Jonathan B McHugh

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. doi request reprint The clinical significance of focally enhanced gastritis in children
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
    Am J Surg Pathol 37:295-9. 2013
  2. ncbi request reprint Atypical compound nevus arising in mature cystic ovarian teratoma
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
    Med Sci Monit 12:CS34-7. 2006
  3. doi request reprint Update on selected salivary gland neoplasms
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Pathol Lab Med 133:1763-74. 2009
  4. doi request reprint Sino-orbital osteoma: a clinicopathologic study of 45 surgically treated cases with emphasis on tumors with osteoblastoma-like features
    Jonathan B McHugh
    Department of Pathology, University of Michigan Health System, Ann Arbor, MI 48109 0054, USA
    Arch Pathol Lab Med 133:1587-93. 2009
  5. pmc p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma
    Jonathan B McHugh
    Department of Pathology, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0054, USA
    Head Neck Pathol 1:123-31. 2007
  6. doi request reprint Association of cystic neck metastases and human papillomavirus-positive oropharyngeal squamous cell carcinoma
    Jonathan B McHugh
    Department of Pathology, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
    Arch Pathol Lab Med 133:1798-803. 2009
  7. pmc HPV-positive/p16-positive/EBV-negative nasopharyngeal carcinoma in white North Americans
    Jessica H Maxwell
    University of Michigan Medical School, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI, USA
    Head Neck 32:562-7. 2010
  8. pmc Comprehensive analysis of DNA methylation in head and neck squamous cell carcinoma indicates differences by survival and clinicopathologic characteristics
    Justin A Colacino
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    PLoS ONE 8:e54742. 2013
  9. pmc Head and neck squamous cell carcinoma in pregnant women
    Anna M Eliassen
    Department of Otolaryngology Head and Neck Surgery, The University of Michigan, Ann Arbor, Michigan, USA
    Head Neck 35:335-42. 2013
  10. pmc Matted nodes: poor prognostic marker in oropharyngeal squamous cell carcinoma independent of HPV and EGFR status
    Matthew E Spector
    Departments of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
    Head Neck 34:1727-33. 2012

Detail Information

Publications44

  1. doi request reprint The clinical significance of focally enhanced gastritis in children
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
    Am J Surg Pathol 37:295-9. 2013
    ..The presence of FEG is highly associated with IBD in pediatric patients. The presence of FEG does not reliably distinguish between patients with CD and those with UC...
  2. ncbi request reprint Atypical compound nevus arising in mature cystic ovarian teratoma
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
    Med Sci Monit 12:CS34-7. 2006
    ..Mature cystic ovarian teratoma (MCOT) is the most common primary ovarian tumor. Rarely, MCOT may undergo malignant transformation. Melanoma arising primarily in MCOT is a rare event. Melanocytic nevi have also rarely been reported in MCOT...
  3. doi request reprint Update on selected salivary gland neoplasms
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Pathol Lab Med 133:1763-74. 2009
    ..3% of all malignancies. In addition to their rarity, diagnosing these tumors can be challenging given the histologic overlap among various subtypes, their morphologic heterogeneity, and the recent recognition of new entities...
  4. doi request reprint Sino-orbital osteoma: a clinicopathologic study of 45 surgically treated cases with emphasis on tumors with osteoblastoma-like features
    Jonathan B McHugh
    Department of Pathology, University of Michigan Health System, Ann Arbor, MI 48109 0054, USA
    Arch Pathol Lab Med 133:1587-93. 2009
    ..Osteomas may have osteoblastoma-like areas and distinguishing it from true osteoblastoma can be challenging. Some believe osteomas with osteoblastoma-like features behave more aggressively...
  5. pmc p63 immunohistochemistry differentiates salivary gland oncocytoma and oncocytic carcinoma from metastatic renal cell carcinoma
    Jonathan B McHugh
    Department of Pathology, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0054, USA
    Head Neck Pathol 1:123-31. 2007
    ..While RCCm, CD10, and vimentin performed adequately, they were significantly less reliable than p63 with both false positives and false negatives...
  6. doi request reprint Association of cystic neck metastases and human papillomavirus-positive oropharyngeal squamous cell carcinoma
    Jonathan B McHugh
    Department of Pathology, University of Michigan Health Systems, Ann Arbor, MI 48109, USA
    Arch Pathol Lab Med 133:1798-803. 2009
    ..Recognition of this unique clinicopathologic subset of head and neck carcinoma is important because these patients typically respond more favorably to organ-sparing treatment modalities and have an improved prognosis...
  7. pmc HPV-positive/p16-positive/EBV-negative nasopharyngeal carcinoma in white North Americans
    Jessica H Maxwell
    University of Michigan Medical School, The University of Michigan Health System and Comprehensive Cancer Center, Ann Arbor, MI, USA
    Head Neck 32:562-7. 2010
    ..The HPV, p16, and EBV status was examined in current University of Michigan patients with NPC...
  8. pmc Comprehensive analysis of DNA methylation in head and neck squamous cell carcinoma indicates differences by survival and clinicopathologic characteristics
    Justin A Colacino
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA
    PLoS ONE 8:e54742. 2013
    ..These findings provide insight into the epigenetic regulation of viral vs. chemical carcinogenesis and could provide novel targets for development of individualized therapeutic and prevention regimens based on environmental exposures...
  9. pmc Head and neck squamous cell carcinoma in pregnant women
    Anna M Eliassen
    Department of Otolaryngology Head and Neck Surgery, The University of Michigan, Ann Arbor, Michigan, USA
    Head Neck 35:335-42. 2013
    ..The aim of this study was to investigate oral cancer in pregnant women, a rare but therapeutically challenging patient subset...
  10. pmc Matted nodes: poor prognostic marker in oropharyngeal squamous cell carcinoma independent of HPV and EGFR status
    Matthew E Spector
    Departments of Otolaryngology Head and Neck Surgery, University of Michigan Health System, Ann Arbor, Michigan, USA
    Head Neck 34:1727-33. 2012
    ..Despite better prognosis, there is a group of oropharyngeal squamous cell carcinoma (SCC) human papillomavirus (HPV)+ patients who experience treatment failure and succumb to distant metastasis...
  11. doi request reprint High-risk human papillomavirus detection in oropharyngeal, nasopharyngeal, and oral cavity cancers: comparison of multiple methods
    Heather M Walline
    Cancer Biology Program, Program in the Biomedical Sciences, Rackham Graduate School, University of Michigan, Ann Arbor
    JAMA Otolaryngol Head Neck Surg 139:1320-7. 2013
    ..PCR-MA together with p16INK4a provided accurate assessment of HPV presence, type, and activity and was determined to be the best approach for HPV testing in FFPE head and neck tumor tissue specimens. ..
  12. doi request reprint Undifferentiated small round cell sarcoma with t(4;19)(q35;q13.1) CIC-DUX4 fusion: a novel highly aggressive soft tissue tumor with distinctive histopathology
    Eun Young Karen Choi
    Departments of Pathology Internal Medicine Orthopedic Surgery, University of Michigan, Ann Arbor, MI
    Am J Surg Pathol 37:1379-86. 2013
    ..8 months. CIC-DUX4 sarcoma represents a novel translocation-associated sarcoma with distinctive histopathologic features and rapid disease progression. ..
  13. doi request reprint Predictors of recurrence and survival for head and neck mucoepidermoid carcinoma
    Serena A Byrd
    Departments of Otolaryngology Head and Neck Surgery, Pathology, University of Michigan Health System, Ann Arbor, Michigan, USA
    Otolaryngol Head Neck Surg 149:402-8. 2013
    ..To describe the epidemiology and determine the clinicopathologic predictors of recurrence and survival in patients with head and neck mucoepidermoid carcinoma (MEC)...
  14. doi request reprint Impact of perineural invasion in the pathologically N0 neck in oral cavity squamous cell carcinoma
    Steven B Chinn
    Department of Otolaryngology Head and Neck Surgery, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Otolaryngol Head Neck Surg 149:893-9. 2013
    ..In the absence of these high-risk features, our objective was to determine if perineural invasion (PNI) is an independent risk factor and if adjuvant radiation (XRT) improves disease control rates...
  15. doi request reprint CT and MRI appearances and radiologic staging of pediatric renal cell carcinoma
    Ryan T Downey
    Department of Radiology, University of Michigan Health System, Ann Arbor, MI 48109, USA
    Pediatr Radiol 42:410-7; quiz 513-4. 2012
    ..There is a paucity of published data regarding the CT/MRI appearances and accuracy of pretreatment radiologic staging of this form of cancer in children...
  16. doi request reprint CD34-positive superficial myxofibrosarcoma: a potential diagnostic pitfall
    Steven C Smith
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0602, USA
    J Cutan Pathol 40:639-45. 2013
    ..Case series have not assessed prevalence of CD34 reactivity among cutaneous examples of MFS...
  17. doi request reprint p63, CK7, PAX8 and INI-1: an optimal immunohistochemical panel to distinguish poorly differentiated urothelial cell carcinoma from high-grade tumours of the renal collecting system
    Jason C Carvalho
    Department of Pathology, University of Michigan Medical Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109 0602, USA
    Histopathology 60:597-608. 2012
    ..Accurate classification, especially the distinction of UC from RCC, is critical, as therapeutic approaches differ...
  18. pmc Sinonasal lobular capillary hemangioma: a clinicopathologic study of 34 cases characterizing potential for local recurrence
    Steven C Smith
    Department of Pathology, University of Michigan Health System, 2G332 UH, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA
    Head Neck Pathol 7:129-34. 2013
    ..Awareness of this may aid in avoiding misdiagnosis of these lesions as more aggressive entities such as angiofibroma and angiosarcoma...
  19. doi request reprint MRI diffusion-weighted imaging (DWI) in pediatric small bowel Crohn disease: correlation with MRI findings of active bowel wall inflammation
    Justin M Ream
    Department of Radiology, University of Michigan Health System, Ann Arbor, MI, USA
    Pediatr Radiol 43:1077-85. 2013
    ..However, the exact meaning of this finding, particularly within the pediatric Crohn disease population, is poorly understood...
  20. doi request reprint Sinonasal undifferentiated carcinoma and esthesioneuroblastoma recurring as nonintestinal adenocarcinoma
    Stephen Y Kang
    Department of Otolaryngology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    Laryngoscope 123:1121-4. 2013
    ..While rare, this report highlights the possibility of encountering a distinct tumor type in the posttreatment surveillance of patients with anterior cranial base malignancies...
  21. doi request reprint Cross-sectional imaging of primary thoracic sarcomas with histopathologic correlation: a review for the radiologist
    Jonathan R Dillman
    Department of Radiology, University of Michigan Health System, C S Mott Children s Hospital, Section of Pediatric Radiology, Ann Arbor, MI 48109 0252, USA
    Curr Probl Diagn Radiol 39:17-29. 2010
    ..The purpose of this article is to review the various forms of primary sarcoma that may affect the thorax as well as illustrate pertinent cross-sectional radiologic findings with histopathologic correlation...
  22. doi request reprint Fine-needle aspiration cytology of Rosai-Dorfman disease of bone
    Xin Jing
    Department of Pathology, University of Michigan Health System, Ann Arbor, Michigan 48109, USA
    Diagn Cytopathol 36:516-8. 2008
    ..The diagnosis was confirmed by concurrent biopsy with immunhistochemical study. Our case highlighted the role of fine-needle aspiration with ThinPrep technique in the diagnosis of Rosai-Dorfman disease...
  23. doi request reprint Synchronous ipsilateral sebaceous lymphadenoma and membranous basal cell adenoma of the parotid
    Erica L Scheller
    Department of Periodontics and Oral Medicine, University of Michigan, Ann Arbor, Michigan, USA
    Oral Surg Oral Med Oral Pathol Oral Radiol 115:e41-6. 2013
    ..In this report, we present the case with its management, followed by a discussion of the histopathologic nature of each tumor including the possible overlap between these two entities...
  24. doi request reprint Epidermal growth factor receptor, p16, cyclin D1, and p53 staining patterns for inverted papilloma
    Giant C Lin
    Department of Otolaryngology, University of Michigan Health Systems, Ann Arbor, MI
    Int Forum Allergy Rhinol 3:885-9. 2013
    ....
  25. doi request reprint Napsin A is differentially expressed in sclerosing hemangiomas of the lung
    Lindsay A Schmidt
    Department of Pathology, University of Michigan Health System, Ann Arbor, MI 48109 0054, USA
    Arch Pathol Lab Med 136:1580-4. 2012
    ....
  26. doi request reprint Cutaneous and subcutaneous pleomorphic liposarcoma: a clinicopathologic study of 29 cases with evaluation of MDM2 gene amplification in 26
    Jerad M Gardner
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
    Am J Surg Pathol 36:1047-51. 2012
    ..The low incidence of MDM2 gene amplification in our series indicates that most superficial PLs are unrelated to WDL/DL. PL likely evolves by way of more than 1 molecular pathway...
  27. pmc Tobacco use in human papillomavirus-positive advanced oropharynx cancer patients related to increased risk of distant metastases and tumor recurrence
    Jessica H Maxwell
    Departments of Otolaryngology Head and Neck Surgery, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Clin Cancer Res 16:1226-35. 2010
    ....
  28. pmc Effect of abrupt substitution of gadobenate dimeglumine for gadopentetate dimeglumine on rate of allergic-like reactions
    Matthew S Davenport
    Department of Radiology, B2 A209P, University of Michigan Health System, 1500 E Medical Center Dr, Ann Arbor, MI 48103, USA
    Radiology 266:773-82. 2013
    ..To evaluate the effect of abruptly substituting gadobenate dimeglumine for gadopentetate dimeglumine on allergic-like reactions...
  29. doi request reprint Sinonasal glomangiopericytoma: case report with emphasis on the differential diagnosis
    Monisha Dandekar
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109, USA
    Arch Pathol Lab Med 134:1444-9. 2010
    ..We report the case of a 48-year-old woman with epistaxis and nasal obstruction who was diagnosed with glomangiopericytoma and discuss the histologic differential diagnosis...
  30. pmc Pilomatrixoma of the forearm: a case report
    Michael V Birman
    Department of Orthopaedic Surgery, University of Michigan, Ann Arbor 48109 5328, USA
    Iowa Orthop J 29:121-3. 2009
    ..We present the case of a 52-year-old woman with a pilomatrixoma of the forearm, and we review the literature regarding pilomatrixomas in the upper extremity...
  31. pmc Receptor-type Protein tyrosine phosphatase β regulates met phosphorylation and function in head and neck squamous cell carcinoma
    Yiru Xu
    Department of Dermatology, University of Michigan, Ann Arbor, MI 48109 5609, USA
    Neoplasia 14:1015-22. 2012
    ..Reduced RPTP-β levels, with or without Met overexpression, could promote Met activation in HNSCC tumors...
  32. pmc UM-SCC-104: a new human papillomavirus-16-positive cancer stem cell-containing head and neck squamous cell carcinoma cell line
    Alice L Tang
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Head Neck 34:1480-91. 2012
    ..We established University of Michigan-squamous cell carcinoma-104 (UM-SCC-104), a new HPV(+) HNSCC cell line from a recurrent oral cavity tumor, and characterized it for the presence of cancer stem cells (CSCs)...
  33. doi request reprint Pathology quiz case. Nasal hamartoma, fibroglandular type
    Jonathan G Thomas
    University of Michigan Medical School, Ann Arbor, Michigan, USA
    Arch Otolaryngol Head Neck Surg 134:783-5. 2008
  34. pmc Pretreatment dietary intake is associated with tumor suppressor DNA methylation in head and neck squamous cell carcinomas
    Justin A Colacino
    Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, USA
    Epigenetics 7:883-91. 2012
    ..These preliminary results suggest that intake of folate, vitamin A and vitamin B12 may be associated with the tumor DNA methylation profile in HNC and enhance tumor suppression...
  35. doi request reprint Complete devascularization of a juvenile angiofibroma by direct percutaneous embolization with only ethylene vinyl alcohol copolymer (Onyx) through a single needle placement
    Joseph J Gemmete
    Department of Interventional Neuroradiology, University of Michigan Hospitals, Ann Arbor, MI, USA
    J Neurointerv Surg 3:191-3. 2011
    ..A midfacial degloving and medial maxillectomy/maxillotomy was then performed and the tumor extirpated with blunt finger dissection and the assistance of an endoscope, with 200 ml of blood loss...
  36. ncbi request reprint Primary versus radiation-associated craniofacial osteosarcoma: Biologic and clinicopathologic comparisons
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109 0054, USA
    Cancer 107:554-62. 2006
    ..Although most are sporadic, some tumors occur in association with prior radiation therapy. The purpose of the current study was to compare clinicopathologic and prognostic features of primary and radiation-associated osteosarcoma...
  37. doi request reprint Dedifferentiated liposarcoma with inflammatory myofibroblastic tumor-like features
    David R Lucas
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
    Am J Surg Pathol 34:844-51. 2010
    ..Awareness of this finding can prevent one from misdiagnosing dedifferentiated liposarcoma as inflammatory myofibroblastic tumor, a much less aggressive neoplasm...
  38. doi request reprint Cutaneous adnexal differentiation and stromal metaplasia in palate pleomorphic adenomas: a potential diagnostic pitfall that may be mistaken for malignancy
    Lindsay A Schmidt
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Am J Surg Pathol 34:1205-10. 2010
    ..When cutaneous adnexal differentiation occurs in salivary gland pleomorphic adenomas, it can present a diagnostic pitfall that must not be misinterpreted as carcinoma at biopsy, fine needle aspiration, or frozen section...
  39. doi request reprint Can lymphangiosarcoma be resurrected? A clinicopathological and immunohistochemical study of lymphatic differentiation in 49 angiosarcomas
    Cohra C Mankey
    Department of Pathology, University of Michigan, Ann Arbor, MI 48109 0054, USA
    Histopathology 56:364-71. 2010
    ..The aim was to investigate further lymphatic antigen expression, and to explore the relation of immunohistochemistry to morphological and clinical findings...
  40. pmc Recurrent orbital schwannomas: clinical course and histopathologic correlation
    Michelle Kron
    University of Michigan Medical School, Ann Arbor, MI, USA
    BMC Ophthalmol 12:44. 2012
    ..The presence of multiple schwannomas in a single patient suggests possible association with neurofibromatosis type 2 (NF2) or schwannomatosis...
  41. ncbi request reprint The diagnostic value of endoscopic terminal ileum biopsies
    Jonathan B McHugh
    Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA
    Am J Gastroenterol 102:1084-9. 2007
    ..We see many such biopsies in our gastrointestinal pathology service and have been impressed by the subjectively low yield of TI biopsies. Therefore, we studied this to obtain objective data...
  42. doi request reprint Comparison of MR enterography and histopathology in the evaluation of pediatric Crohn disease
    Jonathan R Dillman
    Department of Radiology, CS Mott Children s Hospital, Section of Pediatric Radiology, University of Michigan Health System, 1500 East Medical Center Drive, Ann Arbor, MI 48109, USA
    Pediatr Radiol 41:1552-8. 2011
    ..While MR enterography (MRE) is commonly used to identify segments of bowel affected by Crohn disease in children, there is little data to support this practice...
  43. ncbi request reprint Expression of polycomb group protein EZH2 in nevi and melanoma
    Jonathan B McHugh
    Department of Pathology, University of Michigan, 1301 Catherine Road, Ann Arbor, MI 48109, USA
    J Cutan Pathol 34:597-600. 2007
    ..We sought to determine the pattern of EZH2 expression in benign and malignant melanocytic tumors to see if EZH2 might play a role in melanoma pathogenesis and progression...
  44. doi request reprint Clinical and pathologic predictors of recurrence and survival in spindle cell squamous cell carcinoma
    Matthew E Spector
    Department of Otolaryngology Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, USA
    Otolaryngol Head Neck Surg 145:242-7. 2011
    ..To determine clinicopathologic predictors of recurrence and survival in patients with spindle cell squamous cell carcinoma (SpSCC)...