EDWARD MCKONE

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi Role of arterial hypoxemia and pulmonary mechanics in exercise limitation in adults with cystic fibrosis
    Edward F McKone
    Dept of Respiratory Medicine, St Vincent s Univ Hospital, Elm Park, Dublin 4, Republic of Ireland
    J Appl Physiol 99:1012-8. 2005
  2. ncbi Adrenal insufficiency and testicular failure secondary to megestrol acetate therapy in a patient with cystic fibrosis
    Edward F McKone
    Adult Cystic Fibrosis Center, University of Washington Medical Center, Seattle, Washington, USA
    Pediatr Pulmonol 34:381-3. 2002
  3. ncbi Effect of genotype on phenotype and mortality in cystic fibrosis: a retrospective cohort study
    Edward F McKone
    Division of Pulmonary and Critical Care Medicine and Adult Cystic Fibrosis Center, University of Washington, Seattle, WA, USA
    Lancet 361:1671-6. 2003
  4. ncbi CFTR genotype as a predictor of prognosis in cystic fibrosis
    Edward F McKone
    Division of Pulmonary and Critical Care Medicine and Adult Cystic Fibrosis Center, University of Washington Medical Center, Seattle, WA 98195 6522, USA
    Chest 130:1441-7. 2006
  5. pmc Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease
    Edward F McKone
    Department of Environmental and Occupational Health Sciences, University of Washington Mail Box 354695, Seattle, WA 98195, USA
    Am J Respir Crit Care Med 174:415-9. 2006
  6. ncbi Comparison of scholarly productivity of general and subspecialty clinician-educators in internal medicine
    Robert R Kempainen
    Department of Internal Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Teach Learn Med 16:323-8. 2004
  7. ncbi Aggressive prenatal care results in successful fetal outcomes in CF women
    Edith Y Cheng
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
    J Cyst Fibros 5:85-91. 2006
  8. ncbi Use of the gas exchange threshold to noninvasively determine the lactate threshold in patients with cystic fibrosis
    Alasdair G Thin
    Department of Physiology, Conway Institute of Biomedical and Biomolecular Research, University College, Dublin, Ireland
    Chest 121:1761-70. 2002

Research Grants

Collaborators

Detail Information

Publications8

  1. ncbi Role of arterial hypoxemia and pulmonary mechanics in exercise limitation in adults with cystic fibrosis
    Edward F McKone
    Dept of Respiratory Medicine, St Vincent s Univ Hospital, Elm Park, Dublin 4, Republic of Ireland
    J Appl Physiol 99:1012-8. 2005
    ..control. The increase in maximal O2 consumption and peak ventilation with added dead space and 38% O2 suggests that maximal exercise in cystic fibrosis is limited by arterial hypoxemia...
  2. ncbi Adrenal insufficiency and testicular failure secondary to megestrol acetate therapy in a patient with cystic fibrosis
    Edward F McKone
    Adult Cystic Fibrosis Center, University of Washington Medical Center, Seattle, Washington, USA
    Pediatr Pulmonol 34:381-3. 2002
    ..This is followed by a review of the literature on the use of megestrol acetate in the treatment of weight loss in CF, AIDS, and cancer, with particular emphasis on the adverse effects that should be looked for in CF patients...
  3. ncbi Effect of genotype on phenotype and mortality in cystic fibrosis: a retrospective cohort study
    Edward F McKone
    Division of Pulmonary and Critical Care Medicine and Adult Cystic Fibrosis Center, University of Washington, Seattle, WA, USA
    Lancet 361:1671-6. 2003
    ..Over 1000 mutations of the cystic fibrosis transmembrane conductance regulator gene (CFTR) that cause cystic fibrosis have been identified. We examined the effect of CFTR genotype on mortality and disease phenotype...
  4. ncbi CFTR genotype as a predictor of prognosis in cystic fibrosis
    Edward F McKone
    Division of Pulmonary and Critical Care Medicine and Adult Cystic Fibrosis Center, University of Washington Medical Center, Seattle, WA 98195 6522, USA
    Chest 130:1441-7. 2006
    ..STUDY RATIONALE: Certain CFTR genotypes are associated with reduced mortality. The accuracy of using CFTR genotype as a predictor of survival and the mechanisms through which CFTR genotype influences survival are unknown...
  5. pmc Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease
    Edward F McKone
    Department of Environmental and Occupational Health Sciences, University of Washington Mail Box 354695, Seattle, WA 98195, USA
    Am J Respir Crit Care Med 174:415-9. 2006
    ..Chronic progressive lung disease is the most serious complication of cystic fibrosis (CF). Glutathione plays an important role in the protection of the CF lung against oxidant-induced lung injury...
  6. ncbi Comparison of scholarly productivity of general and subspecialty clinician-educators in internal medicine
    Robert R Kempainen
    Department of Internal Medicine, University of Washington School of Medicine, Seattle, Washington, USA
    Teach Learn Med 16:323-8. 2004
    ..There is concern that these criteria may be disadvantageous to clinician-educators in generalist fields relative to their specialist counterparts...
  7. ncbi Aggressive prenatal care results in successful fetal outcomes in CF women
    Edith Y Cheng
    Department of Obstetrics and Gynecology, University of Washington, Seattle, WA, USA
    J Cyst Fibros 5:85-91. 2006
    ..The impact of pre-pregnancy pulmonary and nutritional status in pregnancy outcomes of women with cystic fibrosis (CF) is not clearly defined...
  8. ncbi Use of the gas exchange threshold to noninvasively determine the lactate threshold in patients with cystic fibrosis
    Alasdair G Thin
    Department of Physiology, Conway Institute of Biomedical and Biomolecular Research, University College, Dublin, Ireland
    Chest 121:1761-70. 2002
    ..This study was undertaken to validate the use of GET in patients with cystic fibrosis (CF) with a wide range of disease severity, and to assess the reproducibility of this index...

Research Grants1

  1. Genetic epidemiology of glutathione and CF lung disease
    EDWARD MCKONE; Fiscal Year: 2005
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