Affiliation: University of Pittsburgh
Country: USA


  1. request reprint
    McGaffin K, Sun C, Rager J, Romano L, Zou B, Mathier M, et al. Leptin signalling reduces the severity of cardiac dysfunction and remodelling after chronic ischaemic injury. Cardiovasc Res. 2008;77:54-63 pubmed
    ..These data demonstrate that HF increases ObR signalling in cardiomyocytes and that activation of ObR signalling improves functional outcomes in chronic ischaemic injury leading to HF. ..
  2. McGaffin K, Zou B, McTiernan C, O Donnell C. Leptin attenuates cardiac apoptosis after chronic ischaemic injury. Cardiovasc Res. 2009;83:313-24 pubmed publisher
  3. McGaffin K, Moravec C, McTiernan C. Leptin signaling in the failing and mechanically unloaded human heart. Circ Heart Fail. 2009;2:676-83 pubmed publisher
    ..Further, a cardioprotective role for leptin in the failing human heart is suggested through the activation of signal transducer and activator of transcription-3 and AMP-activated kinase signaling. ..
  4. McGaffin K, Witham W, Yester K, Romano L, O Doherty R, McTiernan C, et al. Cardiac-specific leptin receptor deletion exacerbates ischaemic heart failure in mice. Cardiovasc Res. 2011;89:60-71 pubmed publisher