Paul G McGuire

Summary

Affiliation: University of New Mexico
Country: USA

Publications

  1. pmc Pericyte-derived sphingosine 1-phosphate induces the expression of adhesion proteins and modulates the retinal endothelial cell barrier
    Paul G McGuire
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA
    Arterioscler Thromb Vasc Biol 31:e107-15. 2011
  2. pmc Suppression of retinal neovascularization with an antagonist to vascular endothelial cadherin
    Deepti Navaratna
    Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Arch Ophthalmol 126:1082-8. 2008
  3. ncbi Hepatocyte growth factor/scatter factor promotes retinal angiogenesis through increased urokinase expression
    Elizabeth S Colombo
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Invest Ophthalmol Vis Sci 48:1793-800. 2007
  4. ncbi Inhibition of choroidal neovascularization by a peptide inhibitor of the urokinase plasminogen activator and receptor system in a mouse model
    Arup Das
    Department of Surgery, University of New Mexico School of Medicine, Albuquerque 87131, USA
    Arch Ophthalmol 122:1844-9. 2004
  5. pmc A potential role for angiopoietin 2 in the regulation of the blood-retinal barrier in diabetic retinopathy
    Sampathkumar Rangasamy
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Invest Ophthalmol Vis Sci 52:3784-91. 2011
  6. ncbi Proteolytic degradation of VE-cadherin alters the blood-retinal barrier in diabetes
    Deepti Navaratna
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Diabetes 56:2380-7. 2007
  7. doi Pattern recognition receptor gene expression in ischemia-induced flap revascularization
    Thomas R Howdieshell
    Department of Surgery, University of New Mexico HSC, Albuquerque, NM, USA
    Surgery 150:418-28. 2011
  8. doi The role of monocyte subsets in myocutaneous revascularization
    Bilal Khan
    Department of Surgery, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    J Surg Res 183:963-75. 2013
  9. ncbi Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood-retinal barrier
    Stephen J Giebel
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
    Lab Invest 85:597-607. 2005
  10. doi The importance of engraftment in flap revascularization: confirmation by laser speckle perfusion imaging
    Paul G McGuire
    Department of Cell Biology and Physiology, University of New Mexico HSC, Albuquerque, New Mexico 87131, USA
    J Surg Res 164:e201-12. 2010

Collaborators

  • Arup Das
  • Thomas R Howdieshell
  • Jun Xu
  • Xiao Yang
  • Sampathkumar Rangasamy
  • Finny Monickaraj
  • Deepti Navaratna
  • Carolina Franco Nitta
  • Gina Menicucci
  • Bilal Khan
  • Naveed U Saqib
  • Joann Maestas
  • Elizabeth S Colombo
  • Stephen J Giebel
  • Kaustabh Ghosh
  • Sreenivasa R Oruganti
  • Susan Majka
  • Ramprasad Srinivasan

Detail Information

Publications20

  1. pmc Pericyte-derived sphingosine 1-phosphate induces the expression of adhesion proteins and modulates the retinal endothelial cell barrier
    Paul G McGuire
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA
    Arterioscler Thromb Vasc Biol 31:e107-15. 2011
    ..We determined the extent to which vascular pericytes could regulate pericyte-endothelial adhesion and the consequences that this disruption might have on the function of the endothelial barrier...
  2. pmc Suppression of retinal neovascularization with an antagonist to vascular endothelial cadherin
    Deepti Navaratna
    Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, NM 87131 0001, USA
    Arch Ophthalmol 126:1082-8. 2008
    ..To examine the role of vascular endothelial cadherin (VE-cadherin) in cellular processes underlying angiogenesis and the effects of VE-cadherin inhibition on retinal angiogenesis...
  3. ncbi Hepatocyte growth factor/scatter factor promotes retinal angiogenesis through increased urokinase expression
    Elizabeth S Colombo
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    Invest Ophthalmol Vis Sci 48:1793-800. 2007
    ....
  4. ncbi Inhibition of choroidal neovascularization by a peptide inhibitor of the urokinase plasminogen activator and receptor system in a mouse model
    Arup Das
    Department of Surgery, University of New Mexico School of Medicine, Albuquerque 87131, USA
    Arch Ophthalmol 122:1844-9. 2004
    ....
  5. pmc A potential role for angiopoietin 2 in the regulation of the blood-retinal barrier in diabetic retinopathy
    Sampathkumar Rangasamy
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Invest Ophthalmol Vis Sci 52:3784-91. 2011
    ..The expression of angiopoietins was analyzed in an animal model of diabetic retinopathy, and the role of Ang-2 in the regulation of diabetes-induced alterations of vascular permeability was characterized...
  6. ncbi Proteolytic degradation of VE-cadherin alters the blood-retinal barrier in diabetes
    Deepti Navaratna
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Diabetes 56:2380-7. 2007
    ....
  7. doi Pattern recognition receptor gene expression in ischemia-induced flap revascularization
    Thomas R Howdieshell
    Department of Surgery, University of New Mexico HSC, Albuquerque, NM, USA
    Surgery 150:418-28. 2011
    ..We performed microarray analyses on ischemic wound tissue to investigate the temporal relationship between PRR gene expression, wound perfusion, and flap revascularization...
  8. doi The role of monocyte subsets in myocutaneous revascularization
    Bilal Khan
    Department of Surgery, University of New Mexico Health Sciences Center, Albuquerque, NM 87131, USA
    J Surg Res 183:963-75. 2013
    ..Subsets of monocytes/macrophages have been implicated in the pathogenesis of atherosclerosis and tumor vascularity; however, the significance of monocyte heterogeneity in physiologic neovascularization is just emerging...
  9. ncbi Matrix metalloproteinases in early diabetic retinopathy and their role in alteration of the blood-retinal barrier
    Stephen J Giebel
    Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center, Albuquerque, NM, USA
    Lab Invest 85:597-607. 2005
    ....
  10. doi The importance of engraftment in flap revascularization: confirmation by laser speckle perfusion imaging
    Paul G McGuire
    Department of Cell Biology and Physiology, University of New Mexico HSC, Albuquerque, New Mexico 87131, USA
    J Surg Res 164:e201-12. 2010
    ..Therefore, elucidation of the mechanisms involved in ischemia-induced blood vessel growth has potential diagnostic and therapeutic implications in wound healing...
  11. pmc Novel pharmacotherapies in diabetic retinopathy: Current status and what's in the horizon?
    Arup Das
    Department of Surgery, Division of Ophthalmology, University of New Mexico School of Medicine Department of Surgery, New Mexico VA Health Care System Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico, USA
    Indian J Ophthalmol 64:4-13. 2016
    ..The effect seems transient in this latter group, and many patients do not show complete resolution of fluid. Potential novel therapies targeting molecules beyond VEGF are being developed and examined in clinical trials. ..
  12. pmc Cathepsin D: an Mϕ-derived factor mediating increased endothelial cell permeability with implications for alteration of the blood-retinal barrier in diabetic retinopathy
    Finny Monickaraj
    Department of Surgery and Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, USA New Mexico Veterans Affairs Health Care System, Albuquerque, New Mexico, USA and Department of Bioengineering, University of California, Riverside, Riverside, California, USA
    FASEB J 30:1670-82. 2016
    ..Monickaraj, F., McGuire, P. G., Nitta, C. F., Ghosh, K., Das, A. Cathepsin D: an Mϕ-derived factor mediating increased endothelial cell permeability with implications for alteration of the blood-retinal barrier in diabetic retinopathy. ..
  13. doi Basement membrane stiffening promotes retinal endothelial activation associated with diabetes
    Xiao Yang
    Department of Bioengineering and Department of Physics and Astronomy, University of California, Riverside, Riverside, California, USA Department of Surgery and Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico, USA and New Mexico Veterans Affairs Health Care System, Albuquerque, New Mexico, USA
    FASEB J 30:601-11. 2016
    ....
  14. doi Diabetic Macular Edema: Pathophysiology and Novel Therapeutic Targets
    Arup Das
    Department of Surgery Ophthalmology, University of New Mexico School of Medicine, Albuquerque, New Mexico New Mexico VA Health Care System, Albuquerque, New Mexico Electronic address
    Ophthalmology 122:1375-94. 2015
    ..Potential novel therapies targeting molecules other than VEGF and using new drug-delivery systems currently are being developed and evaluated in clinical trials...
  15. pmc Chemokine mediated monocyte trafficking into the retina: role of inflammation in alteration of the blood-retinal barrier in diabetic retinopathy
    Sampathkumar Rangasamy
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico, United States of America
    PLoS ONE 9:e108508. 2014
    ..Thus, CCL2 may be an important therapeutic target for the treatment of diabetic macular edema. ..
  16. pmc Diabetic retinopathy and inflammation: novel therapeutic targets
    Sampathkumar Rangasamy
    Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM 87131
    Middle East Afr J Ophthalmol 19:52-9. 2012
    ....
  17. doi The omentum is a site of stromal cell-derived factor 1alpha production and reservoir for CXC chemokine receptor 4-positive cell recruitment
    Naveed U Saqib
    Department of Surgery, University of New Mexico HSC, Albuquerque, 87131, USA
    Am J Surg 200:276-82. 2010
    ..This study investigates the omental reaction to a foreign body, examining the role of a chemokine ligand/receptor pair known to play a crucial role in angiogenesis and wound healing...
  18. ncbi Retinal and choroidal angiogenesis: pathophysiology and strategies for inhibition
    Arup Das
    School of Medicine, University of New Mexico, Albuquerque, USA
    Prog Retin Eye Res 22:721-48. 2003
    ..This review discusses the pathogenesis of retinal and choroidal angiogenesis, and alternative pharmacological approaches to inhibit angiogenesis in ocular diseases...
  19. ncbi The urokinase/urokinase receptor system in retinal neovascularization: inhibition by A6 suggests a new therapeutic target
    Paul G McGuire
    Departments of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Invest Ophthalmol Vis Sci 44:2736-42. 2003
    ....
  20. ncbi Regulation of matrix metalloproteinase expression by tumor necrosis factor in a murine model of retinal neovascularization
    Susan Majka
    Division of Ophthalmology, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Invest Ophthalmol Vis Sci 43:260-6. 2002
    ..The present study examines the potential role of tumor necrosis factor (TNF)-alpha as a regulator of MMPs in the retinal neovascularization process...