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Genomes and Genes | Robert K McNamaraSummaryAffiliation: University of Cincinnati Country: USA Publications
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Publications
Effect of myristoylated alanine-rich C kinase substrate (MARCKS) overexpression on hippocampus-dependent learning and hippocampal synaptic plasticity in MARCKS transgenic miceRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
Hippocampus 15:675-83. 2005..Collectively, these results indicate that elevations in MARCKS expression are detrimental to specific aspects of hippocampal function...
Evaluation of docosahexaenoic acid deficiency as a preventable risk factor for recurrent affective disorders: current status, future directions, and dietary recommendationsRobert K McNamara
Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Prostaglandins Leukot Essent Fatty Acids 81:223-31. 2009..Such early intervention studies are currently feasible and will ultimately be required to definitively evaluate whether DHA is a required nutrient for the prevention of affective disorders...- Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathologyRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
Prostaglandins Leukot Essent Fatty Acids 75:329-49. 2006.... - Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorderRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
Biol Psychiatry 62:17-24. 2007..It was hypothesized that patients with MDD would exhibit lower frontal cortical concentrations of docosahexaenoic acid (DHA), the principal omega-3 fatty acid in brain, relative to normal controls... 
Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: gender differences and partial normalization with antipsychotic medicationsRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, United States
Schizophr Res 91:37-50. 2007....- Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult mice: prevention by chronic lithium treatmentRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, United States
J Psychiatr Res 42:458-68. 2008.... - The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activityRobert K McNamara
Department of Psychiatry, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
Prostaglandins Leukot Essent Fatty Acids 78:293-304. 2008..The implications of age-related reductions in OFC PUFA composition for affective dysregulation in the elderly are discussed... - Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult DBA/2J mice: relationship with ventral striatum dopamine concentrationsRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
Synapse 62:725-35. 2008.... - Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorderRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Psychiatry Res 160:285-99. 2008..low alcohol abuse severity. These results add to a growing body of evidence implicating omega-3 fatty acid deficiency as well as the OFC in the pathoaetiology of bipolar disorder... - Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo (1)H-MRS studyRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
J Lipid Res 50:405-11. 2009..02). These data demonstrate that perinatal deficits in cortical DHA accrual significantly and selectively reduce mI concentrations and augment receptor-generated mI synthesis... - Inbred C57BL/6J and DBA/2J mouse strains exhibit constitutive differences in regional brain fatty acid compositionRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0516, USA
Lipids 44:1-8. 2009.... - Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effectsRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati OH 45267 0559, United States
J Psychiatr Res 43:656-63. 2009..03). These preclinical data support a causal link between perinatal omega-3 fatty acid deficiency and reduced central serotonin synthesis in adult female rats that is independent of ovarian hormones including estrogen... - Chronic risperidone treatment preferentially increases rat erythrocyte and prefrontal cortex omega-3 fatty acid composition: evidence for augmented biosynthesisRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, United States
Schizophr Res 107:150-7. 2009..Augmented omega-3 fatty acid biosynthesis and membrane composition represents a novel mechanism of action that may contribute in part to the efficacy of RISP in the treatment of SZ... - Gender differences in rat erythrocyte and brain docosahexaenoic acid composition: role of ovarian hormones and dietary omega-3 fatty acid compositionRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0516, United States
Psychoneuroendocrinology 34:532-9. 2009.... - Modulation of phosphoinositide-protein kinase C signal transduction by omega-3 fatty acids: implications for the pathophysiology and treatment of recurrent neuropsychiatric illnessRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
Prostaglandins Leukot Essent Fatty Acids 75:237-57. 2006..The data reviewed in this paper outline a potential molecular mechanism by which omega-3 fatty acids could contribute to the pathophysiology and treatment of recurrent neuropsychiatric illness... - Acute restraint stress reduces protein kinase C gamma in the hippocampus of C57BL/6 but not DBA/2 miceRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Medical Science Building, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
Neurosci Lett 368:293-6. 2004..The role of stress-induced regulation of hippocampal PKC gamma expression in hippocampal synaptic plasticity is discussed... - Dose-response analysis of locomotor activity and stereotypy in dopamine D3 receptor mutant mice following acute amphetamineRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
Synapse 60:399-405. 2006..0 and 10 mg/kg AMPH doses. These findings provide further support for an inhibitory role for the D3R in AMPH-induced locomotor activity, and demonstrate a more limited role for the D3R in modulating AMPH-induced stereotypy... - Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorderRobert K McNamara
Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45219 0516, USA
J Affect Disord 126:303-11. 2010..However, there is limited comparative information available regarding the n-3 fatty acid status and associated mood symptoms in medication-free patients with major depressive disorder (MDD) and bipolar disorder (BD)... - Omega-3 fatty acid deficiency augments risperidone-induced hepatic steatosis in rats: positive association with stearoyl-CoA desaturaseRobert K McNamara
Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA
Pharmacol Res 66:283-91. 2012..These preclinical data support the hypothesis that low n-3 fatty acid status exacerbates RSP-induced hepatic steatosis by augmenting SCD1 expression and activity... - Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levelsRylon Hofacer
Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA
Prostaglandins Leukot Essent Fatty Acids 86:71-7. 2012.... - Fluoxetine and aripiprazole treatment following prenatal immune activation exert longstanding effects on rat locomotor responseNeil M Richtand
Cincinnati Veterans Affairs Medical Center, Psychiatry Service V116A, 3200 Vine Street, Cincinnati, Ohio 45220, United States
Physiol Behav 106:171-7. 2012..We sought to extend those findings by examining the effects of fluoxetine, as well as the antipsychotic medication aripiprazole, in a rat prenatal immune activation model... - Effect of chronic fluoxetine treatment on male and female rat erythrocyte and prefrontal cortex fatty acid compositionRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Prog Neuropsychopharmacol Biol Psychiatry 34:1317-21. 2010..These preclinical findings do not support the hypothesis that chronic FLX treatment increases n-3 fatty acid biosynthesis or membrane composition... - Elevated delta-6 desaturase (FADS2) expression in the postmortem prefrontal cortex of schizophrenic patients: relationship with fatty acid compositionYanhong Liu
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, United States
Schizophr Res 109:113-20. 2009..Greater Delta6 desaturase expression and activity could have implications for central prostaglandin synthesis and proinflammatory signaling... - Effects of risperidone and paliperidone pre-treatment on locomotor response following prenatal immune activationNeil M Richtand
Cincinnati Veterans Affairs Medical Center, Psychiatry Service V116A, Cincinnati, OH 45220, USA
J Psychiatr Res 45:1194-201. 2011..We evaluated a later developmental time point to determine persistent effects of drug treatment... - The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotionLaurel M Pritchard
Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
Pharmacol Biochem Behav 86:718-26. 2007..In combination, these data add to the behavioral profile of this novel D3 receptor ligand and provide further support for a role for dopamine D3 receptor inhibitory function in the modulation of rodent locomotion... - Myristoylated alanine rich C kinase substrate (MARCKS) heterozygous mutant mice exhibit deficits in hippocampal mossy fiber-CA3 long-term potentiationRifat J Hussain
Department of Psychiatry, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, Pennsylvania, USA
Hippocampus 16:495-503. 2006..The implications of these findings for the role of the mossy fiber-CA3 pathway in hippocampus-dependent learning processes are discussed... - Fatty acid composition of the postmortem prefrontal cortex of adolescent male and female suicide victimsRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Medical Science Building, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
Prostaglandins Leukot Essent Fatty Acids 80:19-26. 2009.... - Differential expression and regulation of myristoylated alanine-rich C kinase substrate (MARCKS) in the hippocampus of C57/BL6J and DBA/2J miceRobert K McNamara
Department of Psychiatry, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, Pennsylvania, USA
J Neurochem 85:462-8. 2003..These strain differences in hippocampal MARCKS expression and subcellular translocation following stress may contribute to the differences in behaviors requiring hippocampal plasticity observed between these strains... - Dopaminergic regulation of dopamine D3 and D3nf receptor mRNA expressionNeil M Richtand
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Synapse 64:634-43. 2010..Finally, the observation of regulated TH mRNA expression in dopamine terminal fields provides experimental support for the model of local control of mRNA expression in adaptation to synaptic activity... - Chronic risperidone normalizes elevated pro-inflammatory cytokine and C-reactive protein production in omega-3 fatty acid deficient ratsRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45219, United States
Eur J Pharmacol 652:152-6. 2011.... - Serotonin and dopamine interactions in psychosis preventionNeil M Richtand
Cincinnati Veterans Affairs Medical Center, Psychiatry Service V116A, 3200 Vine Street, Cincinnati, OH 45220, USA
Prog Brain Res 172:141-53. 2008..These observations also suggest a potential role for selective 5-HT(2A) receptor antagonists as drug development targets for psychosis prevention... - Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging studyRobert K McNamara
Department of Psychiatry, Center for Imaging Research, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45219 0516, USA
Am J Clin Nutr 91:1060-7. 2010..However, the effects of DHA supplementation on functional cortical activity in human subjects are unknown... - Differential effects of antipsychotic medications on polyunsaturated fatty acid biosynthesis in rats: Relationship with liver delta6-desaturase expressionRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45219, United States
Schizophr Res 129:57-65. 2011.... - Omega-3 fatty acid deficiency selectively up-regulates delta6-desaturase expression and activity indices in rat liver: prevention by normalization of omega-3 fatty acid statusRylon Hofacer
Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45219 0516, USA
Nutr Res 31:715-22. 2011..These results confirm previous findings that liver, but not brain, delta6-desaturase expression and activity indices are negatively regulated by dietary n-3 fatty acids... - Role of serotonin and dopamine receptor binding in antipsychotic efficacyNeil M Richtand
Cincinnati Veterans Affairs Medical Center, 3200 Vine Street, ML0559, Cincinnati, OH 45220, USA
Prog Brain Res 172:155-75. 2008.... - Atypical antipsychotic medications increase postprandial triglyceride and glucose levels in male rats: relationship with stearoyl-CoA desaturase activityRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45219, United States
Schizophr Res 129:66-73. 2011.... - Risperidone pretreatment prevents elevated locomotor activity following neonatal hippocampal lesionsNeil M Richtand
Cincinnati Veterans Affairs Medical Center, Psychiatry Service V116A, Cincinnati, OH, USA
Neuropsychopharmacology 31:77-89. 2006..Additionally, these data support the use of low-dose risperidone in psychosis prevention, and suggest the possibility that higher risperidone doses could be less effective in this application... - Preventative strategies for early-onset bipolar disorder: towards a clinical staging modelRobert K McNamara
Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
CNS Drugs 24:983-96. 2010..This approach warrants evaluation in prospective longitudinal trials in youth determined to be at ultra-high risk for bipolar I disorder... - Low docosahexaenoic acid status is associated with reduced indices in cortical integrity in the anterior cingulate of healthy male children: A (1)H MRS StudyRobert K McNamara
University of Cincinnati College of Medicine, Cincinnati, OH, USA
Nutr Neurosci 16:183-90. 2013..These data indicate that low-DHA status is associated with reduced indices of metabolic function in the ACC and slower reaction time during sustained attention in developing male children... - Interventions for youth at high risk for bipolar disorder and schizophreniaRobert K McNamara
Division of Bipolar Disorders Research, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
Child Adolesc Psychiatr Clin N Am 21:739-51. 2012..A clinical vignette describing antidepressant-induced manic symptoms in an adolescent with a family history of bipolar disorder is provided... - Reduced expression of fatty acid biosynthesis genes in the prefrontal cortex of patients with major depressive disorderRobert K McNamara
Department of Psychiatry, Lipidomics Research Program, University of Cincinnati College of Medicine, Cincinnati, OH 45219, United States
J Affect Disord 129:359-63. 2011..However, the etiology of these deficits remains poorly understood, and there is currently little known about the expression of genes that mediate fatty acid biosynthesis in MDD patients... - Adult medication-free schizophrenic patients exhibit long-chain omega-3 Fatty Acid deficiency: implications for cardiovascular disease riskRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45219 0516, USA
Cardiovasc Psychiatry Neurol 2013:796462. 2013..008) and female (+22%, P = 0.04) SZ patients. These results suggest that the majority of SZ patients exhibit low LCn - 3 fatty acid levels which may place them at increased risk for cardiovascular morbidity and mortality... - Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnoverRobert K McNamara
Department of Psychiatry, University of Cincinnati College of Medicine, 260 Stetson Street, Suite 3306, Cincinnati, OH 45219 0516, USA
Prostaglandins Leukot Essent Fatty Acids 83:185-91. 2010..These preclinical data provide evidence for a functional link between n-3 fatty acid deficiency, elevated peripheral inflammatory signaling, and increased central 5-HT turnover... - Elevated Delta-6 desaturase (FADS2) gene expression in the prefrontal cortex of patients with bipolar disorderYanhong Liu
Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, 260 Stetson Street, Suite 3306, Cincinnati, OH 45219, USA
J Psychiatr Res 45:269-72. 2011.... - Postnatal maternal separation elevates the expression of the postsynaptic protein kinase C substrate RC3, but not presynaptic GAP-43, in the developing rat hippocampusRobert K McNamara
Molecular Neuropsychopharmacology Laboratory, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Dev Neurosci 24:485-94. 2002..Elevations in RC3 expression would be predicted to perturb calcium-calmodulin signaling that may, in turn, impair the formation and/or maintenance of mossy fiber-CA3 synapses during postnatal development... - Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target?Robert K McNamara
Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH, USA
Expert Rev Neurother 12:1143-61. 2012.... - Neuroprogression in bipolar disorderMarguerite Reid Schneider
Physician Scientist Training Program, Neuroscience Graduate Program Department, University of Cincinnati College of Medicine, Cincinnati, OH 45219 0516, USA
Bipolar Disord 14:356-74. 2012..The aim of our review is to examine the extant literature for developmental and progressive structural and functional changes in individuals with and at risk for bipolar disorder... - Dopamine and serotonin receptor binding and antipsychotic efficacyNeil M Richtand
Psychiatry Service, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH, USA
Neuropsychopharmacology 32:1715-26. 2007..2) Increasing 5-HT(2C) and 5-HT(2A) receptor-binding affinities also facilitate antipsychotic efficacy. (3) Increasing 5-HT(1A) receptor-binding affinity, in contrast, reduces antipsychotic efficacy... - DHA deficiency and prefrontal cortex neuropathology in recurrent affective disordersRobert K McNamara
Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA
J Nutr 140:864-8. 2010.... - Sexual functioning assessed in 4 double-blind placebo- and paroxetine-controlled trials of duloxetine for major depressive disorderPedro L Delgado
Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA
J Clin Psychiatry 66:686-92. 2005..However, the incidence of acute treatment-emergent dysfunction for duloxetine was significantly lower than that observed for paroxetine... - The emerging role of omega-3 fatty acids in psychiatryRobert K McNamara
Prostaglandins Leukot Essent Fatty Acids 75:223-5. 2006 - Neonatal maternal separation reduces hippocampal mossy fiber density in adult Long Evans ratsRebecca L Huot
Stress Neurobiology Laboratory, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
Brain Res 950:52-63. 2002..The resulting change in morphology may contribute to the subtle, but consistent learning deficit and overall stress hyper-responsive phenotype observed in these animals... - Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampusThomas Krucker
Departments of Neuropharmacology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
J Neurosci 22:5525-35. 2002..We propose an mGluR-dependent CaM-based sliding threshold mechanism for metaplasticity that is governed by the phosphorylation states of RC3 and CaMKII... - Incidence and duration of antidepressant-induced nausea: duloxetine compared with paroxetine and fluoxetineJohn Greist
Healthcare Technology Systems, Madison, Wisconsin 53717, USA
Clin Ther 26:1446-55. 2004..This analysis assessed the incidence, severity, onset, and duration of nausea among patients with major depressive disorder (MDD) treated with the new antidepressant duloxetine... - Duloxetine 60 mg once daily dosing versus placebo in the acute treatment of major depressionMichael J Detke
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA
J Psychiatr Res 36:383-90. 2002..There was no significant incidence of hypertension, nor any other safety issues. Duloxetine 60 mg administered once daily appears to be a safe and effective treatment for MDD... - New approaches to developing antidepressants by enhancing monoaminergic neurotransmissionFrank P Bymaster
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285 0510, USA
Expert Opin Investig Drugs 12:531-43. 2003..The differing mechanisms of action possessed by these novel monoamine-enhancing compounds will offer greater treatment flexibility in the therapeutic management of MDD... - Dual monoamine modulation for improved treatment of major depressive disorderPierre V Tran
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
J Clin Psychopharmacol 23:78-86. 2003..Potential neurobiological substrates mediating the enhanced antidepressant activity of dual reuptake inhibitors are discussed... - Duloxetine in the acute and long-term treatment of major depressive disorder: a placebo- and paroxetine-controlled trialMichael J Detke
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
Eur Neuropsychopharmacol 14:457-70. 2004..This placebo-controlled study assesses the safety and efficacy of duloxetine (80 or 120 mg/day) and paroxetine (20 mg QD) during an initial 8-week acute phase and subsequent 6-month continuation phase treatment of MDD...
Research Grants
- Brain Fatty Acid Composition and PKC ActivityRobert McNamara; Fiscal Year: 2007..The proposed experiments are innovative and exploratory in that the effect of altered DHA concentrations on PKC and dopamine D2 receptor expression have not been systematically examined in brain. ..
- Omega-3 Fatty Acid Deficient Rat Model of SchizophreniaRobert McNamara; Fiscal Year: 2007....