Alan McLachlan

Summary

Affiliation: University of Illinois at Chicago
Country: USA

Publications

  1. pmc Limited effects of bile acids and small heterodimer partner on hepatitis B virus biosynthesis in vivo
    Vanessa C Reese
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
    J Virol 86:2760-8. 2012
  2. pmc Role of peroxisome proliferator-activated receptor gamma coactivator 1alpha in AKT/PKB-mediated inhibition of hepatitis B virus biosynthesis
    Caitlin R Ondracek
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 909 South Wolcott Avenue, Chicago, IL 60612, USA
    J Virol 85:11891-900. 2011
  3. pmc Multiple nuclear receptors may regulate hepatitis B virus biosynthesis during development
    VANESSA REESE
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612 7344, USA
    Int J Biochem Cell Biol 43:230-7. 2011
  4. pmc Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha
    Lie Li
    Department of Microbiology and Immunology College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 4:e5489. 2009
  5. pmc Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease
    Eric R Kallwitz
    Department of Medicine, University of Illinois, 840 S Wood Street, 7th Floor, MC 716, Chicago, IL 60612, USA
    World J Gastroenterol 14:22-8. 2008
  6. pmc Complementarity between epsilon and phi sequences in pregenomic RNA influences hepatitis B virus replication efficiency
    Claudia E Oropeza
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 909 South Wolcott Avenue, Chicago, IL 60612, USA
    Virology 359:371-81. 2007
  7. pmc Differential inhibition of nuclear hormone receptor-dependent hepatitis B virus replication by the small heterodimer partner
    Claudia E Oropeza
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 909 South Wolcott Avenue, Chicago, IL 60612, USA
    J Virol 82:3814-21. 2008
  8. pmc Limited effects of fasting on hepatitis B virus (HBV) biosynthesis in HBV transgenic mice
    Lie Li
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 60612, USA
    J Virol 83:1682-8. 2009
  9. pmc Distinct regulation of hepatitis B virus biosynthesis by peroxisome proliferator-activated receptor gamma coactivator 1alpha and small heterodimer partner in human hepatoma cell lines
    Caitlin R Ondracek
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Virol 83:12545-51. 2009
  10. pmc Peroxisome proliferator-activated receptor gamma Coactivator 1alpha and small heterodimer partner differentially regulate nuclear receptor-dependent hepatitis B virus biosynthesis
    Caitlin R Ondracek
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 909 South Wolcott Avenue, Chicago, Illinois 60612, USA
    J Virol 83:12535-44. 2009

Research Grants

  1. REGULATION OF HEPATITIS B VIRUS TRANSCRIPTION
    Alan McLachlan; Fiscal Year: 2007
  2. Initiation of Hepatitis B Virus Replication
    Alan McLachlan; Fiscal Year: 2004
  3. REGULATION OF HEPATITIS B VIRUS TRANSCRIPTION
    Alan McLachlan; Fiscal Year: 2002
  4. REGULATION OF HEPATITIS B VIRUS TRANSCRIPTION
    Alan McLachlan; Fiscal Year: 1993

Collaborators

Detail Information

Publications16

  1. pmc Limited effects of bile acids and small heterodimer partner on hepatitis B virus biosynthesis in vivo
    Vanessa C Reese
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA
    J Virol 86:2760-8. 2012
    ..These observations suggest that hepatic bile acid levels or therapeutic agents targeting FXR may not greatly modulate viremia during natural infection...
  2. pmc Role of peroxisome proliferator-activated receptor gamma coactivator 1alpha in AKT/PKB-mediated inhibition of hepatitis B virus biosynthesis
    Caitlin R Ondracek
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 909 South Wolcott Avenue, Chicago, IL 60612, USA
    J Virol 85:11891-900. 2011
    ..These observations demonstrate that growth and nutritional signals have the capacity to influence viral production, but the magnitude of these effects will depend on the precise cellular context in which they occur...
  3. pmc Multiple nuclear receptors may regulate hepatitis B virus biosynthesis during development
    VANESSA REESE
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612 7344, USA
    Int J Biochem Cell Biol 43:230-7. 2011
    ..Alternatively, HNF4α may support viral biosynthesis in vivo indirectly by activating a network of liver-enriched nuclear receptors that, in combination, direct HBV 3.5 kb pregenomic RNA transcription and replication...
  4. pmc Developmental regulation of hepatitis B virus biosynthesis by hepatocyte nuclear factor 4alpha
    Lie Li
    Department of Microbiology and Immunology College of Medicine, University of Illinois at Chicago, Chicago, Illinois, United States of America
    PLoS ONE 4:e5489. 2009
    ..The dependency of HBV transcription on HNF4alpha links viral biosynthesis and persistence to a developmentally regulated transcription factor essential for host viability...
  5. pmc Role of peroxisome proliferators-activated receptors in the pathogenesis and treatment of nonalcoholic fatty liver disease
    Eric R Kallwitz
    Department of Medicine, University of Illinois, 840 S Wood Street, 7th Floor, MC 716, Chicago, IL 60612, USA
    World J Gastroenterol 14:22-8. 2008
    ..The aim of this review is to describe the data linking PPAR alpha and PPAR gamma to NAFLD/NASH and to discuss the use of PPAR ligands for the treatment of NASH...
  6. pmc Complementarity between epsilon and phi sequences in pregenomic RNA influences hepatitis B virus replication efficiency
    Claudia E Oropeza
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 909 South Wolcott Avenue, Chicago, IL 60612, USA
    Virology 359:371-81. 2007
    ....
  7. pmc Differential inhibition of nuclear hormone receptor-dependent hepatitis B virus replication by the small heterodimer partner
    Claudia E Oropeza
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 909 South Wolcott Avenue, Chicago, IL 60612, USA
    J Virol 82:3814-21. 2008
    ....
  8. pmc Limited effects of fasting on hepatitis B virus (HBV) biosynthesis in HBV transgenic mice
    Lie Li
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 60612, USA
    J Virol 83:1682-8. 2009
    ....
  9. pmc Distinct regulation of hepatitis B virus biosynthesis by peroxisome proliferator-activated receptor gamma coactivator 1alpha and small heterodimer partner in human hepatoma cell lines
    Caitlin R Ondracek
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA
    J Virol 83:12545-51. 2009
    ..Therefore, this approach indicates that the transcriptional regulation of HBV biosynthesis in HepG2 and Huh7 cells is primarily controlled by different transcription factors...
  10. pmc Peroxisome proliferator-activated receptor gamma Coactivator 1alpha and small heterodimer partner differentially regulate nuclear receptor-dependent hepatitis B virus biosynthesis
    Caitlin R Ondracek
    Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, 909 South Wolcott Avenue, Chicago, Illinois 60612, USA
    J Virol 83:12535-44. 2009
    ..Additionally, this functional approach may help to distinguish the transcription factors in various liver cells governing viral biosynthesis under a variety of physiologically relevant conditions...
  11. pmc Alpha/beta interferon differentially modulates the clearance of cytoplasmic encapsidated replication intermediates and nuclear covalently closed circular hepatitis B virus (HBV) DNA from the livers of hepatocyte nuclear factor 1alpha-null HBV transgenic m
    Aimee L Anderson
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Virol 79:11045-52. 2005
    ..Consequently it appears that for therapies to resolve chronic HBV infection efficiently, they will have to target the elimination of the most stable HBV replication intermediate, nuclear HBV CCC DNA...
  12. ncbi request reprint A pregenomic RNA sequence adjacent to DR1 and complementary to epsilon influences hepatitis B virus replication efficiency
    Hong Tang
    Viral Hepatitis Research Unit, West China Hospital, West China Medical School, Sichuan University, Guo Xue Xiang, No 37, Chengdu, Sichuan, 610041, People s Republic of China
    Virology 303:199-210. 2002
    ....
  13. pmc Hepatocyte nuclear factor 3beta inhibits hepatitis B virus replication in vivo
    Krista E Banks
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    J Virol 76:12974-80. 2002
    ..This suggests that altering the activity of this transcription factor in vivo in chronic HBV carriers might be therapeutically beneficial...
  14. pmc Mechanisms of inhibition of nuclear hormone receptor-dependent hepatitis B virus replication by hepatocyte nuclear factor 3beta
    Hong Tang
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:8572-81. 2002
    ..5-kb HBV RNA, possibly by interfering with the elongation rate of these transcripts. Therefore, transcriptional interference mediated by HNF3 may also regulate HBV RNA synthesis and viral replication...
  15. pmc Avian and Mammalian hepadnaviruses have distinct transcription factor requirements for viral replication
    Hong Tang
    Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:7468-72. 2002
    ..These observations indicate that avian and mammalian hepadnaviruses have distinct transcription factor requirements for viral replication...
  16. pmc Functional characterization of the interferon regulatory element in the enhancer 1 region of the hepatitis B virus genome
    Flavio F Alcantara
    Department of Cell Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Nucleic Acids Res 30:2068-75. 2002
    ..In contrast, IFNalpha and the IRFs had minimal effect on HBV transcription and replication in the context of the viral genome in cell culture...

Research Grants18

  1. REGULATION OF HEPATITIS B VIRUS TRANSCRIPTION
    Alan McLachlan; Fiscal Year: 2007
    ..All of these studies are aimed at identifying possible targets for therapeutic intervention in HBV infection. ..
  2. Initiation of Hepatitis B Virus Replication
    Alan McLachlan; Fiscal Year: 2004
    ..This approach is aimed at identifying possible targets for therapeutic intervention in chronic HBV infection. ..
  3. REGULATION OF HEPATITIS B VIRUS TRANSCRIPTION
    Alan McLachlan; Fiscal Year: 2002
    ..This mechanism will be tested directly by functional and in vivo footprinting analysis. ..
  4. REGULATION OF HEPATITIS B VIRUS TRANSCRIPTION
    Alan McLachlan; Fiscal Year: 1993
    ..The cloning of the genes for these factors will permit the analysis of the mechanism by which these factors interact with their recognition sequences and influence the transcriptional activity of the HBV promoters...