M C McKenna

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. pmc Substrate competition studies demonstrate oxidative metabolism of glucose, glutamate, glutamine, lactate and 3-hydroxybutyrate in cortical astrocytes from rat brain
    Mary C McKenna
    Department of Pediatrics and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA
    Neurochem Res 37:2613-26. 2012
  2. pmc Glutamate dehydrogenase in brain mitochondria: do lipid modifications and transient metabolon formation influence enzyme activity?
    Mary C McKenna
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Neurochem Int 59:525-33. 2011
  3. ncbi request reprint The glutamate-glutamine cycle is not stoichiometric: fates of glutamate in brain
    Mary C McKenna
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Neurosci Res 85:3347-58. 2007
  4. ncbi request reprint Aspartate aminotransferase in synaptic and nonsynaptic mitochondria: differential effect of compounds that influence transient hetero-enzyme complex (metabolon) formation
    Mary C McKenna
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, 21201, USA
    Neurochem Int 48:629-36. 2006
  5. ncbi request reprint GABA alters the metabolic fate of [U-13C]glutamate in cultured cortical astrocytes
    Mary C McKenna
    Department of Pediatrics, University of Maryland School of Medicine, 655 W Baltimore Street, Room 10 031, Baltimore, MD 21201, USA
    J Neurosci Res 79:81-7. 2005
  6. ncbi request reprint Glutamate metabolism in primary cultures of rat brain astrocytes: rationale and initial efforts toward developing a compartmental model
    Mary C McKenna
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Adv Exp Med Biol 537:317-41. 2003
  7. ncbi request reprint Alpha-cyano-4-hydroxycinnamate decreases both glucose and lactate metabolism in neurons and astrocytes: implications for lactate as an energy substrate for neurons
    M C McKenna
    Department of Pediatrics, University of Maryland School of Medicine, 10 035 BRB, 655 W Baltimore Street, Baltimore, MD 21201, USA
    J Neurosci Res 66:747-54. 2001
  8. ncbi request reprint Lactate transport by cortical synaptosomes from adult rat brain: characterization of kinetics and inhibitor specificity
    M C McKenna
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA
    Dev Neurosci 20:300-9. 1998
  9. ncbi request reprint Mitochondrial malic enzyme activity is much higher in mitochondria from cortical synaptic terminals compared with mitochondria from primary cultures of cortical neurons or cerebellar granule cells
    M C McKenna
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA
    Neurochem Int 36:451-9. 2000
  10. ncbi request reprint Differential distribution of the enzymes glutamate dehydrogenase and aspartate aminotransferase in cortical synaptic mitochondria contributes to metabolic compartmentation in cortical synaptic terminals
    M C McKenna
    Department of Pediatrics, School of Medicine, University of Maryland, Baltimore 21201, USA
    Neurochem Int 37:229-41. 2000

Collaborators

Detail Information

Publications19

  1. pmc Substrate competition studies demonstrate oxidative metabolism of glucose, glutamate, glutamine, lactate and 3-hydroxybutyrate in cortical astrocytes from rat brain
    Mary C McKenna
    Department of Pediatrics and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA
    Neurochem Res 37:2613-26. 2012
    ..The data also provide evidence of interactions of substrates and multiple compartments of TCA cycle activity in cultured astrocytes...
  2. pmc Glutamate dehydrogenase in brain mitochondria: do lipid modifications and transient metabolon formation influence enzyme activity?
    Mary C McKenna
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Neurochem Int 59:525-33. 2011
    ..It is likely that these modifications and interactions contribute additional levels of regulation of GDH activity and glutamate metabolism...
  3. ncbi request reprint The glutamate-glutamine cycle is not stoichiometric: fates of glutamate in brain
    Mary C McKenna
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    J Neurosci Res 85:3347-58. 2007
    ..However, the glutamate-glutamine cycle is not a stoichiometric cycle but rather an open pathway that interfaces with many other metabolic pathways to varying extents depending on cellular requirements and priorities...
  4. ncbi request reprint Aspartate aminotransferase in synaptic and nonsynaptic mitochondria: differential effect of compounds that influence transient hetero-enzyme complex (metabolon) formation
    Mary C McKenna
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, 21201, USA
    Neurochem Int 48:629-36. 2006
    ..This may have a role in the compartmentation of glutamate metabolism in brain...
  5. ncbi request reprint GABA alters the metabolic fate of [U-13C]glutamate in cultured cortical astrocytes
    Mary C McKenna
    Department of Pediatrics, University of Maryland School of Medicine, 655 W Baltimore Street, Room 10 031, Baltimore, MD 21201, USA
    J Neurosci Res 79:81-7. 2005
    ....
  6. ncbi request reprint Glutamate metabolism in primary cultures of rat brain astrocytes: rationale and initial efforts toward developing a compartmental model
    Mary C McKenna
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Adv Exp Med Biol 537:317-41. 2003
  7. ncbi request reprint Alpha-cyano-4-hydroxycinnamate decreases both glucose and lactate metabolism in neurons and astrocytes: implications for lactate as an energy substrate for neurons
    M C McKenna
    Department of Pediatrics, University of Maryland School of Medicine, 10 035 BRB, 655 W Baltimore Street, Baltimore, MD 21201, USA
    J Neurosci Res 66:747-54. 2001
    ....
  8. ncbi request reprint Lactate transport by cortical synaptosomes from adult rat brain: characterization of kinetics and inhibitor specificity
    M C McKenna
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA
    Dev Neurosci 20:300-9. 1998
    ..Uptake of lactate by synaptic terminals also has differences from the systems described for neurons...
  9. ncbi request reprint Mitochondrial malic enzyme activity is much higher in mitochondria from cortical synaptic terminals compared with mitochondria from primary cultures of cortical neurons or cerebellar granule cells
    M C McKenna
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA
    Neurochem Int 36:451-9. 2000
    ..The extremely high activity of mME in synaptic mitochondria is consistent with a role for mME in the pyruvate recycling pathway, and a function in maintaining the intramitochondrial reduced glutathione in synaptic terminals...
  10. ncbi request reprint Differential distribution of the enzymes glutamate dehydrogenase and aspartate aminotransferase in cortical synaptic mitochondria contributes to metabolic compartmentation in cortical synaptic terminals
    M C McKenna
    Department of Pediatrics, School of Medicine, University of Maryland, Baltimore 21201, USA
    Neurochem Int 37:229-41. 2000
    ..1998b. Dev. Neurosci. 20, 310-320)...
  11. ncbi request reprint Regulation of malate dehydrogenases from neonatal, adolescent, and mature rat brain
    P Malik
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201
    Neurochem Res 18:247-57. 1993
    ..The greater sensitivity of mMDH, compared to cMDH, to certain effectors may be related to the dual role of mMDH in the tricarboxylic acid cycle and the malate-aspartate shuttle...
  12. ncbi request reprint Kinetic parameters and lactate dehydrogenase isozyme activities support possible lactate utilization by neurons
    Koffi M Kla
    Department of Pediatrics, University of Maryland School of Medicine, 655 W Baltimore Street, Baltimore, MD 21201 1559, USA
    Neurochem Res 32:597-607. 2007
    ..However, the kinetics of LDH in brain are consistent with the possible release of lactate by astrocytes and oxidative use of lactate for energy in synaptic terminals...
  13. pmc Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature rats
    Paula A Casey
    Department of Pediatrics, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
    J Neurotrauma 25:603-14. 2008
    ..Evaluation of early metabolic alterations after TBI could identify novel targets for neuroprotection in the developing brain...
  14. ncbi request reprint Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools
    Mary C McKenna
    Department of Pediatrics, University of Maryland School of Medicine, 655 West Baltimore Street, Room 10 031, Baltimore, MD 21201 1509, USA
    Biochem Pharmacol 71:399-407. 2006
    ..This report evaluates the evidence for each shuttle in brain cells and the drugs that can be used as pharmacological tools to study these shuttles...
  15. pmc Isolation of mitochondria with high respiratory control from primary cultures of neurons and astrocytes using nitrogen cavitation
    Tibor Kristian
    Department of Anesthesiology, School of Medicine, University of Maryland, 685 West Baltimore Street, MSTF 534, Baltimore, MD 21201, USA
    J Neurosci Methods 152:136-43. 2006
    ..This technique thus will allow examination of mitochondria that are exclusively cell specific in origin...
  16. doi request reprint Metabolism of acetyl-L-carnitine for energy and neurotransmitter synthesis in the immature rat brain
    Susanna Scafidi
    Department of Pediatrics, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurochem 114:820-31. 2010
    ..This is, to our knowledge, the first study to determine the extent and pathways of ALCAR metabolism for energy and neurotransmitter biosynthesis in the brain...
  17. pmc Hyperoxic reperfusion after global ischemia decreases hippocampal energy metabolism
    Erica M Richards
    Program in Neuroscience, The Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, USA
    Stroke 38:1578-84. 2007
    ..Using a clinically relevant canine cardiac arrest model, in this study we tested the hypothesis that hyperoxic reperfusion decreases hippocampal glucose metabolism and glutamate synthesis...
  18. pmc Postischemic oxidative stress promotes mitochondrial metabolic failure in neurons and astrocytes
    Gary Fiskum
    Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Ann N Y Acad Sci 1147:129-38. 2008
    ..These results support the hypothesis that release and or consumption of mitochondrial NAD(H) is at least partially responsible for respiratory inhibition, particularly in neurons...
  19. pmc Mitochondrial mechanisms of cell death and neuroprotection in pediatric ischemic and traumatic brain injury
    Courtney L Robertson
    Department of Pediatrics, University of Maryland School of Medicine, Baltimore, 21201, USA
    Exp Neurol 218:371-80. 2009
    ..g., ketone bodies, directly interfering with apoptotic pathways at the mitochondrial level, and pharmacologic induction of antioxidant and anti-inflammatory gene expression...