J Denis McGarry

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. ncbi request reprint Travels with carnitine palmitoyltransferase I: from liver to germ cell with stops in between
    J D McGarry
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, U S A
    Biochem Soc Trans 29:241-5. 2001
  2. ncbi request reprint Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    J Denis McGarry
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9135, USA
    Diabetes 51:7-18. 2002
  3. ncbi request reprint Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion
    Robert L Dobbins
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9135, USA
    Am J Physiol Endocrinol Metab 284:E778-87. 2003
  4. ncbi request reprint The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats
    Robert L Dobbins
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9135, USA
    Diabetes 51:1825-33. 2002
  5. ncbi request reprint Glucose-fatty acid interactions in health and disease
    J D McGarry
    Department of Internal Medicine, University of Texas, Southwestern Medical Center at Dallas, 75235 9135, USA
    Am J Clin Nutr 67:500S-504S. 1998
  6. ncbi request reprint Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity
    Gregor Majdic
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Endocrinology 143:607-14. 2002
  7. ncbi request reprint Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function
    V Esser
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 268:5817-22. 1993
  8. ncbi request reprint Fine chromosome mapping of the genes for human liver and muscle carnitine palmitoyltransferase I (CPT1A and CPT1B)
    C H Britton
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas 75235, USA
    Genomics 40:209-11. 1997
  9. ncbi request reprint Molecular characterization of L-CPT I deficiency in six patients: insights into function of the native enzyme
    N F Brown
    Departments of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, TX 75390, USA
    J Lipid Res 42:1134-42. 2001
  10. ncbi request reprint Expression of a cDNA isolated from rat brown adipose tissue and heart identifies the product as the muscle isoform of carnitine palmitoyltransferase I (M-CPT I). M-CPT I is the predominant CPT I isoform expressed in both white (epididymal) and brown adipo
    V Esser
    Department of Internal Medicine, Gifford Laboratories, Center for Diabetes Research, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9135, USA
    J Biol Chem 271:6972-7. 1996

Collaborators

  • Robert L Dobbins
  • Lidia S Szczepaniak
  • Weiguo Zhang
  • Alaattin Sen
  • M J Bennett
  • B B Zhang
  • V Esser
  • N F Brown
  • C H Britton
  • D W Foster
  • Gregor Majdic
  • H Mulder
  • Keith L Parker
  • Elise Gomez-Sanchez
  • Morag Young
  • Paul Anderson
  • P A Antinozzi
  • D Lu
  • J Finley
  • J C Cohen
  • J Cohen
  • J An
  • I Subramanian
  • A S Feigenbaum
  • C B Newgard
  • J M Saudubray
  • P M MacLeod
  • J A Kobari
  • R S Mullur
  • D P Yarnall
  • P Froguel
  • D W Mackey
  • D K Burns
  • A T Cowan
  • R A Schultz
  • B C Weis
  • K Krishnan
  • M Kuwajima
  • C A Slaughter
  • K F Woeltje
  • M J McPhaul
  • C T Evans
  • A D Gonzalez
  • W F Cox

Detail Information

Publications16

  1. ncbi request reprint Travels with carnitine palmitoyltransferase I: from liver to germ cell with stops in between
    J D McGarry
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, U S A
    Biochem Soc Trans 29:241-5. 2001
    ..The intriguing question of whether CPT I has an important function in sperm development is also addressed briefly...
  2. ncbi request reprint Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    J Denis McGarry
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9135, USA
    Diabetes 51:7-18. 2002
  3. ncbi request reprint Chemical sympathectomy alters regulation of body weight during prolonged ICV leptin infusion
    Robert L Dobbins
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9135, USA
    Am J Physiol Endocrinol Metab 284:E778-87. 2003
    ..In conclusion, activation of the SNS by leptin increases energy expenditure by augmenting the resting metabolic rate...
  4. ncbi request reprint The composition of dietary fat directly influences glucose-stimulated insulin secretion in rats
    Robert L Dobbins
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9135, USA
    Diabetes 51:1825-33. 2002
    ..Inferences regarding the impact of fatty acids on GSIS that are based on models using unsaturated fat may not reflect the effects of saturated fat...
  5. ncbi request reprint Glucose-fatty acid interactions in health and disease
    J D McGarry
    Department of Internal Medicine, University of Texas, Southwestern Medical Center at Dallas, 75235 9135, USA
    Am J Clin Nutr 67:500S-504S. 1998
    ....
  6. ncbi request reprint Knockout mice lacking steroidogenic factor 1 are a novel genetic model of hypothalamic obesity
    Gregor Majdic
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Endocrinology 143:607-14. 2002
    ..These SF-1 KO mice are a genetic model of late-onset obesity that may help elucidate the role of the VMH in weight regulation...
  7. ncbi request reprint Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyltransferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function
    V Esser
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 268:5817-22. 1993
    ..They also establish unequivocally that CPT I and CPT II are distinct proteins and that inhibitors of CPT I interact within its catalytic domain, not with an associated regulatory component...
  8. ncbi request reprint Fine chromosome mapping of the genes for human liver and muscle carnitine palmitoyltransferase I (CPT1A and CPT1B)
    C H Britton
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas 75235, USA
    Genomics 40:209-11. 1997
  9. ncbi request reprint Molecular characterization of L-CPT I deficiency in six patients: insights into function of the native enzyme
    N F Brown
    Departments of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, TX 75390, USA
    J Lipid Res 42:1134-42. 2001
    ..The demonstration of L-CPT I deficiency in this patient suggests that the spectrum of clinical sequelae associated with loss or alteration of L-CPT I function may be broader than was previously recognized...
  10. ncbi request reprint Expression of a cDNA isolated from rat brown adipose tissue and heart identifies the product as the muscle isoform of carnitine palmitoyltransferase I (M-CPT I). M-CPT I is the predominant CPT I isoform expressed in both white (epididymal) and brown adipo
    V Esser
    Department of Internal Medicine, Gifford Laboratories, Center for Diabetes Research, University of Texas Southwestern Medical Center, Dallas, Texas 75235 9135, USA
    J Biol Chem 271:6972-7. 1996
    ..These findings, coupled with the kinetic properties and migration profiles on SDS gels of CPT I in brown and white adipocytes, indicate that the muscle form of the enzyme is the dominant, if not exclusive, species in both cell types...
  11. ncbi request reprint Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats
    R L Dobbins
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 75235 9135, USA
    Diabetes 50:123-30. 2001
    ..In conclusion, either a diet rich in saturated fat or prolonged inhibition of fatty acid oxidation impairs IMGD in rats via a mechanism related to the accumulation of IMCL...
  12. ncbi request reprint Overexpression of a modified human malonyl-CoA decarboxylase blocks the glucose-induced increase in malonyl-CoA level but has no impact on insulin secretion in INS-1-derived (832/13) beta-cells
    H Mulder
    Touchstone Center for Diabetes Research and Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Biol Chem 276:6479-84. 2001
    ..These findings extend our previous observations and are not consistent with the LC-CoA hypothesis as originally set forth...
  13. ncbi request reprint Inhibitors of mitochondrial carnitine palmitoyltransferase I limit the action of proteases on the enzyme. Isolation and partial amino acid analysis of a truncated form of the rat liver isozyme
    V Esser
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 268:5810-6. 1993
    ..Finally, the 82-kDa truncated form of rat liver CPT I was isolated and subjected to partial amino acid analysis. Four unambiguous peptide sequences were obtained...
  14. pmc Human liver mitochondrial carnitine palmitoyltransferase I: characterization of its cDNA and chromosomal localization and partial analysis of the gene
    C H Britton
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235
    Proc Natl Acad Sci U S A 92:1984-8. 1995
    ....
  15. ncbi request reprint Cloning, sequencing, and expression of a cDNA encoding rat liver mitochondrial carnitine palmitoyltransferase II
    K F Woeltje
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Southwestern Medical School, Dallas 75235
    J Biol Chem 265:10720-5. 1990
    ..The predicted amino acid sequence of CPT II shows strong identity with those of two other acyltransferases, namely, rat liver peroxisomal carnitine octanoyltransferase and porcine choline acetyltransferase...
  16. ncbi request reprint Mitochondrial import and processing of rat liver carnitine palmitoyltransferase II defines the amino terminus of the mature protein. Possibility of differential modification of the rat and human isoforms
    N F Brown
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235
    J Biol Chem 266:15446-9. 1991
    ..Finally, the recent suggestion by Brady et al. (Brady, P. S., Liu, J. S., Park, E. A., Hanson, R. W., and Brady, L. J. (1991) FASEB J. 5, A817) that our CPT II cDNA construct is incomplete in the 5'-coding region is refuted...