Michael J McGuire

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Genetic immunization: what's in a name?
    Stephen Albert Johnston
    Center for Biomedical Inventions, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Arch Med Res 33:325-9. 2002
  2. pmc Novel immune-modulator identified by a rapid, functional screen of the parapoxvirus ovis (Orf virus) genome
    Michael J McGuire
    Center for Innovations in Medicine, The Biodesign Institute School of Life Sciences, Arizona State University, 1001 McAllister Ave, Tempe, AZ 85287 5901, USA
    Proteome Sci 10:4. 2012
  3. ncbi request reprint Novel ligands for cancer diagnosis: selection of peptide ligands for identification and isolation of B-cell lymphomas
    Michael J McGuire
    Division of Translational Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Exp Hematol 34:443-52. 2006
  4. pmc Synthesis and characterization of a high-affinity {alpha}v{beta}6-specific ligand for in vitro and in vivo applications
    Shunzi Li
    Division of Translational Research, Department of Internal Medicine, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9185, USA
    Mol Cancer Ther 8:1239-49. 2009
  5. pmc A liposomal drug platform overrides peptide ligand targeting to a cancer biomarker, irrespective of ligand affinity or density
    Bethany Powell Gray
    Department of Internal Medicine and The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    PLoS ONE 8:e72938. 2013
  6. ncbi request reprint A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for nonsmall cell lung cancer
    Anissa N Elayadi
    Division of Translational Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Res 67:5889-95. 2007
  7. pmc Synthesis and biological evaluation of a peptide-paclitaxel conjugate which targets the integrin αvβ₆
    Shunzi Li
    Department of Internal Medicine and The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8852, USA
    Bioorg Med Chem 19:5480-9. 2011
  8. pmc Peptide-targeted polyglutamic acid doxorubicin conjugates for the treatment of alpha(v)beta(6)-positive cancers
    Huili Guan
    Division of Translational Research, Department of Internal Medicine and The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Bioconjug Chem 19:1813-21. 2008
  9. ncbi request reprint Peptide-mediated targeting of the islets of Langerhans
    Kausar N Samli
    Center for Biomedical Inventions, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9185, USA
    Diabetes 54:2103-8. 2005
  10. ncbi request reprint In vitro selection of a peptide with high selectivity for cardiomyocytes in vivo
    Michael J McGuire
    Department of Internal Medicine, Center for Biomedical Inventions, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas 75390 9185, USA
    J Mol Biol 342:171-82. 2004

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Genetic immunization: what's in a name?
    Stephen Albert Johnston
    Center for Biomedical Inventions, University of Texas Southwestern Medical Center, Dallas, TX 75390 8573, USA
    Arch Med Res 33:325-9. 2002
    ..This dearth of imaginative use is manifested in the tendency by some to term the technique DNA immunization. The apparent limitations of DNA vaccines may not be limitations for gene vaccines...
  2. pmc Novel immune-modulator identified by a rapid, functional screen of the parapoxvirus ovis (Orf virus) genome
    Michael J McGuire
    Center for Innovations in Medicine, The Biodesign Institute School of Life Sciences, Arizona State University, 1001 McAllister Ave, Tempe, AZ 85287 5901, USA
    Proteome Sci 10:4. 2012
    ..abstract:..
  3. ncbi request reprint Novel ligands for cancer diagnosis: selection of peptide ligands for identification and isolation of B-cell lymphomas
    Michael J McGuire
    Division of Translational Research, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Exp Hematol 34:443-52. 2006
    ..New reagents that distinguish malignant cells and enable the isolation of these cells from the normal background will enhance the molecular characterization of disease and specificity of treatment...
  4. pmc Synthesis and characterization of a high-affinity {alpha}v{beta}6-specific ligand for in vitro and in vivo applications
    Shunzi Li
    Division of Translational Research, Department of Internal Medicine, Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9185, USA
    Mol Cancer Ther 8:1239-49. 2009
    ..We anticipate that this high-affinity ligand for α(v)β(6) will find clinical use as a diagnostic and therapeutic reagent...
  5. pmc A liposomal drug platform overrides peptide ligand targeting to a cancer biomarker, irrespective of ligand affinity or density
    Bethany Powell Gray
    Department of Internal Medicine and The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    PLoS ONE 8:e72938. 2013
    ..Therefore, using a high affinity and high specificity ligand targeting an over-expressed tumor biomarker does not guarantee enhanced efficacy of a liposomal drug. These results highlight the complexity of in vivo targeting. ..
  6. ncbi request reprint A peptide selected by biopanning identifies the integrin alphavbeta6 as a prognostic biomarker for nonsmall cell lung cancer
    Anissa N Elayadi
    Division of Translational Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cancer Res 67:5889-95. 2007
    ..Thus, cell-specific peptides isolated from phage biopanning can be used for the discovery of cell surface biomarkers, emphasizing the utility of peptide libraries to probe the surface of a cell...
  7. pmc Synthesis and biological evaluation of a peptide-paclitaxel conjugate which targets the integrin αvβ₆
    Shunzi Li
    Department of Internal Medicine and The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 8852, USA
    Bioorg Med Chem 19:5480-9. 2011
    ..The conjugate demonstrates anti-tumor activity in a H2009 xenograft model of NSCLC with efficacy comparable to treatment with free paclitaxel...
  8. pmc Peptide-targeted polyglutamic acid doxorubicin conjugates for the treatment of alpha(v)beta(6)-positive cancers
    Huili Guan
    Division of Translational Research, Department of Internal Medicine and The Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Bioconjug Chem 19:1813-21. 2008
    ..Importantly, the conjugate is more cytotoxic toward a targeted cell than a cell line that does not express the integrin...
  9. ncbi request reprint Peptide-mediated targeting of the islets of Langerhans
    Kausar N Samli
    Center for Biomedical Inventions, Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9185, USA
    Diabetes 54:2103-8. 2005
    ..Furthermore, this peptide does not target beta-cells in a type 2 diabetes animal model, suggesting that the peptide can discriminate between glucose-stimulated insulin secretion-functional and -dysfunctional beta-cells...
  10. ncbi request reprint In vitro selection of a peptide with high selectivity for cardiomyocytes in vivo
    Michael J McGuire
    Department of Internal Medicine, Center for Biomedical Inventions, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas 75390 9185, USA
    J Mol Biol 342:171-82. 2004
    ..1 phage was associated with cardiomyocytes isolated from mice treated with a phage in vivo. These results demonstrate the utility of biopanning on isolated cells for identifying specific binding peptides that can target a tissue in vivo...
  11. pmc Biopanning of phage displayed peptide libraries for the isolation of cell-specific ligands
    Michael J McGuire
    Division of Translational Research, Department of Internal Medicine and Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Methods Mol Biol 504:291-321. 2009
    ..In addition, we provide methods for the synthesis of the selected peptides as both monomers and tetramers. Downstream uses for the peptides are illustrated...
  12. ncbi request reprint A library-selected, Langerhans cell-targeting peptide enhances an immune response
    Michael J McGuire
    Center for Biomedical Inventions, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    DNA Cell Biol 23:742-52. 2004
    ..Furthermore, we demonstrate that a low-dose injection into mice of phage bearing the LC-targeting peptide yields faster and higher immune responses against phage-associated antigens than control-phage injections...
  13. ncbi request reprint Cell-specific delivery of a chemotherapeutic to lung cancer cells
    Xin Zhou
    Center for Biomedical Inventions and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9185, USA
    J Am Chem Soc 126:15656-7. 2004
    ..As such, we have demonstrated that cell-specific targeted drugs can be synthesized, even when the cell surface target is unknown...
  14. pmc Advances in molecular imaging of pancreatic beta cells
    Mai Lin
    Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, Texas 75390, USA
    Front Biosci 13:4558-75. 2008
    ..Progress for obtaining such ligands is presented. We report our preliminary efforts of developing such a peptidic ligand for PET imaging of pancreatic beta cells...