Research Topics
Species | Tracy R McKnightSummaryAffiliation: University of California Country: USA Publications
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Publications
Choline metabolism, proliferation, and angiogenesis in nonenhancing grades 2 and 3 astrocytomaTracy R McKnight
Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
J Magn Reson Imaging 33:808-16. 2011..PC and glycerophosphocholine (GPC) are involved in phospholipid metabolism that accompanies mitosis. PC is the predominant peak in Grade 4 astrocytoma (GBM) while GPC dominates in AS2...
Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brainRyuta Saito
Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco, 1855 Folsom Street, Room 226, San Francisco, CA 94103, USA
Exp Neurol 196:381-9. 2005..Our ability to directly monitor and to control local delivery of liposomal drugs will most likely result in greater clinical efficacy when using CED in management of patients...- MRI apparent diffusion coefficient reflects histopathologic subtype, axonal disruption, and tumor fraction in diffuse-type grade II gliomasInas S Khayal
UCSF UCB Joint Graduate Group in Bioengineering, University of California, San Francisco, CA, USA
Neuro Oncol 13:1192-201. 2011..Further, the ADC in grade II gliomas is associated with the fraction of tumor cells and degree of axonal disruption in tumor subregions... - Correlation of magnetic resonance spectroscopic and growth characteristics within Grades II and III gliomasTracy R McKnight
Department of Radiology, University of California, San Francisco 94107, USA
J Neurosurg 106:660-6. 2007.... - Relationship between choline and apparent diffusion coefficient in patients with gliomasInas S Khayal
University of California, San Francisco, California, USA
J Magn Reson Imaging 27:718-25. 2008.... - Histopathological validation of a three-dimensional magnetic resonance spectroscopy index as a predictor of tumor presenceTracy R McKnight
Department of Radiology, Biostatistics Core, Comprehensive Cancer Center, University of California, San Francisco 94143, USA
J Neurosurg 97:794-802. 2002..The information gleaned from the biopsy correlation study was used to test the hypothesis that there is metabolically active tumor in nonenhancing regions of the T2-hyperintense lesion that can be detected using MR spectroscopy... - Real-time visualization and characterization of liposomal delivery into the monkey brain by magnetic resonance imagingMichal T Krauze
Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, 1855 Folsom Street, Room 226, San Francisco, CA 94103, USA
Brain Res Brain Res Protoc 16:20-6. 2005..Findings presented in this manuscript may allow for modeling of parameters used for direct delivery of therapeutics into various regions of the brain... - 1H-MRSI of radiation effects in normal-appearing white matter: dose-dependence and impact on automated spectral classificationMichael C Lee
Magnetic Resonance Science Center, Department of Radiology, University of California San Francisco, San Francisco, California 94107 1739, USA
J Magn Reson Imaging 19:379-88. 2004..To identify radiation-induced changes in healthy white-matter spectra in the first six months following radiotherapy, and assess the impact of these changes on an automated algorithm for detecting spectral abnormalities... - Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapyAnne Laprie
Department of Radiology, University of California, San Francisco, San Francisco, CA 94107-1739, USA
Int J Radiat Oncol Biol Phys 62:20-31. 2005..Longitudinal multivoxel MRSI measurements have potential value in assessing response to radiation or other therapies, because they offer more coverage than single-voxel techniques and provide reliable spectral data... 
Apparent diffusion coefficient and fractional anisotropy of newly diagnosed grade II gliomasInas S Khayal
UCSF UCB Joint Graduate Group in Bioengineering, University of California, San Francisco, CA, USA
NMR Biomed 22:449-55. 2009..This suggests that ADC and FA may be helpful in directing tissue sampling to the most appropriate regions for taking biopsies in order to make a definitive diagnosis...- In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSISarah J Nelson
Mgnetic Resonance Science Center, Department of Radiology, University of California, San Francisco, California 94143, USA
J Magn Reson Imaging 16:464-76. 2002..Further work is required to integrate the results of the H-MRSI examination into the treatment planning workstation, and to improve the quality of the data using more sensitive phased array coils and higher field strength magnets... - Characterization of untreated gliomas by magnetic resonance spectroscopic imagingSarah J Nelson
Magnetic Resonance Science Center, Department of Radiology, University of California at San Francisco, One Irving Street, Box 1290, San Francisco, CA 94143, USA
Neuroimaging Clin N Am 12:599-613. 2002.... - Distribution of liposomes into brain and rat brain tumor models by convection-enhanced delivery monitored with magnetic resonance imagingRyuta Saito
Department of Neurological Surgery, Brain Tumor Research Center, University of California, San Francisco, San Francisco, California 94103, USA
Cancer Res 64:2572-9. 2004..By permitting in vivo monitoring of therapeutic distribution in brain tumors, this technique optimizes local drug delivery and may provide a basis for clinical applications in the treatment of malignant glioma... - Effects of the perivascular space on convection-enhanced delivery of liposomes in primate putamenMichal T Krauze
Department of Neurological Surgery, Laboratory of Molecular Therapeutics, University of California, 1855 Folsom Street, Room 226, San Francisco, CA 94103, USA
Exp Neurol 196:104-11. 2005..Based on these findings, we believe that the physiological concept that the perivascular space serves as a conduit for distribution of endogenous molecules within the CNS also applies to interstitially infused agents... - Metabolic imaging of low-grade gliomas with three-dimensional magnetic resonance spectroscopyAndrea Pirzkall
Department of Radiation Oncology, University of California, San Francisco, School of Medicine, San Francisco, CA 94143, USA
Int J Radiat Oncol Biol Phys 53:1254-64. 2002..We performed a study examining the impact MRSI would have on the routine addition of 2-3-cm margins around MRI T2-weighted hyperintensity to generate the treatment planning clinical target volume (CTV) for low-grade gliomas... - Characterization of a diffuse intrinsic pontine glioma cell line: implications for future investigations and treatmentRintaro Hashizume
Department of Neurological Surgery, Brain Tumor Research Center, University of California San Francisco, San Francisco, CA 94143 0520, USA
J Neurooncol 110:305-13. 2012..The hTERT modified cells are tumorigenic in athymic rodents, and produce brainstem tumors that recapitulate the infiltrative growth of brainstem gliomas in patients... - Non-stem cell origin for oligodendrogliomaAnders I Persson
Department of Neurology, University of California, San Francisco, 94158, USA
Cancer Cell 18:669-82. 2010..Our results suggest that oligodendroglioma cells show hallmarks of OPCs, and that a progenitor rather than a NSC origin underlies improved prognosis in patients with this tumor...