Susan C McKarns

Summary

Affiliation: University of Missouri
Country: USA

Publications

  1. ncbi Smad3 is essential for TGF-beta 1 to suppress IL-2 production and TCR-induced proliferation, but not IL-2-induced proliferation
    Susan C McKarns
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 USA
    J Immunol 172:4275-84. 2004
  2. ncbi Distinct effects of TGF-beta 1 on CD4+ and CD8+ T cell survival, division, and IL-2 production: a role for T cell intrinsic Smad3
    Susan C McKarns
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:2071-83. 2005
  3. ncbi Biphasic regulation of Il2 transcription in CD4+ T cells: roles for TNF-alpha receptor signaling and chromatin structure
    Susan C McKarns
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:1272-81. 2008

Collaborators

Detail Information

Publications3

  1. ncbi Smad3 is essential for TGF-beta 1 to suppress IL-2 production and TCR-induced proliferation, but not IL-2-induced proliferation
    Susan C McKarns
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 USA
    J Immunol 172:4275-84. 2004
    ..Thus, we establish that TGF-beta1 signals through multiple pathways to suppress T cell proliferation...
  2. ncbi Distinct effects of TGF-beta 1 on CD4+ and CD8+ T cell survival, division, and IL-2 production: a role for T cell intrinsic Smad3
    Susan C McKarns
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 174:2071-83. 2005
    ..Collectively, these findings firmly establish for the first time that TGF-beta1 discriminately regulates CD4+ and CD8+ T cell expansion by signaling through distinct intracellular pathways...
  3. ncbi Biphasic regulation of Il2 transcription in CD4+ T cells: roles for TNF-alpha receptor signaling and chromatin structure
    Susan C McKarns
    Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 181:1272-81. 2008
    ..This is provided, at least partially, by TNFR signaling during priming, but not during recall...