C F McTiernan

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. ncbi Interleukin-1 beta inhibits phospholamban gene expression in cultured cardiomyocytes
    C F McTiernan
    Division of Cardiology, University of Pittsburgh, PA 15213, USA
    Circ Res 81:493-503. 1997
  2. ncbi The human phospholamban gene: structure and expression
    C F McTiernan
    Cardiovascular Institute, University of Pittsburgh Medical Center, PA 15213, USA
    J Mol Cell Cardiol 31:679-92. 1999
  3. ncbi Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cells
    Y Y Li
    Research Laboratories, University of Pittsburgh School of Medicine, PA 15213, USA
    Cardiovasc Res 42:162-72. 1999
  4. ncbi Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling
    Y Y Li
    1750 Biomedical Science Tower, Cardiovascular Institute, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Cardiovasc Res 46:214-24. 2000
  5. ncbi Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-alpha
    T Kubota
    Cardiovascular Research Laboratories, University of Pittsburgh Medical Center, PA 15213, USA
    Circ Res 81:627-35. 1997
  6. ncbi The role of tumor necrosis factor alpha in the pathophysiology of congestive heart failure
    C F McTiernan
    Cardiovascular Institute, University of Pittsburgh, Biomedical Science Tower 1744 1, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Curr Cardiol Rep 2:189-97. 2000
  7. ncbi Myocarditis following adeno-associated viral gene expression of human soluble TNF receptor (TNFRII-Fc) in baboon hearts
    C F McTiernan
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Gene Ther 14:1613-22. 2007
  8. ncbi Effects of soluble TNF receptor treatment on lipopolysaccharide-induced myocardial cytokine expression
    T Kadokami
    Cardiovascular Institute of the University of Pittsburgh Medical Center Health System, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Heart Circ Physiol 280:H2281-91. 2001
  9. ncbi IL-1 beta alters the expression of the receptor tyrosine kinase gene r-EphA3 in neonatal rat cardiomyocytes
    Y Y Li
    Cardiovascular Research Laboratories, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    Am J Physiol 274:H331-41. 1998
  10. ncbi Demonstration of direct effects of growth hormone on neonatal cardiomyocytes
    C Lu
    Departments of Pediatrics, Molecular Genetics and Biochemistry, and Cardiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 276:22892-900. 2001

Collaborators

Detail Information

Publications14

  1. ncbi Interleukin-1 beta inhibits phospholamban gene expression in cultured cardiomyocytes
    C F McTiernan
    Division of Cardiology, University of Pittsburgh, PA 15213, USA
    Circ Res 81:493-503. 1997
    ..The results suggest novel mechanisms by which IL-1 beta may modify cardiac function...
  2. ncbi The human phospholamban gene: structure and expression
    C F McTiernan
    Cardiovascular Institute, University of Pittsburgh Medical Center, PA 15213, USA
    J Mol Cell Cardiol 31:679-92. 1999
    ..Activity of these reporters in HeLa cells was markedly lower than that observed in rat cardiomyocytes, suggesting at least a partial tissue selectivity of these reporter constructs...
  3. ncbi Proinflammatory cytokines regulate tissue inhibitors of metalloproteinases and disintegrin metalloproteinase in cardiac cells
    Y Y Li
    Research Laboratories, University of Pittsburgh School of Medicine, PA 15213, USA
    Cardiovasc Res 42:162-72. 1999
    ..Tissue inhibitors of metalloproteinases (TIMPs) are downregulated in the failing human heart. The objective of the present study was to test the hypothesis that cytokines might be involved in the regulation of TIMPs in cardiac cells...
  4. ncbi Interplay of matrix metalloproteinases, tissue inhibitors of metalloproteinases and their regulators in cardiac matrix remodeling
    Y Y Li
    1750 Biomedical Science Tower, Cardiovascular Institute, University of Pittsburgh School of Medicine, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Cardiovasc Res 46:214-24. 2000
    ..It is therefore suggested that the interplay of MMPs and their regulators is important in the development of the heart failure phenotype, and myocardial fibrosis in heart failure may be modified by modulating MMP activity...
  5. ncbi Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-alpha
    T Kubota
    Cardiovascular Research Laboratories, University of Pittsburgh Medical Center, PA 15213, USA
    Circ Res 81:627-35. 1997
    ..In conclusion, the mouse overexpressing TNF-alpha recapitulated the phenotype of congestive heart failure. This provides a novel model to elucidate the role of this cytokine in the development of congestive heart failure...
  6. ncbi The role of tumor necrosis factor alpha in the pathophysiology of congestive heart failure
    C F McTiernan
    Cardiovascular Institute, University of Pittsburgh, Biomedical Science Tower 1744 1, 200 Lothrop Street, Pittsburgh, PA 15213, USA
    Curr Cardiol Rep 2:189-97. 2000
    ..Recent studies in both animal models and clinical investigations suggest that anti-TNF-alpha therapies may limit the pathophysiologic consequences of congestive heart failure...
  7. ncbi Myocarditis following adeno-associated viral gene expression of human soluble TNF receptor (TNFRII-Fc) in baboon hearts
    C F McTiernan
    Cardiovascular Institute, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Gene Ther 14:1613-22. 2007
    ..Thus, a cellular immune response to cardiac delivery of AAV encoding foreign proteins may be an important consideration for AAV-based cardiac gene therapy...
  8. ncbi Effects of soluble TNF receptor treatment on lipopolysaccharide-induced myocardial cytokine expression
    T Kadokami
    Cardiovascular Institute of the University of Pittsburgh Medical Center Health System, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Heart Circ Physiol 280:H2281-91. 2001
    ..Inability to block myocardial expression of IL-6 and MCP-1 suggests a possible mechanism for the failure of anti-TNF therapies in the treatment of endotoxin shock...
  9. ncbi IL-1 beta alters the expression of the receptor tyrosine kinase gene r-EphA3 in neonatal rat cardiomyocytes
    Y Y Li
    Cardiovascular Research Laboratories, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    Am J Physiol 274:H331-41. 1998
    ..In the adult rat, r-EphA3 transcripts were most abundant in the heart, brain, and lung. These results suggest that IL-1 beta may exert its effect on cardiac myocytes at least in part by altering r-EphA3 expression...
  10. ncbi Demonstration of direct effects of growth hormone on neonatal cardiomyocytes
    C Lu
    Departments of Pediatrics, Molecular Genetics and Biochemistry, and Cardiology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 276:22892-900. 2001
    ....
  11. ncbi Overexpression of tumor necrosis factor- alpha activates both anti- and pro-apoptotic pathways in the myocardium
    T Kubota
    Cardiovascular Institute of the UPMC Health System, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    J Mol Cell Cardiol 33:1331-44. 2001
    ..These results suggest that TNF- alpha by itself is not sufficient to induce apoptosis in cardiac myocytes in vivo...
  12. ncbi Anti-tumor necrosis factor-alpha antibody limits heart failure in a transgenic model
    T Kadokami
    Cardiovascular Institute of the University of Pittsburgh Medical Center Health System, Pittsburgh, PA, USA
    Circulation 104:1094-7. 2001
    ..CONCLUSIONS: Blockade of TNF-alpha bioactivity by antibody therapy may both preserve cardiac function and partially reverse pathological changes in congestive heart failure...
  13. ncbi Downregulation of matrix metalloproteinases and reduction in collagen damage in the failing human heart after support with left ventricular assist devices
    Y Y Li
    Cardiovascular Institute, Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Circulation 104:1147-52. 2001
    ..These changes may contribute to the functional recovery and LV plasticity after LVAD support...
  14. ncbi Myotrophin induces early response genes and enhances cardiac gene expression
    D P Mukherjee
    Department of Heart and Hypertension Research, Cleveland Clinic Foundation, OH 44195 5071
    Hypertension 21:142-8. 1993
    ....