Cliona M McHale

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Prenatal origin of childhood acute myeloid leukemias harboring chromosomal rearrangements t(15;17) and inv(16)
    Cliona M McHale
    Blood 101:4640-1. 2003
  2. ncbi request reprint Prenatal origin of chromosomal translocations in acute childhood leukemia: implications and future directions
    Cliona M McHale
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California 94720 7360, USA
    Am J Hematol 75:254-7. 2004
  3. pmc Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by cross-comparison on two microarray platforms
    Cliona M McHale
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Genomics 93:343-9. 2009
  4. pmc Toxicogenomic profiling of chemically exposed humans in risk assessment
    Cliona M McHale
    School of Public Health, Divisions of Environmental Health Sciences, and Biostatistics, University of California, Berkeley, CA 94720, USA
    Mutat Res 705:172-83. 2010
  5. pmc Global gene expression profiling of a population exposed to a range of benzene levels
    Cliona M McHale
    School of Public Health, University of California Berkeley, Berkeley, California 64720, USA
    Environ Health Perspect 119:628-34. 2011
  6. ncbi request reprint Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjects
    Cliona M McHale
    School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Toxicology 229:101-13. 2007
  7. pmc Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    Carcinogenesis 32:605-12. 2011
  8. pmc Systems biology of human benzene exposure
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 184:86-93. 2010
  9. doi request reprint Global gene expression response of a population exposed to benzene: A pilot study exploring the use of RNA-sequencing technology
    Reuben Thomas
    School of Public Health, University of California, Berkeley, California
    Environ Mol Mutagen 54:566-73. 2013
  10. pmc An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis
    Xuefeng Ren
    Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 119:11-9. 2011

Detail Information

Publications22

  1. ncbi request reprint Prenatal origin of childhood acute myeloid leukemias harboring chromosomal rearrangements t(15;17) and inv(16)
    Cliona M McHale
    Blood 101:4640-1. 2003
  2. ncbi request reprint Prenatal origin of chromosomal translocations in acute childhood leukemia: implications and future directions
    Cliona M McHale
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, California 94720 7360, USA
    Am J Hematol 75:254-7. 2004
    ..This would help to elucidate the molecular pathways involved in the progression from preleukemic clone harboring a translocation to fully disseminated leukemia...
  3. pmc Changes in the peripheral blood transcriptome associated with occupational benzene exposure identified by cross-comparison on two microarray platforms
    Cliona M McHale
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Genomics 93:343-9. 2009
    ..The two-platform approach allows for robust changes in the PBMC transcriptome of benzene-exposed individuals to be identified...
  4. pmc Toxicogenomic profiling of chemically exposed humans in risk assessment
    Cliona M McHale
    School of Public Health, Divisions of Environmental Health Sciences, and Biostatistics, University of California, Berkeley, CA 94720, USA
    Mutat Res 705:172-83. 2010
    ....
  5. pmc Global gene expression profiling of a population exposed to a range of benzene levels
    Cliona M McHale
    School of Public Health, University of California Berkeley, Berkeley, California 64720, USA
    Environ Health Perspect 119:628-34. 2011
    ..Previously, we identified genes and pathways associated with exposure to high (> 10 ppm) levels of benzene through transcriptomic analyses of blood cells from a small number of occupationally exposed workers...
  6. ncbi request reprint Microarray analysis of gene expression in peripheral blood mononuclear cells from dioxin-exposed human subjects
    Cliona M McHale
    School of Public Health, University of California, Berkeley, CA 94720 7360, USA
    Toxicology 229:101-13. 2007
    ..Further examination of the role of these genes in dioxin induced-toxicity is warranted...
  7. pmc Chromosome-wide aneuploidy study (CWAS) in workers exposed to an established leukemogen, benzene
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    Carcinogenesis 32:605-12. 2011
    ..Together, these findings confirm that benzene exposure is associated with specific chromosomal aneuploidies in hematopoietic cells, which suggests that such aneuploidies may play roles in benzene-induced leukemogenesis...
  8. pmc Systems biology of human benzene exposure
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 184:86-93. 2010
    ....
  9. doi request reprint Global gene expression response of a population exposed to benzene: A pilot study exploring the use of RNA-sequencing technology
    Reuben Thomas
    School of Public Health, University of California, Berkeley, California
    Environ Mol Mutagen 54:566-73. 2013
    ..Environ. Mol. Mutagen. 54:566-573, 2013. © 2013 Wiley Periodicals, Inc. ..
  10. pmc An emerging role for epigenetic dysregulation in arsenic toxicity and carcinogenesis
    Xuefeng Ren
    Division of Environmental Health Sciences, School of Public Health, University of California Berkeley, Berkeley, California 94720, USA
    Environ Health Perspect 119:11-9. 2011
    ..Recent studies have suggested that epigenetic mechanisms may also mediate toxicity and carcinogenicity resulting from arsenic exposure...
  11. ncbi request reprint Molecular biomarkers for the study of childhood leukemia
    Martyn T Smith
    Division of Environmental Health Sciences, School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
    Toxicol Appl Pharmacol 206:237-45. 2005
    ..Several proteins have been identified that may serve as useful biomarkers for rapidly identifying different forms of childhood leukemia...
  12. pmc Current understanding of the mechanism of benzene-induced leukemia in humans: implications for risk assessment
    Cliona M McHale
    Division of Environmental Health Sciences, Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Carcinogenesis 33:240-52. 2012
    ..These approaches will inform our understanding of the mechanisms of benzene toxicity and identify additional biomarkers of exposure, early effect and susceptibility useful for risk assessment...
  13. doi request reprint The impact of FANCD2 deficiency on formaldehyde-induced toxicity in human lymphoblastoid cell lines
    Xuefeng Ren
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Arch Toxicol 87:189-96. 2013
    ..Future studies are needed to delineate the role of this pathway in mitigating FA-induced toxicity, particularly in hematopoietic stem cells, the target cells in leukemia...
  14. pmc Using bioinformatic approaches to identify pathways targeted by human leukemogens
    Reuben Thomas
    Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720, USA
    Int J Environ Res Public Health 9:2479-503. 2012
    ..However, using two-class random forests to estimate leukemogen and non-leukemogen patterns, we estimated a 76% chance of distinguishing a random leukemogen/non-leukemogen pair from each other...
  15. pmc Benzene, the exposome and future investigations of leukemia etiology
    Martyn T Smith
    Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, CA 94720 7356, USA
    Chem Biol Interact 192:155-9. 2011
    ..We propose that we should attempt to characterize the 'exposome' of human leukemia by using unbiased laboratory-based methods to find the unknown 'environmental' factors that contribute to leukemia etiology...
  16. pmc Lack of increased genetic damage in 1,3-butadiene-exposed Chinese workers studied in relation to EPHX1 and GST genotypes
    Luoping Zhang
    School of Public Health, University of California, 140 Warren Hall, Berkeley, CA 94720 7360, USA
    Mutat Res 558:63-74. 2004
    ..Together, these studies suggest that low levels of occupational BD exposure do not pose a significant risk of genetic damage...
  17. pmc The benzene metabolite, hydroquinone and etoposide both induce endoreduplication in human lymphoblastoid TK6 cells
    Zhiying Ji
    Department of Environmental Health Sciences, University of California, Berkeley, 94720, USA
    Mutagenesis 24:367-72. 2009
    ....
  18. pmc Alterations in serum immunoglobulin levels in workers occupationally exposed to trichloroethylene
    Luoping Zhang
    Division of Environmental Health Sciences, School of Public Health, University of California at Berkeley, Berkeley, CA 94720, USA
    Carcinogenesis 34:799-802. 2013
    ..These results provide further evidence that TCE is immunotoxic at relatively low exposure levels and provide additional biologic plausibility for the reported association of TCE with NHL...
  19. doi request reprint Analysis of the transcriptome in molecular epidemiology studies
    Cliona M McHale
    Division of Environmental Health Sciences, Genes and Environment Laboratory, School of Public Health, University of California, Berkeley, California
    Environ Mol Mutagen 54:500-17. 2013
    ..Environ. Mol. Mutagen. 54:500-517, 2013. © 2013 Wiley Periodicals, Inc. ..
  20. pmc Reproductive and developmental toxicity of formaldehyde: a systematic review
    Anh Duong
    School of Public Health, University of California, Berkeley, CA 94720, USA
    Mutat Res 728:118-38. 2011
    ..Together with mechanistic and animal studies, this will allow us to better understand the systemic effect of formaldehyde exposure...
  21. pmc Paternal smoking and risk of childhood acute lymphoblastic leukemia: systematic review and meta-analysis
    Ruiling Liu
    Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720, USA
    J Oncol 2011:854584. 2011
    ..Future epidemiologic studies should assess paternal smoking during well-defined exposure windows and should include biomarkers to assess smoking exposure and toxicological mechanisms...
  22. ncbi request reprint Prenatal origin of TEL-AML1-positive acute lymphoblastic leukemia in children born in California
    Cliona M McHale
    School of Public Health, University of California, Berkeley 94720 7360, USA
    Genes Chromosomes Cancer 37:36-43. 2003
    ..Secondary changes were also similar to those described previously, with deletion of the second TEL allele being the most common. Other secondary changes included duplication of the fusion gene, trisomy 21, and monosomy X...