Bruce L McNaughton

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi request reprint Path integration and the neural basis of the 'cognitive map'
    Bruce L McNaughton
    Arizona Research Laboratories Division of Neural Systems, Memory and Aging, and Department of Psychology, University of Arizona, Tucson 85724, USA
    Nat Rev Neurosci 7:663-78. 2006
  2. ncbi request reprint A binless correlation measure reduces the variability of memory reactivation estimates
    Peter B Kruskal
    Oberlin College Department of Mathematics, Oberlin, OH 44074, USA
    Stat Med 26:3997-4008. 2007
  3. pmc Long-term potentiation, cooperativity and Hebb's cell assemblies: a personal history
    Bruce L McNaughton
    Room 384, Life Sciences North Building, University of Arizona, Tucson, AZ 85724, USA
    Philos Trans R Soc Lond B Biol Sci 358:629-34. 2003
  4. pmc Stored-trace reactivation in rat prefrontal cortex is correlated with down-to-up state fluctuation density
    Lise A Johnson
    Graduate Program in Biomedical Engineering, University of Arizona, Tucson, Arizona 85721 0093, USA
    J Neurosci 30:2650-61. 2010
  5. ncbi request reprint Organization of hippocampal cell assemblies based on theta phase precession
    Andrew P Maurer
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724, USA
    Hippocampus 16:785-94. 2006
  6. ncbi request reprint Self-motion and the origin of differential spatial scaling along the septo-temporal axis of the hippocampus
    Andrew P Maurer
    Neural Systems, Memory, and Aging, University of Arizona, Tucson, 85724, USA
    Hippocampus 15:841-52. 2005
  7. ncbi request reprint Phase precession in hippocampal interneurons showing strong functional coupling to individual pyramidal cells
    Andrew P Maurer
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724, USA
    J Neurosci 26:13485-92. 2006
  8. ncbi request reprint Differential encoding of behavior and spatial context in deep and superficial layers of the neocortex
    Sara N Burke
    Neural Systems, Memory, and Aging Division, Life Sciences North Building, Room 384, University of Arizona, Tucson, AZ 85724, USA
    Neuron 45:667-74. 2005
  9. pmc Sequence reactivation in the hippocampus is impaired in aged rats
    Jason L Gerrard
    Arizona Research Laboratories Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724, USA
    J Neurosci 28:7883-90. 2008
  10. ncbi request reprint Fast-forward playback of recent memory sequences in prefrontal cortex during sleep
    David R Euston
    Arizona Research Laboratories Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85724 5115, USA
    Science 318:1147-50. 2007

Research Grants

  1. CELL ASSEMBLIES, PHASE SEQUENCES AND MEMORY DYNAMICS
    Bruce McNaughton; Fiscal Year: 2002
  2. NEURAL BASIS OF INTERNAL REPRESENTATION OF PLACE
    Bruce McNaughton; Fiscal Year: 2007
  3. HEBB MARR NETWORKS THE HIPPOCAMPUS AND SPATIAL MEMORY
    Bruce McNaughton; Fiscal Year: 2007

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Path integration and the neural basis of the 'cognitive map'
    Bruce L McNaughton
    Arizona Research Laboratories Division of Neural Systems, Memory and Aging, and Department of Psychology, University of Arizona, Tucson 85724, USA
    Nat Rev Neurosci 7:663-78. 2006
    ..Convergence of spatially periodic input at multiple scales, from so-called grid cells in the entorhinal cortex, might result in non-periodic spatial firing patterns (place fields) in the hippocampus...
  2. ncbi request reprint A binless correlation measure reduces the variability of memory reactivation estimates
    Peter B Kruskal
    Oberlin College Department of Mathematics, Oberlin, OH 44074, USA
    Stat Med 26:3997-4008. 2007
    ....
  3. pmc Long-term potentiation, cooperativity and Hebb's cell assemblies: a personal history
    Bruce L McNaughton
    Room 384, Life Sciences North Building, University of Arizona, Tucson, AZ 85724, USA
    Philos Trans R Soc Lond B Biol Sci 358:629-34. 2003
    ..In addition, the fallacy underlying the sometimes presumed distinction between 'cooperativity' and 'associativity' in the induction of LTP is pointed out...
  4. pmc Stored-trace reactivation in rat prefrontal cortex is correlated with down-to-up state fluctuation density
    Lise A Johnson
    Graduate Program in Biomedical Engineering, University of Arizona, Tucson, Arizona 85721 0093, USA
    J Neurosci 30:2650-61. 2010
    ....
  5. ncbi request reprint Organization of hippocampal cell assemblies based on theta phase precession
    Andrew P Maurer
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724, USA
    Hippocampus 16:785-94. 2006
    ..Thus, the same neuron can participate in different cell assemblies within a single theta cycle...
  6. ncbi request reprint Self-motion and the origin of differential spatial scaling along the septo-temporal axis of the hippocampus
    Andrew P Maurer
    Neural Systems, Memory, and Aging, University of Arizona, Tucson, 85724, USA
    Hippocampus 15:841-52. 2005
    ..We conclude that variation in the neuronal response to movement speed is the likely basis for the systematic variation in spatial scaling along the septo-temporal axis of the hippocampus...
  7. ncbi request reprint Phase precession in hippocampal interneurons showing strong functional coupling to individual pyramidal cells
    Andrew P Maurer
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724, USA
    J Neurosci 26:13485-92. 2006
    ....
  8. ncbi request reprint Differential encoding of behavior and spatial context in deep and superficial layers of the neocortex
    Sara N Burke
    Neural Systems, Memory, and Aging Division, Life Sciences North Building, Room 384, University of Arizona, Tucson, AZ 85724, USA
    Neuron 45:667-74. 2005
    ..Increased context sensitivity of superficial neocortical layers, which receive more hippocampal outflow, may reflect a general principle of neocortical organization for memory retrieval...
  9. pmc Sequence reactivation in the hippocampus is impaired in aged rats
    Jason L Gerrard
    Arizona Research Laboratories Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724, USA
    J Neurosci 28:7883-90. 2008
    ..The novel finding that weak replay of temporal patterns has behavioral consequences, strengthens the idea that reactivation processes are integral to memory consolidation...
  10. ncbi request reprint Fast-forward playback of recent memory sequences in prefrontal cortex during sleep
    David R Euston
    Arizona Research Laboratories Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85724 5115, USA
    Science 318:1147-50. 2007
    ..Given recent evidence implicating the medial prefrontal cortex in retrieval of long-term memories, the observed replay may play a role in the process of memory consolidation...
  11. ncbi request reprint Selective delay activity in the medial prefrontal cortex of the rat: contribution of sensorimotor information and contingency
    Stephen L Cowen
    Arizona Research Labs, Division of Neural Systems, Memory and Aging and Department of Psychology, The University of Arizona, Tucson, AZ 85721, USA
    J Neurophysiol 98:303-16. 2007
    ....
  12. doi request reprint Immediate-early gene expression at rest recapitulates recent experience
    Diano F Marrone
    Division of Neural Systems, Memory, and Aging, Arizona Research Laboratories, Tucson, Arizona 85724, USA
    J Neurosci 28:1030-3. 2008
    ..Rather, consistent with proposed memory consolidation mechanisms, it recapitulates a subset of the pattern generated by recent experience...
  13. pmc Hippocampal sharp wave bursts coincide with neocortical "up-state" transitions
    Francesco P Battaglia
    Arizona Research Laboratories Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, Arizona 85724, USA
    Learn Mem 11:697-704. 2004
    ..The neocortical up-states starting in correspondence with sharp waves may be influenced by the reactivated information carried by the hippocampal sharp wave...
  14. pmc Synaptic commitment: developmentally regulated reciprocal changes in hippocampal granule cell NMDA and AMPA receptors over the lifespan
    Zhiyong Yang
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85724 5115, USA
    J Neurophysiol 99:2760-8. 2008
    ..One possible implication of this effect includes preservation of selected memories, ultimately at the expense of a reduced capacity to store new information...
  15. ncbi request reprint 3D-catFISH: a system for automated quantitative three-dimensional compartmental analysis of temporal gene transcription activity imaged by fluorescence in situ hybridization
    Monica K Chawla
    Neural Systems, Memory, and Aging Division, Life Sciences North Bldg, Rm 384, University of Arizona, Tucson, AZ 85724, USA
    J Neurosci Methods 139:13-24. 2004
    ..5% concordance with multi-expert consensus). The high degree of reliability and accuracy suggests that the software will generalize well to multiple brain areas and eventually to large-scale brain analysis...
  16. ncbi request reprint Methodological considerations on the use of template matching to study long-lasting memory trace replay
    Masami Tatsuno
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724 5115, USA
    J Neurosci 26:10727-42. 2006
    ....
  17. doi request reprint Spontaneous changes of neocortical code for associative memory during consolidation
    Kaori Takehara-Nishiuchi
    Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, AZ 85724 5115, USA
    Science 322:960-3. 2008
    ..Thus, in agreement with a central tenet of consolidation theory, acquired associations initiate subsequent, gradual processes that result in lasting changes of the mPFC's code, without continued training...
  18. ncbi request reprint EEG sharp waves and sparse ensemble unit activity in the macaque hippocampus
    William E Skaggs
    Arizona Research Laboratories Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724, USA
    J Neurophysiol 98:898-910. 2007
    ....
  19. pmc Advanced imaging of multiple mRNAs in brain tissue using a custom hyperspectral imager and multivariate curve resolution
    Vicki L Sutherland
    Arizona Research Laboratories, Division of Neural Systems Memory and Aging, University of Arizona, Tucson, AZ, United States
    J Neurosci Methods 160:144-8. 2007
    ....
  20. ncbi request reprint Network and intrinsic cellular mechanisms underlying theta phase precession of hippocampal neurons
    Andrew P Maurer
    Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85724, USA
    Trends Neurosci 30:325-33. 2007
    ..This review is part of the INMED/TINS special issue Physiogenic and pathogenic oscillations: the beauty and the beast, based on presentations at the annual INMED/TINS symposium (http://inmednet.com)...
  21. ncbi request reprint Self-motion and the hippocampal spatial metric
    Alejandro Terrazas
    Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724, USA
    J Neurosci 25:8085-96. 2005
    ....
  22. ncbi request reprint Local sensory cues and place cell directionality: additional evidence of prospective coding in the hippocampus
    Francesco P Battaglia
    Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, Arizona 85724 5115, USA
    J Neurosci 24:4541-50. 2004
    ....
  23. ncbi request reprint Hippocampal map realignment and spatial learning
    Ephron S Rosenzweig
    Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, 384 Life Sciences North, University of Arizona, Tucson, Arizona 85724, USA
    Nat Neurosci 6:609-15. 2003
    ..Thus, changes in the effectiveness with which the hippocampal spatial representation is updated on the basis of external cues may contribute to both within-age-group spatial learning variability and age-related spatial learning deficits...
  24. ncbi request reprint Sleep on it: cortical reorganization after-the-fact
    Kari L Hoffman
    ARL Division of Neural Systems, Memory and Aging, University of Arizona, 384 Life Sciences North, Tucson, AZ 85719, USA
    Trends Neurosci 25:1-2. 2002
    ..Experience-dependent plasticity during sleep could be part of a more global process of memory consolidation...
  25. ncbi request reprint Apparent encoding of sequential context in rat medial prefrontal cortex is accounted for by behavioral variability
    David R Euston
    Arizona Research Laboratories, Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson, Arizona 85724 5115, USA
    J Neurosci 26:13143-55. 2006
    ..The finding that the rodent medial prefrontal cortex is highly sensitive to sensory-behavioral variables raises doubts about previous experiments that purport to show working memory-related activity in this region...
  26. ncbi request reprint Experience-dependent coincident expression of the effector immediate-early genes arc and Homer 1a in hippocampal and neocortical neuronal networks
    Almira Vazdarjanova
    Arizona Research Laboratories, Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, Arizona 85724 5115, USA
    J Neurosci 22:10067-71. 2002
    ....
  27. ncbi request reprint Making room for new memories
    Ephron S Rosenzweig
    Nat Neurosci 5:6-8. 2002
  28. pmc Recent behavioral history modifies coupling between cell activity and Arc gene transcription in hippocampal CA1 neurons
    John F Guzowski
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Proc Natl Acad Sci U S A 103:1077-82. 2006
    ..This state-dependence of neuronal transcriptional coupling provides a mechanism of metaplasticity and may regulate capacity for synaptic modification in neural networks...
  29. ncbi request reprint Progressive transformation of hippocampal neuronal representations in "morphed" environments
    Jill K Leutgeb
    Center for the Biology of Memory, Norwegian University of Science and Technology, NO 7489 Trondheim, Norway
    Neuron 48:345-58. 2005
    ..These observations suggest that hippocampal cell assemblies are capable of incremental plastic deformation, with incongruous information being incorporated into pre-existing representations...
  30. ncbi request reprint Bimodality of theta phase precession in hippocampal place cells in freely running rats
    Yoko Yamaguchi
    RIKEN, Brain Science Institute, 2 1 Hirosawa, Wako, Saitama 351 0198 Japan
    J Neurophysiol 87:2629-42. 2002
    ..The functional implications of the two components are discussed with respect to their possible contribution to learning and memory mechanisms...
  31. ncbi request reprint Independent codes for spatial and episodic memory in hippocampal neuronal ensembles
    Stefan Leutgeb
    Centre for the Biology of Memory, Medical Technical Research Centre, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 309:619-23. 2005
    ..These independent encoding schemes may enable simultaneous representation of spatial and episodic memory information...
  32. ncbi request reprint Cannabinoids reveal importance of spike timing coordination in hippocampal function
    David Robbe
    Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA
    Nat Neurosci 9:1526-33. 2006
    ..We hypothesize that reduced spike timing coordination and the associated impairment of physiological oscillations are responsible for cannabinoid-induced memory deficits...
  33. ncbi request reprint Hippocampal population activity during the small-amplitude irregular activity state in the rat
    Beata Jarosiewicz
    Department of Neuroscience and Center for the Neural Basis of Cognition, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Neurosci 22:1373-84. 2002
    ....
  34. ncbi request reprint Sequential-context-dependent hippocampal activity is not necessary to learn sequences with repeated elements
    Mark R Bower
    Department of Comparative Medicine, Stanford University, Stanford, California 94305 5342, USA
    J Neurosci 25:1313-23. 2005
    ....
  35. ncbi request reprint Mapping behaviorally relevant neural circuits with immediate-early gene expression
    John F Guzowski
    Department of Neurosciences, University of New Mexico Health Sciences Center, Albuquerque, NM 87131 5223, USA
    Curr Opin Neurobiol 15:599-606. 2005
    ....
  36. pmc Selective excitotoxic lesions of the hippocampus and basolateral amygdala have dissociable effects on appetitive cue and place conditioning based on path integration in a novel Y-maze procedure
    Rutsuko Ito
    Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK
    Eur J Neurosci 23:3071-80. 2006
    ..Here we provide strong support for the notion that the HPC and BLA subserve complementary and competing roles in appetitive cue and contextual conditioning...
  37. ncbi request reprint Conjunctive representation of position, direction, and velocity in entorhinal cortex
    Francesca Sargolini
    Centre for the Biology of Memory, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Science 312:758-62. 2006
    ..All cell types were modulated by running speed. The conjunction of positional, directional, and translational information in a single MEC cell type may enable grid coordinates to be updated during self-motion-based navigation...

Research Grants4

  1. CELL ASSEMBLIES, PHASE SEQUENCES AND MEMORY DYNAMICS
    Bruce McNaughton; Fiscal Year: 2002
    ..The specific research projects deal with the questions of the reactivation of memory traces during sleep, how this is orchestrated by the hippocampus, and whether the process itself is truly of behavioral significance. ..
  2. NEURAL BASIS OF INTERNAL REPRESENTATION OF PLACE
    Bruce McNaughton; Fiscal Year: 2007
    ..The experiments described in this proposal address these issues. ..
  3. HEBB MARR NETWORKS THE HIPPOCAMPUS AND SPATIAL MEMORY
    Bruce McNaughton; Fiscal Year: 2007
    ..abstract_text> ..