Research Topics
| James L McGaughSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
The amygdala modulates the consolidation of memories of emotionally arousing experiencesJames L McGaugh
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine 92697 3800
Annu Rev Neurosci 27:1-28. 2004....- Basolateral amygdala noradrenergic activity mediates corticosterone-induced enhancement of auditory fear conditioningBenno Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA
Neurobiol Learn Mem 86:249-55. 2006.... - Glucocorticoid effects on memory retrieval require concurrent noradrenergic activity in the hippocampus and basolateral amygdalaBenno Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
J Neurosci 24:8161-9. 2004.... - Post-training intrabasolateral amygdala infusions of dopamine modulate consolidation of inhibitory avoidance memory: involvement of noradrenergic and cholinergic systemsRyan T Lalumiere
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Eur J Neurosci 20:2804-10. 2004.... 
Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD miceLani K Clinton
Department of Neurobiology and Behavior, 1109 Gillespie Neuroscience Research Facility, University of California, Irvine, Irvine, CA 92697 4545, USA
Neurobiol Dis 28:76-82. 2007..Thus, the enhanced corticosterone response of the young female mice likely underlies their poorer performance on stressful tasks...- Learning decreases A beta*56 and tau pathology and ameliorates behavioral decline in 3xTg-AD miceLauren M Billings
Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697 4545, USA
J Neurosci 27:751-61. 2007..These findings indicate that, in young and middle-aged 3xTg-AD mice, repeated spatial training can significantly delay the development of neuropathology and decline in spatial memory... - Enhancement of extinction memory consolidation: the role of the noradrenergic and GABAergic systems within the basolateral amygdalaDaniel J Berlau
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Neurobiol Learn Mem 86:123-32. 2006..The findings also suggest that the BLA influence on extinction is not mediated by an interaction with the dorsal hippocampus... - Posttraining handling facilitates memory for auditory-cue fear conditioning in ratsIsabel R Hui
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA
Neurobiol Learn Mem 86:160-3. 2006..These findings thus indicate that the posttraining injection or handling procedure is sufficiently arousing or stressful to facilitate memory consolidation of auditory-cue classical fear conditioning... - Corticotropin-releasing factor in the basolateral amygdala enhances memory consolidation via an interaction with the beta-adrenoceptor-cAMP pathway: dependence on glucocorticoid receptor activationBenno Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
J Neurosci 28:6642-51. 2008.... - Glucocorticoid enhancement of memory requires arousal-induced noradrenergic activation in the basolateral amygdalaBenno Roozendaal
Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Proc Natl Acad Sci U S A 103:6741-6. 2006.... - Involvement of the rostral anterior cingulate cortex in consolidation of inhibitory avoidance memory: interaction with the basolateral amygdalaEmily L Malin
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Neurobiol Learn Mem 87:295-302. 2007.... - Enhancement of inhibitory avoidance and conditioned taste aversion memory with insular cortex infusions of 8-Br-cAMP: involvement of the basolateral amygdalaMaría I Miranda
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
Learn Mem 11:312-7. 2004..These findings provide additional evidence that the BLA interacts with other brain regions, including sensory cortex, in modulating memory consolidation... - The basolateral amygdala interacts with the medial prefrontal cortex in regulating glucocorticoid effects on working memory impairmentBenno Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
J Neurosci 24:1385-92. 2004..These findings indicate that BLA activity is essential for enabling glucocorticoid effects in the mPFC on working memory and suggest that stress hormone-induced modulation of working memory involves noradrenergic activation... - Role of the basolateral amygdala in memory consolidationChrista K McIntyre
Center for the Neurobiology of Learning and Memory, University of California, Irvine, California 92697 3800, USA
Ann N Y Acad Sci 985:273-93. 2003..The findings suggest further that this memory-modulatory system may be involved in the formation of traumatic memories and posttraumatic stress disorder in human subjects... - Noradrenergic activation of the basolateral amygdala modulates consolidation of object recognition memoryBenno Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Neurobiol Learn Mem 90:576-9. 2008..Thus, regardless of the degree of emotional arousal induced by an experience, noradrenergic activation of the BLA after the experience ensures that it will be better remembered... - Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampusChrista K McIntyre
Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behavior, 218 Bonney Research Laboratory, University of California, Irvine, CA 92697 3800, USA
Proc Natl Acad Sci U S A 102:10718-23. 2005.... - Memory enhancement induced by post-training intrabasolateral amygdala infusions of beta-adrenergic or muscarinic agonists requires activation of dopamine receptors: Involvement of right, but not left, basolateral amygdalaRyan T Lalumiere
Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA
Learn Mem 12:527-32. 2005..Additionally, these findings indicate that the enhancement, but not impairment, of memory consolidation is lateralized to the right BLA... - A systemically administered beta-adrenoceptor antagonist blocks corticosterone-induced impairment of contextual memory retrieval in ratsBenno Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Neurobiol Learn Mem 81:150-4. 2004..These findings provide evidence for the view that glucocorticoids interact with noradrenergic mechanisms in influencing memory retrieval... - Glucocorticoid effects on object recognition memory require training-associated emotional arousalShoki Okuda
Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Proc Natl Acad Sci U S A 101:853-8. 2004..Thus, the present findings suggest that training-induced emotional arousal may be essential for glucocorticoid effects on object recognition memory... - Memory enhancement of classical fear conditioning by post-training injections of corticosterone in ratsGabriel K Hui
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA
Neurobiol Learn Mem 81:67-74. 2004.... - Amygdala modulation of memory consolidation: interaction with other brain systemsJames L McGaugh
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California at Irvine, 92697 3800, USA
Neurobiol Learn Mem 78:539-52. 2002..These findings provide strong support for the hypothesis that the BLA plays a critical role in regulating the consolidation of lasting memories of significant experiences... 
The basolateral amygdala modulates specific sensory memory representations in the cerebral cortexCandice M Chavez
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California Irvine, Qureshey Research Laboratory, Irvine, CA 92697 3800, USA
Neurobiol Learn Mem 91:382-92. 2009..These findings suggest that the ability of the BLA to alter specific cortical representations may underlie, at least in part, the modulatory influence of BLA activity on strengthening long-term memory...- Memory consolidation and the amygdala: a systems perspectiveJames L McGaugh
Dept of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA 92697-3800, USA
Trends Neurosci 25:456. 2002..Investigation of the involvement of BLA projections to other brain regions is essential for understanding influences of the amygdala on different aspects and forms of memory... - Differential involvement of the hippocampus, anterior cingulate cortex, and basolateral amygdala in memory for context and footshockEmily L Malin
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA
Proc Natl Acad Sci U S A 103:1959-63. 2006..Additionally, they provide further evidence that the BLA is more liberally involved in modulating memory consolidation for various aspects of emotionally arousing experiences... - Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's diseaseKim N Green
Department of Neurobiology and Behavior, and Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, California 92697 4545, USA
J Neurosci 26:9047-56. 2006..These findings suggest that high levels of glucocorticoids, found in AD, are not merely a consequence of the disease process but rather play a central role in the development and progression of AD... - Glucocorticoids interact with the basolateral amygdala beta-adrenoceptor--cAMP/cAMP/PKA system in influencing memory consolidationBenno Roozendaal
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Eur J Neurosci 15:553-60. 2002.... - Modulation of memory consolidation by the basolateral amygdala or nucleus accumbens shell requires concurrent dopamine receptor activation in both brain regionsRyan T Lalumiere
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
Learn Mem 12:296-301. 2005..Together with previous findings, these results suggest that the dopaminergic innervation of the BLA and NAc shell is critically involved in the modulation of memory consolidation... - Anisomycin infused into the hippocampus fails to block "reconsolidation" but impairs extinction: the role of re-exposure durationAnn E Power
Department of Anatomy and Neurobiology, Reeve Irvine Research Center, University of California Irvine, California 92697, USA
Learn Mem 13:27-34. 2006..The findings indicate that post-retrieval administration of anisomycin impairs subsequent retention performance only in the absence of extinction and that this impairment is temporary... - Make mild moments memorable: add a little arousalJames L McGaugh
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Trends Cogn Sci 10:345-7. 2006.... - Amygdala norepinephrine levels after training predict inhibitory avoidance retention performance in ratsChrista K McIntyre
Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behaviour, 218 Bonney Research Laboratory, University of California Irvine, Irvine, CA 92697 3800, USA
Eur J Neurosci 16:1223-6. 2002..These findings indicate that the degree of activation of the noradrenergic system within the amygdala in response to a novel, emotionally arousing experience predicts the extent of long-term memory for that experience... - The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval: dependence on the basolateral amygdalaBenno Roozendaal
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Proc Natl Acad Sci U S A 100:1328-33. 2003.... - Orphanin FQ/nociceptin interacts with the basolateral amygdala noradrenergic system in memory consolidationBenno Roozendaal
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
Learn Mem 14:29-35. 2007..These findings indicate that endogenously released OFQ/N interacts with noradrenergic activity within the BLA in modulating memory consolidation... - Muscarinic cholinergic influences in memory consolidationAnn E Power
Reeve Irvine Research Center and Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697 4292, USA
Neurobiol Learn Mem 80:178-93. 2003..Furthermore, the findings indicating that mR drug treatments influence plasticity in the hippocampus and in sensory cortices strongly suggest that mR activation is involved in the storage of information in these brain regions... - Basolateral amygdala lesions do not prevent memory of context-footshock trainingDaniel J Berlau
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, California 92697 3800, USA
Learn Mem 10:495-502. 2003..These findings provide additional evidence that an intact BLA is not required for the acquisition or retention of context-footshock training... - Post-training intra-basolateral amygdala infusions of norepinephrine enhance consolidation of memory for contextual fear conditioningRyan T Lalumiere
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697 3800, USA
J Neurosci 23:6754-8. 2003..Thus, the findings provide additional evidence consistent with the hypothesis that the BLA has a general role in modulating memory consolidation... - Drug enhancement of memory consolidation: historical perspective and neurobiological implicationsJames L McGaugh
Center for the Neurobiology of Learning and Memory, University of California, Irvine, CA 92697 3800, USA
Psychopharmacology (Berl) 202:3-14. 2009..Many subsequent studies confirmed that finding and found that stimulant drugs also enhance the learning of a wide range of tasks... - Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidationBenno Roozendaal
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 99:13908-13. 2002..These findings indicate that activation of CRH receptors in the BLA, likely by training-induced release of endogenous peptide originating from the CEA, participates in mediating stress effects on memory consolidation... - Intra-basolateral amygdala infusions of AP-5 impair or enhance retention of inhibitory avoidance depending on training conditionsRyan T Lalumiere
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Neurobiol Learn Mem 81:60-6. 2004.... - Lesions of the nucleus basalis magnocellularis induced by 192 IgG-saporin block memory enhancement with posttraining norepinephrine in the basolateral amygdalaAnn E Power
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697 3800, USA
Proc Natl Acad Sci U S A 99:2315-9. 2002..Choline acetyltransferase assays of frontal and occipital cortices confirmed the NBM lesions. These findings indicate that cholinergic NBM-cortex projections are required for BLA-mediated modulation of memory consolidation... - Phthalic acid amygdalopetal lesion of the nucleus basalis magnocellularis induces reversible memory deficits in ratsAnn E Power
Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, CA 92697 3800, USA
Neurobiol Learn Mem 77:372-88. 2002..These findings suggest that the dense cholinergic projection from the nucleus basalis magnocellularis to the BLA is involved in both the acquisition and the consolidation of the aversive inhibitory avoidance task... - Memory reconsolidation hypothesis revived but restrained: theoretical comment on Biedenkapp and Rudy (2004)James L McGaugh
Center for the Neurobiology of Learning and Memory, University of California, 334 Qureshy Laboratory, Irvine, CA 92697 3800, USA
Behav Neurosci 118:1140-2. 2004..Thus, it is not yet clear whether their findings can be explained by a revised reconsolidation hypothesis, or whether some other hypothesis is required to account for postretrieval memory impairment, when it is observed... - Cholinergic activation of the basolateral amygdala regulates unlearned freezing behavior in ratsAnn E Power
Department of Neurobiology and Behavior, Center for the Neurobiology of Learning and Memory, University of California, 218 BRL, Irvine, CA 92697 3800, USA
Behav Brain Res 134:307-15. 2002..The PA NBM-lesion did not affect open field activity. These findings indicate that muscarinic cholinergic activation in the BLA from the NBM influences fear-motivated freezing behavior... - Behavioral and neuroanatomical investigation of Highly Superior Autobiographical Memory (HSAM)Aurora K R Leport
Center for the Neurobiology of Learning and Memory, Department of Neurobiology and Behavior, University of California, Irvine, CA 92697, USA
Neurobiol Learn Mem 98:78-92. 2012..Neuroanatomical results identified nine structures as being morphologically different from those of control participants. The study of HSAM may provide new insights into the neurobiology of autobiographical memory... - Glucocorticoids enhance taste aversion memory via actions in the insular cortex and basolateral amygdalaMaria Isabel Miranda
Departamento de Neurobiologia Conductual y Cognitiva, Instituto de Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro, 76230, Mexico
Learn Mem 15:468-76. 2008.... - Role of adrenal stress hormones in forming lasting memories in the brainJames L McGaugh
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, California 92697-3800, USA
Curr Opin Neurobiol 12:205-10. 2002..Release of norepinephrine and activation of beta-adrenoceptors within the basolateral amygdala is critical in mediating adrenal stress hormone regulation of memory consolidation... - Basolateral amygdala lesions block the memory-enhancing effect of 8-Br-cAMP infused into the entorhinal cortex of rats after trainingRafael Roesler
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA
Eur J Neurosci 15:905-10. 2002.... - Emotional arousal and enhanced amygdala activity: new evidence for the old perseveration-consolidation hypothesisJames L McGaugh
Learn Mem 12:77-9. 2005 - The role of NMDA glutamate receptors, PKA, MAPK, and CAMKII in the hippocampus in extinction of conditioned fearGerman Szapiro
Instituto de Biologia Celular y Neurociencias, Facultad de Medicina, Buenos Aires, Argentina
Hippocampus 13:53-8. 2003..Thus, the molecular mechanisms underlying acquisition and/or consolidation of the memory for extinction are similar to those described for the acquisition and/or consolidation of the original contextual fear... - Involvement of basolateral amygdala alpha2-adrenoceptors in modulating consolidation of inhibitory avoidance memoryBarbara Ferry
Laboratoire de Neurosciences Sensorielles Comportementales et Cognitives, UMR 5020 CNRS Université Lyon 1, 69366 Lyon Cedex 07, France
Learn Mem 15:238-43. 2008.... - Insular cortex is involved in consolidation of object recognition memoryFederico Bermudez-Rattoni
Center for the Neurobiology of Learning and Memory and Department of Neurobiology and Behavior, University of California, Irvine, CA 92697-3800, USA
Learn Mem 12:447-9. 2005 - Relaxin receptor activation in the basolateral amygdala impairs memory consolidationSherie Ma
Howard Florey Institute of Experimental Physiology and Medicine, The University of Melbourne, Victoria 3010, Australia
Eur J Neurosci 22:2117-22. 2005..These findings suggest a novel function for endogenous relaxin-LGR7 signalling in rat brain involving regulation of memory consolidation... - Amygdala or hippocampus inactivation after retrieval induces temporary memory deficitRoberto A Prado-Alcalá
Institute of Neurobiology and FES Iztacala, National University of Mexico, Mexico
Neurobiol Learn Mem 86:144-9. 2006..These findings challenge the reconsolidation hypothesis and suggest that the post-retrieval retention performance impairment is best explained as due to temporary retrieval failure... - A case of unusual autobiographical rememberingElizabeth S Parker
Department of Neurology, University of California, Los Angeles, Irvine, USA
Neurocase 12:35-49. 2006..We propose the name hyperthymestic syndrome, from the Greek word thymesis meaning remembering, and that AJ is the first reported case... - Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic miceLauren M Billings
Department of Neurobiology and Behavior and Center for the Neurobiology of Learning and Memory, University of California, Irvine, Irvine, CA 92697, USA
Neuron 45:675-88. 2005..Reemergence of the Abeta pathology again leads to cognitive deficits. This study strongly implicates intraneuronal Abeta in the onset of cognitive dysfunction... - The consolidation of object and context recognition memory involve different regions of the temporal lobeIsraela Balderas
Departamento de Neurociencias, Instituto de Fisiologia Celular, Universidad Nacional Autonoma de Mexico, Apartado Postal 70 253, 04510 Mexico DF, Mexico
Learn Mem 15:618-24. 2008..Altogether, these results suggest that temporal lobe structures are differentially involved in recognition memory consolidation... - Glucocorticoid-induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobeDominique J F de Quervain
Division of Psychiatry Research, University of Zurich, Lenggstr 31, 8029 Zurich, Switzerland
Eur J Neurosci 17:1296-302. 2003....