Research Topics
Species | Bruce L McNaughtonSummaryAffiliation: University of Arizona Country: USA Publications
Research Grants
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Detail Information
Publications
Path integration and the neural basis of the 'cognitive map'Bruce L McNaughton
Arizona Research Laboratories Division of Neural Systems, Memory and Aging, and Department of Psychology, University of Arizona, Tucson 85724, USA
Nat Rev Neurosci 7:663-78. 2006..Convergence of spatially periodic input at multiple scales, from so-called grid cells in the entorhinal cortex, might result in non-periodic spatial firing patterns (place fields) in the hippocampus...- A binless correlation measure reduces the variability of memory reactivation estimatesPeter B Kruskal
Oberlin College Department of Mathematics, Oberlin, OH 44074, USA
Stat Med 26:3997-4008. 2007.... 
Long-term potentiation, cooperativity and Hebb's cell assemblies: a personal historyBruce L McNaughton
Room 384, Life Sciences North Building, University of Arizona, Tucson, AZ 85724, USA
Philos Trans R Soc Lond B Biol Sci 358:629-34. 2003..In addition, the fallacy underlying the sometimes presumed distinction between 'cooperativity' and 'associativity' in the induction of LTP is pointed out...- Stored-trace reactivation in rat prefrontal cortex is correlated with down-to-up state fluctuation densityLise A Johnson
Graduate Program in Biomedical Engineering, University of Arizona, Tucson, Arizona 85721 0093, USA
J Neurosci 30:2650-61. 2010.... - Organization of hippocampal cell assemblies based on theta phase precessionAndrew P Maurer
Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724, USA
Hippocampus 16:785-94. 2006..Thus, the same neuron can participate in different cell assemblies within a single theta cycle... - Self-motion and the origin of differential spatial scaling along the septo-temporal axis of the hippocampusAndrew P Maurer
Neural Systems, Memory, and Aging, University of Arizona, Tucson, 85724, USA
Hippocampus 15:841-52. 2005..We conclude that variation in the neuronal response to movement speed is the likely basis for the systematic variation in spatial scaling along the septo-temporal axis of the hippocampus... - Phase precession in hippocampal interneurons showing strong functional coupling to individual pyramidal cellsAndrew P Maurer
Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724, USA
J Neurosci 26:13485-92. 2006.... - Differential encoding of behavior and spatial context in deep and superficial layers of the neocortexSara N Burke
Neural Systems, Memory, and Aging Division, Life Sciences North Building, Room 384, University of Arizona, Tucson, AZ 85724, USA
Neuron 45:667-74. 2005..Increased context sensitivity of superficial neocortical layers, which receive more hippocampal outflow, may reflect a general principle of neocortical organization for memory retrieval... - Sequence reactivation in the hippocampus is impaired in aged ratsJason L Gerrard
Arizona Research Laboratories Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724, USA
J Neurosci 28:7883-90. 2008..The novel finding that weak replay of temporal patterns has behavioral consequences, strengthens the idea that reactivation processes are integral to memory consolidation... - Fast-forward playback of recent memory sequences in prefrontal cortex during sleepDavid R Euston
Arizona Research Laboratories Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85724 5115, USA
Science 318:1147-50. 2007..Given recent evidence implicating the medial prefrontal cortex in retrieval of long-term memories, the observed replay may play a role in the process of memory consolidation... - Selective delay activity in the medial prefrontal cortex of the rat: contribution of sensorimotor information and contingencyStephen L Cowen
Arizona Research Labs, Division of Neural Systems, Memory and Aging and Department of Psychology, The University of Arizona, Tucson, AZ 85721, USA
J Neurophysiol 98:303-16. 2007.... 
Immediate-early gene expression at rest recapitulates recent experienceDiano F Marrone
Division of Neural Systems, Memory, and Aging, Arizona Research Laboratories, Tucson, Arizona 85724, USA
J Neurosci 28:1030-3. 2008..Rather, consistent with proposed memory consolidation mechanisms, it recapitulates a subset of the pattern generated by recent experience...- Hippocampal sharp wave bursts coincide with neocortical "up-state" transitionsFrancesco P Battaglia
Arizona Research Laboratories--Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, Arizona 85724, USA
Learn Mem 11:697-704. 2004..The neocortical up-states starting in correspondence with sharp waves may be influenced by the reactivated information carried by the hippocampal sharp wave... - Synaptic commitment: developmentally regulated reciprocal changes in hippocampal granule cell NMDA and AMPA receptors over the lifespanZhiyong Yang
Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85724 5115, USA
J Neurophysiol 99:2760-8. 2008..One possible implication of this effect includes preservation of selected memories, ultimately at the expense of a reduced capacity to store new information... - 3D-catFISH: a system for automated quantitative three-dimensional compartmental analysis of temporal gene transcription activity imaged by fluorescence in situ hybridizationMonica K Chawla
Neural Systems, Memory, and Aging Division, Life Sciences North Bldg, Rm. 384, University of Arizona, Tucson, AZ 85724, USA
J Neurosci Methods 139:13-24. 2004..5% concordance with multi-expert consensus). The high degree of reliability and accuracy suggests that the software will generalize well to multiple brain areas and eventually to large-scale brain analysis... - Methodological considerations on the use of template matching to study long-lasting memory trace replayMasami Tatsuno
Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724-5115, USA
J Neurosci 26:10727-42. 2006.... - Spontaneous changes of neocortical code for associative memory during consolidationKaori Takehara-Nishiuchi
Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, AZ 85724 5115, USA
Science 322:960-3. 2008..Thus, in agreement with a central tenet of consolidation theory, acquired associations initiate subsequent, gradual processes that result in lasting changes of the mPFC's code, without continued training... - EEG sharp waves and sparse ensemble unit activity in the macaque hippocampusWilliam E Skaggs
Arizona Research Laboratories Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724, USA
J Neurophysiol 98:898-910. 2007.... - Advanced imaging of multiple mRNAs in brain tissue using a custom hyperspectral imager and multivariate curve resolutionVicki L Sutherland
Arizona Research Laboratories, Division of Neural Systems Memory and Aging, University of Arizona, Tucson, AZ, United States
J Neurosci Methods 160:144-8. 2007.... - Network and intrinsic cellular mechanisms underlying theta phase precession of hippocampal neuronsAndrew P Maurer
Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85724, USA
Trends Neurosci 30:325-33. 2007..This review is part of the INMED/TINS special issue Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com)... - Self-motion and the hippocampal spatial metricAlejandro Terrazas
Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724, USA
J Neurosci 25:8085-96. 2005.... - Local sensory cues and place cell directionality: additional evidence of prospective coding in the hippocampusFrancesco P Battaglia
Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, Arizona 85724-5115, USA
J Neurosci 24:4541-50. 2004.... - Hippocampal map realignment and spatial learningEphron S Rosenzweig
Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, 384 Life Sciences North, University of Arizona, Tucson, Arizona 85724, USA
Nat Neurosci 6:609-15. 2003..Thus, changes in the effectiveness with which the hippocampal spatial representation is updated on the basis of external cues may contribute to both within-age-group spatial learning variability and age-related spatial learning deficits... - Sleep on it: cortical reorganization after-the-factKari L Hoffman
ARL Division of Neural Systems, Memory and Aging, University of Arizona, 384 Life Sciences North, Tucson, AZ 85719, USA
Trends Neurosci 25:1-2. 2002..Experience-dependent plasticity during sleep could be part of a more global process of memory consolidation... - Apparent encoding of sequential context in rat medial prefrontal cortex is accounted for by behavioral variabilityDavid R Euston
Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, Arizona 85724-5115, USA
J Neurosci 26:13143-55. 2006..The finding that the rodent medial prefrontal cortex is highly sensitive to sensory-behavioral variables raises doubts about previous experiments that purport to show working memory-related activity in this region... - Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networksAlmira Vazdarjanova
Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724 5115, USA
J Neurosci 22:10067-71. 2002.... - Making room for new memoriesEphron S Rosenzweig
Nat Neurosci 5:6-8. 2002 - Recent behavioral history modifies coupling between cell activity and Arc gene transcription in hippocampal CA1 neuronsJohn F Guzowski
Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
Proc Natl Acad Sci U S A 103:1077-82. 2006..This state-dependence of neuronal transcriptional coupling provides a mechanism of metaplasticity and may regulate capacity for synaptic modification in neural networks... - Progressive transformation of hippocampal neuronal representations in "morphed" environmentsJill K Leutgeb
Center for the Biology of Memory, Norwegian University of Science and Technology, NO-7489 Trondheim, Norway
Neuron 48:345-58. 2005..These observations suggest that hippocampal cell assemblies are capable of incremental plastic deformation, with incongruous information being incorporated into pre-existing representations... - Bimodality of theta phase precession in hippocampal place cells in freely running ratsYoko Yamaguchi
RIKEN, Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198 Japan
J Neurophysiol 87:2629-42. 2002..The functional implications of the two components are discussed with respect to their possible contribution to learning and memory mechanisms... - Independent codes for spatial and episodic memory in hippocampal neuronal ensemblesStefan Leutgeb
Centre for the Biology of Memory, Medical-Technical Research Centre, Norwegian University of Science and Technology, 7489 Trondheim, Norway
Science 309:619-23. 2005..These independent encoding schemes may enable simultaneous representation of spatial and episodic memory information... - Cannabinoids reveal importance of spike timing coordination in hippocampal functionDavid Robbe
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
Nat Neurosci 9:1526-33. 2006..We hypothesize that reduced spike timing coordination and the associated impairment of physiological oscillations are responsible for cannabinoid-induced memory deficits... - Hippocampal population activity during the small-amplitude irregular activity state in the ratBeata Jarosiewicz
Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Neurosci 22:1373-84. 2002.... - Sequential-context-dependent hippocampal activity is not necessary to learn sequences with repeated elementsMark R Bower
Department of Comparative Medicine, Stanford University, Stanford, California 94305-5342, USA
J Neurosci 25:1313-23. 2005.... - Mapping behaviorally relevant neural circuits with immediate-early gene expressionJohn F Guzowski
Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 5223, USA
Curr Opin Neurobiol 15:599-606. 2005.... - Selective excitotoxic lesions of the hippocampus and basolateral amygdala have dissociable effects on appetitive cue and place conditioning based on path integration in a novel Y-maze procedureRutsuko Ito
Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
Eur J Neurosci 23:3071-80. 2006..Here we provide strong support for the notion that the HPC and BLA subserve complementary and competing roles in appetitive cue and contextual conditioning... - Conjunctive representation of position, direction, and velocity in entorhinal cortexFrancesca Sargolini
Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
Science 312:758-62. 2006..All cell types were modulated by running speed. The conjunction of positional, directional, and translational information in a single MEC cell type may enable grid coordinates to be updated during self-motion-based navigation...
Research Grants
- CELL ASSEMBLIES, PHASE SEQUENCES AND MEMORY DYNAMICSBruce McNaughton; Fiscal Year: 2002..The specific research projects deal with the questions of the reactivation of memory traces during sleep, how this is orchestrated by the hippocampus, and whether the process itself is truly of behavioral significance. ..
- NEURAL BASIS OF INTERNAL REPRESENTATION OF PLACEBruce McNaughton; Fiscal Year: 2007..The experiments described in this proposal address these issues. ..
- HEBB MARR NETWORKS THE HIPPOCAMPUS AND SPATIAL MEMORYBruce McNaughton; Fiscal Year: 2007..abstract_text> ..