Robert K McNamara

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi Effect of myristoylated alanine-rich C kinase substrate (MARCKS) overexpression on hippocampus-dependent learning and hippocampal synaptic plasticity in MARCKS transgenic mice
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Hippocampus 15:675-83. 2005
  2. doi Evaluation of docosahexaenoic acid deficiency as a preventable risk factor for recurrent affective disorders: current status, future directions, and dietary recommendations
    Robert K McNamara
    Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Prostaglandins Leukot Essent Fatty Acids 81:223-31. 2009
  3. ncbi Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Prostaglandins Leukot Essent Fatty Acids 75:329-49. 2006
  4. ncbi Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 62:17-24. 2007
  5. pmc Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: gender differences and partial normalization with antipsychotic medications
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, United States
    Schizophr Res 91:37-50. 2007
  6. ncbi Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult mice: prevention by chronic lithium treatment
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, United States
    J Psychiatr Res 42:458-68. 2008
  7. pmc The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Prostaglandins Leukot Essent Fatty Acids 78:293-304. 2008
  8. doi Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult DBA/2J mice: relationship with ventral striatum dopamine concentrations
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Synapse 62:725-35. 2008
  9. pmc Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Psychiatry Res 160:285-99. 2008
  10. pmc Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo (1)H-MRS study
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Lipid Res 50:405-11. 2009

Research Grants

  1. Brain Fatty Acid Composition and PKC Activity
    Robert McNamara; Fiscal Year: 2007
  2. Omega-3 Fatty Acid Deficient Rat Model of Schizophrenia
    Robert McNamara; Fiscal Year: 2007

Detail Information

Publications63

  1. ncbi Effect of myristoylated alanine-rich C kinase substrate (MARCKS) overexpression on hippocampus-dependent learning and hippocampal synaptic plasticity in MARCKS transgenic mice
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Hippocampus 15:675-83. 2005
    ..Collectively, these results indicate that elevations in MARCKS expression are detrimental to specific aspects of hippocampal function...
  2. doi Evaluation of docosahexaenoic acid deficiency as a preventable risk factor for recurrent affective disorders: current status, future directions, and dietary recommendations
    Robert K McNamara
    Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Prostaglandins Leukot Essent Fatty Acids 81:223-31. 2009
    ..Such early intervention studies are currently feasible and will ultimately be required to definitively evaluate whether DHA is a required nutrient for the prevention of affective disorders...
  3. ncbi Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Prostaglandins Leukot Essent Fatty Acids 75:329-49. 2006
    ....
  4. ncbi Selective deficits in the omega-3 fatty acid docosahexaenoic acid in the postmortem orbitofrontal cortex of patients with major depressive disorder
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 62:17-24. 2007
    ..It was hypothesized that patients with MDD would exhibit lower frontal cortical concentrations of docosahexaenoic acid (DHA), the principal omega-3 fatty acid in brain, relative to normal controls...
  5. pmc Abnormalities in the fatty acid composition of the postmortem orbitofrontal cortex of schizophrenic patients: gender differences and partial normalization with antipsychotic medications
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, United States
    Schizophr Res 91:37-50. 2007
    ....
  6. ncbi Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult mice: prevention by chronic lithium treatment
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, United States
    J Psychiatr Res 42:458-68. 2008
    ....
  7. pmc The aging human orbitofrontal cortex: decreasing polyunsaturated fatty acid composition and associated increases in lipogenic gene expression and stearoyl-CoA desaturase activity
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati, College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Prostaglandins Leukot Essent Fatty Acids 78:293-304. 2008
    ..The implications of age-related reductions in OFC PUFA composition for affective dysregulation in the elderly are discussed...
  8. doi Omega-3 fatty acid deficiency augments amphetamine-induced behavioral sensitization in adult DBA/2J mice: relationship with ventral striatum dopamine concentrations
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Synapse 62:725-35. 2008
    ....
  9. pmc Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Psychiatry Res 160:285-99. 2008
    ..low alcohol abuse severity. These results add to a growing body of evidence implicating omega-3 fatty acid deficiency as well as the OFC in the pathoaetiology of bipolar disorder...
  10. pmc Perinatal n-3 fatty acid deficiency selectively reduces myo-inositol levels in the adult rat PFC: an in vivo (1)H-MRS study
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Lipid Res 50:405-11. 2009
    ..02). These data demonstrate that perinatal deficits in cortical DHA accrual significantly and selectively reduce mI concentrations and augment receptor-generated mI synthesis...
  11. doi Inbred C57BL/6J and DBA/2J mouse strains exhibit constitutive differences in regional brain fatty acid composition
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0516, USA
    Lipids 44:1-8. 2009
    ....
  12. pmc Omega-3 fatty acid deficiency during perinatal development increases serotonin turnover in the prefrontal cortex and decreases midbrain tryptophan hydroxylase-2 expression in adult female rats: dissociation from estrogenic effects
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati OH 45267 0559, United States
    J Psychiatr Res 43:656-63. 2009
    ..03). These preclinical data support a causal link between perinatal omega-3 fatty acid deficiency and reduced central serotonin synthesis in adult female rats that is independent of ovarian hormones including estrogen...
  13. pmc Chronic risperidone treatment preferentially increases rat erythrocyte and prefrontal cortex omega-3 fatty acid composition: evidence for augmented biosynthesis
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, United States
    Schizophr Res 107:150-7. 2009
    ..Augmented omega-3 fatty acid biosynthesis and membrane composition represents a novel mechanism of action that may contribute in part to the efficacy of RISP in the treatment of SZ...
  14. pmc Gender differences in rat erythrocyte and brain docosahexaenoic acid composition: role of ovarian hormones and dietary omega-3 fatty acid composition
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0516, United States
    Psychoneuroendocrinology 34:532-9. 2009
    ....
  15. ncbi Modulation of phosphoinositide-protein kinase C signal transduction by omega-3 fatty acids: implications for the pathophysiology and treatment of recurrent neuropsychiatric illness
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Prostaglandins Leukot Essent Fatty Acids 75:237-57. 2006
    ..The data reviewed in this paper outline a potential molecular mechanism by which omega-3 fatty acids could contribute to the pathophysiology and treatment of recurrent neuropsychiatric illness...
  16. pmc Dose-response analysis of locomotor activity and stereotypy in dopamine D3 receptor mutant mice following acute amphetamine
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Synapse 60:399-405. 2006
    ..0 and 10 mg/kg AMPH doses. These findings provide further support for an inhibitory role for the D3R in AMPH-induced locomotor activity, and demonstrate a more limited role for the D3R in modulating AMPH-induced stereotypy...
  17. ncbi Acute restraint stress reduces protein kinase C gamma in the hippocampus of C57BL/6 but not DBA/2 mice
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Medical Science Building, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
    Neurosci Lett 368:293-6. 2004
    ..The role of stress-induced regulation of hippocampal PKC gamma expression in hippocampal synaptic plasticity is discussed...
  18. pmc Selective deficits in erythrocyte docosahexaenoic acid composition in adult patients with bipolar disorder and major depressive disorder
    Robert K McNamara
    Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45219 0516, USA
    J Affect Disord 126:303-11. 2010
    ..However, there is limited comparative information available regarding the n-3 fatty acid status and associated mood symptoms in medication-free patients with major depressive disorder (MDD) and bipolar disorder (BD)...
  19. pmc Omega-3 fatty acid deficiency augments risperidone-induced hepatic steatosis in rats: positive association with stearoyl-CoA desaturase
    Robert K McNamara
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA
    Pharmacol Res 66:283-91. 2012
    ..These preclinical data support the hypothesis that low n-3 fatty acid status exacerbates RSP-induced hepatic steatosis by augmenting SCD1 expression and activity...
  20. pmc Omega-3 fatty acid deficiency increases stearoyl-CoA desaturase expression and activity indices in rat liver: positive association with non-fasting plasma triglyceride levels
    Rylon Hofacer
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA
    Prostaglandins Leukot Essent Fatty Acids 86:71-7. 2012
    ....
  21. pmc Fluoxetine and aripiprazole treatment following prenatal immune activation exert longstanding effects on rat locomotor response
    Neil M Richtand
    Cincinnati Veterans Affairs Medical Center, Psychiatry Service V116A, 3200 Vine Street, Cincinnati, Ohio 45220, United States
    Physiol Behav 106:171-7. 2012
    ..We sought to extend those findings by examining the effects of fluoxetine, as well as the antipsychotic medication aripiprazole, in a rat prenatal immune activation model...
  22. pmc Effect of chronic fluoxetine treatment on male and female rat erythrocyte and prefrontal cortex fatty acid composition
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:1317-21. 2010
    ..These preclinical findings do not support the hypothesis that chronic FLX treatment increases n-3 fatty acid biosynthesis or membrane composition...
  23. doi Elevated delta-6 desaturase (FADS2) expression in the postmortem prefrontal cortex of schizophrenic patients: relationship with fatty acid composition
    Yanhong Liu
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, United States
    Schizophr Res 109:113-20. 2009
    ..Greater Delta6 desaturase expression and activity could have implications for central prostaglandin synthesis and proinflammatory signaling...
  24. doi Low docosahexaenoic acid status is associated with reduced indices in cortical integrity in the anterior cingulate of healthy male children: a 1H MRS Study
    Robert K McNamara
    Department of Psychiatry and Behavioral Neuroscience, Center for Imaging Research, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Nutr Neurosci 16:183-90. 2013
    ..These data indicate that low-DHA status is associated with reduced indices of metabolic function in the ACC and slower reaction time during sustained attention in developing male children...
  25. pmc Myristoylated alanine rich C kinase substrate (MARCKS) heterozygous mutant mice exhibit deficits in hippocampal mossy fiber-CA3 long-term potentiation
    Rifat J Hussain
    Department of Psychiatry, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, Pennsylvania, USA
    Hippocampus 16:495-503. 2006
    ..The implications of these findings for the role of the mossy fiber-CA3 pathway in hippocampus-dependent learning processes are discussed...
  26. ncbi The dopamine D3 receptor antagonist NGB 2904 increases spontaneous and amphetamine-stimulated locomotion
    Laurel M Pritchard
    Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Pharmacol Biochem Behav 86:718-26. 2007
    ..In combination, these data add to the behavioral profile of this novel D3 receptor ligand and provide further support for a role for dopamine D3 receptor inhibitory function in the modulation of rodent locomotion...
  27. pmc Effects of risperidone and paliperidone pre-treatment on locomotor response following prenatal immune activation
    Neil M Richtand
    Cincinnati Veterans Affairs Medical Center, Psychiatry Service V116A, Cincinnati, OH 45220, USA
    J Psychiatr Res 45:1194-201. 2011
    ..We evaluated a later developmental time point to determine persistent effects of drug treatment...
  28. doi Fatty acid composition of the postmortem prefrontal cortex of adolescent male and female suicide victims
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Medical Science Building, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
    Prostaglandins Leukot Essent Fatty Acids 80:19-26. 2009
    ....
  29. pmc Chronic risperidone normalizes elevated pro-inflammatory cytokine and C-reactive protein production in omega-3 fatty acid deficient rats
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45219, United States
    Eur J Pharmacol 652:152-6. 2011
    ....
  30. ncbi Differential expression and regulation of myristoylated alanine-rich C kinase substrate (MARCKS) in the hippocampus of C57/BL6J and DBA/2J mice
    Robert K McNamara
    Department of Psychiatry, University of Pennsylvania School of Medicine, Clinical Research Building, Philadelphia, Pennsylvania, USA
    J Neurochem 85:462-8. 2003
    ..These strain differences in hippocampal MARCKS expression and subcellular translocation following stress may contribute to the differences in behaviors requiring hippocampal plasticity observed between these strains...
  31. doi Serotonin and dopamine interactions in psychosis prevention
    Neil M Richtand
    Cincinnati Veterans Affairs Medical Center, Psychiatry Service V116A, 3200 Vine Street, Cincinnati, OH 45220, USA
    Prog Brain Res 172:141-53. 2008
    ..These observations also suggest a potential role for selective 5-HT(2A) receptor antagonists as drug development targets for psychosis prevention...
  32. pmc Dopaminergic regulation of dopamine D3 and D3nf receptor mRNA expression
    Neil M Richtand
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Synapse 64:634-43. 2010
    ..Finally, the observation of regulated TH mRNA expression in dopamine terminal fields provides experimental support for the model of local control of mRNA expression in adaptation to synaptic activity...
  33. pmc Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging study
    Robert K McNamara
    Department of Psychiatry, Center for Imaging Research, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45219 0516, USA
    Am J Clin Nutr 91:1060-7. 2010
    ..However, the effects of DHA supplementation on functional cortical activity in human subjects are unknown...
  34. pmc Differential effects of antipsychotic medications on polyunsaturated fatty acid biosynthesis in rats: Relationship with liver delta6-desaturase expression
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45219, United States
    Schizophr Res 129:57-65. 2011
    ....
  35. pmc Omega-3 fatty acid deficiency selectively up-regulates delta6-desaturase expression and activity indices in rat liver: prevention by normalization of omega-3 fatty acid status
    Rylon Hofacer
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45219 0516, USA
    Nutr Res 31:715-22. 2011
    ..These results confirm previous findings that liver, but not brain, delta6-desaturase expression and activity indices are negatively regulated by dietary n-3 fatty acids...
  36. doi Role of serotonin and dopamine receptor binding in antipsychotic efficacy
    Neil M Richtand
    Cincinnati Veterans Affairs Medical Center, 3200 Vine Street, ML0559, Cincinnati, OH 45220, USA
    Prog Brain Res 172:155-75. 2008
    ....
  37. pmc Atypical antipsychotic medications increase postprandial triglyceride and glucose levels in male rats: relationship with stearoyl-CoA desaturase activity
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45219, United States
    Schizophr Res 129:66-73. 2011
    ....
  38. doi Preventative strategies for early-onset bipolar disorder: towards a clinical staging model
    Robert K McNamara
    Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    CNS Drugs 24:983-96. 2010
    ..This approach warrants evaluation in prospective longitudinal trials in youth determined to be at ultra-high risk for bipolar I disorder...
  39. pmc Risperidone pretreatment prevents elevated locomotor activity following neonatal hippocampal lesions
    Neil M Richtand
    Cincinnati Veterans Affairs Medical Center, Psychiatry Service V116A, Cincinnati, OH, USA
    Neuropsychopharmacology 31:77-89. 2006
    ..Additionally, these data support the use of low-dose risperidone in psychosis prevention, and suggest the possibility that higher risperidone doses could be less effective in this application...
  40. pmc Omega-3 fatty acid deficiency does not alter the effects of chronic fluoxetine treatment on central serotonin turnover or behavior in the forced swim test in female rats
    Robert K McNamara
    Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45267, United States Electronic address
    Pharmacol Biochem Behav 114:1-8. 2013
    ..These preclinical data demonstrate that n-3 fatty acid deficiency does not significantly reduce the effects of chronic FLX treatment on central 5-HT turnover or behavior in the FST in female rats. ..
  41. pmc Interventions for youth at high risk for bipolar disorder and schizophrenia
    Robert K McNamara
    Division of Bipolar Disorders Research, Department of Psychiatry and Behavioral Neuroscience, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    Child Adolesc Psychiatr Clin N Am 21:739-51. 2012
    ..A clinical vignette describing antidepressant-induced manic symptoms in an adolescent with a family history of bipolar disorder is provided...
  42. pmc Reduced expression of fatty acid biosynthesis genes in the prefrontal cortex of patients with major depressive disorder
    Robert K McNamara
    Department of Psychiatry, Lipidomics Research Program, University of Cincinnati College of Medicine, Cincinnati, OH 45219, United States
    J Affect Disord 129:359-63. 2011
    ..However, the etiology of these deficits remains poorly understood, and there is currently little known about the expression of genes that mediate fatty acid biosynthesis in MDD patients...
  43. pmc Adult medication-free schizophrenic patients exhibit long-chain omega-3 Fatty Acid deficiency: implications for cardiovascular disease risk
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45219 0516, USA
    Cardiovasc Psychiatry Neurol 2013:796462. 2013
    ..008) and female (+22%, P = 0.04) SZ patients. These results suggest that the majority of SZ patients exhibit low LCn - 3 fatty acid levels which may place them at increased risk for cardiovascular morbidity and mortality...
  44. pmc Omega-3 fatty acid deficiency increases constitutive pro-inflammatory cytokine production in rats: relationship with central serotonin turnover
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, 260 Stetson Street, Suite 3306, Cincinnati, OH 45219 0516, USA
    Prostaglandins Leukot Essent Fatty Acids 83:185-91. 2010
    ..These preclinical data provide evidence for a functional link between n-3 fatty acid deficiency, elevated peripheral inflammatory signaling, and increased central 5-HT turnover...
  45. pmc Elevated Delta-6 desaturase (FADS2) gene expression in the prefrontal cortex of patients with bipolar disorder
    Yanhong Liu
    Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, 260 Stetson Street, Suite 3306, Cincinnati, OH 45219, USA
    J Psychiatr Res 45:269-72. 2011
    ....
  46. ncbi Postnatal maternal separation elevates the expression of the postsynaptic protein kinase C substrate RC3, but not presynaptic GAP-43, in the developing rat hippocampus
    Robert K McNamara
    Molecular Neuropsychopharmacology Laboratory, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Dev Neurosci 24:485-94. 2002
    ..Elevations in RC3 expression would be predicted to perturb calcium-calmodulin signaling that may, in turn, impair the formation and/or maintenance of mossy fiber-CA3 synapses during postnatal development...
  47. pmc Lower docosahexaenoic acid concentrations in the postmortem prefrontal cortex of adult depressed suicide victims compared with controls without cardiovascular disease
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Medical Science Building, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
    J Psychiatr Res 47:1187-91. 2013
    ....
  48. pmc Elevated immune-inflammatory signaling in mood disorders: a new therapeutic target?
    Robert K McNamara
    Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH, USA
    Expert Rev Neurother 12:1143-61. 2012
    ....
  49. pmc Elevated ratio of arachidonic acid to long-chain omega-3 fatty acids predicts depression development following interferon-alpha treatment: relationship with interleukin-6
    Francis E Lotrich
    Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain Behav Immun 31:48-53. 2013
    ..These prospective data support the role of fatty acid status in depression vulnerability and indicate a potential role for omega-3 fatty acids in the prevention of inflammation-induced depression...
  50. pmc Deciphering the role of docosahexaenoic acid in brain maturation and pathology with magnetic resonance imaging
    Robert K McNamara
    Department of Psychiatry and Behavioral Neuroscience, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA
    Prostaglandins Leukot Essent Fatty Acids 88:33-42. 2013
    ....
  51. doi Neuroprogression in bipolar disorder
    Marguerite Reid Schneider
    Physician Scientist Training Program, Neuroscience Graduate Program Department, University of Cincinnati College of Medicine, Cincinnati, OH 45219 0516, USA
    Bipolar Disord 14:356-74. 2012
    ..The aim of our review is to examine the extant literature for developmental and progressive structural and functional changes in individuals with and at risk for bipolar disorder...
  52. ncbi Dopamine and serotonin receptor binding and antipsychotic efficacy
    Neil M Richtand
    Psychiatry Service, Cincinnati Veterans Affairs Medical Center, Cincinnati, OH, USA
    Neuropsychopharmacology 32:1715-26. 2007
    ..2) Increasing 5-HT(2C) and 5-HT(2A) receptor-binding affinities also facilitate antipsychotic efficacy. (3) Increasing 5-HT(1A) receptor-binding affinity, in contrast, reduces antipsychotic efficacy...
  53. pmc DHA deficiency and prefrontal cortex neuropathology in recurrent affective disorders
    Robert K McNamara
    Department of Psychiatry, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA
    J Nutr 140:864-8. 2010
    ....
  54. ncbi Long-chain omega-3 fatty acid deficiency in mood disorders: rationale for treatment and prevention
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45219 0516, USA
    Curr Drug Discov Technol 10:233-44. 2013
    ....
  55. ncbi Sexual functioning assessed in 4 double-blind placebo- and paroxetine-controlled trials of duloxetine for major depressive disorder
    Pedro L Delgado
    Department of Psychiatry, Case Western Reserve University, Cleveland, Ohio, USA
    J Clin Psychiatry 66:686-92. 2005
    ..Post hoc analyses of pooled data from placebo-controlled studies were utilized to assess sexual functioning in patients receiving duloxetine or paroxetine...
  56. ncbi Neonatal maternal separation reduces hippocampal mossy fiber density in adult Long Evans rats
    Rebecca L Huot
    Stress Neurobiology Laboratory, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Brain Res 950:52-63. 2002
    ..The resulting change in morphology may contribute to the subtle, but consistent learning deficit and overall stress hyper-responsive phenotype observed in these animals...
  57. ncbi The emerging role of omega-3 fatty acids in psychiatry
    Robert K McNamara
    Prostaglandins Leukot Essent Fatty Acids 75:223-5. 2006
  58. ncbi Targeted disruption of RC3 reveals a calmodulin-based mechanism for regulating metaplasticity in the hippocampus
    Thomas Krucker
    Departments of Neuropharmacology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Neurosci 22:5525-35. 2002
    ..We propose an mGluR-dependent CaM-based sliding threshold mechanism for metaplasticity that is governed by the phosphorylation states of RC3 and CaMKII...
  59. ncbi Duloxetine in the acute and long-term treatment of major depressive disorder: a placebo- and paroxetine-controlled trial
    Michael J Detke
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Eur Neuropsychopharmacol 14:457-70. 2004
    ..This placebo-controlled study assesses the safety and efficacy of duloxetine (80 or 120 mg/day) and paroxetine (20 mg QD) during an initial 8-week acute phase and subsequent 6-month continuation phase treatment of MDD...
  60. ncbi New approaches to developing antidepressants by enhancing monoaminergic neurotransmission
    Frank P Bymaster
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285 0510, USA
    Expert Opin Investig Drugs 12:531-43. 2003
    ..The differing mechanisms of action possessed by these novel monoamine-enhancing compounds will offer greater treatment flexibility in the therapeutic management of MDD...
  61. ncbi Dual monoamine modulation for improved treatment of major depressive disorder
    Pierre V Tran
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    J Clin Psychopharmacol 23:78-86. 2003
    ..Potential neurobiological substrates mediating the enhanced antidepressant activity of dual reuptake inhibitors are discussed...
  62. ncbi Duloxetine 60 mg once daily dosing versus placebo in the acute treatment of major depression
    Michael J Detke
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN, USA
    J Psychiatr Res 36:383-90. 2002
    ..There was no significant incidence of hypertension, nor any other safety issues. Duloxetine 60 mg administered once daily appears to be a safe and effective treatment for MDD...
  63. ncbi Incidence and duration of antidepressant-induced nausea: duloxetine compared with paroxetine and fluoxetine
    John Greist
    Healthcare Technology Systems, Madison, Wisconsin 53717, USA
    Clin Ther 26:1446-55. 2004
    ..This analysis assessed the incidence, severity, onset, and duration of nausea among patients with major depressive disorder (MDD) treated with the new antidepressant duloxetine...

Research Grants2

  1. Brain Fatty Acid Composition and PKC Activity
    Robert McNamara; Fiscal Year: 2007
    ..The proposed experiments are innovative and exploratory in that the effect of altered DHA concentrations on PKC and dopamine D2 receptor expression have not been systematically examined in brain. ..
  2. Omega-3 Fatty Acid Deficient Rat Model of Schizophrenia
    Robert McNamara; Fiscal Year: 2007
    ....