MAUREEN A MCMAHON

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids
    Maureen McMahon
    Division Department of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, California, USA
    Ann Rheum Dis 70:1619-24. 2011
  2. ncbi Systemic lupus erythematosus and cardiovascular disease: prediction and potential for therapeutic intervention
    Maureen McMahon
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA
    Expert Rev Clin Immunol 7:227-41. 2011
  3. ncbi Dysfunctional proinflammatory high-density lipoproteins confer increased risk of atherosclerosis in women with systemic lupus erythematosus
    Maureen McMahon
    David Geffen School of Medicine, UCLA Medical Center, University of California, Los Angeles, CA 90095, USA
    Arthritis Rheum 60:2428-37. 2009
  4. ncbi Inflammatory lipids as a target for therapy in the rheumatic diseases
    Maureen McMahon
    David Geffen School of Medicine at the University of California Los Angeles, Division of Rheumatology, Department of Medicine, UCLA Rheumatology, 1000 Veteran Avenue, Los Angeles, CA 90095 1670, USA
    Expert Opin Investig Drugs 17:1213-24. 2008
  5. ncbi Atherosclerosis and systemic lupus erythematosus: mechanistic basis of the association
    Maureen McMahon
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA
    Curr Opin Immunol 19:633-9. 2007
  6. ncbi Proinflammatory high-density lipoprotein as a biomarker for atherosclerosis in patients with systemic lupus erythematosus and rheumatoid arthritis
    Maureen McMahon
    University of California at Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Arthritis Rheum 54:2541-9. 2006
  7. ncbi Effects of high-dose atorvastatin on antiinflammatory properties of high density lipoprotein in patients with rheumatoid arthritis: a pilot study
    Christina Charles-Schoeman
    Division of Rheumatology, University of California, Los Angeles David Geffen School of Medicine, Los Angeles, California 90095 1670, USA
    J Rheumatol 34:1459-64. 2007
  8. ncbi Dysfunctional, pro-inflammatory HDL directly upregulates monocyte PDGFRβ, chemotaxis and TNFα production
    Brian J Skaggs
    Division of Rheumatology, David Geffen UCLA School of Medicine, 32 59 Rehab Center, Los Angeles, CA 90095, USA
    Clin Immunol 137:147-56. 2010
  9. ncbi Low physical activity is associated with proinflammatory high-density lipoprotein and increased subclinical atherosclerosis in women with systemic lupus erythematosus
    Elizabeth R Volkmann
    David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1670, USA
    Arthritis Care Res (Hoboken) 62:258-65. 2010
  10. ncbi Abnormal function of high-density lipoprotein is associated with poor disease control and an altered protein cargo in rheumatoid arthritis
    Christina Charles-Schoeman
    David Geffen School of Medicine at University of California, Los Angeles, CA 90095 1670, USA
    Arthritis Rheum 60:2870-9. 2009

Research Grants

  1. Pro-Inflammatory HDL as a Novel Target for the Indentification of Atherosclerosis
    Maureen McMahon; Fiscal Year: 2007

Detail Information

Publications15

  1. ncbi High plasma leptin levels confer increased risk of atherosclerosis in women with systemic lupus erythematosus, and are associated with inflammatory oxidised lipids
    Maureen McMahon
    Division Department of Rheumatology, UCLA David Geffen School of Medicine, Los Angeles, California, USA
    Ann Rheum Dis 70:1619-24. 2011
    ..High levels of leptin and low levels of adiponectin are associated with both atherosclerosis and immunomodulatory functions in the general population...
  2. ncbi Systemic lupus erythematosus and cardiovascular disease: prediction and potential for therapeutic intervention
    Maureen McMahon
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA
    Expert Rev Clin Immunol 7:227-41. 2011
    ..Future preventive strategies may include therapies that counteract the immunologic responses that lead to plaque formation...
  3. ncbi Dysfunctional proinflammatory high-density lipoproteins confer increased risk of atherosclerosis in women with systemic lupus erythematosus
    Maureen McMahon
    David Geffen School of Medicine, UCLA Medical Center, University of California, Los Angeles, CA 90095, USA
    Arthritis Rheum 60:2428-37. 2009
    ..The aim of this study was to determine whether dysfunctional proinflammatory HDL (piHDL) is associated with subclinical atherosclerosis in SLE...
  4. ncbi Inflammatory lipids as a target for therapy in the rheumatic diseases
    Maureen McMahon
    David Geffen School of Medicine at the University of California Los Angeles, Division of Rheumatology, Department of Medicine, UCLA Rheumatology, 1000 Veteran Avenue, Los Angeles, CA 90095 1670, USA
    Expert Opin Investig Drugs 17:1213-24. 2008
    ....
  5. ncbi Atherosclerosis and systemic lupus erythematosus: mechanistic basis of the association
    Maureen McMahon
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, Los Angeles, CA, USA
    Curr Opin Immunol 19:633-9. 2007
    ..As in the pathogenesis of many lupus disease processes, the increased risk of atherosclerosis seen in SLE is likely due to the complex interplay of many of these inflammatory and immune mediators...
  6. ncbi Proinflammatory high-density lipoprotein as a biomarker for atherosclerosis in patients with systemic lupus erythematosus and rheumatoid arthritis
    Maureen McMahon
    University of California at Los Angeles David Geffen School of Medicine, Los Angeles, CA 90095, USA
    Arthritis Rheum 54:2541-9. 2006
    ..This study was undertaken to determine whether patients with SLE, who have chronic inflammation that causes oxidative damage, have more proinflammatory HDL and higher levels of ox-LDL, thus predisposing them to atherosclerosis...
  7. ncbi Effects of high-dose atorvastatin on antiinflammatory properties of high density lipoprotein in patients with rheumatoid arthritis: a pilot study
    Christina Charles-Schoeman
    Division of Rheumatology, University of California, Los Angeles David Geffen School of Medicine, Los Angeles, California 90095 1670, USA
    J Rheumatol 34:1459-64. 2007
    ..We examined the effects of atorvastatin 80 mg daily on the inflammatory properties of HDL and clinical disease activity in RA...
  8. ncbi Dysfunctional, pro-inflammatory HDL directly upregulates monocyte PDGFRβ, chemotaxis and TNFα production
    Brian J Skaggs
    Division of Rheumatology, David Geffen UCLA School of Medicine, 32 59 Rehab Center, Los Angeles, CA 90095, USA
    Clin Immunol 137:147-56. 2010
    ..Dysfunctional piHDL directly influences expression of a small number of transcripts and proteins, and piHDL inhibition through reducing piHDL oxidation or blocking PDGFRβ kinase activity restored normal monocyte chemotaxis...
  9. ncbi Low physical activity is associated with proinflammatory high-density lipoprotein and increased subclinical atherosclerosis in women with systemic lupus erythematosus
    Elizabeth R Volkmann
    David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1670, USA
    Arthritis Care Res (Hoboken) 62:258-65. 2010
    ..To investigate the association between physical activity, functional activity of high-density lipoprotein (HDL), and subclinical cardiovascular disease in patients with systemic lupus erythematosus (SLE)...
  10. ncbi Abnormal function of high-density lipoprotein is associated with poor disease control and an altered protein cargo in rheumatoid arthritis
    Christina Charles-Schoeman
    David Geffen School of Medicine at University of California, Los Angeles, CA 90095 1670, USA
    Arthritis Rheum 60:2870-9. 2009
    ....
  11. ncbi Altered lipoprotein metabolism in chronic inflammatory states: proinflammatory high-density lipoprotein and accelerated atherosclerosis in systemic lupus erythematosus and rheumatoid arthritis
    Bevra H Hahn
    Division of Rheumatology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA 90095, USA
    Arthritis Res Ther 10:213. 2008
    ....
  12. ncbi The pathogenesis of atherosclerosis in autoimmune rheumatic diseases: roles of inflammation and dyslipidemia
    Bevra H Hahn
    Division of Rheumatology, Department of Medicine, David Geffen School of Medicine at the University of California Los Angeles, 1000 Veteran Avenue, Los Angeles, CA 90095, USA
    J Autoimmun 28:69-75. 2007
    ..In this review we will discuss the mechanisms involved as well as an overview of the natural history in pathobiology...
  13. ncbi Association of increased interferon-inducible gene expression with disease activity and lupus nephritis in patients with systemic lupus erythematosus
    Xuebing Feng
    David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1670, USA
    Arthritis Rheum 54:2951-62. 2006
    ..IFN scores, or LY6E levels, may be useful as a biomarker for lupus nephritis therapy...
  14. ncbi Safety of tumour necrosis factor-alpha antagonists
    Dinesh Khanna
    Division of Rheumatology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Drug Saf 27:307-24. 2004
    ..At present there is no evidence implicating TNFalpha antagonists with embryotoxicity, teratogenicity or increased pregnancy loss...
  15. ncbi Anti-tumor necrosis factor alpha therapy and heart failure: what have we learned and where do we go from here?
    Dinesh Khanna
    University of California, Los Angeles 90095, USA
    Arthritis Rheum 50:1040-50. 2004

Research Grants2

  1. Pro-Inflammatory HDL as a Novel Target for the Indentification of Atherosclerosis
    Maureen McMahon; Fiscal Year: 2007
    ..Targeting PiHDL with interventions that restore protective function to HDL might be considered for prevention of ATH in both lupus and non lupus patients. ..