David D McManus

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. doi request reprint Relations between circulating microRNAs and atrial fibrillation: Data from the Framingham Offspring Study
    David D McManus
    National Heart Lung and Blood Institute s and Boston University s Framingham Heart Study, Framingham, Massachusetts Cardiology Division, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts Epidemiology Division, Department of Quantitative Health Sciences, University of Massachusetts Medical School Worcester, Massachusetts Electronic address
    Heart Rhythm 11:663-9. 2014
  2. pmc Atrial fibrillation and outcomes in heart failure with preserved versus reduced left ventricular ejection fraction
    David D McManus
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    J Am Heart Assoc 2:e005694. 2013
  3. pmc A novel application for the detection of an irregular pulse using an iPhone 4S in patients with atrial fibrillation
    David D McManus
    Cardiac Electrophysiology Section, Cardiovascular Medicine Division, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Heart Rhythm 10:315-9. 2013
  4. pmc Atrial fibrillation and heart failure parallels: lessons for atrial fibrillation prevention
    David D McManus
    Departments of Medicine and Quantitative Health Sciences, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    Crit Pathw Cardiol 10:46-51. 2011
  5. doi request reprint Recent trends in the incidence, treatment, and prognosis of patients with heart failure and atrial fibrillation (the Worcester Heart Failure Study)
    David D McManus
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Am J Cardiol 111:1460-5. 2013
  6. pmc Risk assessment for incident heart failure in individuals with atrial fibrillation
    Renate B Schnabel
    NHLBI s and Boston University s Framingham Heart Study, Framingham, MA, USA
    Eur J Heart Fail 15:843-9. 2013
  7. pmc Contemporary prevalence and correlates of incident heart failure with preserved ejection fraction
    Jerry H Gurwitz
    Meyers Primary Care Institute and Fallon Community Health Plan, Worcester, MA 01605, USA
    Am J Med 126:393-400. 2013
  8. pmc Management and outcomes of renal disease and acute myocardial infarction
    Paul A Santolucito
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Am J Med 123:847-55. 2010
  9. pmc Comparison of medication practices in patients with heart failure and preserved versus those with reduced ejection fraction (from the Cardiovascular Research Network [CVRN])
    Robert J Goldberg
    Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA
    Am J Cardiol 111:1324-9. 2013
  10. doi request reprint Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk
    David D McManus
    From the National Heart Lung and Blood Institute s and Boston University s Framingham Heart Study, Framingham, MA D D M, K T, M G L, J E F Cardiology Division, Department of Medicine D D M, L M B, K T, J F K, J E F and Epidemiology Division, Department of Quantitative Health Sciences D D M, E M, University of Massachusetts Medical School, Worcester, MA Section of Cardiovascular Medicine, Department of Medicine E J B and Department of Mathematics and Statistics M G L, Boston University, Boston, MA Preventive Medicine Section, Department of Medicine, Boston University School of Medicine, Boston, MA E J B and Department of Epidemiology E J B and Department of Biostatistics M G L, Boston University School of Public Health, Boston, MA
    Arterioscler Thromb Vasc Biol 33:2666-73. 2013

Collaborators

Detail Information

Publications38

  1. doi request reprint Relations between circulating microRNAs and atrial fibrillation: Data from the Framingham Offspring Study
    David D McManus
    National Heart Lung and Blood Institute s and Boston University s Framingham Heart Study, Framingham, Massachusetts Cardiology Division, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts Epidemiology Division, Department of Quantitative Health Sciences, University of Massachusetts Medical School Worcester, Massachusetts Electronic address
    Heart Rhythm 11:663-9. 2014
    ..MicroRNA (miRNA) expression in atrial tissue has been implicated in pathologic susceptibility to atrial fibrillation (AF). Nevertheless, data on how circulating levels relate to AF are limited...
  2. pmc Atrial fibrillation and outcomes in heart failure with preserved versus reduced left ventricular ejection fraction
    David D McManus
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    J Am Heart Assoc 2:e005694. 2013
    ..We examined how AF has impacts on adverse outcomes in HF-PEF versus HF-REF within a large, contemporary cohort...
  3. pmc A novel application for the detection of an irregular pulse using an iPhone 4S in patients with atrial fibrillation
    David D McManus
    Cardiac Electrophysiology Section, Cardiovascular Medicine Division, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Heart Rhythm 10:315-9. 2013
    ..Timely detection of AF can be challenging using traditional diagnostic tools. Smartphone use is increasing and may provide an inexpensive and user-friendly means to diagnoseAF...
  4. pmc Atrial fibrillation and heart failure parallels: lessons for atrial fibrillation prevention
    David D McManus
    Departments of Medicine and Quantitative Health Sciences, University of Massachusetts Medical Center, Worcester, MA 01655, USA
    Crit Pathw Cardiol 10:46-51. 2011
    ..By reviewing some of the mechanistic parallels between AF and HF, we hope to emphasize the connection between established cardiovascular risk factors, cardiac remodeling and AF, with a view to promote strategies for AF prevention...
  5. doi request reprint Recent trends in the incidence, treatment, and prognosis of patients with heart failure and atrial fibrillation (the Worcester Heart Failure Study)
    David D McManus
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Am J Cardiol 111:1460-5. 2013
    ..Despite improving trends in survival, patients with ADHF and AF are at increased risk of in-hospital and postdischarge mortality...
  6. pmc Risk assessment for incident heart failure in individuals with atrial fibrillation
    Renate B Schnabel
    NHLBI s and Boston University s Framingham Heart Study, Framingham, MA, USA
    Eur J Heart Fail 15:843-9. 2013
    ..Risk factors that predict HF in individuals with AF in the community are not well established...
  7. pmc Contemporary prevalence and correlates of incident heart failure with preserved ejection fraction
    Jerry H Gurwitz
    Meyers Primary Care Institute and Fallon Community Health Plan, Worcester, MA 01605, USA
    Am J Med 126:393-400. 2013
    ....
  8. pmc Management and outcomes of renal disease and acute myocardial infarction
    Paul A Santolucito
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Am J Med 123:847-55. 2010
    ....
  9. pmc Comparison of medication practices in patients with heart failure and preserved versus those with reduced ejection fraction (from the Cardiovascular Research Network [CVRN])
    Robert J Goldberg
    Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA
    Am J Cardiol 111:1324-9. 2013
    ..In conclusion, the present results from a large, population-based sample suggest considerable variation in the previous and new use of different cardiac medication classes of drugs in patients with HF-PEF versus HF-REF...
  10. doi request reprint Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk
    David D McManus
    From the National Heart Lung and Blood Institute s and Boston University s Framingham Heart Study, Framingham, MA D D M, K T, M G L, J E F Cardiology Division, Department of Medicine D D M, L M B, K T, J F K, J E F and Epidemiology Division, Department of Quantitative Health Sciences D D M, E M, University of Massachusetts Medical School, Worcester, MA Section of Cardiovascular Medicine, Department of Medicine E J B and Department of Mathematics and Statistics M G L, Boston University, Boston, MA Preventive Medicine Section, Department of Medicine, Boston University School of Medicine, Boston, MA E J B and Department of Epidemiology E J B and Department of Biostatistics M G L, Boston University School of Public Health, Boston, MA
    Arterioscler Thromb Vasc Biol 33:2666-73. 2013
    ....
  11. pmc Trends in atrial fibrillation in patients hospitalized with an acute coronary syndrome
    David D McManus
    Department of Medicine, University of Massachusetts Medical School, Worcester Division of Epidemiology, Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am J Med 125:1076-84. 2012
    ..Data are needed on recent trends in the magnitude, clinical features, treatment, and prognostic impact of preexisting and new-onset atrial fibrillation in patients hospitalized with an acute coronary syndrome...
  12. doi request reprint Outcomes from patients with multi-vessel disease following primary PCI: staged PCI imparts very low mortality
    Kurt G Barringhaus
    University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Catheter Cardiovasc Interv 77:617-22. 2011
    ..CABG and PCI are effective means for revascularization of patients with multi-vessel coronary artery disease, but previous studies have not focused on treatment of patients that first undergo primary PCI...
  13. pmc Patterns of comorbidity in older adults with heart failure: the Cardiovascular Research Network PRESERVE study
    Jane S Saczynski
    Meyers Primary Care Institute and Fallon Community Health Plan, Worcester, Massachusetts 01605, USA
    J Am Geriatr Soc 61:26-33. 2013
    ..To examine whether the total burden of comorbidity and pattern of co-occurring conditions varies in individuals with heart failure (HF) with preserved left ventricular ejection fraction (LVEF) (HF-P) or HF with reduced LVEF (HF-R)...
  14. pmc Speckle echocardiographic left atrial strain and stiffness index as predictors of maintenance of sinus rhythm after cardioversion for atrial fibrillation: a prospective study
    Amir Y Shaikh
    Department of Internal Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cardiovasc Ultrasound 10:48. 2012
    ..Our goal was to determine if strain measures [peak systolic longitudinal strain (LAS) and stiffness index (LASt)] changed after cardioversion (CV); and their relation to AF recurrence...
  15. pmc Thirty-year (1975 to 2005) trends in the incidence rates, clinical features, treatment practices, and short-term outcomes of patients <55 years of age hospitalized with an initial acute myocardial infarction
    David D McManus
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Am J Cardiol 108:477-82. 2011
    ..Decreasing odds of developing or dying from an initial AMI during the 30 years under study likely reflect increased primary and secondary prevention and treatment efforts...
  16. pmc 30-year trends in heart failure in patients hospitalized with acute myocardial infarction
    David D McManus
    Department of Medicine, University of Massachusetts Medical School, Worcester, USA
    Am J Cardiol 107:353-9. 2011
    ..In conclusion, HF remains a common and frequently fatal complication of AMI to which increased surveillance and treatment efforts should be directed...
  17. pmc Transitions, Risks, and Actions in Coronary Events--Center for Outcomes Research and Education (TRACE-CORE): design and rationale
    Molly E Waring
    Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Circ Cardiovasc Qual Outcomes 5:e44-50. 2012
    ....
  18. pmc Improved survival after heart failure: a community-based perspective
    Samuel W Joffe
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Am Heart Assoc 2:e000053. 2013
    ..A secondary objective was to examine patient characteristics associated with decreased long-term survival...
  19. doi request reprint 30-year trends in patient characteristics, treatment practices, and long-term outcomes of adults aged 35 to 54 years hospitalized with acute myocardial infarction
    Mayra Tisminetzky
    Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, Massachusetts
    Am J Cardiol 113:1137-41. 2014
    ..The present results provide insights into the changing characteristics, management, and improving long-term outcomes of relatively young patients hospitalized with AMI. ..
  20. pmc Cardiometabolic correlates and heritability of fetuin-A, retinol-binding protein 4, and fatty-acid binding protein 4 in the Framingham Heart Study
    Bernhard M Kaess
    National Heart, Blood, and Lung Institute s Framingham Heart Study, Framingham, MA 01702, USA
    J Clin Endocrinol Metab 97:E1943-7. 2012
    ..Fetuin-A, retinol-binding protein 4 (RBP4), and fatty-acid binding protein 4 (FABP4) are novel biomarkers that may link adiposity to insulin resistance and the metabolic syndrome (MetSyn)...
  21. doi request reprint Atrial fibrillation detection using a smart phone
    Jinseok Lee
    WPI, Worcester, MA 01609, USA
    Conf Proc IEEE Eng Med Biol Soc 2012:1177-80. 2012
    ..Using this criterion, we achieved an accuracy of 100% for both detecting the presence of either AF or NSR...
  22. pmc Delayed hospital presentation in acute decompensated heart failure: clinical and patient reported factors
    Chad Darling
    Department of Emergency Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Heart Lung 42:281-6. 2013
    ..Prior studies have examined the reasons why such delays may occur, but additional studies are needed to identify modifiable factors contributing to these delays...
  23. pmc Increase in the proportion of patients hospitalized with acute myocardial infarction with do-not-resuscitate orders already in place between 2001 and 2007: a nonconcurrent prospective study
    Jane S Saczynski
    Department of Medicine, University of Massachusetts Medical School, Worcester Meyers Primary Care Institute, Worcester Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester
    Clin Epidemiol 4:267-74. 2012
    ..Here, we describe the use and timing of do-not-resuscitate (DNR) orders in patients hospitalized with acute myocardial infarction (AMI)...
  24. pmc Incidence, prognosis, and factors associated with cardiac arrest in patients hospitalized with acute coronary syndromes (the Global Registry of Acute Coronary Events Registry)
    David D McManus
    Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Coron Artery Dis 23:105-12. 2012
    ..The objectives of this multinational study were to characterize trends in the magnitude of in-hospital VF-CA complicating an ACS and to describe its impact over time on hospital prognosis...
  25. pmc Meta-analysis of increased heart rate and blood pressure associated with CNS stimulant treatment of ADHD in adults
    Eric Mick
    Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA
    Eur Neuropsychopharmacol 23:534-41. 2013
    ....
  26. doi request reprint Management strategies in atrial fibrillation in patients with heart failure
    Amir Y Shaikh
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Cardiol Rev 20:288-96. 2012
    ..This article focuses on reviewing contemporary data as it pertains to AF management in patients with HF and provides insight into investigational therapies currently under development...
  27. pmc Recent trends in the incidence, treatment, and outcomes of patients with STEMI and NSTEMI
    David D McManus
    Department of Medicine, Division of Cardiovascular Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am J Med 124:40-7. 2011
    ....
  28. pmc Trends in the medical management of patients with heart failure
    Samuel W Joffe
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA
    J Clin Med Res 5:194-204. 2013
    ....
  29. doi request reprint Targeted sequencing in candidate genes for atrial fibrillation: The Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Targeted Sequencing Study
    Honghuang Lin
    Department of Medicine, Boston University School of Medicine, Boston, Massachusetts The NHLBI s Framingham Heart Study, Framingham, Massachusetts Electronic address
    Heart Rhythm 11:452-7. 2014
    ..Genome-wide association studies (GWAS) have identified common genetic variants that predispose to atrial fibrillation (AF). It is unclear whether rare and low-frequency variants in genes implicated by such GWAS confer additional risk of AF...
  30. doi request reprint Gene expression and genetic variation in human atria
    Honghuang Lin
    National Heart Lung and Blood Institute s and Boston University s Framingham Heart Study, Framingham, Massachusetts Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts Electronic address
    Heart Rhythm 11:266-71. 2014
    ..The human left and right atria have different susceptibilities to develop atrial fibrillation (AF). However, the molecular events related to structural and functional changes that enhance AF susceptibility are still poorly understood...
  31. pmc Relations of circulating resistin and adiponectin and cardiac structure and function: the Framingham Offspring Study
    David D McManus
    National Heart, Lung, and Blood Institute s and Boston University s Framingham Heart Study, Framingham, Massachusetts, USA
    Obesity (Silver Spring) 20:1882-6. 2012
    ..In conclusion, these associations identify potential mechanisms by which excess adiposity may mediate adverse cardiac remodeling and HF risk...
  32. pmc Commonly used data-collection approaches in clinical research
    Jane S Saczynski
    Department of Medicine, University of Massachusetts Medical School, Worcester Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester
    Am J Med 126:946-50. 2013
    ..We hope that the points raised in this overview will lead to the collection of rich and high-quality data in observational studies and randomized controlled trials. ..
  33. pmc Prognostic value of left ventricular end-systolic volume index as a predictor of heart failure hospitalization in stable coronary artery disease: data from the Heart and Soul Study
    David D McManus
    Division of Cardiology, Department of Medicine, University of California, San Francisco, California 94143, USA
    J Am Soc Echocardiogr 22:190-7. 2009
    ..The prognostic value of ESVI and its merit relative to other markers of LV remodeling in patients with coronary heart disease are unknown...
  34. pmc Relation of kidney function and albuminuria with atrial fibrillation (from the Heart and Soul Study)
    David D McManus
    Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, University of Massachusetts, Worcester, Massachusetts, USA
    Am J Cardiol 104:1551-5. 2009
    ..36, 95% CI 1.45 to 13.05) or eGFR(Cr) (OR 4.61, 95% CI 1.56 to 13.66). In conclusion, among outpatients with coronary artery disease, lower eGFR(cys) and higher ACR were associated with prevalent AF, independent of each other...
  35. pmc Multiple cardiovascular comorbidities and acute myocardial infarction: temporal trends (1990-2007) and impact on death rates at 30 days and 1 year
    David D McManus
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA, USA
    Clin Epidemiol 4:115-23. 2012
    ....
  36. pmc Greater knowledge and appreciation of commonly-used research study designs
    Robert J Goldberg
    Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Am J Med 126:169.e1-8. 2013
    ..It is hoped that careful attention to the concerns we have raised will lead to the design and conduct of high-quality research projects and their write-up...
  37. doi request reprint Automatic motion and noise artifact detection in Holter ECG data using empirical mode decomposition and statistical approaches
    Jinseok Lee
    Department of Biomedical Engineering, Worcester Polytechnic Institute, MA 01609, USA
    IEEE Trans Biomed Eng 59:1499-506. 2012
    ..48%-74.62%) on six subjects diagnosed with AF. Finally, the computation time was less than 0.2 s using a MATLAB code, indicating that real-time application of the algorithms is possible for Holter monitoring...
  38. doi request reprint Atrial fibrillation detection using an iPhone 4S
    Jinseok Lee
    Department of Biomedical Engineering, Worcester Polytechnic Institute, MA 01609, USA
    IEEE Trans Biomed Eng 60:203-6. 2013
    ..It should be recognized that for clinical applications, the most relevant objective is to detect the presence of AF in the data. Using this criterion, we achieved an accuracy of 100% for both the MIT-BIH AF and iPhone 4S databases...