S E McGowan


Affiliation: University of Iowa
Country: USA


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    McGowan S, Holmes A. Vitamin A deficiency alters pulmonary parenchymal collagen and tissue mechanics. Respir Physiol Neurobiol. 2007;156:312-9 pubmed
    ..Retinoic acid (RA) administration restored the parenchymal collagen and mechanical properties. ..
  2. McGowan S, McCoy D. Fibroblast growth factor signaling in myofibroblasts differs from lipofibroblasts during alveolar septation in mice. Am J Physiol Lung Cell Mol Physiol. 2015;309:L463-74 pubmed publisher
    ..These studies also emphasize the importance of particular cellular locations of FGFR3 and PDGFR-α, which may modify their effects during alveolar development or repair. ..
  3. McGowan S. Understanding the developmental pathways pulmonary fibroblasts may follow during alveolar regeneration. Cell Tissue Res. 2017;367:707-719 pubmed publisher
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    McGowan S, Jackson S, Jenkins Moore M, Dai H, Chambon P, Snyder J. Mice bearing deletions of retinoic acid receptors demonstrate reduced lung elastin and alveolar numbers. Am J Respir Cell Mol Biol. 2000;23:162-7 pubmed
    ..These data indicate that RARgamma is required for the formation of normal alveoli and alveolar elastic fibers in the mouse, and that RAR/RXR heterodimers are involved in alveolar morphogenesis. ..
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    McGowan S, Smith J, Holmes A, Smith L, Businga T, Madsen M, et al. Vitamin A deficiency promotes bronchial hyperreactivity in rats by altering muscarinic M(2) receptor function. Am J Physiol Lung Cell Mol Physiol. 2002;282:L1031-9 pubmed
    ..Vitamin A (retinol) and its congeners (retinoids) may be required to regulate bronchial responsiveness in addition to maintaining a normal bronchial epithelium. ..
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    McGowan S, Holmes A, Mecham R, Ritty T. Arg-Gly-Asp-containing domains of fibrillins-1 and -2 distinctly regulate lung fibroblast migration. Am J Respir Cell Mol Biol. 2008;38:435-45 pubmed
    ..Understanding how fibrillins regulate LF migration may help elucidate how the elastic fiber system could be restored as an interconnected unit, which fails to occur in emphysematous lungs. ..
  7. McGowan S, Grossmann R, Kimani P, Holmes A. Platelet-derived growth factor receptor-alpha-expressing cells localize to the alveolar entry ring and have characteristics of myofibroblasts during pulmonary alveolar septal formation. Anat Rec (Hoboken). 2008;291:1649-61 pubmed publisher
    ..In addition to defining how alveolar septa form, these findings may have implications for the treatment of diseases which involve alveolar effacement such as emphysema and pulmonary fibrosis. ..
  8. McGowan S, McCoy D. Fibroblasts expressing PDGF-receptor-alpha diminish during alveolar septal thinning in mice. Pediatr Res. 2011;70:44-9 pubmed publisher
    ..Our findings are relevant to bronchopulmonary dysplasia in which positive pressure ventilation interferes with myofibroblast depletion, septal thinning, and capillary maturation. ..
  9. McGowan S, McCoy D. Platelet-derived growth factor-A and sonic hedgehog signaling direct lung fibroblast precursors during alveolar septal formation. Am J Physiol Lung Cell Mol Physiol. 2013;305:L229-39 pubmed publisher
    ..Better understanding how LF are positioned during alveolar development could identify signaling pathways, which promote alveolar septal regeneration. ..

More Information


  1. McGowan S, McCoy D. Platelet-derived growth factor-A regulates lung fibroblast S-phase entry through p27(kip1) and FoxO3a. Respir Res. 2013;14:68 pubmed publisher
    ..These mechanisms for diminishing the effects of PDGFR?-mediated signaling likely regulate secondary septal formation and their derangement may contribute to imbalanced fibroblast cell kinetics in parenchymal lung diseases. ..
  2. McGowan S, McCoy D. Regulation of fibroblast lipid storage and myofibroblast phenotypes during alveolar septation in mice. Am J Physiol Lung Cell Mol Physiol. 2014;307:L618-31 pubmed publisher
  3. McGowan S, McCoy D. Platelet-derived growth factor receptor-α and Ras-related C3 botulinum toxin substrate-1 regulate mechano-responsiveness of lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2017;313:L1174-L1187 pubmed publisher
    ..Because emphysema and interstitial fibrosis disrupt the parenchymal mechanical continuum, understanding how mechanical factors regulate fibroblast migration could elicit strategies for alveolar repair and regeneration. ..