Research Topics
Genomes and GenesSpecies | JAMES JOHN MCGOUGHSummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Dexmethylphenidate extended-release capsules for attention deficit hyperactivity disorderJames J McGough
David Geffen School of Medicine, 300 UCLA Medical Plaza, Suite 1414, Los Angeles, CA 90095, USA
Expert Rev Neurother 5:437-41. 2005..Given its duration of effect, favorable tolerability and flexibility in dosing, dexmethylphenidate extended release is likely to gain considerable use as an ADHD treatment...- Assessment of attention deficit hyperactivity disorder: a review of recent literatureJ J McGough
Division of Child and Adolescent Psychiatry, UCLA Neuropsychiatric Institute, Los Angeles, California, USA
Curr Opin Pediatr 12:319-24. 2000.... - Attention-deficit/hyperactivity disorder pharmacogenomicsJames J McGough
Neuropsychiatric Institute and David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095, USA
Biol Psychiatry 57:1367-73. 2005..Future studies should emphasize large, prospective trials, assess multiple medications in individual subjects, and consider a full range of pharmacodynamic and pharmacokinetic outcomes... - Long-term tolerability and effectiveness of once-daily mixed amphetamine salts (Adderall XR) in children with ADHDJames J McGough
Division of Child and Adolescent Psychiatry, UCLA Neuropsychiatric Institute, Los Angeles, CA, USA
J Am Acad Child Adolesc Psychiatry 44:530-8. 2005..To evaluate the long-term tolerability and effectiveness of extended-release mixed amphetamine salts (MAS XR; Adderall XR) in children with attention-deficit/hyperactivity disorder (ADHD)... - Psychiatric comorbidity in adult attention deficit hyperactivity disorder: findings from multiplex familiesJames J McGough
Center for Neurobehavioral Genetics, David Geffen School of Medicine, Suite 1414, 300 UCLA Medical Plaza, Los Angeles, CA 90095, USA
Am J Psychiatry 162:1621-7. 2005..Patterns of psychiatric comorbidity were assessed in adults with and without attention deficit hyperactivity disorder (ADHD) identified through a genetic study of families containing multiple children with ADHD... - Diagnostic controversies in adult attention deficit hyperactivity disorderJames J McGough
Department of Psychiastry and Biobehavioral Sciences, University of California Los Angeles, Suite 1414, 300 UCLA Medical Plaza, Los Angeles, CA 90095, USA
Am J Psychiatry 161:1948-56. 2004..In this article the authors describe and contrast competing approaches for diagnosis of adult ADHD used in clinical and research practice... - A randomized, double-blind, placebo-controlled, laboratory classroom assessment of methylphenidate transdermal system in children with ADHDJames J McGough
University of California, Los Angeles, Semel Institute for Neuroscience and Human Behavior, 90095, USA
J Atten Disord 9:476-85. 2006..This study evaluates the efficacy, duration of action, and tolerability of methylphenidate transdermal system (MTS) in children with ADHD... - Pharmacokinetics of SLI381 (ADDERALL XR), an extended-release formulation of AdderallJames J McGough
Department of Psychiatry and Biobehavioral Sciences, Division of Child and Adolescent Psychiatry, UCLA Neuropsychiatric Institute, Los Angeles, USA
J Am Acad Child Adolesc Psychiatry 42:684-91. 2003..To assess the pharmacokinetic (PK) properties of a single daily dose of Adderall (mixed amphetamine salts) and the extended-release formulation, SLI381 (ADDERALL XR), in pediatric attention-deficit/hyperactivity disorder (ADHD)... - Once-daily OROS methylphenidate is safe and well tolerated in adolescents with attention-deficit/hyperactivity disorderJames J McGough
Semel Institute for Neuroscience and Human Behavior, and David Geffen School of Medicine at UCLA, 300 UCLA Medical Plaza, Los Angeles, CA 90095, USA
J Child Adolesc Psychopharmacol 16:351-6. 2006..Headache, anorexia, and insomnia were the most frequently reported treatment-related adverse events. The incidence of adverse events was not related to dose. OROS MPH was safe and well tolerated at doses up to 72 mg/day... - Pharmacogenetics of methylphenidate response in preschoolers with ADHDJames McGough
UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90095, USA
J Am Acad Child Adolesc Psychiatry 45:1314-22. 2006..The authors explored genetic moderators of symptom reduction and side effects in methylphenidate-treated preschool-age children diagnosed with attention-deficit/hyperactivity disorder (ADHD)... - A candidate gene analysis of methylphenidate response in attention-deficit/hyperactivity disorderJames J McGough
Semel Institute for Neuroscience and Human Behavior and David Geffen School of Medicine, University of California, Los Angeles, USA
J Am Acad Child Adolesc Psychiatry 48:1155-64. 2009..This study examines the potential role of candidate genes in moderating treatment effects of methylphenidate (MPH) in attention-deficit/hyperactivity disorder (ADHD)... - Association of the cannabinoid receptor gene (CNR1) with ADHD and post-traumatic stress disorderAke T Lu
Department of Human Genetics, University of California, Los Angeles, California, USA
Am J Med Genet B Neuropsychiatr Genet 147:1488-94. 2008..01 for C-G). These observations require replication, however, they suggest that the CNR1 gene may be a risk factor for ADHD and possibly PTSD, and that this gene warrants further investigation for a role in neuropsychiatric disorders... - A laboratory school comparison of mixed amphetamine salts extended release (Adderall XR) and atomoxetine (Strattera) in school-aged children with attention deficit/hyperactivity disorderSharon B Wigal
Child Development Center, University of California, Irvine, CA 92612, USA
J Atten Disord 9:275-89. 2005..001). Adverse events were similar for both treatment groups. The extended time course of action and greater therapeutic efficacy of MAS XR suggests that it is more effective than atomoxetine in children with ADHD... - Relationship of family environment and parental psychiatric diagnosis to impairment in ADHDLeah J Pressman
Department of Psychiatry, UCLA Semel Institute, Los Angeles, CA 90095-1759, USA
J Am Acad Child Adolesc Psychiatry 45:346-54. 2006..CONCLUSIONS: There are strong links between impairment in children with ADHD and family environment. Different processes and mechanisms may contribute to impairment in different children in the same family... - Atypical EEG beta asymmetry in adults with ADHDT Sigi Hale
Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, USA
Neuropsychologia 48:3532-9. 2010..The current study investigates whether this ABL characteristic occurs in adults with ADHD absent comorbid language impairment... - CBCL pediatric bipolar disorder profile and ADHD: comorbidity and quantitative trait loci analysisJames J McGough
Division of Child and Adolescent Psychiatry, UCLA Semel Institute for Neuroscience and Human Behavior and David Geffen School of Medicine
J Am Acad Child Adolesc Psychiatry 47:1151-7. 2008..We used CBCL-PBD profiles to distinguish patterns of comorbidity and to search for quantitative trait loci in a genomewide scan in a sample of multiple affected ADHD sibling pairs... - Atypical alpha asymmetry in adults with ADHDT Sigi Hale
Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, United States
Neuropsychologia 47:2082-8. 2009..The current study explores whether increased rightward alpha asymmetry is also evident in adults with ADHD... - Genetic linkage of attention-deficit/hyperactivity disorder on chromosome 16p13, in a region implicated in autismSusan L Smalley
Center for Neurobehavioral Genetics and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles 90024USA
Am J Hum Genet 71:959-63. 2002..These findings suggest that variations in a gene on 16p13 may contribute to common deficits found in both ADHD and autism... - Prevalence and psychiatric comorbidity of attention-deficit/hyperactivity disorder in an adolescent Finnish populationSusan L Smalley
Semel Institute, University of California, Los Angeles, CA 90095, USA
J Am Acad Child Adolesc Psychiatry 46:1575-83. 2007..The purpose of the study was to estimate the prevalence of attention-deficit/hyperactivity disorder (ADHD) and its clinical characteristics in the Northern Finland Birth Cohort 1986... - Atypical brain activation during simple & complex levels of processing in adult ADHD: an fMRI studyT Sigi Hale
Division of Child and Adolescent Psychiatry, Neuropsychiatric Institute and David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
J Atten Disord 11:125-40. 2007..Executive dysfunction in ADHD is well supported. However, recent studies suggest that more fundamental impairments may be contributing. We assessed brain function in adults with ADHD during simple and complex forms of processing... - ADHD familial loading and abnormal EEG alpha asymmetry in children with ADHDT Sigi Hale
Division of Child and Adolescent Psychiatry and Center for Neurobehavioral Genetics at the UCLA Semel Institute, 760 Westwood Plaza, Room 47 448, Los Angeles, CA 90095, United States
J Psychiatr Res 44:605-15. 2010..Previous studies have shown increased rightward alpha asymmetry in ADHD. We tested whether this was more pronounced in ADHD children with increased ADHD family loading... - Analog classroom assessment of a once-daily mixed amphetamine formulation, SLI381 (Adderall XR), in children with ADHDJames T McCracken
Department of Psychiatry and Biobehavioral Sciences, Division of Child andAdolescent Psychiatry, UCLA Neuropsychiatric Institute, Los Angeles, CA 90024 1759, USA
J Am Acad Child Adolesc Psychiatry 42:673-83. 2003..Secondary objectives included examination of the time course, pharmacokinetic, and pharmacodynamic properties of SLI381... - Familial clustering and DRD4 effects on electroencephalogram measures in multiplex families with attention deficit/hyperactivity disorderSandra K Loo
Semel Institute for Neuroscience and Human Behavior and David Geffen School of Medicine at the University of California, Los Angeles, CA 90095, USA
J Am Acad Child Adolesc Psychiatry 49:368-77. 2010.... - New drugs for the treatment of attention-deficit/hyperactivity disorderCaroly S Pataki
UCLA Neuropsychiatric Institute, Room 27 370C, 760 Westwood Plaza, Los Angeles, CA 90024, USA
Expert Opin Emerg Drugs 9:293-302. 2004..Ongoing development of new ADHD medications is expected to emphasise alternative and extended-release delivery systems and non-stimulant compounds... - Atypical brain laterality in adults with ADHD during dichotic listening for emotional intonation and wordsT Sigi Hale
Division of Child and Adolescent Psychiatry, UCLA Neuropsychiatric Institute and David Geffen School of Medicine, 760 Westwood Plaza, Room 48 270, Los Angeles, CA 90024, USA
Neuropsychologia 44:896-904. 2006..We posit that these hemispheric differences were due to management or use of available cognitive resources rather than inherent capacity... - Cortical activity patterns in ADHD during arousal, activation and sustained attentionSandra K Loo
Department of Psychiatry and Biobehavioral Sciences, UCLA Semel Institute for Neuroscience and Human Behavior, Los Angeles, CA 90024, United States
Neuropsychologia 47:2114-9. 2009..The goal of the present study is to test whether there are Attention-Deficit Hyperactivity Disorder (ADHD)-related differences in brain electrical activity patterns across arousal, activation and vigilance states... - MethyPatch NovenNatasha Sane
University of California at Los Angeles, 90095, USA
Curr Opin Investig Drugs 3:1222-4. 2002..Analysts at Morgan Stanley predicted in May 2002 that the product would make US sales of US $9.1 million in 2003, rising to US $22.5 million in 2006 [454573]... - Executive functioning among Finnish adolescents with attention-deficit/hyperactivity disorderSandra K Loo
University of California, Los Angeles, CA 90095, USA
J Am Acad Child Adolesc Psychiatry 46:1594-604. 2007..The present study examined cognitive functioning in a population sample of adolescents with and without attention-deficit/hyperactivity disorder (ADHD) from the Northern Finland Birth Cohort 1986... - Temperament and character profiles and the dopamine D4 receptor gene in ADHDDeborah E Lynn
UCLA Department of Child and Adolescent Psychiatry, 10850 Wilshire Blvd, Suite 200, Los Angeles, CA 90024, USA
Am J Psychiatry 162:906-13. 2005..This study was designed to investigate the link among attention deficit hyperactivity disorder (ADHD) in adults, novelty-seeking temperament, and the 48-base pair (bp) dopamine D4 receptor (DRD4) gene variant... - A genomewide scan for attention-deficit/hyperactivity disorder in an extended sample: suggestive linkage on 17p11Matthew N Ogdie
Department of Human Genetics, University of California, Los Angeles, Los Angeles, CA, USA
Am J Hum Genet 72:1268-79. 2003..Interestingly, both regions, as well as 5p13, have been highlighted in genomewide scans for autism... - Attention deficit hyperactivity disorder: fine mapping supports linkage to 5p13, 6q12, 16p13, and 17p11Matthew N Ogdie
Human Genetics, University of California Los Angeles, Los Angeles, CA, USA
Am J Hum Genet 75:661-8. 2004..The refinement of linkage within each of these regions lays the foundation for subsequent investigations using association methods to detect risk genes of moderate effect size...
Research Grants
- RESPONSE VARIABILITY IN STIMULANT TREATMENT OF ADHDJames McGough; Fiscal Year: 2004..In addition to funding the candidate's transition to independent research the proposed study would also contribute to our knowledge of the basis of individual response to medication in psychiatric disorders. ..