Research Topics
| James L McGrathSummaryAffiliation: University of Rochester Country: USA Publications
Research Grants
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Detail Information
Publications
Cell spreading: the power to simplifyJames L McGrath
Department of Biomedical Engineering, University of Rochester, Rochester, New York 14627, USA
Curr Biol 17:R357-8. 2007..Recent work suggests a common physical mechanism can explain the early stages of cell spreading for a wide range of cell types and substrates...- Cell mechanics: filaminA leads the wayJames L McGrath
Department of Biomedical Engineering, University of Rochester, PO Box 639, Rochester, New York 14450, USA
Curr Biol 16:R326-7. 2006..A new study has found that reconstituted networks that include the cross-linker filaminA can replicate many of the mechanical properties of cells if they are stressed prior to mechanical measurement... - Microtubule mechanics: a little flexibility goes a long wayJames L McGrath
Department of Biomedical Engineering, University of Rochester Medical Center, 601 Elmwood Avenue, PO Box 639, Rochester, New York 14642, USA
Curr Biol 16:R800-2. 2006..A recent analysis suggests these buckles are evidence of high contractile forces throughout the cytoplasm, and that the other elements of the cytoskeleton laterally reinforce microtubules to help prevent their collapse... 
The influence of protein adsorption on nanoparticle association with cultured endothelial cellsMorton S Ehrenberg
Department of Biomedical Engineering, University of Rochester, Goergen Hall, Rochester, NY 14627, USA
Biomaterials 30:603-10. 2009..We therefore conclude that cellular association is not dependent on the identity of adsorbed proteins and therefore unlikely to require specific binding to any particular cellular receptors...
Pore size control of ultrathin silicon membranes by rapid thermal carbonizationDavid Z Fang
Department of Electrical and Computer Engineering, Box 270231, University of Rochester, Rochester, New York 14627, USA
Nano Lett 10:3904-8. 2010..Initial experiments show that carbonized membranes follow theoretical predictions for hydraulic permeability and retain the precise separation capabilities of untreated membranes...- Charge- and size-based separation of macromolecules using ultrathin silicon membranesChristopher C Striemer
Department of Electrical and Computer Engineering, University of Rochester, Rochester, New York 14627, USA
Nature 445:749-53. 2007.... - Opposing roles for RhoH GTPase during T-cell migration and activationChristina M Baker
Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY 14642, USA
Proc Natl Acad Sci U S A 109:10474-9. 2012..Thus, we conclude that RhoH expression provides a key molecular determinant that allows T cells to switch between sensing chemokine-mediated go signals and TCR-dependent stop signals... - Membrane mobility of beta2 integrins and rolling associated adhesion molecules in resting neutrophilsThomas R Gaborski
Department of Biomedical Engineering and Department of Mechanical Engineering, University of Rochester, Rochester, New York 14642, USA
Biophys J 95:4934-47. 2008.... - High-performance separation of nanoparticles with ultrathin porous nanocrystalline silicon membranesThomas R Gaborski
Department of Biomedical Engineering, University of Rochester, Rochester, New York 14627, United States
ACS Nano 4:6973-81. 2010..These performance characteristics, combined with scalable manufacturing, make pnc-Si filtration a straightforward solution to many nanoparticle and biological separation problems... - Relationships between actin regulatory mechanisms and measurable state variablesMichael Bindschadler
Department of Biomedical Engineering, University of Rochester, Rochester, NY 14642, USA
Ann Biomed Eng 35:995-1011. 2007.... - LC/LC-MS/MS of an innovative prostate human epithelial cancer (PHEC) in vitro model systemJohn D Lapek
University of Rochester Medical Center, Department of Environmental Medicine, Rochester, NY 14642, United States
J Chromatogr B Analyt Technol Biomed Life Sci 893:34-42. 2012..The combination of the two dimensional liquid:liquid separation and mass spectral identifications was used to successfully analyze differential protein expression between multiple cell lines... - Robust antigen-specific humoral immune responses to sublingually delivered adenoviral vectors encoding HIV-1 Env: association with mucoadhesion and efficient penetration of the sublingual barrierWilliam Domm
Department of Microbiology and Immunology, University of Rochester, Rochester, NY 14627, USA
Vaccine 29:7080-9. 2011..Overall, these findings support the further exploration of the SL delivery route for HIV-1 vaccine delivery... - Activated integrin VLA-4 localizes to the lamellipodia and mediates T cell migration on VCAM-1Young Min Hyun
Department of Microbiology and Immunology, David H Smith Center for Vaccine Biology and Immunology, University of Rochester, NY 14642, USA
J Immunol 183:359-69. 2009..These data suggest that a subpopulation of activated VLA-4 is mainly localized to the leading edge of polarized human T cells and is critical for T cell migration on VCAM-1... - Metallization of surface-attached actin networksMichael Springer
Department of Biomedical Engineering, University of Rochester, Rochester, NY 14642, USA
Conf Proc IEEE Eng Med Biol Soc 1:1466-9. 2006..As a step toward the use of actin in more sophisticated constructs, we report here on methods for the successful metallization of surface-attached actin networks... - Sheet migration by wounded monolayers as an emergent property of single-cell dynamicsMichael Bindschadler
Department of Biomedical Engineering, University of Rochester, Rochester, NY 14450, USA
J Cell Sci 120:876-84. 2007..Instead, our analysis suggests that steady sheet migration can be explained by cell spreading in the monolayer... - Dynein motility: four heads are better than twoJames L McGrath
Department of Biomedical Engineering, University of Rochester, NY 14450, USA
Curr Biol 15:R970-2. 2005..The movement driven by a single dynein molecule in vitro is not as robust as dynein-driven movements in cells. A new study suggests that transport by multiple dyneins is more similar to cellular motions... - Actin motility: staying on track takes a little more effortMorton Ehrenberg
University of Rochester, Department of Biomedical Engineering, 601 Elmwood Ave, PO Box 639, Rochester, New York 14642, USA
Curr Biol 14:R931-2. 2004..Recent work provides more evidence that these motors are engaged in a continuous tug-of-war... - The role of substrate curvature in actin-based pushing forcesIan M Schwartz
Department of Biomedical Engineering, University of Rochester, 601 Elmwood Avenue, P.O. Box 639, Rochester, NY 14642 USA
Curr Biol 14:1094-8. 2004..Collectively the data indicate that curvature-dependent mechanisms are not required for actin-based pushing... - A structure-permeability relationship of ultrathin nanoporous silicon membrane: a comparison with the nuclear envelopeEunkyoung Kim
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
J Am Chem Soc 130:4230-1. 2008....
Research Grants
- Ultrathin silicon nanofilters for efficient and small scale molecular separationsJames McGrath; Fiscal Year: 2007..These abilities are expected to enable a host of new small scale clinical and diagnostic devices. ..
- Charge and size based filtration by ultrathin silicon membranesJames McGrath; Fiscal Year: 2007..These abilities are expected to enable a host of new small scale clinical and diagnostic devices. ..