William M McMahon

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. ncbi request reprint Genetic counseling and ethical issues for autism
    William M McMahon
    Utah Autism Research Program, University of Utah, 421 Wakara Way, Salt Lake City, UT 84108, USA
    Am J Med Genet C Semin Med Genet 142:52-7. 2006
  2. ncbi request reprint Movement disorders in children and adolescents
    William M McMahon
    Departments of Psychiatry and Pediatrics, University of Utah, Salt Lake City, UT, USA
    Neurol Clin 20:1101-24, vii-viii. 2002
  3. ncbi request reprint Children at familial risk for Tourette's disorder: Child and parent diagnoses
    William M McMahon
    Departments of Psychiatry and Pediatrics at University of Utah and Primary Children s Medical Center, Salt Lake City, Utah 84108 1241, USA
    Am J Med Genet B Neuropsychiatr Genet 121:105-11. 2003
  4. ncbi request reprint Are there enhanced MBP autoantibodies in autism?
    Jane E Libbey
    Department of Neurology, University of Utah, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132 2305, USA
    J Autism Dev Disord 38:324-32. 2008
  5. ncbi request reprint Are there altered antibody responses to measles, mumps, or rubella viruses in autism?
    Jane E Libbey
    Department of Neurology, University of Utah, Salt Lake City, Utah 84132 2305, USA
    J Neurovirol 13:252-9. 2007
  6. pmc Maternal prenatal weight gain and autism spectrum disorders
    Deborah A Bilder
    Utah Autism Research Program, 650 Komas Dr, Suite 206, Salt Lake City, UT 84108
    Pediatrics 132:e1276-83. 2013
  7. doi request reprint Autism spectrum disorder reclassified: a second look at the 1980s Utah/UCLA Autism Epidemiologic Study
    Judith S Miller
    Department of Psychiatry, University of Utah, 650 Komas Drive, Salt Lake City, UT 84108, USA
    J Autism Dev Disord 43:200-10. 2013
  8. pmc Genome-wide linkage using the Social Responsiveness Scale in Utah autism pedigrees
    Hilary Coon
    Utah Autism Research Project, Department of Psychiatry and Division of Genetic Epidemiology, University of Utah, 650 Komas Drive, Suite 206, Salt Lake City, UT 84108, USA
    Mol Autism 1:8. 2010
  9. ncbi request reprint Intact emotion facilitation for nonsocial stimuli in autism: is amygdala impairment in autism specific for social information?
    Mikle South
    Department of Psychology, University of Utah, Salt Lake City, Utah, USA
    J Int Neuropsychol Soc 14:42-54. 2008
  10. ncbi request reprint How relevant are GFAP autoantibodies in autism and Tourette Syndrome?
    Nikki J Kirkman
    Department of Neurology, University of Utah, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132 2305, USA
    J Autism Dev Disord 38:333-41. 2008

Research Grants

  1. UTAH AUTISM PROGRAM
    William McMahon; Fiscal Year: 2006

Detail Information

Publications43

  1. ncbi request reprint Genetic counseling and ethical issues for autism
    William M McMahon
    Utah Autism Research Program, University of Utah, 421 Wakara Way, Salt Lake City, UT 84108, USA
    Am J Med Genet C Semin Med Genet 142:52-7. 2006
    ....
  2. ncbi request reprint Movement disorders in children and adolescents
    William M McMahon
    Departments of Psychiatry and Pediatrics, University of Utah, Salt Lake City, UT, USA
    Neurol Clin 20:1101-24, vii-viii. 2002
    ..Most provocative is the new conceptual model of poststreptococcal autoimmune neuropsychiatric disorder. Although unproven, substantial support for this model comes from immunologic, family, neuroimaging, and treatment studies...
  3. ncbi request reprint Children at familial risk for Tourette's disorder: Child and parent diagnoses
    William M McMahon
    Departments of Psychiatry and Pediatrics at University of Utah and Primary Children s Medical Center, Salt Lake City, Utah 84108 1241, USA
    Am J Med Genet B Neuropsychiatr Genet 121:105-11. 2003
    ..Furthermore, the risk is even greater when both parents are affected. Finally, our diagnosis of tic disorders in 21% of subjects initially reported by parents to be unaffected affirms the value of structured clinical assessments...
  4. ncbi request reprint Are there enhanced MBP autoantibodies in autism?
    Jane E Libbey
    Department of Neurology, University of Utah, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132 2305, USA
    J Autism Dev Disord 38:324-32. 2008
    ..Autoantibody responses against MBP are unlikely to play a pathogenic role in autism...
  5. ncbi request reprint Are there altered antibody responses to measles, mumps, or rubella viruses in autism?
    Jane E Libbey
    Department of Neurology, University of Utah, Salt Lake City, Utah 84132 2305, USA
    J Neurovirol 13:252-9. 2007
    ....
  6. pmc Maternal prenatal weight gain and autism spectrum disorders
    Deborah A Bilder
    Utah Autism Research Program, 650 Komas Dr, Suite 206, Salt Lake City, UT 84108
    Pediatrics 132:e1276-83. 2013
    ..This study's objective is to determine whether prepregnancy BMI and pregnancy weight gain are associated with increased ASD risk across study designs and cohorts while controlling for important confounding variables...
  7. doi request reprint Autism spectrum disorder reclassified: a second look at the 1980s Utah/UCLA Autism Epidemiologic Study
    Judith S Miller
    Department of Psychiatry, University of Utah, 650 Komas Drive, Salt Lake City, UT 84108, USA
    J Autism Dev Disord 43:200-10. 2013
    ..The current analysis puts this historic work into context and highlights differences in ascertainment between epidemiological studies performed decades ago and those of today...
  8. pmc Genome-wide linkage using the Social Responsiveness Scale in Utah autism pedigrees
    Hilary Coon
    Utah Autism Research Project, Department of Psychiatry and Division of Genetic Epidemiology, University of Utah, 650 Komas Drive, Suite 206, Salt Lake City, UT 84108, USA
    Mol Autism 1:8. 2010
    ..Such data are available from the Social Responsiveness Scale (SRS) which is a continuous, quantitative measure of social ability giving scores that range from significant impairment to above average ability...
  9. ncbi request reprint Intact emotion facilitation for nonsocial stimuli in autism: is amygdala impairment in autism specific for social information?
    Mikle South
    Department of Psychology, University of Utah, Salt Lake City, Utah, USA
    J Int Neuropsychol Soc 14:42-54. 2008
    ....
  10. ncbi request reprint How relevant are GFAP autoantibodies in autism and Tourette Syndrome?
    Nikki J Kirkman
    Department of Neurology, University of Utah, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132 2305, USA
    J Autism Dev Disord 38:333-41. 2008
    ..Autoantibody responses against GFAP are unlikely to play a pathogenic role in autism or Tourette Syndrome...
  11. doi request reprint No evidence for IL1RAPL1 involvement in selected high-risk autism pedigrees from the AGRE data set
    Kristina Allen-Brady
    Utah ASD Research Project, Department of Psychiatry, University of Utah, Salt Lake City, Utah 84108, USA
    Autism Res 4:293-6. 2011
    ..In conclusion, coding changes of the IL1RAPL1 gene do not appear to be associated with ASD in selected AGRE families with linkage evidence to the chromosome Xp22.11-p21.2 region...
  12. ncbi request reprint The relationship between executive functioning, central coherence, and repetitive behaviors in the high-functioning autism spectrum
    Mikle South
    University of Utah, USA
    Autism 11:437-51. 2007
    ..Further research on repetitive behaviors in autism may benefit from a focus on narrow behavioral and cognitive constructs rather than general categories...
  13. doi request reprint Excess mortality and causes of death in autism spectrum disorders: a follow up of the 1980s Utah/UCLA autism epidemiologic study
    Deborah Bilder
    Department of Psychiatry, University of Utah, 650 Komas Drive, Suite 206, Salt Lake City, UT 84108, USA
    J Autism Dev Disord 43:1196-204. 2013
    ....
  14. ncbi request reprint The PHQ-9 as a brief assessment of lifetime major depression
    Dale S Cannon
    Department of Psychiatry, University of Utah, Salt Lake City, UT, USA
    Psychol Assess 19:247-51. 2007
    ..09, p<.001; was correlated with number of MDE Criterion A symptoms, r(525)=.67, p<.001; and detected MDE Criterion A (AUC=0.88). The PHQ-9 as a lifetime measure may be used to complement or replace more costly interview assessments...
  15. pmc Linkage analysis of Tourette syndrome in a large Utah pedigree
    Stacey Knight
    Department of Biomedical Informatics, University of Utah, Salt Lake City, UT 84108, USA
    Am J Med Genet B Neuropsychiatr Genet 153:656-62. 2010
    ..03). The significant linkage peaks on chromosomes 1p and 3p are in new areas of the genome for TS, and replication of these findings is necessary...
  16. pmc A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction
    Robert B Weiss
    Department of Human Genetics, Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, United States of America
    PLoS Genet 4:e1000125. 2008
    ..The identification of an age-dependent susceptibility haplotype reinforces the importance of preventing early exposure to tobacco through public health policies...
  17. doi request reprint Prenatal and perinatal factors associated with intellectual disability
    Deborah A Bilder
    University of Utah School of Medicine, Psychiatry, Salt Lake City, UT, USA
    Am J Intellect Dev Disabil 118:156-76. 2013
    ..Although several risk factors lost significance once children with underlying genetic disorders were excluded, socioeconomic variables were among those that maintained a prominent association with increased ID risk...
  18. pmc Genome-wide linkage analyses of two repetitive behavior phenotypes in Utah pedigrees with autism spectrum disorders
    Dale S Cannon
    Utah Autism Research Project, Department of Psychiatry, University of Utah, 650 Komas Drive, Suite 206, Salt Lake City, UT, 84108 3528, USA
    Mol Autism 1:3. 2010
    ..Secondary aims were to examine the correlates of IS and RSMA and to assess the heritability of both scales...
  19. ncbi request reprint Hyperserotoninemia and altered immunity in autism
    Nancy K Burgess
    Department of Neurology, University of Utah, 30 North 1900 East, 3R330 SOM, Salt Lake City, UT 84132 2305, USA
    J Autism Dev Disord 36:697-704. 2006
    ..Further research is needed to determine the interactions between neuropsychiatric and immune dysfunction in autism and related disorders...
  20. doi request reprint A unified theory of autism revisited: linkage evidence points to chromosome X using a high-risk subset of AGRE families
    Kristina Allen-Brady
    Department of Psychiatry, Utah Autism Research Project, University of Utah, Salt Lake City, Utah, 84108, USA
    Autism Res 3:47-52. 2010
    ..These results demonstrate that identification of a more homogeneous subset of autism cases, which was based on family structure in this study, may help to identify, localize and further our understanding of autism predisposition genes...
  21. pmc Effect of Neuronal Nicotinic Acetylcholine Receptor Genes (CHRN) on Longitudinal Cigarettes per Day in Adolescents and Young Adults
    Dale S Cannon
    Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT
    Nicotine Tob Res 16:137-44. 2014
    ..Few studies have sought to identify specific genetic markers associated with cigarettes per day (CPD) during adolescence and young adulthood, the period of greatest vulnerability for the development of nicotine dependence...
  22. pmc D8/17 and CD19 expression on lymphocytes of patients with acute rheumatic fever and Tourette's disorder
    Julie L Weisz
    Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA
    Clin Diagn Lab Immunol 11:330-6. 2004
    ....
  23. doi request reprint Twenty-year outcome for individuals with autism and average or near-average cognitive abilities
    Megan A Farley
    Utah Autism Research Program, Department of Psychiatry, University of Utah, 650 Komas Dr, Ste 206, Salt Lake City, UT 84108, USA
    Autism Res 2:109-18. 2009
    ..While all participants had baseline IQs in the nonimpaired range, there was limited evidence to support the use of other early childhood variables to predict adult outcome...
  24. doi request reprint Best practices: the Utah Youth Suicide Study: best practices for suicide prevention through the juvenile court system
    Doug Gray
    Universityof Utah School of Medicine, Salt Lake City, UT, USA
    Psychiatr Serv 62:1416-8. 2011
    ..The model includes screening at-risk teenagers with the Youth Outcome Questionnaire. Treatment includes both psychiatric care and in-home behavioral intervention. Services were effectively delivered on a large scale...
  25. doi request reprint Changes in the administrative prevalence of autism spectrum disorders: contribution of special education and health from 2002-2008
    Judith Pinborough-Zimmerman
    Department of Psychiatry, University of Utah, Salt Lake City, UT 84108, USA
    J Autism Dev Disord 42:521-30. 2012
    ..Most children with an ASD health diagnosis did not have an autism special education classification. Findings highlight the growing health and educational impact of ASD...
  26. ncbi request reprint Performance on Cambridge Neuropsychological Test Automated Battery subtests sensitive to frontal lobe function in people with autistic disorder: evidence from the Collaborative Programs of Excellence in Autism network
    Sally Ozonoff
    Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, Utah, USA
    J Autism Dev Disord 34:139-50. 2004
    ....
  27. ncbi request reprint Autistic disorder and viral infections
    Jane E Libbey
    Department of Neurology, University of Utah, Salt Lake City, Utah 84132 2305, USA
    J Neurovirol 11:1-10. 2005
    ..Further research is needed to clarify both the mechanisms whereby viral infection early in development may lead to autism and the possible involvement of the MMR vaccine in the development of autism...
  28. ncbi request reprint Face processing in children with autism: effects of stimulus contents and type
    Leslie L Speer
    University of Utah, Salt Lake City, UT 84112, USA
    Autism 11:265-77. 2007
    ..These findings reconcile differences in previous reports by identifying the specific social and dynamic task components associated with autism-related face processing impairments...
  29. ncbi request reprint Associations between phenylthiocarbamide gene polymorphisms and cigarette smoking
    Dale S Cannon
    Department of Psychiatry, University of Utah, Salt Lake City, UT, USA
    Nicotine Tob Res 7:853-8. 2005
    ..392, p = .001. The predicted relationship between PAV and AVI and taste motivation was found, F(2, 348) = 3.303, p = .038. The results encourage further exploration of the role of taste/sensory processes in tobacco dependence...
  30. ncbi request reprint Web-based consensus diagnosis for genetics studies of Gilles de la Tourette syndrome
    William M McMahon
    Tourette Research Program, University of Utah, Division of Child and Adolescent Psychiatry, Salt Lake City, Utah, USA
    Adv Neurol 99:136-43. 2006
  31. ncbi request reprint Utah youth suicide study, phase I: government agency contact before death
    Doug Gray
    Department of Psychiatry, University of Utah, Salt Lake City 84108, USA
    J Am Acad Child Adolesc Psychiatry 41:427-34. 2002
    ..To delineate the probability of contact between government agencies and youths who complete suicide, to investigate the nature of those contacts, and to identify new risk factors for suicide...
  32. ncbi request reprint Utility of the Gilliam Autism Rating Scale in research and clinical populations
    Mikle South
    Department of Psychology, University of Utah, USA
    J Autism Dev Disord 32:593-9. 2002
    ..It is recommended that clinicians and researchers using or considering using the GARS for autism diagnosis or ratings of autism severity recognize the need for further research regarding its use...
  33. ncbi request reprint A liquid chromatographic-tandem mass spectrometric method for the analysis of serotonin and related indoles in human whole blood
    Jonathan P Danaceau
    Center for Human Toxicology, Department of Pharmacology and Toxicology, University of Utah, 20 South 2030 East, Room 490, Salt Lake City, Utah 84112, USA
    J Anal Toxicol 27:440-4. 2003
    ..A regression analysis of the two data sets resulted in correlation coefficients of 0.981, 0.964, and 0.987 for 5-HT, TRP, and IAA, respectively...
  34. ncbi request reprint Heterogeneous association between engrailed-2 and autism in the CPEA network
    Camille W Brune
    Department of Psychiatry, Institute for Juvenile Research, University of Illinois Chicago, Chicago, Illinois, USA
    Am J Med Genet B Neuropsychiatr Genet 147:187-93. 2008
    ..Future studies investigating EN2 should consider how the association of variants in this gene with autism could be influenced by differences in phenotype and possible interactions with genotypes at other autism candidate genes...
  35. ncbi request reprint Repetitive behavior profiles in Asperger syndrome and high-functioning autism
    Mikle South
    Department of Psychology, University of Utah and Utah Autism Research Project, USA
    J Autism Dev Disord 35:145-58. 2005
    ..The importance of expanding research in the repetitive behavior domain is highlighted as part of the necessary integration of behavioral and neurobiological approaches to understanding the etiology of autism...
  36. ncbi request reprint Mapping autism risk loci using genetic linkage and chromosomal rearrangements
    Peter Szatmari
    Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada
    Nat Genet 39:319-28. 2007
    ..Neurexins team with previously implicated neuroligins for glutamatergic synaptogenesis, highlighting glutamate-related genes as promising candidates for contributing to ASDs...
  37. ncbi request reprint Obsessive-compulsive symptom dimensions in affected sibling pairs diagnosed with Gilles de la Tourette syndrome
    James F Leckman
    Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Med Genet B Neuropsychiatr Genet 116:60-8. 2003
    ..We conclude that familial factors contribute significantly to OC symptom dimension phenotypes in GTS families. This familial contribution could be genetic or environmental...
  38. ncbi request reprint Diffusion tensor imaging of the corpus callosum in Autism
    Andrew L Alexander
    Department of Medical Physics, University of Wisconsin, Madison, WI, USA
    Neuroimage 34:61-73. 2007
    ..These results suggest that the microstructure of the corpus callosum is affected in autism, which may be related to nonverbal cognitive performance...
  39. ncbi request reprint Is there a 'regressive phenotype' of Autism Spectrum Disorder associated with the measles-mumps-rubella vaccine? A CPEA Study
    Jennifer Richler
    University of Michigan, Ann Arbor, 48109 2054, USA
    J Autism Dev Disord 36:299-316. 2006
    ..There was no evidence that onset of autistic symptoms or of regression was related to measles-mumps-rubella vaccination. The implications of these findings for the existence of a 'regressive phenotype' of ASD are discussed...
  40. ncbi request reprint Familial autoimmune thyroid disease as a risk factor for regression in children with Autism Spectrum Disorder: a CPEA Study
    Cynthia A Molloy
    Center for Epidemiology and Biostatistics, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Ohio 45229 3039, USA
    J Autism Dev Disord 36:317-24. 2006
    ..89; 95% CI: 1.17, 3.10). The only specific autoimmune disorder found to be associated with regression was autoimmune thyroid disease (adjusted OR=2.09; 95% CI: 1.28, 3.41)...
  41. ncbi request reprint Confirmation of the association of the C4B null allelle in autism
    Dennis Odell
    Center for Persons with Disabilities, Utah State University, Logan, UT 84322, USA
    Hum Immunol 66:140-5. 2005
    ..1 that lacks a C4B gene and has 2 C4A genes was also observed. The results of this study suggest that the human leukocyte antigen class III C4BQ0 significantly increases the risk for autism...
  42. ncbi request reprint Diffusion tensor imaging of white matter in the superior temporal gyrus and temporal stem in autism
    Jee Eun Lee
    Waisman Laboratory for Brain Imaging and Behavior, Waisman Center, Madison, WI, United States
    Neurosci Lett 424:127-32. 2007
    ..These results suggest that white matter microstructure in autism is abnormal in these temporal lobe regions, which is consistent with theories of aberrant brain connectivity in autism...
  43. ncbi request reprint Early regression in social communication in autism spectrum disorders: a CPEA Study
    Rhiannon Luyster
    Autism and Communication Disorders Center, University of Michigan, Ann Arbor 48109 2054, USA
    Dev Neuropsychol 27:311-36. 2005
    ..A significant minority of children with autism without word loss showed a very similar pattern of loss of social-communication skills, a pattern not observed in the children with developmental delays or typical development...

Research Grants6

  1. UTAH AUTISM PROGRAM
    William McMahon; Fiscal Year: 2006
    ..Finally, he proposes to perform microarray analyses on RNA isolated from peripheral blood mononucler cells of autistic children versus control subjects. ..