D K McGuire

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. doi request reprint The effects of rosiglitazone on myocardial triglyceride content in patients with type 2 diabetes: a randomised, placebo-controlled trial
    Jonathan McGavock
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, TX 75235 9047, USA
    Diab Vasc Dis Res 9:131-7. 2012
  2. doi request reprint The effect of rosiglitazone on integrated cardiovascular performance, cardiac structure, function and myocardial triglyceride: trial design and rationale
    Darren K McGuire
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9047, USA
    Diab Vasc Dis Res 6:43-50. 2009
  3. doi request reprint Blocking the renin-angiotensin-aldosterone system to prevent diabetes mellitus
    Darren K McGuire
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Diab Vasc Dis Res 5:59-66. 2008
  4. doi request reprint New drugs for the treatment of diabetes mellitus: part I: Thiazolidinediones and their evolving cardiovascular implications
    Darren K McGuire
    Cardiovascular Division and Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, 5909 Harry Hines Blvd, Dallas, TX 75235 9047, USA
    Circulation 117:440-9. 2008
  5. ncbi request reprint Rosiglitazone and cardiovascular disease: an epidemiologist's perspective
    Darren K McGuire
    Donald W Reynolds Cardiovascular Clinical Research Center, UT Southwestern Cardiology, Dallas, TX 75390 9047, USA
    Diab Vasc Dis Res 4:77-9. 2007
  6. ncbi request reprint Association of diabetes mellitus and glycemic control strategies with clinical outcomes after acute coronary syndromes
    Darren K McGuire
    Donald W Reynolds Cardiovascular Clinical Research Center at the University of Texas Southwestern Medical Center, Dallas, Tex, USA
    Am Heart J 147:246-52. 2004
  7. ncbi request reprint A 30-year follow-up of the Dallas Bedrest and Training Study: I. Effect of age on the cardiovascular response to exercise
    D K McGuire
    Pauline and Adolph Weinberger Laboratory for Cardiopulmonary Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Circulation 104:1350-7. 2001
  8. ncbi request reprint A 30-year follow-up of the Dallas Bedrest and Training Study: II. Effect of age on cardiovascular adaptation to exercise training
    D K McGuire
    Pauline and Adolph Weinberger Laboratory for Cardiopulmonary Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Circulation 104:1358-66. 2001
  9. pmc Randomized comparison of the effects of rosiglitazone vs. placebo on peak integrated cardiovascular performance, cardiac structure, and function
    Darren K McGuire
    Cardiovascular Division, University of Texas Southwestern Medical Center, 5909 Harry Hines Blvd, Room HA9 133, Dallas, TX 75235 9047, USA
    Eur Heart J 31:2262-70. 2010
  10. ncbi request reprint Influence of the Angioplasty Revascularization Investigation National Heart, Lung, and Blood Institute Diabetic Clinical Alert on practice patterns: results from the National Cardiovascular Network Database
    Darren K McGuire
    University of Texas Southwestern Medical Center, Dallas, Tex, USA
    Circulation 107:1864-70. 2003

Detail Information

Publications89

  1. doi request reprint The effects of rosiglitazone on myocardial triglyceride content in patients with type 2 diabetes: a randomised, placebo-controlled trial
    Jonathan McGavock
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, TX 75235 9047, USA
    Diab Vasc Dis Res 9:131-7. 2012
    ..Compared with placebo, treatment with rosiglitazone for 6 months had no discernible effect on mTG or left ventricular function in this population with long-standing diabetes and CVD...
  2. doi request reprint The effect of rosiglitazone on integrated cardiovascular performance, cardiac structure, function and myocardial triglyceride: trial design and rationale
    Darren K McGuire
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9047, USA
    Diab Vasc Dis Res 6:43-50. 2009
    ..The present study will combine a series of state-of-the-art assessments to evaluate the cardiac effects of rosiglitazone treatment...
  3. doi request reprint Blocking the renin-angiotensin-aldosterone system to prevent diabetes mellitus
    Darren K McGuire
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Diab Vasc Dis Res 5:59-66. 2008
    ..Here we review the evidence accumulated to date from animal studies, clinical mechanistic studies and clinical trials regarding the effect of RAAS inhibition and incident DM...
  4. doi request reprint New drugs for the treatment of diabetes mellitus: part I: Thiazolidinediones and their evolving cardiovascular implications
    Darren K McGuire
    Cardiovascular Division and Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, 5909 Harry Hines Blvd, Dallas, TX 75235 9047, USA
    Circulation 117:440-9. 2008
  5. ncbi request reprint Rosiglitazone and cardiovascular disease: an epidemiologist's perspective
    Darren K McGuire
    Donald W Reynolds Cardiovascular Clinical Research Center, UT Southwestern Cardiology, Dallas, TX 75390 9047, USA
    Diab Vasc Dis Res 4:77-9. 2007
  6. ncbi request reprint Association of diabetes mellitus and glycemic control strategies with clinical outcomes after acute coronary syndromes
    Darren K McGuire
    Donald W Reynolds Cardiovascular Clinical Research Center at the University of Texas Southwestern Medical Center, Dallas, Tex, USA
    Am Heart J 147:246-52. 2004
    ..The relative effect of glucose-lowering strategies of "insulin provision" versus "insulin sensitization" among patients with CAD remains unclear...
  7. ncbi request reprint A 30-year follow-up of the Dallas Bedrest and Training Study: I. Effect of age on the cardiovascular response to exercise
    D K McGuire
    Pauline and Adolph Weinberger Laboratory for Cardiopulmonary Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Circulation 104:1350-7. 2001
    ..Our study objective was to assess the effect of a 30-year interval on body composition and cardiovascular response to acute exercise in 5 healthy subjects originally evaluated in 1966...
  8. ncbi request reprint A 30-year follow-up of the Dallas Bedrest and Training Study: II. Effect of age on cardiovascular adaptation to exercise training
    D K McGuire
    Pauline and Adolph Weinberger Laboratory for Cardiopulmonary Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Circulation 104:1358-66. 2001
    ..4 versus 21.7 L/min); submaximal heart rates also declined to a similar degree. Maximal AVDO(2) increased by 10% (13.8 versus 15.2 vol%) and accounted for the entire improvement of aerobic power associated with training...
  9. pmc Randomized comparison of the effects of rosiglitazone vs. placebo on peak integrated cardiovascular performance, cardiac structure, and function
    Darren K McGuire
    Cardiovascular Division, University of Texas Southwestern Medical Center, 5909 Harry Hines Blvd, Room HA9 133, Dallas, TX 75235 9047, USA
    Eur Heart J 31:2262-70. 2010
    ..To assess the effect of rosiglitazone on cardiovascular performance and cardiac function...
  10. ncbi request reprint Influence of the Angioplasty Revascularization Investigation National Heart, Lung, and Blood Institute Diabetic Clinical Alert on practice patterns: results from the National Cardiovascular Network Database
    Darren K McGuire
    University of Texas Southwestern Medical Center, Dallas, Tex, USA
    Circulation 107:1864-70. 2003
    ..The influence of the BARI findings and of the Clinical Alert on practice patterns is unknown...
  11. ncbi request reprint Increased cardiovascular risk associated with diabetes in Dallas County
    Sandeep R Das
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75235 9047, USA
    Am Heart J 151:1087-93. 2006
    ..We assess the prevalence of diabetes in Dallas County, quantify the association between diabetes and subclinical cardiovascular disease, and assess the use of evidence-based cardiovascular disease risk-modifying therapies...
  12. doi request reprint Independent associations between metabolic syndrome, diabetes mellitus and atherosclerosis: observations from the Dallas Heart Study
    Karen Chen
    The School of Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75235 9047, USA
    Diab Vasc Dis Res 5:96-101. 2008
    ..In conclusion, both MetS and DM are independently associated with an increased prevalence of atherosclerosis, with the highest observed prevalence in subjects with both DM and MetS...
  13. ncbi request reprint Comparison of coronary artery calcium detected by electron beam tomography in patients with to those without symptomatic coronary heart disease
    Yiling J Cheng
    The Cooper Institute, Dallas, Texas, USA
    Am J Cardiol 92:498-503. 2003
    ..These observations support the potential of EBT as a sensitive test for detection of CHD...
  14. ncbi request reprint Thiazolidinediones, peripheral oedema and congestive heart failure: what is the evidence?
    Chetan Patel
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Diab Vasc Dis Res 2:61-6. 2005
    ..Ongoing clinical trials examining the use of these agents in patients at risk for heart failure will probably provide further insight into the aggregate cardiovascular effects of this promising class of medications...
  15. ncbi request reprint Association among plasma levels of monocyte chemoattractant protein-1, traditional cardiovascular risk factors, and subclinical atherosclerosis
    Rajat Deo
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Am Coll Cardiol 44:1812-8. 2004
    ..We sought to evaluate the association between plasma levels of monocyte chemoattractant protein (MCP)-1 and the risk for subclinical atherosclerosis...
  16. ncbi request reprint African Americans and Caucasians have a similar prevalence of coronary calcium in the Dallas Heart Study
    Tulika Jain
    Donald W Reynolds Cardiovascular Clinical Research Center and the Department of Internal Medicine, Dallas, Texas, USA
    J Am Coll Cardiol 44:1011-7. 2004
    ..We sought to compare the prevalence of coronary atherosclerosis in a cohort of middle-age African American (black) and non-Hispanic Caucasian (white) men and women from a population-based probability sample...
  17. ncbi request reprint Infarct-related coronary artery patency and medication use prior to ST-segment elevation myocardial infarction
    Christina R Robinson
    The Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Cardiol 97:7-9. 2006
    ..Further, our data demonstrate a graded association according to the number of such medications being administered: the likelihood of a patent infarct-related artery increased to >50% as the number of these medications increased...
  18. ncbi request reprint The association of differing measures of overweight and obesity with prevalent atherosclerosis: the Dallas Heart Study
    Raphael See
    Division of Cardiology, Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9037, USA
    J Am Coll Cardiol 50:752-9. 2007
    ..This study sought to evaluate the associations between different measures of obesity and prevalent atherosclerosis in a large population-based cohort...
  19. ncbi request reprint Relation of osteoprotegerin to coronary calcium and aortic plaque (from the Dallas Heart Study)
    Moeen Abedin
    Donald W Reynolds Cardiovascular Clinical Research Center at the University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Cardiol 99:513-8. 2007
    ..In conclusion, plasma OPG is independently associated with CAC and aortic plaque in an unselected population, suggesting it may be a novel biomarker for atherosclerosis in humans...
  20. ncbi request reprint Relation of coronary atherosclerosis determined by electron beam computed tomography and plasma levels of n-terminal pro-brain natriuretic peptide in a multiethnic population-based sample (the Dallas Heart Study)
    Shuaib M Abdullah
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Am J Cardiol 96:1284-9. 2005
    ..In conclusion, these findings support the hypothesis that coronary atherosclerosis may directly influence the activation of the cardiac neurohormonal system...
  21. ncbi request reprint Thiazolidinediones and risk for atherosclerosis: pleiotropic effects of PPar gamma agonism
    Chetan B Patel
    Department of Internal Medicine, Duke University Medical Center, Durham, NC, USA
    Diab Vasc Dis Res 3:65-71. 2006
    ..In this review, we summarise the experimental, preclinical and clinical data regarding the effects of the thiazolidinediones on cardiovascular risk factors and clinical outcomes...
  22. ncbi request reprint Cardiovascular disease and type 2 diabetes mellitus: regulating glucose and regulating drugs
    M Odette Gore
    Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75235 9047, USA
    Curr Cardiol Rep 11:258-63. 2009
    ....
  23. doi request reprint Evaluation of the glycometabolic effects of ranolazine in patients with and without diabetes mellitus in the MERLIN-TIMI 36 randomized controlled trial
    David A Morrow
    TIMI Study Group, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Circulation 119:2032-9. 2009
    ..We designed a prospective evaluation of the effect of ranolazine on hyperglycemia as part of a randomized, double-blind, placebo-controlled outcomes trial...
  24. doi request reprint The peroxisome proliferator-activated receptor-gamma agonist rosiglitazone increases bone resorption in women with type 2 diabetes: a randomized, controlled trial
    Ugis Gruntmanis
    Division of Endocrinology, Department of Medicine, University of Texas, Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA
    Calcif Tissue Int 86:343-9. 2010
    ..Women taking rosiglitazone had higher circulating markers of bone resorption, which is contrary to prior studies of shorter duration, where the principal observation was a decrease in markers of bone formation...
  25. doi request reprint Association of troponin T detected with a highly sensitive assay and cardiac structure and mortality risk in the general population
    James A de Lemos
    Division of Cardiology, University of Texas Southwestern Medical Center, 5909 Harry Hines Blvd, Dallas, TX 75390 9047, USA
    JAMA 304:2503-12. 2010
    ....
  26. pmc Influence of race and sex on lipoprotein-associated phospholipase A2 levels: observations from the Dallas Heart Study
    Emmanouil S Brilakis
    The Donald W Reynolds Cardiovascular Clinical Research Center at the University of Texas Southwestern Medical Center in Dallas, TX, United States
    Atherosclerosis 199:110-5. 2008
    ..Most lipoprotein-associated phospholipase A2 (Lp-PLA2) studies included mainly white men. We sought to determine whether Lp-PLA2 levels differ according to race and sex...
  27. ncbi request reprint Associations among androgens, estrogens, and natriuretic peptides in young women: observations from the Dallas Heart Study
    Alice Y Chang
    The Donald W Reynolds Cardiovascular Clinical Research Center and the Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9066, USA
    J Am Coll Cardiol 49:109-16. 2007
    ..We sought to determine if natriuretic peptides are associated with estrogen and androgen status in a population study of young women without known cardiac disease...
  28. ncbi request reprint Sex differences in the association between leptin and CRP: results from the Dallas Heart Study
    Shuaib M Abdullah
    Donald W Reynolds Cardiovascular Clinical Research Center at the University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Atherosclerosis 195:404-10. 2007
    ..Higher C-reactive protein (CRP) levels in women compared with men may reflect sex differences in the relationship between obesity and inflammation. We evaluated how the adipokine leptin influenced these relationships...
  29. doi request reprint Association of lipoprotein-associated phospholipase A2 mass and activity with coronary and aortic atherosclerosis: findings from the Dallas Heart Study
    Emmanouil S Brilakis
    The Donald W Reynolds Cardiovascular Clinical Research Center, Dallas, TX, USA
    Clin Chem 54:1975-81. 2008
    ..Our aim was to characterize the association of lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) with coronary and aortic atherosclerosis in a large population-based study...
  30. ncbi request reprint Racial disparity in clinical outcomes following primary percutaneous coronary intervention for ST elevation myocardial infarction: influence of process of care
    Joshua A Jacobi
    University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Interv Cardiol 20:182-7. 2007
    ..This suggests that the previously observed differences in mortality rates may be, at least in part, attributable to differences in the process of care, and not solely to differences in patient factors or differential therapeutic effects...
  31. pmc Differential associations between soluble cellular adhesion molecules and atherosclerosis in the Dallas Heart Study: a distinct role for soluble endothelial cell-selective adhesion molecule
    Anand Rohatgi
    Division of Cardiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9047, USA
    Arterioscler Thromb Vasc Biol 29:1684-90. 2009
    ..Given its role in endothelial pathobiology, we hypothesized that soluble ESAM (sESAM) would be independently associated with atherosclerosis and vascular stiffness...
  32. pmc Sex differences in the relationship between C-reactive protein and body fat
    Amit Khera
    Division of Cardiology, University of Texas Southwestern Medical Center, 5909 Harry Hines Boulevard, Dallas, Texas 75390 9047, USA
    J Clin Endocrinol Metab 94:3251-8. 2009
    ..C-reactive protein (CRP) levels are significantly influenced by adiposity and are higher in women compared with men. We postulated that there may be sex differences in the relationship between CRP and body fat...
  33. ncbi request reprint Preventing macrovascular complications in type 2 diabetes mellitus: glucose control and beyond
    Amy Stancoven
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5909 Harry Hines Boulevard, St Paul HA9 133, Dallas, Texas 75235 9047, USA
    Am J Cardiol 99:5H-11H. 2007
    ..Thus, all of these interventions should be used in addition to glucose management in all patients with diabetes who are at increased risk for cardiovascular disease...
  34. pmc Evaluation of coronary artery calcium screening strategies focused on risk categories: the Dallas Heart Study
    Mahesh J Patel
    Division of Cardiology, The University of Texas Southwestern Medical Center, Dallas, TX, USA
    Am Heart J 157:1001-9. 2009
    ..A strategy using coronary artery calcium (CAC) screening to refine coronary heart disease risk assessment in moderately high risk (MHR) subjects (10-year risk 10%-20%) has been suggested. The potential impact of this strategy is unknown...
  35. ncbi request reprint Effect of glucose-insulin-potassium (GIK) infusion on biomarkers of cardiovascular risk in ST elevation myocardial infarction (STEMI): insight into the failure of GIK
    Shailja V Parikh
    Department of Internal Medicine, the University of Texas Southwestern Medical Center in Dallas, Texas 75235 9047, USA
    Diab Vasc Dis Res 4:222-5. 2007
    ..In conclusion, GIK had no discernible effect on biomarkers associated with inflammation, neurohormonal activation or myonecrosis, three pathways associated with adverse outcomes in STEMI...
  36. doi request reprint Screening the population for left ventricular hypertrophy and left ventricular systolic dysfunction using natriuretic peptides: results from the Dallas Heart Study
    James A de Lemos
    Donald W Reynolds Cardiovascular Research Center, UT Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Am Heart J 157:746-53.e2. 2009
    ..We performed a comprehensive evaluation of the screening performance of B-type natriuretic peptide (BNP) and N-terminal pro-BNP (NT-proBNP) for LVSD or LVH...
  37. pmc A forty-year follow-up of the Dallas Bed Rest and Training study: the effect of age on the cardiovascular response to exercise in men
    Jonathan M McGavock
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital, 7232 Greenville Ave, Dallas, TX 75231, USA
    J Gerontol A Biol Sci Med Sci 64:293-9. 2009
    ..The aim of the present study was to reexamine these same men 40 years following the original assessments...
  38. doi request reprint Cardiomyopathy in type 2 diabetes: update on pathophysiological mechanisms
    Justin Saunders
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75235 9047, USA
    Herz 33:184-90. 2008
    ..Continued investigation into these mechanistic connections is necessary to better understand the pathophysiology and ideally inform the pursuit of novel therapeutic targets and strategies to intervene on the HF associated with DM...
  39. doi request reprint Association between renal function and circulating levels of natriuretic peptides (from the Dallas Heart Study)
    Sandeep R Das
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Am J Cardiol 102:1394-8. 2008
    ..With eGFR <90 ml/min/1.73 m(2), both NT-pro-BNP and BNP were inversely and independently associated with renal function, with a greater magnitude of association with renal impairment noted for NT-pro-BNP...
  40. ncbi request reprint Race and gender differences in C-reactive protein levels
    Amit Khera
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9047, USA
    J Am Coll Cardiol 46:464-9. 2005
    ..This study sought to determine whether there are race and gender differences in the distribution of C-reactive protein (CRP) levels...
  41. ncbi request reprint Associations between soluble CD40 ligand, atherosclerosis risk factors, and subclinical atherosclerosis: results from the Dallas Heart Study
    James A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Arterioscler Thromb Vasc Biol 25:2192-6. 2005
    ..The purpose of this study was to evaluate the associations between plasma levels of soluble CD40 ligand (sCD40L), atherosclerosis risk factors, and evidence of subclinical atherosclerosis...
  42. ncbi request reprint B-type natriuretic peptide in cardiovascular disease
    James A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center and Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Lancet 362:316-22. 2003
    ....
  43. ncbi request reprint Relationship between C-reactive protein and subclinical atherosclerosis: the Dallas Heart Study
    Amit Khera
    Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Circulation 113:38-43. 2006
    ..However, less is known regarding the relationship between CRP levels and atherosclerotic burden...
  44. doi request reprint Application of the screening for Heart Attack Prevention and Education Task Force recommendations to an urban population: observations from the Dallas Heart Study
    Raphael See
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Arch Intern Med 168:1055-62. 2008
    ....
  45. ncbi request reprint Relation of family history of myocardial infarction and the presence of coronary arterial calcium in various age and risk factor groups
    Binu Philips
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Cardiol 99:825-9. 2007
    ..05 for each). In conclusion, this study suggests that FHMI is a more important predictor of atherosclerosis in young compared with older adults and, among the young, in those with multiple CV risk factors...
  46. ncbi request reprint Prevalence and determinants of troponin T elevation in the general population
    Thomas W Wallace
    Donald W Reynolds Cardiovascular Clinical Research Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Circulation 113:1958-65. 2006
    ..Our objective was to determine the prevalence and determinants of cTnT elevation in a large, representative sample of the general population...
  47. doi request reprint Effects of the thiazolidinedione medications on micro- and macrovascular complications in patients with diabetes--update 2008
    Anand Rohatgi
    Cardiovascular Division, University of Texas Southwestern Medical Center, Dallas, TX 75235 9047, USA
    Cardiovasc Drugs Ther 22:233-40. 2008
    ..However, the data are sparse assessing the effects of TZDs on micro- and macrovascular disease risk...
  48. pmc Association between circulating soluble receptor for advanced glycation end products and atherosclerosis: observations from the Dallas Heart Study
    Jason B Lindsey
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Diabetes Care 32:1218-20. 2009
    ..To determine the association between circulating soluble receptor for advanced glycation end products (sRAGE) and coronary atherosclerosis...
  49. doi request reprint Platelet perturbations in diabetes: implications for cardiovascular disease risk and treatment
    Shiny Mathewkutty
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Expert Rev Cardiovasc Ther 7:541-9. 2009
    ....
  50. ncbi request reprint Urinary tract infection in patients with acute coronary syndrome: a potential systemic inflammatory connection
    John B Sims
    Department of Medicine, University of Texas Southwestern Medical Center, Dallas, USA
    Am Heart J 149:1062-5. 2005
    ..Inflammation has been linked with atherosclerotic disease development and instability. Contributors to systemic inflammation, such as subclinical infection, may trigger acute coronary syndromes (ACSs)...
  51. doi request reprint The association between peptidoglycan recognition protein-1 and coronary and peripheral atherosclerosis: Observations from the Dallas Heart Study
    Anand Rohatgi
    Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, 75390 9047, United States
    Atherosclerosis 203:569-75. 2009
    ..We hypothesized that PGLYRP-1 is associated with subclinical atherosclerosis as measured by computed tomography and magnetic resonance imaging...
  52. doi request reprint Receptor for advanced glycation end-products (RAGE) and soluble RAGE (sRAGE): cardiovascular implications
    Jason B Lindsey
    The Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, University of Texas Southwestern, Medical Center, 5909 Harry Hines Blvd, Dallas, TX 75235 9047, USA
    Diab Vasc Dis Res 6:7-14. 2009
    ....
  53. pmc Associations of four circulating chemokines with multiple atherosclerosis phenotypes in a large population-based sample: results from the dallas heart study
    Leticia Castillo
    Donald W Reynolds Cardiovascular Research Center and Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Interferon Cytokine Res 30:339-47. 2010
    ..The novel chemotactic protein, CCL23, which has not been previously studied in atherosclerosis, is independently associated with coronary atherosclerosis, suggesting that this chemokine merits further study in animal and human models...
  54. ncbi request reprint Sarcoidosis masquerading as an acute coronary syndrome
    Todd Dorfman
    Department of Internal Medicine at the University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Cardiol Rev 13:256-9. 2005
    ..Given the high prevalence of sarcoidosis, it is important to be aware of the myriad of cardiac manifestations of this infiltrative process...
  55. ncbi request reprint Management of diabetic dyslipidemia: need for reappraisal of the goals
    Amit Khera
    Division of Cardiology and the Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9047, USA
    Am J Cardiovasc Drugs 5:83-91. 2005
    ..Several ongoing trials of various pharmacologic agents should help clarify the role of these agents alone and in combination with HMG-CoA reductase inhibitors in the management of diabetic dyslipidemia...
  56. ncbi request reprint Predictors of coronary artery disease in patients with left bundle branch block undergoing coronary angiography
    Rajjit Abrol
    Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Cardiol 98:1307-10. 2006
    ..50. In contrast, patients with heart failure were less likely to have CAD...
  57. ncbi request reprint Severe sinus bradycardia after initiation of bupropion therapy: a probable drug-drug interaction with metoprolol
    David L McCollum
    Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA
    Cardiovasc Drugs Ther 18:329-30. 2004
    ..One of these is its inhibition of the metabolism of the commonly used beta-blocker, metoprolol. The authors describe a case of severe bradycardia related to the addition of bupropion to the medical regimen of a patient on metoprolol...
  58. doi request reprint Systems-based improvement in door-to-balloon times at a large urban teaching hospital: a follow-up study from Parkland Health and Hospital System
    Shailja V Parikh
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Tex, USA
    Circ Cardiovasc Qual Outcomes 2:116-22. 2009
    ..Timely reperfusion in ST-segment elevation myocardial infarction (STEMI) patients improves clinical outcomes. Implementing strategies to target institutional-specific delays are crucial for improved patient care...
  59. ncbi request reprint Cardiac chagas disease masquerading as an acute myocardial infarction
    Badih J ElMunzer
    Department of Internal Medicine, The University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA
    Cardiol Rev 12:69-72. 2004
    ..In the setting of an increasingly diverse global population and immigration of peoples from endemic areas of Trypanasome Cruzi, it is important to be aware of the myriad cardiac manifestations of Chagas disease...
  60. doi request reprint Variability of clopidogrel response in patients with type 2 diabetes mellitus
    Hurst M Hall
    Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX 75235 9047, USA
    Diab Vasc Dis Res 8:245-53. 2011
    ..More research is needed to better understand both the pharmacology and clinical consequences of these observations...
  61. doi request reprint Rationale and design of IMPROVE-IT (IMProved Reduction of Outcomes: Vytorin Efficacy International Trial): comparison of ezetimbe/simvastatin versus simvastatin monotherapy on cardiovascular outcomes in patients with acute coronary syndromes
    Christopher P Cannon
    The TIMI Study Group, Cardiovascular Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am Heart J 156:826-32. 2008
    ....
  62. doi request reprint Purulent pericarditis: report of 2 cases and review of the literature
    Shailja V Parikh
    Departments of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, USA
    Medicine (Baltimore) 88:52-65. 2009
    ..Thus, a high index of clinical suspicion is crucial. We present 2 cases of purulent pericarditis, and provide an updated review of other case series published over the past 60 years...
  63. ncbi request reprint Effect of glucose-insulin-potassium infusion on plasma free fatty acid concentrations in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction
    Tayo A Addo
    Department of Internal Medicine, Donald W Reynolds Cardiovascular Clinical Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9047, USA
    Am J Cardiol 94:1288-9. 2004
    ..Treatment with glucose-insulin-potassium was associated with significantly lower levels of free fatty acid after 24 hours compared with standard care...
  64. ncbi request reprint Implications of family history of myocardial infarction in young women
    Mahesh J Patel
    Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9034, USA
    Am Heart J 154:454-60. 2007
    ....
  65. ncbi request reprint Comparison of one-year outcomes following coronary artery stenting in diabetic versus nondiabetic patients (from the Enhanced Suppression of the Platelet IIb/IIIa Receptor With Integrilin Therapy [ESPRIT] Trial)
    Marino Labinaz
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Am J Cardiol 90:585-90. 2002
    ..There is no evidence of a statistical interaction in the treatment effect of eptifibatide between patients with and without diabetes...
  66. ncbi request reprint Impaired glucose tolerance and impaired fasting glucose--a review of diagnosis, clinical implications and management
    John L Petersen
    Duke Clinical Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    Diab Vasc Dis Res 2:9-15. 2005
    ..In combination with lifestyle modification, these therapies offer hope for effective prevention of T2DM and its consequences in high-risk patients...
  67. ncbi request reprint Nesiritide in acute heart failure
    Mark Drazner
    Lancet 362:998-9. 2003
  68. ncbi request reprint Early statin initiation and outcomes in patients with acute coronary syndromes
    L Kristin Newby
    Duke Clinical Research Institute, Duke University Medical Center, PO Box 17969, Durham, NC 27715, USA
    JAMA 287:3087-95. 2002
    ....
  69. ncbi request reprint Subclinical diabetes mellitus: is it really "sub-clinical"?
    Mary E Keebler
    Am Heart J 146:210-2. 2003
  70. ncbi request reprint Coronary artery calcium score, risk factors, and incident coronary heart disease events
    Timothy S Church
    The Cooper Institute, Dallas, TX 75230, United States
    Atherosclerosis 190:224-31. 2007
    ..We sought to identify a potential threshold of coronary artery calcium for clinical use and examine the predictive power of coronary artery calcium in individuals categorized using conventional coronary heart disease risk assessment...
  71. ncbi request reprint Underuse of evidence-based treatment partly explains the worse clinical outcome in diabetic patients with acute coronary syndromes
    Raymond T Yan
    Terrence Donnelly Heart Centre, Division of Cardiology, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    Am Heart J 152:676-83. 2006
    ..Diabetes-related differences in treatment and clinical outcome of patients across the entire spectrum of acute coronary syndromes (ACSs) have potential clinical implications but have not been well studied...
  72. ncbi request reprint Influence of diabetes on long-term outcome among unselected patients with acute coronary events
    Ann Marie Svensson
    Clinical Experimental Research Laboratory, Sahlgrenska University Hospital Ostra, Goteborg, Sweden
    Scand Cardiovasc J 38:229-34. 2004
    ....
  73. ncbi request reprint Prevalence and management of hypertension in acute coronary syndrome patients varies by sex: observations from the Sibrafiban versus aspirin to Yield Maximum Protection from ischemic Heart events postacute cOroNary sYndromes (SYMPHONY) randomized clinical
    Camille G Frazier
    Duke University Medical Center, Clinical Research Institute, Durham, NC, USA
    Am Heart J 150:1260-7. 2005
    ..Hypertension affects 1 billion individuals worldwide and is an independent risk factor for death after acute coronary syndromes (ACS)...
  74. ncbi request reprint Diabetes-related knowledge, atherosclerotic risk factor control, and outcomes in acute coronary syndromes
    Carlos D Sánchez
    Duke University School of Medicine and Duke Clinical Research Institute, Durham, North Carolina, USA
    Am J Cardiol 95:1290-4. 2005
    ..New strategies must be developed to translate understanding of disease into better risk factor modification among patients who have diabetes and ACS...
  75. ncbi request reprint Association between hyper- and hypoglycaemia and 2 year all-cause mortality risk in diabetic patients with acute coronary events
    Ann Marie Svensson
    Clinical Experimental Research Laboratory, Sahlgrenska University Hospital Ostra, 416 85 Goteborg, Sweden
    Eur Heart J 26:1255-61. 2005
    ....
  76. ncbi request reprint Elevated body mass index and intermediate-term clinical outcomes after acute coronary syndromes
    Eric L Eisenstein
    Duke University Medical Center and the Duke Clinical Research Institute, Durham, NC 27715, USA
    Am J Med 118:981-90. 2005
    ..We evaluated the relationship between elevated body mass index (BMI) and 30-day, 90-day, and 1-year clinical outcomes postacute coronary syndromes...
  77. ncbi request reprint Interleukin-18, the metabolic syndrome, and subclinical atherosclerosis: results from the Dallas Heart Study
    Andreas Zirlik
    Donald W Reynolds Centers of the Brigham and Women s Hospital, Harvard Medical School, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 27:2043-9. 2007
    ..Although IL-18 promotes atherogenesis in animal studies and predicts cardiovascular risk in humans, it is unknown whether elevated IL-18 levels are associated with coronary atherosclerosis in the general population...
  78. ncbi request reprint Metformin therapy in patients with type 2 diabetes complicated by heart failure
    Silvio E Inzucchi
    Am Heart J 154:e45. 2007
  79. ncbi request reprint Metformin in heart failure
    Silvio E Inzucchi
    Diabetes Care 30:e129. 2007
  80. ncbi request reprint Don't miss this opportunity: Diagnosing diabetes
    Moeen Abedin
    Am Heart J 145:195-7. 2003
  81. ncbi request reprint Advances and continued controversy in coronary revascularization of patients with diabetes mellitus
    John L Petersen
    Duke Clinical Research Institute, Duke University Medical Center, 2400 Pratt Street, Room 0311 Terrace Level, Durham, NC 27705, USA
    Curr Diab Rep 3:351-5. 2003
  82. ncbi request reprint Combating childhood type 2 diabetes mellitus: it will take a village
    Darren K McGuire
    Diab Vasc Dis Res 4:283-4. 2007
  83. ncbi request reprint How aggressive should lipid lowering be among patients with acute coronary syndromes?
    Mahesh Patel
    University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Curr Cardiol Rep 7:283-7. 2005
    ....
  84. ncbi request reprint Syndrome of inappropriate antidiuretic hormone secretion induced by amiodarone therapy
    M Kamran Aslam
    Department of Internal Medicine, The University of Texas, Southwestern Medical Center, Dallas, Texas 75390 9047, USA
    Pacing Clin Electrophysiol 27:831-2. 2004
    ..Amiodarone induced SIADH may develop during the loading phase, and may respond to dose reduction without termination of drug...
  85. doi request reprint New drugs for the treatment of diabetes: part II: Incretin-based therapy and beyond
    Silvio E Inzucchi
    Section of Endocrinology, Yale University School of Medicine, New Haven, CT 06520 8020, USA
    Circulation 117:574-84. 2008
    ....
  86. ncbi request reprint Association of race with complications and prognosis following acute coronary syndromes
    Craig R Asher
    Department of Cardiology, The Cleveland Clinic Foundation, Weston, Florida, USA
    Am J Cardiol 94:792-4. 2004
    ..The 1-year mortality rate was 2.9% for black patients and 2.5% for non-black patients (p = 0.93)...
  87. ncbi request reprint Glucose-insulin-potassium therapy for acute myocardial infarction: what goes around comes around
    Charlie I Gnaim
    Am Heart J 148:924-30. 2004
  88. doi request reprint Treatment delay in patients undergoing primary percutaneous coronary intervention for ST-elevation myocardial infarction: a key process analysis of patient and program factors
    Shailja V Parikh
    Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Am Heart J 155:290-7. 2008
    ..There is heightened interest in identifying and eliminating factors that introduce delay...