerta
    Molecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Synapse 59:394-402. 2006
    ..These findings suggest that proteins associated with the regulation of glutamate reuptake may be abnormal in this illness, supporting the hypothesis of altered thalamic glutamatergic neurotransmission in schizophrenia...
  15. ncbi request reprint Dopamine receptor signaling molecules are altered in elderly schizophrenic cortex
    Karen L Baracskay
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, Michigan, USA
    Synapse 60:271-9. 2006
    ..These alterations in spinophilin and calcyon mRNA levels in schizophrenic prefrontal and cingulate cortex provide further evidence of altered dopaminergic neurotransmission in this illness...
  16. ncbi request reprint Dopaminergic abnormalities in select thalamic nuclei in schizophrenia: involvement of the intracellular signal integrating proteins calcyon and spinophilin
    Sarah M Clinton
    Mental Health Research Institute, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Am J Psychiatry 162:1859-71. 2005
    ..In this study, the authors studied this question by measuring in postmortem brain the expression of molecules associated with dopaminergic neurotransmission...
  17. ncbi request reprint Striatal excitatory amino acid transporter transcript expression in schizophrenia, bipolar disorder, and major depressive disorder
    Robert E McCullumsmith
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, 200 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Neuropsychopharmacology 26:368-75. 2002
    ..These results suggest that changes in striatal transporter mRNA expression are restricted to neuronal EAATs and extend the body of evidence implicating abnormal glutamatergic neurotransmission in schizophrenia and mood disorders...
  18. ncbi request reprint Thalamic dysfunction in schizophrenia: neurochemical, neuropathological, and in vivo imaging abnormalities
    Sarah M Clinton
    Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Schizophr Res 69:237-53. 2004
    ..We review these neurochemical findings, as well as the growing body of postmortem and in vivo imaging evidence that supports the hypothesis of thalamic dysfunction in schizophrenia...
  19. ncbi request reprint Differential effects of antipsychotics on haloperidol-induced vacuous chewing movements and subcortical gene expression in the rat
    Robert E McCullumsmith
    Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Eur J Pharmacol 477:101-12. 2003
    ..Changes in expression of other transcripts were not detected. These findings demonstrate important differences in the effects of typical and atypical antipsychotics on chronic vacuous chewing movements...
  20. ncbi request reprint Abnormal glutamate receptor expression in the medial temporal lobe in schizophrenia and mood disorders
    Monica Beneyto
    Department of Psychiatry, University of Pittsburgh, 3801 O Hara Street, Pittsburgh, PA 15213, USA
    Neuropsychopharmacology 32:1888-902. 2007
    ..We propose that disturbances in glutamate-mediated synaptic transmission in the medial temporal lobe are important factors in the pathophysiology of these severe psychiatric illnesses...
  21. ncbi request reprint Increased expression of glutaminase and glutamine synthetase mRNA in the thalamus in schizophrenia
    Emile G Bruneau
    Mental Health Research Institute and Department of Psychiatry, University of Michigan Medical School, 205 Zina Pitcher Place, Ann Arbor, MI 48109, USA
    Schizophr Res 75:27-34. 2005
    ..Increased PAG and GS transcripts suggest enhanced glutamatergic neurotransmission in the thalamus and its efferent targets in schizophrenia...
  22. pmc Cortical expression of glial fibrillary acidic protein and glutamine synthetase is decreased in schizophrenia
    Amy E Steffek
    Molecular and Behavioral Neuroscience Institute, University of Michigan, Ann Arbor, MI 48109 2200, United States
    Schizophr Res 103:71-82. 2008
    ....
  23. ncbi request reprint NR3A NMDA receptor subunit mRNA expression in schizophrenia, depression and bipolar disorder
    Helena T Mueller
    Neuroscience Graduate Program, Department of Psychiatry, Mental Health Research Institute, University of Michigan Medical School, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    Schizophr Res 71:361-70. 2004
    ..These data indicate that the NR3A subunit is abnormally expressed in both schizophrenia and bipolar disorder...
  24. ncbi request reprint Serine racemase protein expression in cortex and hippocampus in schizophrenia
    Amy E Steffek
    Molecular and Behavioral Neuroscience Institute and Department of Psychiatry, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Neuroreport 17:1181-5. 2006
    ....
  25. ncbi request reprint Distribution of the NMDA receptor NR3A subunit in the adult pig-tail macaque brain
    Helena T Mueller
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, 205 Zina Pitcher Place, Ann Arbor, MI 48109 0720, USA
    J Chem Neuroanat 29:157-72. 2005
    ..Particular enrichment in some brain areas may reflect brain-region or circuit-specific functions for this NMDA receptor subunit...
  26. ncbi request reprint Dopaminergic regulation of orexin neurons
    Michael Bubser
    Department of Psychiatry, Vanderbilt University Medical Center, Nashville, TN 37212, USA
    Eur J Neurosci 21:2993-3001. 2005
    ..These data suggest that apomorphine-induced arousal but not accumbens-mediated hyperactivity is required for dopamine to transsynaptically activate orexin neurons...
  27. ncbi request reprint AMPA- and NMDA-associated postsynaptic protein expression in the human dorsolateral prefrontal cortex
    Monica Beneyto
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Ann N Y Acad Sci 1003:352-5. 2003
  28. ncbi request reprint Schizophrenia as a disorder of neuroplasticity
    Robert E McCullumsmith
    Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Int Rev Neurobiol 59:19-45. 2004
    ..We suggest that schizophrenia can be considered a disorder of plasticity, associated with molecular abnormalities of the glutamate synapse...
  29. ncbi request reprint Ontogeny of ionotropic glutamate receptor subunit expression in the rat hippocampus
    Laura M Ritter
    Mental Health Research Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Brain Res Dev Brain Res 139:227-36. 2002
    ..These results suggest the different glutamate receptor subtypes may be critical at specific times during postnatal brain development...
  30. ncbi request reprint Expression of the NR3A subunit of the NMDA receptor in human fetal brain
    Helena T Mueller
    Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109 0720, USA
    Ann N Y Acad Sci 1003:448-51. 2003
  31. ncbi request reprint Calcyon transcript expression in macaque brain
    Scott A Oakman
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Comp Neurol 468:264-76. 2004
    ..A substantial proportion of this may relate to the reported association of calcyon with the D5 receptor, or in addition, may suggest that calcyon has a wider role as a regulator of intracellular signal transduction...
  32. ncbi request reprint Expression of ARHGEF11 mRNA in schizophrenic thalamus
    Genoveva Davidkova
    Mental Health Research Institute and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48109, USA
    Ann N Y Acad Sci 1003:375-7. 2003
  33. ncbi request reprint Effects of 6-cyano-7-nitroquinoxaline-2,3-dione on nicotinic receptor subunit transcript expression in the rat brain
    Robert E McCullumsmith
    Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    Synapse 52:62-72. 2004
    ..Our findings indicate that expression of nicotinic cholinergic receptor subunit transcripts are regulated in a subunit- and region-specific fashion by CNQX, an antagonist of non-NMDA ionotropic glutamate receptors...
  34. pmc Identification of novel targets for PGC-1alpha and histone deacetylase inhibitors in neuroblastoma cells
    Rita M Cowell
    Department of Psychiatry, University of Alabama, Birmingham, AL 35294, USA
    Biochem Biophys Res Commun 379:578-82. 2009
    ..These results suggest that PGC-1alpha regulates multiple pathways in neurons and that HDACi's may be good candidates to target PGC-1alpha and GLUT4 in HD and other neurological disorders...
  35. ncbi request reprint Neurocognitive measures of prefrontal cortical dysfunction in schizophrenia
    Laura M Ritter
    Psychiatry Service, VA Ann Arbor Health Care System, Ann Arbor, MI 48105, USA
    Schizophr Res 68:65-73. 2004
    ....
  36. ncbi request reprint Expression of transcripts for the vesicular glutamate transporters in the human medial temporal lobe
    Robert E McCullumsmith
    Department of Psychiatry and Mental Health Research Institute, University of Michigan Medical School, Ann Arbor, Michigan 48109 0720, USA
    Ann N Y Acad Sci 1003:438-42. 2003
  37. ncbi request reprint Plasma copper, iron, ceruloplasmin and ferroxidase activity in schizophrenia
    Teri L Wolf
    Department of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA
    Schizophr Res 86:167-71. 2006
    ..Increases in ceruloplasmin may result in increased levels of copper, which ultimately proves deleterious in schizophrenia...
  38. ncbi request reprint NMDA receptors and schizophrenia
    Lars V Kristiansen
    University of Alabama at Birmingham, Department of Psychiatry and Behavioral Neurobiology, SC560, 1530 3rd Avenue South, Birmingham, AL 35294 0017, USA
    Curr Opin Pharmacol 7:48-55. 2007
    ..Recent data also implicate abnormalities in cellular functions such as receptor trafficking and synaptic targeting...
  39. pmc Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder
    Robert E McCullumsmith
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, CIRC 576A 0021, 1530 3rd Avenue South, Birmingham, AL 35294, USA
    Brain Res 1127:108-18. 2007
    ..In the present work, we focus on the expression of these molecules in hippocampus in schizophrenia and bipolar affective disorder I...
  40. ncbi request reprint Lamina-specific abnormalities of AMPA receptor trafficking and signaling molecule transcripts in the prefrontal cortex in schizophrenia
    Monica Beneyto
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Alabama 35294 0018, USA
    Synapse 60:585-98. 2006
    ....
  41. ncbi request reprint Neurochemical markers for schizophrenia, bipolar disorder, and major depression in postmortem brains
    E Fuller Torrey
    Stanley Medical Research Institute, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Biol Psychiatry 57:252-60. 2005
    ..Previous studies of postmortem neurochemical markers in severe psychiatric disorders have been carried out on different brain collections, making it difficult to compare results...
  42. ncbi request reprint Contribution of cystine-glutamate antiporters to the psychotomimetic effects of phencyclidine
    David A Baker
    Department of Biomedical Sciences, Marquette University, Milwaukee, WI 53233, USA
    Neuropsychopharmacology 33:1760-72. 2008
    ..These data advance cystine-glutamate antiporters as novel targets capable of reversing the psychotomimetic effects of PCP...
  43. ncbi request reprint Lamina-specific abnormalities of NMDA receptor-associated postsynaptic protein transcripts in the prefrontal cortex in schizophrenia and bipolar disorder
    Monica Beneyto
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL, USA
    Neuropsychopharmacology 33:2175-86. 2008
    ..These alterations likely reflect altered signaling cascades associated with glutamate-mediated neurotransmission within specific cortical circuits in these psychiatric illnesses...
  44. pmc Altered vesicular glutamate transporter expression in the anterior cingulate cortex in schizophrenia
    Akin Oni-Orisan
    Wayne State University School of Medicine, Detroit, Michigan, USA
    Biol Psychiatry 63:766-75. 2008
    ..Recent studies have shown that VGLUTs regulate synaptic activity via the amount of glutamate released. Accordingly, we hypothesized that VGLUTs are altered in schizophrenia, contributing to dysfunction of presynaptic activity...
  45. ncbi request reprint Cortical glutamatergic markers in schizophrenia
    Elizabeth Scarr
    Rebecca L Cooper Research Laboratories, The Mental Health Research Institute of Victoria, Parkville, Australia
    Neuropsychopharmacology 30:1521-31. 2005
    ..These data indicate that the decreased number of kainate receptors in the dorsolateral prefrontal cortex in schizophrenia may result, in part, from reduced expression of the GluR5 receptor subunits...
  46. pmc Expression of transcripts for myelination-related genes in the anterior cingulate cortex in schizophrenia
    Robert E McCullumsmith
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham School of Medicine, Birmingham, AL, USA
    Schizophr Res 90:15-27. 2007
    ..Our results support the hypothesis that myelination and oligodendrocyte function are impaired in schizophrenia...