BENITA MCVICKER

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. doi request reprint Susceptibility to T cell-mediated liver injury is enhanced in asialoglycoprotein receptor-deficient mice
    Benita L McVicker
    Research Service 151, VA Nebraska Western Iowa Health Care System, Omaha, NE 68105, United States
    Int Immunopharmacol 16:17-26. 2013
  2. pmc Relationship between oxidative stress and hepatic glutathione levels in ethanol-mediated apoptosis of polarized hepatic cells
    Benita L McVicker
    Liver Study Unit, Department of Veterans Affairs Medical Center, Research Service 151, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    World J Gastroenterol 15:2609-16. 2009
  3. ncbi request reprint Effect of ethanol on pro-apoptotic mechanisms in polarized hepatic cells
    Benita L McVicker
    Veterans Affairs Medical Center, Research Service 151, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    World J Gastroenterol 13:4960-6. 2007
  4. ncbi request reprint Ethanol-induced apoptosis in polarized hepatic cells possibly through regulation of the Fas pathway
    Benita L McVicker
    The Liver Study Unit, Department of Veterans Affairs Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    Alcohol Clin Exp Res 30:1906-15. 2006
  5. ncbi request reprint The effect of ethanol on asialoglycoprotein receptor-mediated phagocytosis of apoptotic cells by rat hepatocytes
    Benita L McVicker
    Liver Study Unit, Department of Veterans Affairs Medical Center, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
    Hepatology 36:1478-87. 2002
  6. ncbi request reprint Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells
    Natalia A Osna
    Liver Study Unit, The Omaha Veterans Affairs VA Medical Center, Omaha, NE 68105, USA
    Hepatology 45:53-61. 2007
  7. ncbi request reprint Effect of chronic ethanol administration on the in vitro production of proinflammatory cytokines by rat Kupffer cells in the presence of apoptotic cells
    Benita L McVicker
    Liver Study Unit, Department of Veterans Affairs Medical Center, and Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68105, USA
    Alcohol Clin Exp Res 31:122-9. 2007
  8. doi request reprint Impaired receptor-mediated endocytosis: its role in alcohol-induced apoptosis
    Carol A Casey
    Department of Veterans Affairs Medical Center, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA
    J Gastroenterol Hepatol 23:S46-9. 2008
  9. pmc Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats
    Kusum K Kharbanda
    Department of Veterans Affairs Medical Centre, Omaha, NE 68105, USA
    Biochem Biophys Res Commun 381:523-7. 2009
  10. ncbi request reprint Liver asialoglycoprotein receptor levels correlate with severity of alcoholic liver damage in rats
    Carol A Casey
    Liver Study Unit, Department of Internal Medicine and Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha NE 68198, USA
    J Appl Physiol (1985) 96:76-80. 2004

Research Grants

Detail Information

Publications13

  1. doi request reprint Susceptibility to T cell-mediated liver injury is enhanced in asialoglycoprotein receptor-deficient mice
    Benita L McVicker
    Research Service 151, VA Nebraska Western Iowa Health Care System, Omaha, NE 68105, United States
    Int Immunopharmacol 16:17-26. 2013
    ....
  2. pmc Relationship between oxidative stress and hepatic glutathione levels in ethanol-mediated apoptosis of polarized hepatic cells
    Benita L McVicker
    Liver Study Unit, Department of Veterans Affairs Medical Center, Research Service 151, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    World J Gastroenterol 15:2609-16. 2009
    ..To investigate the role of reactive oxygen species (ROS) in ethanol-mediated cell death of polarized hepatic (WIF-B) cells...
  3. ncbi request reprint Effect of ethanol on pro-apoptotic mechanisms in polarized hepatic cells
    Benita L McVicker
    Veterans Affairs Medical Center, Research Service 151, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    World J Gastroenterol 13:4960-6. 2007
    ....
  4. ncbi request reprint Ethanol-induced apoptosis in polarized hepatic cells possibly through regulation of the Fas pathway
    Benita L McVicker
    The Liver Study Unit, Department of Veterans Affairs Medical Center, 4101 Woolworth Avenue, Omaha, NE 68105, USA
    Alcohol Clin Exp Res 30:1906-15. 2006
    ....
  5. ncbi request reprint The effect of ethanol on asialoglycoprotein receptor-mediated phagocytosis of apoptotic cells by rat hepatocytes
    Benita L McVicker
    Liver Study Unit, Department of Veterans Affairs Medical Center, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA
    Hepatology 36:1478-87. 2002
    ....
  6. ncbi request reprint Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells
    Natalia A Osna
    Liver Study Unit, The Omaha Veterans Affairs VA Medical Center, Omaha, NE 68105, USA
    Hepatology 45:53-61. 2007
    ..Treatment of cells with interferon gamma, which enhances proteasome activity, did not reverse the effects of ethanol. Ethanol exerted similar effects on WIFB cells, indicating that its effects are not unique to one cell type...
  7. ncbi request reprint Effect of chronic ethanol administration on the in vitro production of proinflammatory cytokines by rat Kupffer cells in the presence of apoptotic cells
    Benita L McVicker
    Liver Study Unit, Department of Veterans Affairs Medical Center, and Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68105, USA
    Alcohol Clin Exp Res 31:122-9. 2007
    ....
  8. doi request reprint Impaired receptor-mediated endocytosis: its role in alcohol-induced apoptosis
    Carol A Casey
    Department of Veterans Affairs Medical Center, University of Nebraska Medical Center, Omaha, Nebraska 68105, USA
    J Gastroenterol Hepatol 23:S46-9. 2008
    ..The goal of our future work is to show that inadequate removal of apoptotic cells, in part via altered receptor-mediated endocytosis, plays a role in the course of pathogenesis of alcoholic liver injury...
  9. pmc Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats
    Kusum K Kharbanda
    Department of Veterans Affairs Medical Centre, Omaha, NE 68105, USA
    Biochem Biophys Res Commun 381:523-7. 2009
    ..Carbonic anhydrase-III can function to resist oxidative stress, and we therefore hypothesise that carbonic anhydrase-III protein levels compromised by ethanol consumption, contribute to ethanol-induced redox stress...
  10. ncbi request reprint Liver asialoglycoprotein receptor levels correlate with severity of alcoholic liver damage in rats
    Carol A Casey
    Liver Study Unit, Department of Internal Medicine and Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha NE 68198, USA
    J Appl Physiol (1985) 96:76-80. 2004
    ..These results demonstrate that a correlation exists between the progression of alcohol-associated liver injury, as defined by the severity of liver pathology, and an ethanol-induced decline in ASGP-R content...
  11. ncbi request reprint WIF-B cells as a model for alcohol-induced hepatocyte injury
    Courtney S Schaffert
    The Department of Veterans Affairs Medical Center, University of Nebraska Medical Center, Omaha, NE, USA
    Biochem Pharmacol 67:2167-74. 2004
    ..Because of these similarities, WIF-B cells appear to be a suitable model for studying ethanol-induced hepatocyte injury...
  12. pmc Carbon tetrachloride-induced liver damage in asialoglycoprotein receptor-deficient mice
    Shana R Dalton
    Department of Internal Medicine, University of Nebraska Medical Center, Omaha, 68198 2000, USA
    Biochem Pharmacol 77:1283-90. 2009
    ..Thus, receptor-mediated endocytosis by the ASGP receptor could represent a novel molecular mechanism that is responsible for subsequent liver health or injury...
  13. pmc Impact of asialoglycoprotein receptor deficiency on the development of liver injury
    Serene M L Lee
    Departments of Internal Medicine and Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68105, United States
    World J Gastroenterol 15:1194-200. 2009
    ..In particular, adequate function and content of the ASGP receptor may provide protection against various toxin-mediated liver diseases...

Research Grants2

  1. Alcohol & FAS-Mediated Apoptosis in Polarized Liver Cell
    BENITA MCVICKER; Fiscal Year: 2007
    ..C. Overall, the completion of this proposed work will provide the mentored experience to progress to future independent study of liver function and survival following ethanol treatment. ..