Affiliation: University of North Carolina
Location: Chapel Hill, USA
- Identification of internal sequences in the 3' leader region of human respiratory syncytial virus that enhance transcription and confer replication processivityDavid R McGivern
Division of Pathology and Neuroscience, University of Dundee Medical School, Ninewells Hospital, Dundee DD1 9SY, UK
J Virol 79:2449-60. 2005....
- Model systems for hepatitis C research: the cup half empty?David R McGivern
Gastroenterology 141:806-9. 2011
- Hepatitis C virus infection causes cell cycle arrest at the level of initiation of mitosisRathi P Kannan
Division of Infectious Diseases, Department of Medicine, Center for Translational Research, Inﬂammatory Diseases Institute, Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
J Virol 85:7989-8001. 2011..However, the data suggest that cell cycle arrest at the interface of G(2) and mitosis is a common feature of HCV infection...
- Virus-specific mechanisms of carcinogenesis in hepatitis C virus associated liver cancerD R McGivern
Lineberger Comprehensive Cancer Center, Center for Translational Research, Inflammatory Diseases Institute, and the Division of Infectious Diseases, Department of Medicine, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7292, USA
Oncogene 30:1969-83. 2011..Here, we summarize current knowledge of the virus-specific mechanisms that may contribute to HCV-associated HCC...
- Protease inhibitor-resistant hepatitis C virus mutants with reduced fitness from impaired production of infectious virusTetsuro Shimakami
Division of Infectious Diseases, Department of Medicine, Inflammatory Diseases Institute, and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Gastroenterology 140:667-75. 2011..Many of these significantly impair the replication fitness of HCV RNA replicons. However, it is not known whether these mutations also adversely affect infectious virus assembly and release, processes in which NS3 also participates...
- Roles of the respiratory syncytial virus trailer region: effects of mutations on genome production and stress granule formationLaura L Hanley
Department of Microbiology, Boston University School of Medicine, Boston, MA 02118, USA
Virology 406:241-52. 2010..In addition, a sequence at the 5' terminal end of the trailer region allows RSV to subvert stress granule formation...
- Evidence that the polymerase of respiratory syncytial virus initiates RNA replication in a nontemplated fashionSarah L Noton
Division of Pathology and Neuroscience, University of Dundee Medical School, Dundee DD1 9SY, United Kingdom
Proc Natl Acad Sci U S A 107:10226-31. 2010..These findings show that the RSV replicase selects ATP and initiates at the correct position, independently of the first nucleotide of the template, suggesting a mechanism by which highly accurate replication initiation is achieved...
- Requirement of cellular DDX3 for hepatitis C virus replication is unrelated to its interaction with the viral core proteinAllan G N Angus
MRC Virology Unit, Institute of Virology, University of Glasgow, Church Street, Glasgow G11 5JR, UK
J Gen Virol 91:122-32. 2010..Thus, our study shows for the first time that the requirement of DDX3 for HCV replication is unrelated to its interaction with the viral core protein...
- Impaired replication of hepatitis C virus containing mutations in a conserved NS5B retinoblastoma protein-binding motifDavid R McGivern
Center for Hepatitis Research, Institute for Human Infections and Immunity, and Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555 0610, USA
J Virol 83:7422-33. 2009....
- Tumor suppressors, chromosomal instability, and hepatitis C virus-associated liver cancerDavid R McGivern
The Center for Hepatitis Research, Institute for Human Infections and Immunity, Sealy Center for Cancer Cell Biology, Galveston, TX 77555, USA
Annu Rev Pathol 4:399-415. 2009....
- Hepatitis C virus induces E6AP-dependent degradation of the retinoblastoma proteinTsubasa Munakata
Center for Hepatitis Research, University of Texas Medical Branch, Galveston, Texas, USA
PLoS Pathog 3:1335-47. 2007..The disruption of pRb/E2F regulatory pathways in cells infected with HCV is likely to promote hepatocellular proliferation and chromosomal instability, factors important for the development of liver cancer...
- Unravelling the complexities of respiratory syncytial virus RNA synthesisVanessa M Cowton
Division of Pathology and Neuroscience, University of Dundee Medical School, Dundee DD1 9SY, UK
J Gen Virol 87:1805-21. 2006....
- A three-nucleotide mutation altering the Maize streak virus Rep pRBR-interaction motif reduces symptom severity in maize and partially reverts at high frequency without restoring pRBR-Rep bindingDionne N Shepherd
Department of Molecular and Cell Biology, University of Cape Town, Rondebosch 7701, South Africa
J Gen Virol 86:803-13. 2005....
- An intact RBR-binding motif is not required for infectivity of Maize streak virus in cereals, but is required for invasion of mesophyll cellsDavid R McGivern
Department of Disease and Stress Biology, John Innes Centre, Colney, Norwich NR4 7UH, UK
J Gen Virol 86:797-801. 2005..Mature leaves contain high levels of RBR and it is suggested that the MSV RepA-RBR interaction is essential only in tissues with high levels of active RBR...
- Protease Inhibitors Block Multiple Functions of the NS3/4A Protease-Helicase during the Hepatitis C Virus Life CycleDavid R McGivern
Division of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Lineberger Comprehensive Cancer Center, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
J Virol 89:5362-70. 2015..In conclusion, PIs and APHIs can block NS3 functions in RNA synthesis and virus assembly, in addition to inhibiting polyprotein processing...
- Kinetic analyses reveal potent and early blockade of hepatitis C virus assembly by NS5A inhibitorsDavid R McGivern
Departments of Medicine and Microbiology and Immunology and the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Electronic address
Gastroenterology 147:453-62.e7. 2014..To study their mechanisms, we compared their kinetics of antiviral suppression with those of other classes of DAA, using the hepatitis C virus genotype 1a cell culture-infectious virus H77S.3...