Nancy A McNamara

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Molecular mechanism of proinflammatory cytokine-mediated squamous metaplasia in human corneal epithelial cells
    Shimin Li
    Francis I Proctor Foundation, University of California, San Francisco, CA 94143 0412, USA
    Invest Ophthalmol Vis Sci 51:2466-75. 2010
  2. pmc Topical administration of interleukin-1 receptor antagonist as a therapy for aqueous-deficient dry eye in autoimmune disease
    Trinka Vijmasi
    Francis I Proctor Foundation, University of California, San Francisco, 513 Parnassus Avenue, Rm 1349, San Francisco, CA
    Mol Vis 19:1957-65. 2013
  3. pmc Immune profile of squamous metaplasia development in autoimmune regulator-deficient dry eye
    Ying Ting Chen
    University of California, San Francisco, Francis I Proctor Foundation, San Francisco, CA 94143, USA
    Mol Vis 15:563-76. 2009
  4. pmc Cigarette smoke induces epidermal growth factor receptor-dependent redistribution of apical MUC1 and junctional beta-catenin in polarized human airway epithelial cells
    Ying Ting Chen
    University of California, San Francisco, Francis I Proctor Foundation, San Francisco, CA 94143, USA
    Am J Pathol 177:1255-64. 2010
  5. ncbi Molecular mechanisms of keratinizing ocular surface disease
    Nancy A McNamara
    Department of Anatomy, Francis I Proctor Foundation, University of California San Francisco, San Francisco, CA 94143 0412, USA
    Optom Vis Sci 87:233-8. 2010
  6. pmc Interleukin-1 receptor mediates the interplay between CD4+ T cells and ocular resident cells to promote keratinizing squamous metaplasia in Sjögren's syndrome
    Ying Ting Chen
    Francis I Proctor Foundation, University of California at San Francisco, San Francisco, CA 94143, USA
    Lab Invest 92:556-70. 2012
  7. pmc Critical involvement of macrophage infiltration in the development of Sjögren's syndrome-associated dry eye
    Delu Zhou
    Francis I Proctor Foundation, University of California, San Francisco, USA
    Am J Pathol 181:753-60. 2012
  8. pmc Pax6 downregulation mediates abnormal lineage commitment of the ocular surface epithelium in aqueous-deficient dry eye disease
    Ying Ting Chen
    Francis I Proctor Foundation, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e77286. 2013
  9. pmc Cigarette smoke disrupts the integrity of airway adherens junctions through the aberrant interaction of p120-catenin with the cytoplasmic tail of MUC1
    Lili Zhang
    Francis I Proctor Foundation, University of California, San Francisco, California, USA
    J Pathol 229:74-86. 2013
  10. doi Rac1 and Cdc42 differentially modulate cigarette smoke-induced airway cell migration through p120-catenin-dependent and -independent pathways
    Lili Zhang
    Francis I Proctor Foundation, San Francisco, California, USA
    Am J Pathol 182:1986-95. 2013

Research Grants

Collaborators

Detail Information

Publications21

  1. pmc Molecular mechanism of proinflammatory cytokine-mediated squamous metaplasia in human corneal epithelial cells
    Shimin Li
    Francis I Proctor Foundation, University of California, San Francisco, CA 94143 0412, USA
    Invest Ophthalmol Vis Sci 51:2466-75. 2010
    ..Here the molecular mechanisms controlling SPRR1B gene expression in response to IL-1beta and IFN-gamma are elucidated...
  2. pmc Topical administration of interleukin-1 receptor antagonist as a therapy for aqueous-deficient dry eye in autoimmune disease
    Trinka Vijmasi
    Francis I Proctor Foundation, University of California, San Francisco, 513 Parnassus Avenue, Rm 1349, San Francisco, CA
    Mol Vis 19:1957-65. 2013
    ..In the current study, we evaluated the efficacy of topical administration of IL-1R1 antagonist (IL-1RA) anakinra in alleviating ocular surface damage resulting from aqueous-deficient dry eye in the setting of autoimmune disease...
  3. pmc Immune profile of squamous metaplasia development in autoimmune regulator-deficient dry eye
    Ying Ting Chen
    University of California, San Francisco, Francis I Proctor Foundation, San Francisco, CA 94143, USA
    Mol Vis 15:563-76. 2009
    ..Using this murine model, we sought to determine the specific immune events that predict squamous metaplasia of the cornea in Aire deficiency...
  4. pmc Cigarette smoke induces epidermal growth factor receptor-dependent redistribution of apical MUC1 and junctional beta-catenin in polarized human airway epithelial cells
    Ying Ting Chen
    University of California, San Francisco, Francis I Proctor Foundation, San Francisco, CA 94143, USA
    Am J Pathol 177:1255-64. 2010
    ..These data point to EGFR as a portal through which CS mediates its damaging effects on AJ-mediated cell polarity and activation of canonical Wnt/beta-catenin signaling...
  5. ncbi Molecular mechanisms of keratinizing ocular surface disease
    Nancy A McNamara
    Department of Anatomy, Francis I Proctor Foundation, University of California San Francisco, San Francisco, CA 94143 0412, USA
    Optom Vis Sci 87:233-8. 2010
    ..I review recent research and future directions aimed to develop targeted therapies that control or prevent ocular surface keratinization...
  6. pmc Interleukin-1 receptor mediates the interplay between CD4+ T cells and ocular resident cells to promote keratinizing squamous metaplasia in Sjögren's syndrome
    Ying Ting Chen
    Francis I Proctor Foundation, University of California at San Francisco, San Francisco, CA 94143, USA
    Lab Invest 92:556-70. 2012
    ..Collectively, data in this study indicated a central role for IL-1 in orchestrating a functional interplay between immune cells and resident cells of SS-targeted tissues in the pathogenesis of SQM...
  7. pmc Critical involvement of macrophage infiltration in the development of Sjögren's syndrome-associated dry eye
    Delu Zhou
    Francis I Proctor Foundation, University of California, San Francisco, USA
    Am J Pathol 181:753-60. 2012
    ..Our results suggested that autoreactive CD4(+) T cells provoked macrophage infiltration to the eye and lacrimal gland, where they played a functional role in directing the development of autoimmune dry eye...
  8. pmc Pax6 downregulation mediates abnormal lineage commitment of the ocular surface epithelium in aqueous-deficient dry eye disease
    Ying Ting Chen
    Francis I Proctor Foundation, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e77286. 2013
    ....
  9. pmc Cigarette smoke disrupts the integrity of airway adherens junctions through the aberrant interaction of p120-catenin with the cytoplasmic tail of MUC1
    Lili Zhang
    Francis I Proctor Foundation, University of California, San Francisco, California, USA
    J Pathol 229:74-86. 2013
    ..Novel therapeutics designed to inhibit MUC1-CT/p120ctn complex formation may prevent EMT in the smoker's airway...
  10. doi Rac1 and Cdc42 differentially modulate cigarette smoke-induced airway cell migration through p120-catenin-dependent and -independent pathways
    Lili Zhang
    Francis I Proctor Foundation, San Francisco, California, USA
    Am J Pathol 182:1986-95. 2013
    ..Thus, Rac1 may provide an omnipotent therapeutic target in reversing cell migration during the early (intact p120ctn) and late (loss of p120ctn) stages of lung carcinogenesis...
  11. pmc Membrane array analysis of tear proteins in ocular cicatricial pemphigoid
    Matilda F Chan
    Francis I Proctor Research Foundation, University of California, San Francisco Medical School, San Francisco, California, USA
    Optom Vis Sci 88:1005-9. 2011
    ..To explore non-invasive, protein-based, membrane array technology as a means to evaluate the global immune and angiogenic profile of tear proteins in patients with active ocular cicatricial pemphigoid (OCP)...
  12. pmc p120-catenin modulates airway epithelial cell migration induced by cigarette smoke
    Lili Zhang
    Francis I Proctor Foundation, University of California, San Francisco, CA 94143 0412, USA
    Biochem Biophys Res Commun 417:49-55. 2012
    ..Thus, gradual loss of membrane p120ctn with lung cancer progression may contribute to reduced effectiveness of conventional chemotherapies, such as those directed against EGFR...
  13. pmc Interleukin-1 as a phenotypic immunomodulator in keratinizing squamous metaplasia of the ocular surface in Sjögren's syndrome
    Ying Ting Chen
    University of California, San Francisco, Francis I Proctor Foundation, San Francisco, CA 94143, USA
    Am J Pathol 177:1333-43. 2010
    ..These data demonstrate a phenotypic modulation role for IL-1 in the pathogenesis of squamous metaplasia and suggest that IL-1 receptor 1-targeted therapies may be beneficial for treating ocular surface disease associated with SS...
  14. ncbi Interaction of Pseudomonas aeruginosa with human tear fluid components
    Nancy A McNamara
    Morton D Sarver Laboratory for Cornea and Contact Lens Research, School of Optometry, University of California, Berkeley, California, USA
    Curr Eye Res 30:517-25. 2005
    ..In this study, we assessed the effect of eye closure and the role of sialoglycoprotein (SG) in tears on bacterial binding and invasion...
  15. pmc Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease
    Shimin Li
    Francis I Proctor Foundation, University of California San Francisco, 513 Parnassus, San Francisco, CA 94143, USA
    Invest Ophthalmol Vis Sci 49:34-41. 2008
    ..The authors hypothesized that inflammation is a key inducer of pathologic keratinization and that SPRR1B represents an analytical biomarker for the study of the molecular mechanisms...
  16. pmc Antibody protein array analysis of the tear film cytokines
    Shimin Li
    Francis I Proctor Foundation, University of California San Francisco, 513 Parnassus, San Francisco, CA 94143, USA
    Optom Vis Sci 85:653-60. 2008
    ..The current study describes a recent advance in the area of proteomics that has allowed the identification of dozens of low abundance proteins in human tear samples...
  17. pmc Spontaneous development of autoimmune uveitis Is CCR2 dependent
    YuTing Feeling Chen
    Francis I Proctor Foundation, University of California, San Francisco, California
    Am J Pathol 184:1695-705. 2014
    ..These studies identify the CCR2 pathway as a promising therapeutic target that may prove an effective approach to treat uveitis associated with autoimmunity. ..
  18. ncbi Life at the front: dissecting bacterial-host interactions at the ocular surface
    David J Evans
    School of Optometry, University of California, Berkeley, California 94720 2020, USA
    Ocul Surf 5:213-27. 2007
    ..What we learn in the process could yield a wealth of potential therapies for a wide variety of diseases of the eye and of other sites...
  19. ncbi Innate defense of the ocular surface
    Nancy A McNamara
    Department of Anatomy, University of California, San Francisco, CA, USA
    Eye Contact Lens 29:S10-3; discussion S26-9, S192-4. 2003
    ..Mucin, an epithelial glycoprotein, traps contaminants and aids in their removal through normal tear clearance mechanisms...
  20. pmc A simplified quantitative method for assessing keratoconjunctivitis sicca from the Sjögren's Syndrome International Registry
    John P Whitcher
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143 0422, USA
    Am J Ophthalmol 149:405-15. 2010
    ..To describe, apply, and test a new ocular grading system for assessing keratoconjunctivitis sicca (KCS) using lissamine green and fluorescein...
  21. ncbi The tear film and defense against infection
    Suzanne M J Fleiszig
    Morton D Sarver Laboratory for Cornea and Contact Lens Research, School of Optometry, University of California, Berkeley, California, USA
    Adv Exp Med Biol 506:523-30. 2002

Research Grants6

  1. Molecular mechanisms of squamous metaplasia in dry eye
    Nancy McNamara; Fiscal Year: 2007
    ....
  2. Molecular mechanisms of squamous metaplasia in dry eye
    Nancy McNamara; Fiscal Year: 2006
    ....
  3. Molecular mechanisms of squamous metaplasia in dry eye
    Nancy McNamara; Fiscal Year: 2009
    ....
  4. Molecular mechanisms of squamous metaplasia in dry eye
    Nancy A McNamara; Fiscal Year: 2010
    ....
  5. Molecular mechanisms of squamous metaplasia in dry eye
    Nancy McNamara; Fiscal Year: 2009
    ....