James L McGrath

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Highly permeable silicon membranes for shear free chemotaxis and rapid cell labeling
    Henry H Chung
    Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA
    Lab Chip 14:2456-68. 2014
  2. ncbi request reprint Cell spreading: the power to simplify
    James L McGrath
    Department of Biomedical Engineering, University of Rochester, Rochester, New York 14627, USA
    Curr Biol 17:R357-8. 2007
  3. ncbi request reprint Cell mechanics: filaminA leads the way
    James L McGrath
    Department of Biomedical Engineering, University of Rochester, PO Box 639, Rochester, New York 14450, USA
    Curr Biol 16:R326-7. 2006
  4. ncbi request reprint Microtubule mechanics: a little flexibility goes a long way
    James L McGrath
    Department of Biomedical Engineering, University of Rochester Medical Center, 601 Elmwood Avenue, PO Box 639, Rochester, New York 14642, USA
    Curr Biol 16:R800-2. 2006
  5. pmc High-performance, low-voltage electroosmotic pumps with molecularly thin silicon nanomembranes
    Jessica L Snyder
    Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642
    Proc Natl Acad Sci U S A 110:18425-30. 2013
  6. ncbi request reprint Dynamics of adhesion molecule domains on neutrophil membranes: surfing the dynamic cell topography
    Thomas R Gaborski
    Department of Biomedical Engineering, University of Rochester, Rochester, NY, 14627, USA
    Eur Biophys J 42:851-5. 2013
  7. ncbi request reprint Ultrathin silicon membranes for wearable dialysis
    Dean G Johnson
    Department of Biomedical Engineering, University of Rochester, Rochester, NY Electronic address
    Adv Chronic Kidney Dis 20:508-15. 2013
  8. pmc Membrane mobility of beta2 integrins and rolling associated adhesion molecules in resting neutrophils
    Thomas R Gaborski
    Department of Biomedical Engineering and Department of Mechanical Engineering, University of Rochester, Rochester, New York 14642, USA
    Biophys J 95:4934-47. 2008
  9. pmc Pore size control of ultrathin silicon membranes by rapid thermal carbonization
    David Z Fang
    Department of Electrical and Computer Engineering, Box 270231, University of Rochester, Rochester, New York 14627, USA
    Nano Lett 10:3904-8. 2010
  10. ncbi request reprint The influence of protein adsorption on nanoparticle association with cultured endothelial cells
    Morton S Ehrenberg
    Department of Biomedical Engineering, University of Rochester, Goergen Hall, Rochester, NY 14627, USA
    Biomaterials 30:603-10. 2009

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Highly permeable silicon membranes for shear free chemotaxis and rapid cell labeling
    Henry H Chung
    Department of Biomedical Engineering, University of Rochester, Rochester, NY, USA
    Lab Chip 14:2456-68. 2014
    ..Finally we demonstrate that our device allows us to expose migrating neutrophils to a chemotactic gradient or fluorescent label without any influence from flow. ..
  2. ncbi request reprint Cell spreading: the power to simplify
    James L McGrath
    Department of Biomedical Engineering, University of Rochester, Rochester, New York 14627, USA
    Curr Biol 17:R357-8. 2007
    ..Recent work suggests a common physical mechanism can explain the early stages of cell spreading for a wide range of cell types and substrates...
  3. ncbi request reprint Cell mechanics: filaminA leads the way
    James L McGrath
    Department of Biomedical Engineering, University of Rochester, PO Box 639, Rochester, New York 14450, USA
    Curr Biol 16:R326-7. 2006
    ..A new study has found that reconstituted networks that include the cross-linker filaminA can replicate many of the mechanical properties of cells if they are stressed prior to mechanical measurement...
  4. ncbi request reprint Microtubule mechanics: a little flexibility goes a long way
    James L McGrath
    Department of Biomedical Engineering, University of Rochester Medical Center, 601 Elmwood Avenue, PO Box 639, Rochester, New York 14642, USA
    Curr Biol 16:R800-2. 2006
    ..A recent analysis suggests these buckles are evidence of high contractile forces throughout the cytoplasm, and that the other elements of the cytoskeleton laterally reinforce microtubules to help prevent their collapse...
  5. pmc High-performance, low-voltage electroosmotic pumps with molecularly thin silicon nanomembranes
    Jessica L Snyder
    Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642
    Proc Natl Acad Sci U S A 110:18425-30. 2013
    ..5-mm-diameter capillary tubing with as low as 250 mV of applied voltage. This silicon-based platform enables straightforward integration of low-voltage, on-chip EOPs into portable microfluidic devices with low back pressures. ..
  6. ncbi request reprint Dynamics of adhesion molecule domains on neutrophil membranes: surfing the dynamic cell topography
    Thomas R Gaborski
    Department of Biomedical Engineering, University of Rochester, Rochester, NY, 14627, USA
    Eur Biophys J 42:851-5. 2013
    ..The diffusion of pre-assembled integrin domains to zones of neutrophil/endothelial contact may provide a mechanism to facilitate high avidity adhesion during the earliest stages of firm arrest. ..
  7. ncbi request reprint Ultrathin silicon membranes for wearable dialysis
    Dean G Johnson
    Department of Biomedical Engineering, University of Rochester, Rochester, NY Electronic address
    Adv Chronic Kidney Dis 20:508-15. 2013
    ..Finally, surface modifications with thin hydrophilic coatings are shown to block cell and protein adhesion. ..
  8. pmc Membrane mobility of beta2 integrins and rolling associated adhesion molecules in resting neutrophils
    Thomas R Gaborski
    Department of Biomedical Engineering and Department of Mechanical Engineering, University of Rochester, Rochester, New York 14642, USA
    Biophys J 95:4934-47. 2008
    ....
  9. pmc Pore size control of ultrathin silicon membranes by rapid thermal carbonization
    David Z Fang
    Department of Electrical and Computer Engineering, Box 270231, University of Rochester, Rochester, New York 14627, USA
    Nano Lett 10:3904-8. 2010
    ..Initial experiments show that carbonized membranes follow theoretical predictions for hydraulic permeability and retain the precise separation capabilities of untreated membranes...
  10. ncbi request reprint The influence of protein adsorption on nanoparticle association with cultured endothelial cells
    Morton S Ehrenberg
    Department of Biomedical Engineering, University of Rochester, Goergen Hall, Rochester, NY 14627, USA
    Biomaterials 30:603-10. 2009
    ..We therefore conclude that cellular association is not dependent on the identity of adsorbed proteins and therefore unlikely to require specific binding to any particular cellular receptors...
  11. ncbi request reprint Charge- and size-based separation of macromolecules using ultrathin silicon membranes
    Christopher C Striemer
    Department of Electrical and Computer Engineering, University of Rochester, Rochester, New York 14627, USA
    Nature 445:749-53. 2007
    ....
  12. ncbi request reprint Highly porous silicon membranes fabricated from silicon nitride/silicon stacks
    Chengzhu Qi
    Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, 37235, United States Materials Science Program, University of Rochester, Rochester, NY, 14627, United States
    Small 10:2946-53. 2014
    ..It is hypothesized that this could result from the interfacial energy difference between the silicon/silicon nitride and silicon/silicon dioxide, which influences the Si crystallization process. ..
  13. pmc Opposing roles for RhoH GTPase during T-cell migration and activation
    Christina M Baker
    Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY 14642, USA
    Proc Natl Acad Sci U S A 109:10474-9. 2012
    ..Thus, we conclude that RhoH expression provides a key molecular determinant that allows T cells to switch between sensing chemokine-mediated go signals and TCR-dependent stop signals...
  14. pmc Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1
    Young Min Hyun
    Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, University of Rochester, NY 14642, USA
    J Immunol 183:359-69. 2009
    ..These data suggest that a subpopulation of activated VLA-4 is mainly localized to the leading edge of polarized human T cells and is critical for T cell migration on VCAM-1...
  15. pmc High-performance separation of nanoparticles with ultrathin porous nanocrystalline silicon membranes
    Thomas R Gaborski
    Department of Biomedical Engineering, University of Rochester, Rochester, New York 14627, United States
    ACS Nano 4:6973-81. 2010
    ..These performance characteristics, combined with scalable manufacturing, make pnc-Si filtration a straightforward solution to many nanoparticle and biological separation problems...
  16. ncbi request reprint Relationships between actin regulatory mechanisms and measurable state variables
    Michael Bindschadler
    Department of Biomedical Engineering, University of Rochester, Rochester, NY 14642, USA
    Ann Biomed Eng 35:995-1011. 2007
    ....
  17. pmc LC/LC-MS/MS of an innovative prostate human epithelial cancer (PHEC) in vitro model system
    John D Lapek
    University of Rochester Medical Center, Department of Environmental Medicine, Rochester, NY 14642, United States
    J Chromatogr B Analyt Technol Biomed Life Sci 893:34-42. 2012
    ..The combination of the two dimensional liquid:liquid separation and mass spectral identifications was used to successfully analyze differential protein expression between multiple cell lines...
  18. pmc Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: association with mucoadhesion and efficient penetration of the sublingual barrier
    William Domm
    Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14627, USA
    Vaccine 29:7080-9. 2011
    ..Overall, these findings support the further exploration of the SL delivery route for HIV-1 vaccine delivery...
  19. ncbi request reprint Metallization of surface-attached actin networks
    Michael Springer
    Department of Biomedical Engineering, University of Rochester, Rochester, NY 14642, USA
    Conf Proc IEEE Eng Med Biol Soc 1:1466-9. 2006
    ..As a step toward the use of actin in more sophisticated constructs, we report here on methods for the successful metallization of surface-attached actin networks...
  20. ncbi request reprint Sheet migration by wounded monolayers as an emergent property of single-cell dynamics
    Michael Bindschadler
    Department of Biomedical Engineering, University of Rochester, Rochester, NY 14450, USA
    J Cell Sci 120:876-84. 2007
    ..Instead, our analysis suggests that steady sheet migration can be explained by cell spreading in the monolayer...
  21. ncbi request reprint Actin motility: staying on track takes a little more effort
    Morton Ehrenberg
    University of Rochester, Department of Biomedical Engineering, 601 Elmwood Ave, PO Box 639, Rochester, New York 14642, USA
    Curr Biol 14:R931-2. 2004
    ..Recent work provides more evidence that these motors are engaged in a continuous tug-of-war...
  22. ncbi request reprint Dynein motility: four heads are better than two
    James L McGrath
    Department of Biomedical Engineering, University of Rochester, NY 14450, USA
    Curr Biol 15:R970-2. 2005
    ..The movement driven by a single dynein molecule in vitro is not as robust as dynein-driven movements in cells. A new study suggests that transport by multiple dyneins is more similar to cellular motions...
  23. ncbi request reprint The role of substrate curvature in actin-based pushing forces
    Ian M Schwartz
    Department of Biomedical Engineering, University of Rochester, 601 Elmwood Avenue, P O Box 639, Rochester, NY 14642 USA
    Curr Biol 14:1094-8. 2004
    ..Collectively the data indicate that curvature-dependent mechanisms are not required for actin-based pushing...
  24. pmc A structure-permeability relationship of ultrathin nanoporous silicon membrane: a comparison with the nuclear envelope
    Eunkyoung Kim
    Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    J Am Chem Soc 130:4230-1. 2008
    ....

Research Grants4

  1. Ultrathin silicon nanofilters for efficient and small scale molecular separations
    James McGrath; Fiscal Year: 2007
    ..These abilities are expected to enable a host of new small scale clinical and diagnostic devices. ..
  2. Charge and size based filtration by ultrathin silicon membranes
    James McGrath; Fiscal Year: 2007
    ..These abilities are expected to enable a host of new small scale clinical and diagnostic devices. ..