Brian S McKay

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. pmc A role for myocilin in receptor-mediated endocytosis
    Brian S McKay
    Department of Ophthalmology and Vision Science, University of Arizona, Tucson, Arrizona Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arrizona
    PLoS ONE 8:e82301. 2013
  2. ncbi request reprint Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement
    W Daniel Stamer
    Department of Ophthalmology, The University of Arizona, Tucson, Arizona 85711 1824, USA
    Invest Ophthalmol Vis Sci 44:2803-8. 2003
  3. pmc Myocilin, a component of a membrane-associated protein complex driven by a homologous Q-SNARE domain
    W Michael Dismuke
    Ophthalmology and Vision Science, University of Arizona, Tucson, Arizona 85724, United States
    Biochemistry 51:3606-13. 2012
  4. ncbi request reprint Extracellular trafficking of myocilin in human trabecular meshwork cells
    Katharine M Hardy
    Department of Cell Biology, The University of Arizona, Tucson, AZ 85724, USA
    J Biol Chem 280:28917-26. 2005
  5. pmc L-DOPA is an endogenous ligand for OA1
    Vanessa M Lopez
    Department of Ophthalmology and Vision Science, The University of Arizona, Tucson, Arizona, USA
    PLoS Biol 6:e236. 2008
  6. ncbi request reprint Retinal pigment epithelial cell transplantation could provide trophic support in Parkinson's disease: results from an in vitro model system
    Brian S McKay
    Department of Ophthalmology and Vision Science, Cell Biology and Anatomy, The University of Arizona, Tucson, AZ, USA
    Exp Neurol 201:234-43. 2006
  7. ncbi request reprint Ca++-switch induction of RPE differentiation
    Daniel J Rak
    Department of Ophthalmology, The University of Arizona, Tucson, AZ, USA
    Exp Eye Res 82:648-56. 2006
  8. ncbi request reprint Barriers to productive transfection of trabecular meshwork cells
    Emely A Hoffman
    Department of Ophthalmology and Vision Science, The University of Arizona, Tucson, AZ 85711, USA
    Mol Vis 11:869-75. 2005
  9. ncbi request reprint Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells
    Ping Yang
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 45:2438-46. 2004
  10. ncbi request reprint Effect of mutant IkappaB on cytokine-induced activation of NF-kappaB in cultured human RPE cells
    Ping Yang
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 44:1339-47. 2003

Collaborators

  • W Daniel Stamer
  • Dean Bok
  • Pedro Gonzalez
  • Ping Yang
  • Emely A Hoffman
  • W Michael Dismuke
  • Glenn J Jaffe
  • Vanessa M Lopez
  • Daniel J Rak
  • Katharine M Hardy
  • Janice B Allen
  • Ronald M Lynch
  • Christina L Decatur
  • Katherine M Hardy
  • Shannon M Conley
  • Wendy L Roberts

Detail Information

Publications10

  1. pmc A role for myocilin in receptor-mediated endocytosis
    Brian S McKay
    Department of Ophthalmology and Vision Science, University of Arizona, Tucson, Arrizona Department of Cellular and Molecular Medicine, University of Arizona, Tucson, Arrizona
    PLoS ONE 8:e82301. 2013
    ..1% SDS. Collectively, data indicate that myocilin is recruited to the membrane compartment, interacting with GPCR proteins during ligand-mediated endocytosis and that GPCR signaling underlies pathology in myocilin glaucoma. ..
  2. ncbi request reprint Aquaporin-1 channels in human retinal pigment epithelium: role in transepithelial water movement
    W Daniel Stamer
    Department of Ophthalmology, The University of Arizona, Tucson, Arizona 85711 1824, USA
    Invest Ophthalmol Vis Sci 44:2803-8. 2003
    ....
  3. pmc Myocilin, a component of a membrane-associated protein complex driven by a homologous Q-SNARE domain
    W Michael Dismuke
    Ophthalmology and Vision Science, University of Arizona, Tucson, Arizona 85724, United States
    Biochemistry 51:3606-13. 2012
    ..By identifying the Q-SNARE homology within the second coil of myocilin and documenting its participation in a SNARE-like complex, we provide evidence of a SNARE domain-containing protein associated with a human disease...
  4. ncbi request reprint Extracellular trafficking of myocilin in human trabecular meshwork cells
    Katharine M Hardy
    Department of Cell Biology, The University of Arizona, Tucson, AZ 85724, USA
    J Biol Chem 280:28917-26. 2005
    ..Taken together, data suggest that MYOC appears in the extracellular space of trabecular meshwork cells by an unconventional mechanism, likely associated with exosome-like vesicles...
  5. pmc L-DOPA is an endogenous ligand for OA1
    Vanessa M Lopez
    Department of Ophthalmology and Vision Science, The University of Arizona, Tucson, Arizona, USA
    PLoS Biol 6:e236. 2008
    ..Our results suggest that the retinal consequences of albinism caused by changes in melanin synthetic machinery may be treated by L-DOPA supplementation...
  6. ncbi request reprint Retinal pigment epithelial cell transplantation could provide trophic support in Parkinson's disease: results from an in vitro model system
    Brian S McKay
    Department of Ophthalmology and Vision Science, Cell Biology and Anatomy, The University of Arizona, Tucson, AZ, USA
    Exp Neurol 201:234-43. 2006
    ..These results indicate that transplantation RPE cells could potentially provide a dual benefit in Parkinson's disease producing both dopamine and neurotrophic support of the basal ganglia...
  7. ncbi request reprint Ca++-switch induction of RPE differentiation
    Daniel J Rak
    Department of Ophthalmology, The University of Arizona, Tucson, AZ, USA
    Exp Eye Res 82:648-56. 2006
    ..Thus, we suggest that this method produces phenotypic changes through multiple cell signalling pathways...
  8. ncbi request reprint Barriers to productive transfection of trabecular meshwork cells
    Emely A Hoffman
    Department of Ophthalmology and Vision Science, The University of Arizona, Tucson, AZ 85711, USA
    Mol Vis 11:869-75. 2005
    ..We hypothesize that low transfection efficiencies of primary human trabecular meshwork (HTM) cell cultures with plasmid DNA are a function of retained capacity to efficiently degrade exogenous DNA in vitro...
  9. ncbi request reprint Effect of NF-kappa B inhibition on TNF-alpha-induced apoptosis in human RPE cells
    Ping Yang
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 45:2438-46. 2004
    ....
  10. ncbi request reprint Effect of mutant IkappaB on cytokine-induced activation of NF-kappaB in cultured human RPE cells
    Ping Yang
    Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Invest Ophthalmol Vis Sci 44:1339-47. 2003
    ..The persistence of recombinant protein expression and function after the viral infection was also examined...