Kathleen E McGrath

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Multispectral imaging of hematopoietic cells: where flow meets morphology
    Kathleen E McGrath
    University of Rochester Medical Center, Department of Pediatrics, Center for Pediatric Biomedical Research, Box 703, 601 Elmwood Ave, Rochester, NY 14642, United States
    J Immunol Methods 336:91-7. 2008
  2. pmc A transient definitive erythroid lineage with unique regulation of the β-globin locus in the mammalian embryo
    Kathleen E McGrath
    Department of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, NY, USA
    Blood 117:4600-8. 2011
  3. pmc Ontogeny of erythroid gene expression
    Paul D Kingsley
    Department of Pediatrics, University of Rochester Medical Center, Center for Pediatric Biomedical Research, Rochester, NY 14642, USA
    Blood 121:e5-e13. 2013
  4. pmc EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress
    Scott A Peslak
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Blood 120:2501-11. 2012
  5. pmc Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus
    Samantha J England
    Department of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    Blood 117:2708-17. 2011
  6. pmc Sublethal radiation injury uncovers a functional transition during erythroid maturation
    Scott A Peslak
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Exp Hematol 39:434-45. 2011
  7. pmc Primitive erythropoiesis and megakaryopoiesis in the yolk sac are independent of c-myb
    Joanna Tober
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Blood 111:2636-9. 2008
  8. pmc The Chromatin "Landscape" of a Murine Adult β-Globin Gene Is Unaffected by Deletion of Either the Gene Promoter or a Downstream Enhancer
    Brenda Cadiz-Rivera
    Department of Pediatrics, University of Rochester Medical Center and Center for Pediatric Biomedical Research, Rochester, New York, United States of America
    PLoS ONE 9:e92947. 2014
  9. pmc Prostaglandin E2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury
    Rebecca L Porter
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Stem Cells 31:372-83. 2013
  10. pmc Enucleation of primitive erythroid cells generates a transient population of "pyrenocytes" in the mammalian fetus
    Kathleen E McGrath
    University of Rochester Medical Center, Department of Pediatrics, Center for Pediatric Biomedical Research, Rochester, NY 14642, USA
    Blood 111:2409-17. 2008

Collaborators

  • J Palis
  • Stephen D Dertinger
  • Yuhchyau Chen
  • COLIN K PHOON
  • Paul D Kingsley
  • Jenna M Frame
  • Lisa M Niswander
  • Scott A Peslak
  • Joanna Tober
  • Brenda Cadiz-Rivera
  • George Fromm
  • Michael Bulger
  • Rebecca L Porter
  • Jennifer Fields
  • Christina de Vries
  • Steven Fiering
  • Jeffrey C Bemis
  • Jesse Wenger
  • Anne D Koniski
  • Samantha J England
  • Timothy P Bushnell
  • Jeffrey Malik
  • Rui Ping Ji
  • Katherine H Fegan
  • John C Kennedy
  • Michael W Becker
  • Benjamin J Frisch
  • Olga Bromberg
  • Laura M Calvi
  • Mary A Georger
  • Emily Greenfest-Allen
  • Christian J Stoeckert
  • Michael Getman
  • Jacqueline P Williams
  • Anne Koniski
  • Karen K L de Mesy-Bentley
  • Rachael Emerson
  • Radhika Vemishetti
  • Richard Waugh
  • Laura A Bloedorn
  • Rachel L Emerson
  • Orlando Aristizabal
  • Daniel H Turnbull

Detail Information

Publications20

  1. pmc Multispectral imaging of hematopoietic cells: where flow meets morphology
    Kathleen E McGrath
    University of Rochester Medical Center, Department of Pediatrics, Center for Pediatric Biomedical Research, Box 703, 601 Elmwood Ave, Rochester, NY 14642, United States
    J Immunol Methods 336:91-7. 2008
    ....
  2. pmc A transient definitive erythroid lineage with unique regulation of the β-globin locus in the mammalian embryo
    Kathleen E McGrath
    Department of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, NY, USA
    Blood 117:4600-8. 2011
    ..We conclude that yolk sac-derived EMPs, the first of 2 origins of definitive erythropoiesis, express a unique pattern of globin genes as they generate the first definitive erythrocytes in the liver of the mammalian embryo...
  3. pmc Ontogeny of erythroid gene expression
    Paul D Kingsley
    Department of Pediatrics, University of Rochester Medical Center, Center for Pediatric Biomedical Research, Rochester, NY 14642, USA
    Blood 121:e5-e13. 2013
    ..We have created a user-friendly Web site (http://www.cbil.upenn.edu/ErythronDB) to make these global expression data readily accessible and amenable to complex search strategies by the scientific community...
  4. pmc EPO-mediated expansion of late-stage erythroid progenitors in the bone marrow initiates recovery from sublethal radiation stress
    Scott A Peslak
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, 601 Elmwood Ave, Rochester, NY 14642, USA
    Blood 120:2501-11. 2012
    ....
  5. pmc Immature erythroblasts with extensive ex vivo self-renewal capacity emerge from the early mammalian fetus
    Samantha J England
    Department of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    Blood 117:2708-17. 2011
    ..Extensively self-renewing erythroblasts, despite their near complete maturity within the hematopoietic hierarchy, may ultimately serve as a renewable source of red cells for transfusion therapy...
  6. pmc Sublethal radiation injury uncovers a functional transition during erythroid maturation
    Scott A Peslak
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Exp Hematol 39:434-45. 2011
    ..To better understand this phenomenon, we investigated the kinetics and apoptotic response of the erythron to sublethal radiation injury...
  7. pmc Primitive erythropoiesis and megakaryopoiesis in the yolk sac are independent of c-myb
    Joanna Tober
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY 14642, USA
    Blood 111:2636-9. 2008
    ..5 yolk sac and E11.5 liver. Despite this impaired megakaryocyte potential, c-myb-null fetuses had normal platelet numbers at E12.5 but became thrombocytopenic by E15.5, suggesting that c-myb is required for sustained thrombopoiesis...
  8. pmc The Chromatin "Landscape" of a Murine Adult β-Globin Gene Is Unaffected by Deletion of Either the Gene Promoter or a Downstream Enhancer
    Brenda Cadiz-Rivera
    Department of Pediatrics, University of Rochester Medical Center and Center for Pediatric Biomedical Research, Rochester, New York, United States of America
    PLoS ONE 9:e92947. 2014
    ..This observation highlights the difficulty in assigning function to enhancer sequences identified by the chromatin "landscape" or even by functional assays. ..
  9. pmc Prostaglandin E2 increases hematopoietic stem cell survival and accelerates hematopoietic recovery after radiation injury
    Rebecca L Porter
    Department of Medicine, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Stem Cells 31:372-83. 2013
    ..The current data provide rationale for in vivo manipulation of the HSPC pool as a strategy to improve recovery after myelosuppression...
  10. pmc Enucleation of primitive erythroid cells generates a transient population of "pyrenocytes" in the mammalian fetus
    Kathleen E McGrath
    University of Rochester Medical Center, Department of Pediatrics, Center for Pediatric Biomedical Research, Rochester, NY 14642, USA
    Blood 111:2409-17. 2008
    ..Continued studies comparing primitive and definitive erythropoiesis will lead to an improved understanding of terminal erythroid maturation...
  11. pmc An embryonic stage-specific enhancer within the murine β-globin locus mediates domain-wide histone hyperacetylation
    George Fromm
    Department of Pediatrics, University of Rochester Medical Center, Center for Pediatric Biomedical Research, Rochester, NY, USA
    Blood 117:5207-14. 2011
    ....
  12. pmc Erythro-myeloid progenitors: "definitive" hematopoiesis in the conceptus prior to the emergence of hematopoietic stem cells
    Jenna M Frame
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, Rochester, NY, USA Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA
    Blood Cells Mol Dis 51:220-5. 2013
    ....
  13. doi request reprint Primitive erythropoiesis in the mammalian embryo
    James Palis
    University of Rochester Medical Center, Department of Pediatrics, Center for Pediatric Biomedical Research, New York 14642, USA
    Int J Dev Biol 54:1011-8. 2010
    ..This surprising finding indicates that the primitive erythroid lineage is indeed mammalian, rather than non-mammalian, in character...
  14. ncbi request reprint Circulation is established in a stepwise pattern in the mammalian embryo
    Kathleen E McGrath
    Center for Human Genetics and Molecular Pediatric Diseases, Department of Pediatrics, University of Rochester, NY, USA
    Blood 101:1669-76. 2003
    ..We conclude that a functional vascular system develops gradually and that specialized vascular-hematopoietic environments exist after circulation becomes fully established...
  15. ncbi request reprint SDF-1 dynamically mediates megakaryocyte niche occupancy and thrombopoiesis at steady state and following radiation injury
    Lisa M Niswander
    Center for Pediatric Biomedical Research, Department of Pediatrics, and Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY
    Blood 124:277-86. 2014
    ..This knowledge of the microenvironmental regulation of the MK lineage could lead to improved therapeutic strategies for thrombocytopenia. ..
  16. ncbi request reprint Improved quantitative analysis of primary bone marrow megakaryocytes utilizing imaging flow cytometry
    Lisa M Niswander
    Department of Pediatrics, Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, New York, 14642 Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, New York, 14642
    Cytometry A 85:302-12. 2014
    ..The ability to accurately analyze the full spectrum of maturing MKs in the bone marrow now allows for many possible applications of IFC to enhance our understanding of megakaryopoiesis and platelet production...
  17. pmc "Maturational" globin switching in primary primitive erythroid cells
    Paul D Kingsley
    Department of Pediatrics, University of Rochester Medical Center, Center for Pediatric Biomedical Research, Box 703, 601 Elmwood Ave, Rochester, NY 14642, USA
    Blood 107:1665-72. 2006
    ..Globin switching during ontogeny is due not only to the sequential appearance of primitive and definitive lineages but also to changes in globin expression as primitive erythroblasts mature in the bloodstream...
  18. pmc The megakaryocyte lineage originates from hemangioblast precursors and is an integral component both of primitive and of definitive hematopoiesis
    Joanna Tober
    Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester Medical Center, NY 14642, USA
    Blood 109:1433-41. 2007
    ....
  19. ncbi request reprint Hematopoiesis in the yolk sac: more than meets the eye
    Kathleen E McGrath
    Department of Pediatrics and the Center for Pediatric Biomedical Research, University of Rochester Medical Center, Rochester, NY 14642, USA
    Exp Hematol 33:1021-8. 2005
    ....
  20. ncbi request reprint Onset of cardiac function during early mouse embryogenesis coincides with entry of primitive erythroblasts into the embryo proper
    Rui Ping Ji
    Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY, USA
    Circ Res 92:133-5. 2003
    ..In situ hybridization revealed an onset of the heartbeat coincident with the appearance of yolk sac-derived erythroblasts in the embryo proper at 5 S. Early maturation of the circulation follows a tightly coordinated program...