C F McTiernan
Affiliation: University of Pittsburgh
- Interleukin-1 beta inhibits phospholamban gene expression in cultured cardiomyocytesC F McTiernan
Division of Cardiology, University of Pittsburgh, PA 15213, USA
Circ Res 81:493-503. 1997..The results suggest novel mechanisms by which IL-1 beta may modify cardiac function...
- The human phospholamban gene: structure and expressionC F McTiernan
Cardiovascular Institute, University of Pittsburgh Medical Center, PA 15213, USA
J Mol Cell Cardiol 31:679-92. 1999..Activity of these reporters in HeLa cells was markedly lower than that observed in rat cardiomyocytes, suggesting at least a partial tissue selectivity of these reporter constructs...
- Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cellsY Y Li
Research Laboratories, University of Pittsburgh School of Medicine, PA 15213, USA
Cardiovasc Res 42:162-72. 1999..Tissue inhibitors of metalloproteinases (TIMPs) are downregulated in the failing human heart. The objective of the present study was to test the hypothesis that cytokines might be involved in the regulation of TIMPs in cardiac cells...
- Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodelingY Y Li
1750 Biomedical Science Tower, Cardiovascular Institute, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Cardiovasc Res 46:214-24. 2000..It is therefore suggested that the interplay of MMPs and their regulators is important in the development of the heart failure phenotype, and myocardial fibrosis in heart failure may be modified by modulating MMP activity...
- Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-alphaT Kubota
Cardiovascular Research Laboratories, University of Pittsburgh Medical Center, PA 15213, USA
Circ Res 81:627-35. 1997..In conclusion, the mouse overexpressing TNF-alpha recapitulated the phenotype of congestive heart failure. This provides a novel model to elucidate the role of this cytokine in the development of congestive heart failure...
- The role of tumor necrosis factor alpha in the pathophysiology of congestive heart failureC F McTiernan
Cardiovascular Institute, University of Pittsburgh, Biomedical Science Tower 1744 1, 200 Lothrop Street, Pittsburgh, PA 15213, USA
Curr Cardiol Rep 2:189-97. 2000..Recent studies in both animal models and clinical investigations suggest that anti-TNF-alpha therapies may limit the pathophysiologic consequences of congestive heart failure...
- Myocarditis following adeno-associated viral gene expression of human soluble TNF receptor (TNFRII-Fc) in baboon heartsC F McTiernan
Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
Gene Ther 14:1613-22. 2007..Thus, a cellular immune response to cardiac delivery of AAV encoding foreign proteins may be an important consideration for AAV-based cardiac gene therapy...
- Effects of soluble TNF receptor treatment on lipopolysaccharide-induced myocardial cytokine expressionT Kadokami
Cardiovascular Institute of the University of Pittsburgh Medical Center Health System, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
Am J Physiol Heart Circ Physiol 280:H2281-91. 2001..Inability to block myocardial expression of IL-6 and MCP-1 suggests a possible mechanism for the failure of anti-TNF therapies in the treatment of endotoxin shock...
- IL-1 beta alters the expression of the receptor tyrosine kinase gene r-EphA3 in neonatal rat cardiomyocytesY Y Li
Cardiovascular Research Laboratories, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
Am J Physiol 274:H331-41. 1998..In the adult rat, r-EphA3 transcripts were most abundant in the heart, brain, and lung. These results suggest that IL-1 beta may exert its effect on cardiac myocytes at least in part by altering r-EphA3 expression...
- Demonstration of direct effects of growth hormone on neonatal cardiomyocytesC Lu
Departments of Pediatrics, Molecular Genetics and Biochemistry, and Cardiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
J Biol Chem 276:22892-900. 2001....
- Overexpression of tumor necrosis factor- alpha activates both anti- and pro-apoptotic pathways in the myocardiumT Kubota
Cardiovascular Institute of the UPMC Health System, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
J Mol Cell Cardiol 33:1331-44. 2001..These results suggest that TNF- alpha by itself is not sufficient to induce apoptosis in cardiac myocytes in vivo...
- Anti-tumor necrosis factor-alpha antibody limits heart failure in a transgenic modelT Kadokami
Cardiovascular Institute of the University of Pittsburgh Medical Center Health System, Pittsburgh, PA, USA
Circulation 104:1094-7. 2001..CONCLUSIONS: Blockade of TNF-alpha bioactivity by antibody therapy may both preserve cardiac function and partially reverse pathological changes in congestive heart failure...
- Downregulation of matrix metalloproteinases and reduction in collagen damage in the failing human heart after support with left ventricular assist devicesY Y Li
Cardiovascular Institute, Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Circulation 104:1147-52. 2001..These changes may contribute to the functional recovery and LV plasticity after LVAD support...
- Myotrophin induces early response genes and enhances cardiac gene expressionD P Mukherjee
Department of Heart and Hypertension Research, Cleveland Clinic Foundation, OH 44195 5071
Hypertension 21:142-8. 1993....