Lynda McGinnis

Summary

Publications

  1. ncbi request reprint Intracytoplasmic sperm injection (ICSI) enables rescue of valuable mutant mouse strains
    Ming Wen Li
    Murine Targeted Genomics Laboratory, Mouse Biology Program, Center for Comparative Medicine, University of California, Davis, California, USA
    Comp Med 53:265-9. 2003
  2. ncbi request reprint Enhanced effect of glycyl-L-glutamine on mouse preimplantation embryos in vitro
    John D Biggers
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Reprod Biomed Online 9:59-69. 2004
  3. ncbi request reprint Discrepancies between the effects of glutamine in cultures of preimplantation mouse embryos
    John D Biggers
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Reprod Biomed Online 9:70-3. 2004
  4. ncbi request reprint Mouse embryo development following IVF in media containing either L-glutamine or glycyl-L-glutamine
    M C Summers
    Reproductive Science Center, Lexington, MA 02421, USA
    Hum Reprod 20:1364-71. 2005
  5. ncbi request reprint Mouse sperm desiccated and stored in trehalose medium without freezing
    Lynda K McGinnis
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Reprod 73:627-33. 2005
  6. ncbi request reprint One-step versus two-step culture of mouse preimplantation embryos: is there a difference?
    J D Biggers
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA, 02115 Beth Israel Deaconess Hospital, Boston, MA 02115, USA
    Hum Reprod 20:3376-84. 2005
  7. ncbi request reprint Long-term storage of mouse spermatozoa after evaporative drying
    Ming W Li
    School of Veterinary Medicine, Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    Reproduction 133:919-29. 2007
  8. ncbi request reprint Desiccation tolerance of spermatozoa dried at ambient temperature: production of fetal mice
    Sankha Bhowmick
    Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston 02115, USA
    Biol Reprod 68:1779-86. 2003
  9. ncbi request reprint Evidence that glucose is not always an inhibitor of mouse preimplantation development in vitro
    J D Biggers
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Hum Reprod 16:153-163. 2001
  10. ncbi request reprint Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
    P Sicinski
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Nature 384:470-4. 1996

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Intracytoplasmic sperm injection (ICSI) enables rescue of valuable mutant mouse strains
    Ming Wen Li
    Murine Targeted Genomics Laboratory, Mouse Biology Program, Center for Comparative Medicine, University of California, Davis, California, USA
    Comp Med 53:265-9. 2003
    ....
  2. ncbi request reprint Enhanced effect of glycyl-L-glutamine on mouse preimplantation embryos in vitro
    John D Biggers
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Reprod Biomed Online 9:59-69. 2004
    ..Recently, alanyl-L-glutamine has been used to replace glutamine in media for the culture of human preimplantation embryos. The results in this paper suggest that glycyl-L-glutamine may be a better choice of dipeptide...
  3. ncbi request reprint Discrepancies between the effects of glutamine in cultures of preimplantation mouse embryos
    John D Biggers
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Reprod Biomed Online 9:70-3. 2004
    ..The finding that ammonium can also cause exencephaly thus fosters undue concern about the teratological effects of glutamine...
  4. ncbi request reprint Mouse embryo development following IVF in media containing either L-glutamine or glycyl-L-glutamine
    M C Summers
    Reproductive Science Center, Lexington, MA 02421, USA
    Hum Reprod 20:1364-71. 2005
    ....
  5. ncbi request reprint Mouse sperm desiccated and stored in trehalose medium without freezing
    Lynda K McGinnis
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Reprod 73:627-33. 2005
    ..The results show that trehalose has a significant beneficial effect in preserving the developmental potential of mouse sperm following partial desiccation and storage at temperatures above freezing...
  6. ncbi request reprint One-step versus two-step culture of mouse preimplantation embryos: is there a difference?
    J D Biggers
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA, 02115 Beth Israel Deaconess Hospital, Boston, MA 02115, USA
    Hum Reprod 20:3376-84. 2005
    ..A comparison has been made of the development of mouse zygotes in either one-step or two-step culture systems...
  7. ncbi request reprint Long-term storage of mouse spermatozoa after evaporative drying
    Ming W Li
    School of Veterinary Medicine, Center for Comparative Medicine, University of California, Davis, CA 95616, USA
    Reproduction 133:919-29. 2007
    ..The possibility that the storage temperature must be less than the glass transition temperature is discussed...
  8. ncbi request reprint Desiccation tolerance of spermatozoa dried at ambient temperature: production of fetal mice
    Sankha Bhowmick
    Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School, Boston 02115, USA
    Biol Reprod 68:1779-86. 2003
    ..05). The results demonstrate the feasibility of using a convective drying protocol for the successful desiccation of mouse sperm and identifies some of the important parameters required for optimization of the procedure...
  9. ncbi request reprint Evidence that glucose is not always an inhibitor of mouse preimplantation development in vitro
    J D Biggers
    Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    Hum Reprod 16:153-163. 2001
    ..The slight inhibitory effects of KH(2)PO(4) appeared to be due to the inhibition of the development of a few sensitive embryos. No significant effects of glucose and KH(2)PO(4) were observed on the total cell counts...
  10. ncbi request reprint Cyclin D2 is an FSH-responsive gene involved in gonadal cell proliferation and oncogenesis
    P Sicinski
    Whitehead Institute for Biomedical Research and Department of Biology, Massachusetts Institute of Technology, Cambridge 02142, USA
    Nature 384:470-4. 1996
    ..The hypoplasia seen in cyclin D2(-/-) ovaries and testes prompted us to examine human cancers deriving from corresponding tissues. We find that some human ovarian and testicular tumours contain high levels of cyclin D2 messenger RNA...
  11. ncbi request reprint Coordinate action of Wt1 and a modifier gene supports embryonic survival in the oviduct
    J A Kreidberg
    Department of Medicine, Children s Hospital, Boston, Massachusetts 02115, USA
    Mol Reprod Dev 52:366-75. 1999
    ..Wt1 is therefore among a small subset of genes required for survival of the pre-implantation embryo, and appears to function non-autonomously...
  12. pmc Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality
    M E Donohoe
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 19:7237-44. 1999
    ..Our studies demonstrate an essential function for YY1 in the development of the mouse embryo...
  13. ncbi request reprint Amino acids and preimplantation development of the mouse in protein-free potassium simplex optimized medium
    J D Biggers
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Biol Reprod 63:281-93. 2000
    ....
  14. pmc Mammalian oocytes are targets for prostaglandin E2 (PGE2) action
    Diane M Duffy
    Department of Physiological Sciences, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Reprod Biol Endocrinol 8:131. 2010
    ..PGE2 actions on granulosa cells are essential for successful ovulation. The aim of the present study is to determine if PGE2 also acts directly at the oocyte to regulate periovulatory events...
  15. doi request reprint Role of Fyn kinase in oocyte developmental potential
    Jinping Luo
    Center for Reproductive Sciences, University of Kansas Medical Center, Kansas City, KS 66160, USA
    Reprod Fertil Dev 22:966-76. 2010
    ..These defects cause developmental arrest during oocyte maturation and pronuclear congression...
  16. pmc Localized activation of Src-family protein kinases in the mouse egg
    Lynda K McGinnis
    Department of Anatomy and Cell Biology, Center for Reproductive Sciences, University of Kansas Medical Center, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    Dev Biol 306:241-54. 2007
    ..Furthermore, activation of these kinases in the mouse egg is limited to distinct regions and occurs at specific times after fertilization...
  17. doi request reprint Fyn kinase activity is required for normal organization and functional polarity of the mouse oocyte cortex
    Jinping Luo
    Center for Reproductive Sciences, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Mol Reprod Dev 76:819-31. 2009
    ..This was associated with a delay in completion of meiosis II. Pronuclei, however, eventually formed and subsequent mitotic cleavages and blastocyst formation occurred normally...
  18. doi request reprint Multiple mechanisms of germ cell loss in the perinatal mouse ovary
    Patricia Rodrigues
    Department of Molecular and Integrative Physiology, Center for Reproductive Sciences, 3088 Kansas Life Science Innovations Center, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    Reproduction 137:709-20. 2009
    ..From these findings we suggest that multiple perinatal mechanisms establish the primordial follicle reserve in mice...
  19. pmc Dicer1 is essential for female fertility and normal development of the female reproductive system
    Xiaoman Hong
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, Kansas 66160, USA
    Endocrinology 149:6207-12. 2008
    ..These studies implicate Dicer1/miRNA mediated posttranscriptional gene regulation in reproductive somatic tissues as critical for the normal development and function of these tissues and for female fertility...
  20. pmc Dynamics of protein phosphorylation during meiotic maturation
    Lynda K McGinnis
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, 3901 Rainbow Blvd, Mail Stop 3038, Kansas City, KS 66160, USA
    J Assist Reprod Genet 27:169-82. 2010
    ..To ask whether distinct kinase signaling pathways mediate cytoplasmic or nuclear maturation of mouse oocytes and if in vitro maturation influences the distribution and timing of these phosphorylation events...
  21. pmc Functions of Fyn kinase in the completion of meiosis in mouse oocytes
    Lynda K McGinnis
    Department of Molecular and Integrative Physiology, University of Kansas Medical Center, 3901 Rainbow Blvd, Mail Stop 3043, Kansas City, KS 66160, USA
    Dev Biol 327:280-7. 2009
    ..Commonalities in meiotic spindle and chromosome alignment defects under these experimental conditions demonstrate a significant role for Fyn kinase activity in meiotic maturation...
  22. doi request reprint Fer tyrosine kinase is required for germinal vesicle breakdown and meiosis-I in mouse oocytes
    Lynda K McGinnis
    Department of Anatomy and Cell Biology, University of Kansas Medical School, Kansas City, Kansas 66160, USA
    Mol Reprod Dev 78:33-47. 2011
    ..The results demonstrate that FER kinase plays a critical role in oocyte meiotic spindle microtubule dynamics and may have an additional function in GVBD...
  23. pmc Protein tyrosine kinase signaling during oocyte maturation and fertilization
    Lynda K McGinnis
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA
    Mol Reprod Dev 78:831-45. 2011
    ..Future studies will hopefully reveal the extent to which these factors impact clinical assisted reproductive techniques in domestic animals and humans...