Robert W McKenna

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Immunophenotypic analysis of hematogones (B-lymphocyte precursors) and neoplastic lymphoblasts by 4-color flow cytometry
    Robert W McKenna
    The University of Texas Southwestern Medical Center, Department of Pathology, 5323 Harry Hines Blvd, Dallas, Texas 75390 9072, USA
    Leuk Lymphoma 45:277-85. 2004
  2. ncbi request reprint Presence of simian virus 40 DNA sequences in human lymphoid and hematopoietic malignancies and their relationship to aberrant promoter methylation of multiple genes
    Narayan Shivapurkar
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Cancer Res 64:3757-60. 2004
  3. ncbi request reprint Differential methylation of genes that regulate cytokine signaling in lymphoid and hematopoietic tumors
    Jyotsna Reddy
    Hamon Center for Therapeutic Oncology Research, Dallas, TX 75390, USA
    Oncogene 24:732-6. 2005
  4. ncbi request reprint Flow cytometric features of angioimmunoblastic T-cell lymphoma
    Weina Chen
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
    Cytometry B Clin Cytom 70:142-8. 2006
  5. doi request reprint Overexpression of CD7 in classical Hodgkin lymphoma-infiltrating T lymphocytes
    Adam C Seegmiller
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9072, USA
    Cytometry B Clin Cytom 76:169-74. 2009
  6. ncbi request reprint Differential usefulness of various markers in the flow cytometric detection of paroxysmal nocturnal hemoglobinuria in blood and bone marrow
    Horatiu Olteanu
    Department of Pathology, University of Texas, Southwestern Medical Center, Dallas, TX 75390 9073, USA
    Am J Clin Pathol 126:781-8. 2006
  7. ncbi request reprint Comparison of immunophenotypes of small B-cell neoplasms in primary lymph node and concurrent blood or marrow samples
    Yin Xu
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75390 9073, USA
    Am J Clin Pathol 118:758-64. 2002
  8. ncbi request reprint Characterization of incidentally identified minute clonal B-lymphocyte populations in peripheral blood and bone marrow
    Weina Chen
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75390 9072, USA
    Am J Clin Pathol 122:588-95. 2004
  9. ncbi request reprint Haematogones in the peripheral blood of adults: a four-colour flow cytometry study of 102 patients
    Steven H Kroft
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Br J Haematol 126:209-12. 2004
  10. ncbi request reprint Stability of leukemia-associated immunophenotypes in precursor B-lymphoblastic leukemia/lymphoma: a single institution experience
    Weina Chen
    University of Texas Southwestern Medical School, Dallas, TX, USA
    Am J Clin Pathol 127:39-46. 2007

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Immunophenotypic analysis of hematogones (B-lymphocyte precursors) and neoplastic lymphoblasts by 4-color flow cytometry
    Robert W McKenna
    The University of Texas Southwestern Medical Center, Department of Pathology, 5323 Harry Hines Blvd, Dallas, Texas 75390 9072, USA
    Leuk Lymphoma 45:277-85. 2004
    ....
  2. ncbi request reprint Presence of simian virus 40 DNA sequences in human lymphoid and hematopoietic malignancies and their relationship to aberrant promoter methylation of multiple genes
    Narayan Shivapurkar
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 8593, USA
    Cancer Res 64:3757-60. 2004
    ..Our results demonstrate that the presence of SV40 in hematological malignancies is associated with promoter methylation of TSGs and that in all probability, the virus plays a role in tumor pathogenesis...
  3. ncbi request reprint Differential methylation of genes that regulate cytokine signaling in lymphoid and hematopoietic tumors
    Jyotsna Reddy
    Hamon Center for Therapeutic Oncology Research, Dallas, TX 75390, USA
    Oncogene 24:732-6. 2005
    ....
  4. ncbi request reprint Flow cytometric features of angioimmunoblastic T-cell lymphoma
    Weina Chen
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
    Cytometry B Clin Cytom 70:142-8. 2006
    ..The immunophenotypic features of angioimmunoblastic T-cell lymphoma (AILT) have not been well described...
  5. doi request reprint Overexpression of CD7 in classical Hodgkin lymphoma-infiltrating T lymphocytes
    Adam C Seegmiller
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9072, USA
    Cytometry B Clin Cytom 76:169-74. 2009
    ..However, HL-infiltrating T cells have been shown to play a role in HL pathogenesis. This study characterizes the FC immunophenotype of these T lymphocytes to determine whether they can be used to assist in the diagnosis of HL...
  6. ncbi request reprint Differential usefulness of various markers in the flow cytometric detection of paroxysmal nocturnal hemoglobinuria in blood and bone marrow
    Horatiu Olteanu
    Department of Pathology, University of Texas, Southwestern Medical Center, Dallas, TX 75390 9073, USA
    Am J Clin Pathol 126:781-8. 2006
    ....
  7. ncbi request reprint Comparison of immunophenotypes of small B-cell neoplasms in primary lymph node and concurrent blood or marrow samples
    Yin Xu
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75390 9073, USA
    Am J Clin Pathol 118:758-64. 2002
    ..The remaining major and minor variations would not have affected interpretation...
  8. ncbi request reprint Characterization of incidentally identified minute clonal B-lymphocyte populations in peripheral blood and bone marrow
    Weina Chen
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75390 9072, USA
    Am J Clin Pathol 122:588-95. 2004
    ..There were no immunophenotypic differences in patients with and without overt NHL...
  9. ncbi request reprint Haematogones in the peripheral blood of adults: a four-colour flow cytometry study of 102 patients
    Steven H Kroft
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Br J Haematol 126:209-12. 2004
    ..012 x 10(9)/l). PB haematogones belonged exclusively to the most mature maturational stage. These findings have implications for PB analysis of minimal residual disease in acute lymphoblastic leukaemia and follicular lymphoma...
  10. ncbi request reprint Stability of leukemia-associated immunophenotypes in precursor B-lymphoblastic leukemia/lymphoma: a single institution experience
    Weina Chen
    University of Texas Southwestern Medical School, Dallas, TX, USA
    Am J Clin Pathol 127:39-46. 2007
    ..However, new aberrancies were detected in 60% of cases. These findings suggest that FC is suitable for the detection of residual B-ALL, provided that follow-up studies are not too narrowly targeted...
  11. ncbi request reprint Immunophenotypic differentiation between neoplastic plasma cells in mature B-cell lymphoma vs plasma cell myeloma
    Adam C Seegmiller
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Am J Clin Pathol 127:176-81. 2007
    ..However, some extramedullary plasmacytomas showed lymphoma-like phenotypes, suggesting that, in reality, they may represent non-Hodgkin lymphomas with extensive plasmacytic differentiation...
  12. doi request reprint Characterization of immunophenotypic aberrancies in 200 cases of B acute lymphoblastic leukemia
    Adam C Seegmiller
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, USA
    Am J Clin Pathol 132:940-9. 2009
    ..0% aberrantly expressed T cell-associated antigens. There were significant differences in antigen-expression patterns between adult and pediatric B-ALL. Specific aberrancies correlate with recurrent cytogenetic abnormalities in B-ALL...
  13. ncbi request reprint An extranodal nasal natural killer/T-cell lymphoma with isochromosome 7q10 as the sole cytogenetic aberration was initially diagnosed via bone marrow biopsy
    Huan You Wang
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9073, USA
    Arch Pathol Lab Med 131:1709-14. 2007
    ..To our knowledge, this is the first report demonstrating i(7)(q10) as a primary cytogenetic abnormality in an extranodal nasal natural killer cell lymphoma...
  14. ncbi request reprint Comparison of multiparameter flow cytometry with cluster analysis and immunohistochemistry for the detection of CD10 in diffuse large B-Cell lymphomas
    Yin Xu
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
    Mod Pathol 15:413-9. 2002
    ..Our results indicate 75% sensitivity and 100% specificity of CD10 expression by IHC compared with multiparameter FC with cluster analysis and a 6% technical failure rate...
  15. ncbi request reprint Immunophenotype does not correlate with lymph node histology in chronic lymphocytic leukemia/small lymphocytic lymphoma
    Sheryl L Asplund
    University of Texas Southwestern Medical School, Dallas, Texas, USA
    Am J Surg Pathol 26:624-9. 2002
    ..These findings do not support the interpretation that the prominence of proliferation centers in CLL/SLL LNs defines biologically distinct subtypes...
  16. ncbi request reprint Flow cytometric analysis of monocytes as a tool for distinguishing chronic myelomonocytic leukemia from reactive monocytosis
    Yin Xu
    Department of Pathology, University of Texas, Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Am J Clin Pathol 124:799-806. 2005
    ..007). A combination of monocytosis with 2 or more immunophenotypic aberrancies with 20% or more of marrow monocytes showing moderate CD14 expression was 67% sensitive and 100% specific for CMML...
  17. ncbi request reprint ALK-positive diffuse large B-cell lymphoma: report of four cases and review of the literature
    Kaaren K Reichard
    Department of Pathology, University of New Mexico, Albuquerque, NM 87131, USA
    Mod Pathol 20:310-9. 2007
    ..After CHOP and radiotherapy, two stage I patients were free of disease at 58 and 36 months, whereas a stage IV patient was dead of disease at 22 months...
  18. ncbi request reprint The t(14;18) in diffuse large B-cell lymphoma: correlation with germinal center-associated markers and clinical features
    Yin Xu
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9072, USA
    Appl Immunohistochem Mol Morphol 13:116-23. 2005
    ..15 of 34; P = 0.09), but no association with bcl-2 expression, CD10, clinical stage, complete remission, or survival. Among nodal or high-stage (III-IV) DLBCL, cases with the t(14;18) showed a trend toward decreased survival (P = 0.12)...
  19. ncbi request reprint Anaplastic large cell lymphoma: a flow cytometric analysis of 29 cases
    Melissa V Kesler
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Am J Clin Pathol 128:314-22. 2007
    ..042). Most ALCLs can be detected and characterized by multiparameter FC analysis. However, light scatter gating on typical lymphoid regions may yield false-negative results in a substantial number of cases...
  20. doi request reprint A 3-way collision tumor of the upper respiratory tract: a composite of 2 immunophenotypically distinct mantle cell lymphomas and a plasmacytoma
    Huan You Wang
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390 9073, USA
    Hum Pathol 39:781-7. 2008
    ..To our knowledge, this is the first report of a 3-way CL consisting of 2 immunophenotypically distinct MCLs and a plasmacytoma...
  21. ncbi request reprint Unusual immunophenotype of CD8+ T cells in familial hemophagocytic lymphohistiocytosis
    Nitin J Karandikar
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 75390 9072, USA
    Blood 104:2007-9. 2004
    ..This case provides an instructive example of uncontrolled reactive proliferation of CD8+ T cells in FHL, resulting in atypical morphology and unusual immunophenotypic features that might suggest malignancy in other clinical settings...
  22. ncbi request reprint CD5-positive B-cell neoplasms of indeterminate immunophenotype: a clinicopathologic analysis of 26 cases
    Sheryl L Asplund
    Department of Pathology, Hematopathology Division, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Appl Immunohistochem Mol Morphol 13:311-7. 2005
    ..The majority (65%) appear to be chronic lymphocytic leukemia, with most of the remaining cases either definitively mantle cell lymphoma or unclassifiable...
  23. ncbi request reprint Comparative analysis of light chain expression in germinal center cells and mantle cells of reactive lymphoid tissues. A four-color flow cytometric study
    Kaaren K Reichard
    Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75930 9072, USA
    Am J Clin Pathol 119:130-6. 2003
    ..LCRs of GCCs and MCs may differ substantially in reactive lymphoid tissues. These subsets may form distinct clusters and skews in their LCRs and should not be misinterpreted as evidence of occult lymphoma...
  24. ncbi request reprint Composite angioimmunoblastic T-cell lymphoma and diffuse large B-cell lymphoma: a case report and review of the literature
    Yin Xu
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75390 9073, USA
    Am J Clin Pathol 118:848-54. 2002
    ..Ourfindings raise the possibility that the EBV-associated large B-cell lymphoma is a secondary event in AILT via EBV infection or reactivation followed by clonal expansion of an immortalized EBV-infected B cell clone...
  25. ncbi request reprint Assessment of CD10 in the diagnosis of small B-cell lymphomas: a multiparameter flow cytometric study
    Yin Xu
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75390 9073, USA
    Am J Clin Pathol 117:291-300. 2002
    ....
  26. ncbi request reprint Low blast count myeloid disorders with Auer rods: a clinicopathologic analysis of 9 cases
    Monte S Willis
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
    Am J Clin Pathol 124:191-8. 2005
    ..MDSs with fewer than 5% blasts and Auer rods seem to be a heterogeneous group, but rapid progression to death or AML in most cases suggests that Auer rods signify an aggressive biology in MDSs with a low blast count...
  27. ncbi request reprint Zinc-induced copper deficiency: a report of three cases initially recognized on bone marrow examination
    Monte S Willis
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75390 9072, USA
    Am J Clin Pathol 123:125-31. 2005
    ..The morphologic features, clinical manifestations, differential diagnosis, and pathogenetic mechanisms are discussed...
  28. ncbi request reprint Transient stress lymphocytosis: an immunophenotypic characterization of the most common cause of newly identified adult lymphocytosis in a tertiary hospital
    Nitin J Karandikar
    Department of Pathology, University of Texas Southwestern Medical Center at Dallas, USA
    Am J Clin Pathol 117:819-25. 2002
    ..However, naive and memory subsets showed different patterns of alteration within the CD4+ and CD8+ populations, suggesting that acute stress differentially affects the in vivo distribution of these subsets...
  29. ncbi request reprint DNA methylation profiles of lymphoid and hematopoietic malignancies
    Takao Takahashi
    Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Clin Cancer Res 10:2928-35. 2004
    ....
  30. ncbi request reprint Primary effusion lymphomas exhibit complex and recurrent cytogenetic abnormalities
    Kathleen S Wilson
    Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9073, USA
    Br J Haematol 116:113-21. 2002
    ..2 and Xq22 as well as +8, +15, +19, +X and -Y as recurring chromosome abnormalities. The identification of recurring cytogenetic aberrations may lead to delineation of the genetic events in PEL...
  31. ncbi request reprint White blood cell changes in hyperthermia
    Patrick C J Ward
    Department of Anatomy, Microbiology and Pathology, University of Minnesota Medical School Duluth, Duluth, MN, USA
    Br J Haematol 138:130. 2007
  32. ncbi request reprint Isolated bone marrow manifestation of HIV-associated Hodgkin lymphoma
    Maurilio Ponzoni
    Department of Pathology, S Raffaele H Scientific Institute, Milan, Italy
    Mod Pathol 15:1273-8. 2002
    ..A rapid diagnosis of isolated bone marrow HIV-associated Hodgkin lymphoma could expedite therapy...