Michael McGrath

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Increased HLA-DR expression on peripheral blood monocytes in subsets of subjects with primary HIV infection is associated with elevated CD4 T-cell apoptosis and CD4 T-cell depletion
    Ronnie L Gascon
    University of California at San Francisco, Department of Medicine, 94110, USA
    J Acquir Immune Defic Syndr 30:146-53. 2002
  2. ncbi request reprint MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic lateral sclerosis (sALS)
    Rongzhen Zhang
    University of California, San Francisco, San Francisco General Hospital, San Francisco, CA 94110, USA
    J Neuroimmunol 179:87-93. 2006
  3. pmc HIV-1 nef protein structures associated with brain infection and dementia pathogenesis
    Susanna L Lamers
    Polytechnic Institute of New York University, New York, New York, United States of America
    PLoS ONE 6:e16659. 2011
  4. ncbi request reprint Development of WF10, a novel macrophage-regulating agent
    Michael S McGrath
    AIDS Immunobiology Research Laboratory, San Francisco General Hospital Medical Center, CA 94110, USA
    Curr Opin Investig Drugs 3:365-73. 2002
  5. pmc The role of macrophages in the development and progression of AIDS-related non-Hodgkin lymphoma
    Leanne C Huysentruyt
    Department of Medicine, Hematology and Oncology, University of California, San Francisco, California, USA
    J Leukoc Biol 87:627-32. 2010
  6. ncbi request reprint Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load
    Steven G Deeks
    San Francisco General Hospital, 995 Potrero Ave, San Francisco, CA 94110, USA
    Blood 104:942-7. 2004
  7. ncbi request reprint Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS)
    Rongzhen Zhang
    University of California, San Francisco, San Francisco General Hospital, 995 Potrero Avenue, Building 80, Ward 84, Box 0874, San Francisco, CA 94110, USA
    J Neuroimmunol 159:215-24. 2005
  8. pmc Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)
    Rongzhen Zhang
    University of California, San Francisco, San Francisco, CA 94110, USA
    J Neuroimmunol 206:121-4. 2009
  9. pmc HIV-1 nef protein visits B-cells via macrophage nanotubes: a mechanism for AIDS-related lymphoma pathogenesis?
    Susanna L Lamers
    Polytechnic Institute of New York University, Brooklyn, NY, USA
    Curr HIV Res 8:638-40. 2010
  10. ncbi request reprint Differential effects on innate versus adaptive immune responses by WF10
    Thomas Giese
    Institute of Immunology, School of Medicine, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
    Cell Immunol 229:149-58. 2004

Research Grants

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Increased HLA-DR expression on peripheral blood monocytes in subsets of subjects with primary HIV infection is associated with elevated CD4 T-cell apoptosis and CD4 T-cell depletion
    Ronnie L Gascon
    University of California at San Francisco, Department of Medicine, 94110, USA
    J Acquir Immune Defic Syndr 30:146-53. 2002
    ..002). We conclude that monocyte activation as defined by elevation of CD14/DR expression correlates to CD4 T-cell depletion in primary HIV infection, and is predictive of a poor CD4 T-cell response to HAART in a subset of patients...
  2. ncbi request reprint MCP-1 chemokine receptor CCR2 is decreased on circulating monocytes in sporadic amyotrophic lateral sclerosis (sALS)
    Rongzhen Zhang
    University of California, San Francisco, San Francisco General Hospital, San Francisco, CA 94110, USA
    J Neuroimmunol 179:87-93. 2006
    ..Defective monocyte/macrophages may play an active role in sALS...
  3. pmc HIV-1 nef protein structures associated with brain infection and dementia pathogenesis
    Susanna L Lamers
    Polytechnic Institute of New York University, New York, New York, United States of America
    PLoS ONE 6:e16659. 2011
    ..The potential finding of a brain-specific nef structure indicates that HAD may result from genetic alterations that alter the folding or binding potential of the protein...
  4. ncbi request reprint Development of WF10, a novel macrophage-regulating agent
    Michael S McGrath
    AIDS Immunobiology Research Laboratory, San Francisco General Hospital Medical Center, CA 94110, USA
    Curr Opin Investig Drugs 3:365-73. 2002
    ..WF10 is currently being studied in the US, Europe and Asia for treatment of late-stage HIV disease, as well as recurrent prostate cancer, late post-radiation cystitis, autoimmune disease and chronic active hepatitis C disease...
  5. pmc The role of macrophages in the development and progression of AIDS-related non-Hodgkin lymphoma
    Leanne C Huysentruyt
    Department of Medicine, Hematology and Oncology, University of California, San Francisco, California, USA
    J Leukoc Biol 87:627-32. 2010
    ..This review will highlight and discuss the role of macrophage viral reservoirs in the development and progression of ARLs and hopefully, shed light on this new and interesting field...
  6. ncbi request reprint Immune activation set point during early HIV infection predicts subsequent CD4+ T-cell changes independent of viral load
    Steven G Deeks
    San Francisco General Hospital, 995 Potrero Ave, San Francisco, CA 94110, USA
    Blood 104:942-7. 2004
    ..These data indicate that immunologic activation set point is established early in HIV infection, and that this set point determines the rate at which CD4+ T cells are lost over time...
  7. ncbi request reprint Evidence for systemic immune system alterations in sporadic amyotrophic lateral sclerosis (sALS)
    Rongzhen Zhang
    University of California, San Francisco, San Francisco General Hospital, 995 Potrero Avenue, Building 80, Ward 84, Box 0874, San Francisco, CA 94110, USA
    J Neuroimmunol 159:215-24. 2005
    ..These data are consistent with a disease model previously suggested for AD, wherein systemic immunologic activation plays an active role in sALS...
  8. pmc Circulating endotoxin and systemic immune activation in sporadic amyotrophic lateral sclerosis (sALS)
    Rongzhen Zhang
    University of California, San Francisco, San Francisco, CA 94110, USA
    J Neuroimmunol 206:121-4. 2009
    ..These data suggest that systemic LPS levels and activated monocyte/macrophages may play significant roles in the pathogenesis of sALS...
  9. pmc HIV-1 nef protein visits B-cells via macrophage nanotubes: a mechanism for AIDS-related lymphoma pathogenesis?
    Susanna L Lamers
    Polytechnic Institute of New York University, Brooklyn, NY, USA
    Curr HIV Res 8:638-40. 2010
    ..The conduits discovered by Xu et al. may lead to a better understanding of how HIV infection results in lymphomagenesis...
  10. ncbi request reprint Differential effects on innate versus adaptive immune responses by WF10
    Thomas Giese
    Institute of Immunology, School of Medicine, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
    Cell Immunol 229:149-58. 2004
    ..Inhibition of NFAT regulated genes in activated lymphocytes in concert with the induction of several myeloid cell associated pro-inflammatory genes in monocytes represents a novel mechanism of immune modulation...
  11. pmc Prediction of R5, X4, and R5X4 HIV-1 coreceptor usage with evolved neural networks
    Susanna L Lamers
    BioInfoExperts, Gainesville, FL 32606, USA
    IEEE/ACM Trans Comput Biol Bioinform 5:291-300. 2008
    ..We demonstrate the use of artificial neural networks trained via evolutionary computation to predict viral co-receptor usage. The results indicate identification of R5X4 viruses with predictive accuracy of 75.5%...
  12. ncbi request reprint Injection of human primary effusion lymphoma cells or associated macrophages into severe combined immunodeficient mice causes murine lymphomas
    Elisabeth Zenger
    Department of Laboratory Medicine, University of California, San Francisco, California 94110, USA
    Cancer Res 62:5536-42. 2002
    ..S. McGrath et al., Acquir. Immune Defic. Syndr., 8: 379-385, 1995; M. S. McGrath et al., Infectious Causes of Cancer: Targets for Intervention, pp. 231-242, Totowa, NJ: Humana Press, 2000)...
  13. pmc Phylodynamic analysis of human immunodeficiency virus type 1 in distinct brain compartments provides a model for the neuropathogenesis of AIDS
    Marco Salemi
    Department of Ecology and Evolutionary Biology, University of California at Irvine, USA
    J Virol 79:11343-52. 2005
    ....

Research Grants15

  1. HIV Sequence Evolution in AIDS Dementia Pathogenesis
    Michael McGrath; Fiscal Year: 2009
    ..The ultimate goal will be to determine whether specific HIV sequences contribute to HAD pathogenesis and whether those sequences can be identified in the blood of patients at risk for HAD. ..
  2. HIV Sequence Evolution in AIDS Dementia Pathogenesis
    Michael McGrath; Fiscal Year: 2005
    ..The ultimate goal will be to determine whether specific HIV sequences contribute to HAD pathogenesis and whether those sequences can be identified in the blood of patients at risk for HAD. ..
  3. ACSB Central Operations and Data Coodinating Center
    Michael McGrath; Fiscal Year: 2007
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  4. West Coast AIDS and Cancer Specimen Bank Consortium
    Michael McGrath; Fiscal Year: 2007
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  5. Macrophage Targeted Therapy for HAD and HIV Disease
    Michael McGrath; Fiscal Year: 2007
    ..The proposed studies will be coordinated by Michael McGrath M.D., PhD...
  6. HIV Sequence Evolution in AIDS Dementia Pathogenesis
    Michael McGrath; Fiscal Year: 2007
    ..The ultimate goal will be to determine whether specific HIV sequences contribute to HAD pathogenesis and whether those sequences can be identified in the blood of patients at risk for HAD. ..
  7. West Coast AIDS and Cancer Specimen Bank Consortium
    Michael McGrath; Fiscal Year: 2006
    ..The coordinated interaction between this West Coast consortium with other funded ACSB sites will be assured by Dr. McGrath?s continued participation in the overall leadership of the national ACSB. ..
  8. ACSB Central Operations and Data Coodinating Center
    Michael McGrath; Fiscal Year: 2006
    ..The annual planning session is used to evaluate as well as plan for the upcoming year. This newly established CODCC will work the NCI and funded ACSB sites specifically as defined by the current RFA. ..
  9. HIV Sequence Evolution in AIDS Dementia Pathogenesis
    Michael McGrath; Fiscal Year: 2006
    ..The ultimate goal will be to determine whether specific HIV sequences contribute to HAD pathogenesis and whether those sequences can be identified in the blood of patients at risk for HAD. ..
  10. Endogenous Retrovirus Herv-K in Lymphoma and ALS
    Michael McGrath; Fiscal Year: 2004
    ..Additionally this study can open up new avenues of investigation into the etiology, pathogenesis and, ultimately, the treatment of both lymphoma and ALS. ..