Research Topics
Genomes and Genes | Mary M McGraneSummaryAffiliation: University of Connecticut Country: USA Publications
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Publications
Vitamin A regulation of gene expression: molecular mechanism of a prototype geneMary M McGrane
Department of Nutritional Sciences, The University of Connecticut, Storrs, CT 06269, USA
J Nutr Biochem 18:497-508. 2007....
Effects of increased dietary cholesterol with carbohydrate restriction on hepatic lipid metabolism in Guinea pigsRyan DeOgburn
Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut, USA
Comp Med 62:109-15. 2012..LCD livers had more proliferating hepatocytes than did HCD livers, suggesting that in the context of cholesterol-induced hepatic steatosis, dietary carbohydrate restriction enhances liver cell proliferation...
Low-carbohydrate diets reduce lipid accumulation and arterial inflammation in guinea pigs fed a high-cholesterol dietJose O Leite
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
Atherosclerosis 209:442-8. 2010..Low-carbohydrate diets (LCD) efficiently induce weight loss and favorably affect plasma lipids, however, the effect of LCD on atherosclerosis is still argued...- Vitamin A status in mice affects the histone code of the phosphoenolpyruvate carboxykinase gene in liverKelly B Scribner
Departments of Nutritional Sciences and Molecular and Cellular Biology, The University of Connecticut, Storrs, CT 06269, USA
J Nutr 135:2774-9. 2005..These results demonstrate the associated changes that occur in nuclear receptor binding, coactivator recruitment, and histone acetylation in response to vitamin A status, identified at specific RAREs in the PEPCK gene in vivo... - Nuclear receptor binding to the retinoic acid response elements of the phosphoenolpyruvate carboxykinase gene in vivo: effects of vitamin A deficiencyKelly B Scribner
Department of Nutritional Sciences, The University of Connecticut, Storrs, CT 06269, USA
J Nutr Biochem 18:206-14. 2007.... - RNA polymerase II association with the phosphoenolpyruvate carboxykinase (PEPCK) promoter is reduced in vitamin A-deficient miceKelly B Scribner
Department of Nutritional Sciences, The University of Connecticut, Storrs, CT 06269, USA
J Nutr 133:4112-7. 2003..These results increase our understanding of the molecular basis for decreased PEPCK gene expression in VAD mice in vivo and offer additional insight into the regulation of other retinoid-responsive genes... - Vitamin A depletion is associated with low phosphoenolpyruvate carboxykinase mRNA levels during late fetal development and at birth in miceSaheli Ghoshal
Department of Nutritional Sciences and Molecular and Cell Biology, University of Connecticut, Storrs, CT 06269, USA
J Nutr 133:2131-6. 2003..Our findings strongly suggest that vitamin A is required during liver development for staged expression of the PEPCK gene and that HNF4alpha may be involved in mediating vitamin A regulation of the PEPCK gene at these critical periods... - Altered lipid catabolism in the vitamin A deficient liverHye Won Kang
Departments of Nutritional Sciences and Molecular and Cellular Biology, The University of Connecticut, 3624 Horsebarn Hill Road Extension, Storrs, CT 06269, USA
Mol Cell Endocrinol 271:18-27. 2007..Down regulation of the PPAR alpha gene is the likely cause of the altered expression pattern of the above metabolic genes in VAD liver... - Raisins and walking alter appetite hormones and plasma lipids by modifications in lipoprotein metabolism and up-regulation of the low-density lipoprotein receptorMichael J Puglisi
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
Metabolism 58:120-8. 2009..These data suggest that walking and raisin consumption decrease plasma LDL cholesterol by up-regulating the LDL receptor and that raisin consumption may reduce hunger and affect dietary intake by altering hormones influencing satiety... - Carbohydrate restriction and dietary cholesterol modulate the expression of HMG-CoA reductase and the LDL receptor in mononuclear cells from adult menGisella Mutungi
Department of Nutritional Sciences, University of Connecticut, Storrs, CT, 06269 USA
Lipids Health Dis 6:34. 2007..00 +/- 0.60 to 1.67 +/- 1.94 arbitrary units P < 0.05). The findings indicate that dietary cholesterol during a weight loss intervention alters the expression of genes regulating cholesterol homeostasis... - Retinoid regulation of the phosphoenolpyruvate carboxykinase gene in liverDong Ju Shin
Departments of Nutritional Sciences and Molecular and Cell Biology, The University of Connecticut, Storrs, CT 06269, USA
Mol Cell Endocrinol 195:39-54. 2002..The binding of nuclear receptors to PEPCK RARE1, RARE2 and RARE3 indicates a complex pattern of retinoid receptor and orphan nuclear receptor binding... - Low-carbohydrate diet disrupts the association between insulin resistance and weight gainJose O Leite
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
Metabolism 58:1116-22. 2009..The association between weight gain and insulin resistance seems to be dependent on high carbohydrate intake... - A combination of psyllium and plant sterols alters lipoprotein metabolism in hypercholesterolemic subjects by modifying the intravascular processing of lipoproteins and increasing LDL uptakeSudeep Shrestha
Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
J Nutr 137:1165-70. 2007..03). These results indicate that the hypocholesterolemic action of PSY and PS can be explained in part by modifications in the intravascular processing of lipoproteins and by increases in LDL receptor-mediated uptake...