Research Topics
Species | William M McMahonSummaryAffiliation: University of Utah Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Genetic counseling and ethical issues for autismWilliam M McMahon
Utah Autism Research Program, University of Utah, 421 Wakara Way, Salt Lake City, UT 84108, USA
Am J Med Genet C Semin Med Genet 142:52-7. 2006....- Movement disorders in children and adolescentsWilliam M McMahon
Departments of Psychiatry and Pediatrics, University of Utah, Salt Lake City, UT, USA
Neurol Clin 20:1101-24, vii-viii. 2002..Most provocative is the new conceptual model of poststreptococcal autoimmune neuropsychiatric disorder. Although unproven, substantial support for this model comes from immunologic, family, neuroimaging, and treatment studies... - Children at familial risk for Tourette's disorder: Child and parent diagnosesWilliam M McMahon
Departments of Psychiatry and Pediatrics at University of Utah and Primary Children s Medical Center, Salt Lake City, Utah 84108 1241, USA
Am J Med Genet B Neuropsychiatr Genet 121:105-11. 2003..Furthermore, the risk is even greater when both parents are affected. Finally, our diagnosis of tic disorders in 21% of subjects initially reported by parents to be unaffected affirms the value of structured clinical assessments... - Are there enhanced MBP autoantibodies in autism?Jane E Libbey
Department of Neurology, University of Utah, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132 2305, USA
J Autism Dev Disord 38:324-32. 2008..Autoantibody responses against MBP are unlikely to play a pathogenic role in autism... - Are there altered antibody responses to measles, mumps, or rubella viruses in autism?Jane E Libbey
Department of Neurology, University of Utah, Salt Lake City, Utah 84132 2305, USA
J Neurovirol 13:252-9. 2007.... 
Genome-wide linkage using the Social Responsiveness Scale in Utah autism pedigreesHilary Coon
Utah Autism Research Project, Department of Psychiatry and Division of Genetic Epidemiology, University of Utah, 650 Komas Drive, Suite 206, Salt Lake City, UT 84108, USA
Mol Autism 1:8. 2010..Such data are available from the Social Responsiveness Scale (SRS) which is a continuous, quantitative measure of social ability giving scores that range from significant impairment to above average ability...- Intact emotion facilitation for nonsocial stimuli in autism: is amygdala impairment in autism specific for social information?Mikle South
Department of Psychology, University of Utah, Salt Lake City, Utah, USA
J Int Neuropsychol Soc 14:42-54. 2008.... - How relevant are GFAP autoantibodies in autism and Tourette Syndrome?Nikki J Kirkman
Department of Neurology, University of Utah, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132 2305, USA
J Autism Dev Disord 38:333-41. 2008..Autoantibody responses against GFAP are unlikely to play a pathogenic role in autism or Tourette Syndrome... 
No evidence for IL1RAPL1 involvement in selected high-risk autism pedigrees from the AGRE data setKristina Allen-Brady
Utah ASD Research Project, Department of Psychiatry, University of Utah, Salt Lake City, Utah 84108, USA
Autism Res 4:293-6. 2011..In conclusion, coding changes of the IL1RAPL1 gene do not appear to be associated with ASD in selected AGRE families with linkage evidence to the chromosome Xp22.11-p21.2 region...- Autism spectrum disorder reclassified: a second look at the 1980s Utah/UCLA Autism Epidemiologic StudyJudith S Miller
Department of Psychiatry, University of Utah, 650 Komas Drive, Salt Lake City, UT 84108, USA
J Autism Dev Disord 43:200-10. 2013..The current analysis puts this historic work into context and highlights differences in ascertainment between epidemiological studies performed decades ago and those of today... - The relationship between executive functioning, central coherence, and repetitive behaviors in the high-functioning autism spectrumMikle South
University of Utah, USA
Autism 11:437-51. 2007..Further research on repetitive behaviors in autism may benefit from a focus on narrow behavioral and cognitive constructs rather than general categories... - Excess Mortality and Causes of Death in Autism Spectrum Disorders: A Follow up of the 1980s Utah/UCLA Autism Epidemiologic StudyDeborah Bilder
Department of Psychiatry, University of Utah, 650 Komas Drive, Suite 206, Salt Lake City, UT, 84108, USA
J Autism Dev Disord 43:1196-204. 2013.... - Linkage analysis of Tourette syndrome in a large Utah pedigreeStacey Knight
Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, USA
Am J Med Genet B Neuropsychiatr Genet 153:656-62. 2010..03). The significant linkage peaks on chromosomes 1p and 3p are in new areas of the genome for TS, and replication of these findings is necessary... - The PHQ-9 as a brief assessment of lifetime major depressionDale S Cannon
Department of Psychiatry, University of Utah, Salt Lake City, UT, USA
Psychol Assess 19:247-51. 2007..09, p<.001; was correlated with number of MDE Criterion A symptoms, r(525)=.67, p<.001; and detected MDE Criterion A (AUC=0.88). The PHQ-9 as a lifetime measure may be used to complement or replace more costly interview assessments... - A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addictionRobert B Weiss
Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
PLoS Genet 4:e1000125. 2008..The identification of an age-dependent susceptibility haplotype reinforces the importance of preventing early exposure to tobacco through public health policies... - Genome-wide linkage analyses of two repetitive behavior phenotypes in Utah pedigrees with autism spectrum disordersDale S Cannon
Utah Autism Research Project, Department of Psychiatry, University of Utah, 650 Komas Drive, Suite 206, Salt Lake City, UT, 84108 3528, USA
Mol Autism 1:3. 2010..Secondary aims were to examine the correlates of IS and RSMA and to assess the heritability of both scales... - A unified theory of autism revisited: linkage evidence points to chromosome X using a high-risk subset of AGRE familiesKristina Allen-Brady
Department of Psychiatry, Utah Autism Research Project, University of Utah, Salt Lake City, Utah, 84108, USA
Autism Res 3:47-52. 2010..These results demonstrate that identification of a more homogeneous subset of autism cases, which was based on family structure in this study, may help to identify, localize and further our understanding of autism predisposition genes... - Hyperserotoninemia and altered immunity in autismNancy K Burgess
Department of Neurology, University of Utah, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132 2305, USA
J Autism Dev Disord 36:697-704. 2006..Further research is needed to determine the interactions between neuropsychiatric and immune dysfunction in autism and related disorders... - Twenty-year outcome for individuals with autism and average or near-average cognitive abilitiesMegan A Farley
Utah Autism Research Program, Department of Psychiatry, University of Utah, 650 Komas Dr, Ste 206, Salt Lake City, UT 84108, USA
Autism Res 2:109-18. 2009..While all participants had baseline IQs in the nonimpaired range, there was limited evidence to support the use of other early childhood variables to predict adult outcome... - Best practices: the Utah Youth Suicide Study: best practices for suicide prevention through the juvenile court systemDoug Gray
Universityof Utah School of Medicine, Salt Lake City, UT, USA
Psychiatr Serv 62:1416-8. 2011..The model includes screening at-risk teenagers with the Youth Outcome Questionnaire. Treatment includes both psychiatric care and in-home behavioral intervention. Services were effectively delivered on a large scale... - Changes in the administrative prevalence of autism spectrum disorders: contribution of special education and health from 2002-2008Judith Pinborough-Zimmerman
Department of Psychiatry, University of Utah, Salt Lake City, UT 84108, USA
J Autism Dev Disord 42:521-30. 2012..Most children with an ASD health diagnosis did not have an autism special education classification. Findings highlight the growing health and educational impact of ASD... - Face processing in children with autism: effects of stimulus contents and typeLeslie L Speer
University of Utah, Salt Lake City, UT 84112, USA
Autism 11:265-77. 2007..These findings reconcile differences in previous reports by identifying the specific social and dynamic task components associated with autism-related face processing impairments... - D8/17 and CD19 expression on lymphocytes of patients with acute rheumatic fever and Tourette's disorderJulie L Weisz
Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
Clin Diagn Lab Immunol 11:330-6. 2004.... - Performance on Cambridge Neuropsychological Test Automated Battery subtests sensitive to frontal lobe function in people with autistic disorder: evidence from the Collaborative Programs of Excellence in Autism networkSally Ozonoff
Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA
J Autism Dev Disord 34:139-50. 2004.... - Autistic disorder and viral infectionsJane E Libbey
Department of Neurology, University of Utah, Salt Lake City, Utah 84132-2305, USA
J Neurovirol 11:1-10. 2005..Further research is needed to clarify both the mechanisms whereby viral infection early in development may lead to autism and the possible involvement of the MMR vaccine in the development of autism... - Associations between phenylthiocarbamide gene polymorphisms and cigarette smokingDale S Cannon
Department of Psychiatry, University of Utah, Salt Lake City, UT, USA
Nicotine Tob Res 7:853-8. 2005..392, p = .001. The predicted relationship between PAV and AVI and taste motivation was found, F(2, 348) = 3.303, p = .038. The results encourage further exploration of the role of taste/sensory processes in tobacco dependence... - Web-based consensus diagnosis for genetics studies of Gilles de la Tourette syndromeWilliam M McMahon
Tourette Research Program, University of Utah, Division of Child and Adolescent Psychiatry, Salt Lake City, Utah, USA
Adv Neurol 99:136-43. 2006 - Utility of the Gilliam Autism Rating Scale in research and clinical populationsMikle South
Department of Psychology, University of Utah, USA
J Autism Dev Disord 32:593-9. 2002..It is recommended that clinicians and researchers using or considering using the GARS for autism diagnosis or ratings of autism severity recognize the need for further research regarding its use... - Utah youth suicide study, phase I: government agency contact before deathDoug Gray
Department of Psychiatry, University of Utah, Salt Lake City 84108, USA
J Am Acad Child Adolesc Psychiatry 41:427-34. 2002..Few suicide completers had evidence of active psychiatric treatment. CONCLUSIONS: Juvenile Justice is identified as a novel site for the screening and identification of youths at risk for suicide... - A liquid chromatographic-tandem mass spectrometric method for the analysis of serotonin and related indoles in human whole bloodJonathan P Danaceau
Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, 20 South 2030 East, Room 490, Salt Lake City, Utah 84112, USA
J Anal Toxicol 27:440-4. 2003..A regression analysis of the two data sets resulted in correlation coefficients of 0.981, 0.964, and 0.987 for 5-HT, TRP, and IAA, respectively... - Heterogeneous association between engrailed-2 and autism in the CPEA networkCamille W Brune
Department of Psychiatry, Institute for Juvenile Research, University of Illinois Chicago, Chicago, Illinois, USA
Am J Med Genet B Neuropsychiatr Genet 147:187-93. 2008..Future studies investigating EN2 should consider how the association of variants in this gene with autism could be influenced by differences in phenotype and possible interactions with genotypes at other autism candidate genes... - Obsessive-compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndromeJames F Leckman
Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Am J Med Genet B Neuropsychiatr Genet 116:60-8. 2003..We conclude that familial factors contribute significantly to OC symptom dimension phenotypes in GTS families. This familial contribution could be genetic or environmental... - Mapping autism risk loci using genetic linkage and chromosomal rearrangementsPeter Szatmari
Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
Nat Genet 39:319-28. 2007..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs... - Diffusion tensor imaging of the corpus callosum in AutismAndrew L Alexander
Department of Medical Physics, University of Wisconsin, Madison, WI, USA
Neuroimage 34:61-73. 2007..These results suggest that the microstructure of the corpus callosum is affected in autism, which may be related to nonverbal cognitive performance... - Is there a 'regressive phenotype' of Autism Spectrum Disorder associated with the measles-mumps-rubella vaccine? A CPEA StudyJennifer Richler
University of Michigan, Ann Arbor, 48109 2054, USA
J Autism Dev Disord 36:299-316. 2006..There was no evidence that onset of autistic symptoms or of regression was related to measles-mumps-rubella vaccination. The implications of these findings for the existence of a 'regressive phenotype' of ASD are discussed... - Confirmation of the association of the C4B null allelle in autismDennis Odell
Center for Persons with Disabilities, Utah State University, Logan, UT 84322, USA
Hum Immunol 66:140-5. 2005..1 that lacks a C4B gene and has 2 C4A genes was also observed. The results of this study suggest that the human leukocyte antigen class III C4BQ0 significantly increases the risk for autism... - Diffusion tensor imaging of white matter in the superior temporal gyrus and temporal stem in autismJee Eun Lee
Waisman Laboratory for Brain Imaging and Behavior, Waisman Center, Madison, WI, United States
Neurosci Lett 424:127-32. 2007..These results suggest that white matter microstructure in autism is abnormal in these temporal lobe regions, which is consistent with theories of aberrant brain connectivity in autism... - Early regression in social communication in autism spectrum disorders: a CPEA StudyRhiannon Luyster
Autism and Communication Disorders Center, University of Michigan, Ann Arbor 48109-2054, USA
Dev Neuropsychol 27:311-36. 2005..A significant minority of children with autism without word loss showed a very similar pattern of loss of social-communication skills, a pattern not observed in the children with developmental delays or typical development... - Familial autoimmune thyroid disease as a risk factor for regression in children with Autism Spectrum Disorder: a CPEA StudyCynthia A Molloy
Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Ohio 45229 3039, USA
J Autism Dev Disord 36:317-24. 2006..89; 95% CI: 1.17, 3.10). The only specific autoimmune disorder found to be associated with regression was autoimmune thyroid disease (adjusted OR=2.09; 95% CI: 1.28, 3.41)... - Repetitive behavior profiles in Asperger syndrome and high-functioning autismMikle South
Department of Psychology, University of Utah and Utah Autism Research Project, USA
J Autism Dev Disord 35:145-58. 2005..The importance of expanding research in the repetitive behavior domain is highlighted as part of the necessary integration of behavioral and neurobiological approaches to understanding the etiology of autism...
Research Grants
- UTAH AUTISM PROGRAMWilliam McMahon; Fiscal Year: 2006..Finally, he proposes to perform microarray analyses on RNA isolated from peripheral blood mononucler cells of autistic children versus control subjects. ..