Research Topics
| M C McKennaSummaryAffiliation: University of Maryland Country: USA Publications
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Publications
Substrate competition studies demonstrate oxidative metabolism of glucose, glutamate, glutamine, lactate and 3-hydroxybutyrate in cortical astrocytes from rat brainMary C McKenna
Department of Pediatrics and Program in Neuroscience, University of Maryland School of Medicine, Baltimore, MD, USA
Neurochem Res 37:2613-26. 2012..The data also provide evidence of interactions of substrates and multiple compartments of TCA cycle activity in cultured astrocytes...- Glutamate dehydrogenase in brain mitochondria: do lipid modifications and transient metabolon formation influence enzyme activity?Mary C McKenna
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Neurochem Int 59:525-33. 2011..It is likely that these modifications and interactions contribute additional levels of regulation of GDH activity and glutamate metabolism... 
The glutamate-glutamine cycle is not stoichiometric: fates of glutamate in brainMary C McKenna
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
J Neurosci Res 85:3347-58. 2007..However, the glutamate-glutamine cycle is not a stoichiometric cycle but rather an open pathway that interfaces with many other metabolic pathways to varying extents depending on cellular requirements and priorities...- Aspartate aminotransferase in synaptic and nonsynaptic mitochondria: differential effect of compounds that influence transient hetero-enzyme complex (metabolon) formationMary C McKenna
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, 21201, USA
Neurochem Int 48:629-36. 2006..This may have a role in the compartmentation of glutamate metabolism in brain... - GABA alters the metabolic fate of [U-13C]glutamate in cultured cortical astrocytesMary C McKenna
Department of Pediatrics, University of Maryland School of Medicine, 655 W Baltimore Street, Room 10 031, Baltimore, MD 21201, USA
J Neurosci Res 79:81-7. 2005.... - Glutamate metabolism in primary cultures of rat brain astrocytes: rationale and initial efforts toward developing a compartmental modelMary C McKenna
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Adv Exp Med Biol 537:317-41. 2003 - Alpha-cyano-4-hydroxycinnamate decreases both glucose and lactate metabolism in neurons and astrocytes: implications for lactate as an energy substrate for neuronsM C McKenna
Department of Pediatrics, University of Maryland School of Medicine, 10 035 BRB, 655 W Baltimore Street, Baltimore, MD 21201, USA
J Neurosci Res 66:747-54. 2001.... - Lactate transport by cortical synaptosomes from adult rat brain: characterization of kinetics and inhibitor specificityM C McKenna
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, MD, USA
Dev Neurosci 20:300-9. 1998..Uptake of lactate by synaptic terminals also has differences from the systems described for neurons... - Mitochondrial malic enzyme activity is much higher in mitochondria from cortical synaptic terminals compared with mitochondria from primary cultures of cortical neurons or cerebellar granule cellsM C McKenna
Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201, USA
Neurochem Int 36:451-9. 2000..The extremely high activity of mME in synaptic mitochondria is consistent with a role for mME in the pyruvate recycling pathway, and a function in maintaining the intramitochondrial reduced glutathione in synaptic terminals... - Differential distribution of the enzymes glutamate dehydrogenase and aspartate aminotransferase in cortical synaptic mitochondria contributes to metabolic compartmentation in cortical synaptic terminalsM C McKenna
Department of Pediatrics, School of Medicine, University of Maryland, Baltimore 21201, USA
Neurochem Int 37:229-41. 2000..1998b. Dev. Neurosci. 20, 310-320)... - Regulation of malate dehydrogenases from neonatal, adolescent, and mature rat brainP Malik
Department of Pediatrics, University of Maryland School of Medicine, Baltimore 21201
Neurochem Res 18:247-57. 1993..The greater sensitivity of mMDH, compared to cMDH, to certain effectors may be related to the dual role of mMDH in the tricarboxylic acid cycle and the malate-aspartate shuttle... - Kinetic parameters and lactate dehydrogenase isozyme activities support possible lactate utilization by neuronsKoffi M Kla
Department of Pediatrics, University of Maryland School of Medicine, 655 W Baltimore Street, Baltimore, MD 21201 1559, USA
Neurochem Res 32:597-607. 2007..However, the kinetics of LDH in brain are consistent with the possible release of lactate by astrocytes and oxidative use of lactate for energy in synaptic terminals... - Early and sustained alterations in cerebral metabolism after traumatic brain injury in immature ratsPaula A Casey
Department of Pediatrics, University of Maryland School of Medicine, 22 South Greene Street, Baltimore, MD 21201, USA
J Neurotrauma 25:603-14. 2008..Evaluation of early metabolic alterations after TBI could identify novel targets for neuroprotection in the developing brain... - Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological toolsMary C McKenna
Department of Pediatrics, University of Maryland School of Medicine, 655 West Baltimore Street, Room 10-031, Baltimore, MD 21201-1509, USA
Biochem Pharmacol 71:399-407. 2006..This report evaluates the evidence for each shuttle in brain cells and the drugs that can be used as pharmacological tools to study these shuttles... - Isolation of mitochondria with high respiratory control from primary cultures of neurons and astrocytes using nitrogen cavitationTibor Kristian
Department of Anesthesiology, School of Medicine, University of Maryland, 685 West Baltimore Street, MSTF 534, Baltimore, MD 21201, USA
J Neurosci Methods 152:136-43. 2006..This technique thus will allow examination of mitochondria that are exclusively cell specific in origin... 
Metabolism of acetyl-L-carnitine for energy and neurotransmitter synthesis in the immature rat brainSusanna Scafidi
Department of Pediatrics, University of Maryland, Baltimore, Maryland 21201, USA
J Neurochem 114:820-31. 2010..This is, to our knowledge, the first study to determine the extent and pathways of ALCAR metabolism for energy and neurotransmitter biosynthesis in the brain...- Hyperoxic reperfusion after global ischemia decreases hippocampal energy metabolismErica M Richards
Program in Neuroscience, The Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD, USA
Stroke 38:1578-84. 2007..Using a clinically relevant canine cardiac arrest model, in this study we tested the hypothesis that hyperoxic reperfusion decreases hippocampal glucose metabolism and glutamate synthesis... - Postischemic oxidative stress promotes mitochondrial metabolic failure in neurons and astrocytesGary Fiskum
Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Ann N Y Acad Sci 1147:129-38. 2008..These results support the hypothesis that release and or consumption of mitochondrial NAD(H) is at least partially responsible for respiratory inhibition, particularly in neurons... - Mitochondrial mechanisms of cell death and neuroprotection in pediatric ischemic and traumatic brain injuryCourtney L Robertson
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, 21201, USA
Exp Neurol 218:371-80. 2009..g., ketone bodies, directly interfering with apoptotic pathways at the mitochondrial level, and pharmacologic induction of antioxidant and anti-inflammatory gene expression...