E O McFalls

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Coronary-artery revascularization before elective major vascular surgery
    Edward O McFalls
    Minneapolis Veterans Affairs Medical Center, Department of Medicine, Division of Cardiology, University of Minnesota, Minneapolis 55417, USA
    N Engl J Med 351:2795-804. 2004
  2. ncbi request reprint Activation of p38 MAPK and increased glucose transport in chronic hibernating swine myocardium
    Edward O McFalls
    Division of Cardiology, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    Am J Physiol Heart Circ Physiol 287:H1328-34. 2004
  3. ncbi request reprint Mitochondrial adaptations within chronically ischemic swine myocardium
    Edward O McFalls
    Experimental Cardiology, Thoraxcenter, Cardiovascular Research School COEUR, Erasmus MC, Rotterdam, The Netherlands
    J Mol Cell Cardiol 41:980-8. 2006
  4. ncbi request reprint Myocardial glucose uptake after dobutamine stress in chronic hibernating swine myocardium
    Edward O McFalls
    Cardiology 111C, VA Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
    J Nucl Cardiol 10:385-94. 2003
  5. ncbi request reprint Repetitive supply-demand ischemia with dobutamine increases glucose uptake in postischemic and remote myocardium
    Edward O McFalls
    Department of Medicine, VA Medical Center, University of Minnesota, Minneapolis, Minnesota, USA
    J Nucl Med 44:85-91. 2003
  6. ncbi request reprint Glucose uptake and glycogen levels are increased in pig heart after repetitive ischemia
    Edward O McFalls
    Cardiology Dept, 111C, Veterans Affairs Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
    Am J Physiol Heart Circ Physiol 282:H205-11. 2002
  7. ncbi request reprint Effect of regional hyperemia on myocardial uptake of 2-deoxy-2-[(18)F]fluoro-D-glucose
    E O McFalls
    Division of Cardiology, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, Minnesota 55417, USA
    Am J Physiol Endocrinol Metab 278:E96-E102. 2000
  8. ncbi request reprint Regional glucose uptake within hypoperfused swine myocardium as measured by positron emission tomography
    E O McFalls
    Division of Cardiology, Veterans Affairs Medical Center, University of Minnesota, Minneapolis 55417, USA
    Am J Physiol 272:H343-9. 1997
  9. doi request reprint CON: Preoperative coronary revascularization in high-risk patients undergoing vascular surgery
    Santiago Garcia
    Division of Cardiology, VA Medical Center, University of Minnesota, Minneapolis, MN, USA
    Anesth Analg 106:764-6. 2008
  10. ncbi request reprint Glucose uptake increases relative to oxygen consumption during short-term hibernation
    E O McFalls
    Cardiology and Cardiovascular Surgery, VA Medical Center, Minneapolis, MN 55417, USA
    Basic Res Cardiol 95:39-46. 2000

Research Grants

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Coronary-artery revascularization before elective major vascular surgery
    Edward O McFalls
    Minneapolis Veterans Affairs Medical Center, Department of Medicine, Division of Cardiology, University of Minnesota, Minneapolis 55417, USA
    N Engl J Med 351:2795-804. 2004
    ..The benefit of coronary-artery revascularization before elective major vascular surgery is unclear...
  2. ncbi request reprint Activation of p38 MAPK and increased glucose transport in chronic hibernating swine myocardium
    Edward O McFalls
    Division of Cardiology, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    Am J Physiol Heart Circ Physiol 287:H1328-34. 2004
    ..As in preconditioned myocardium, activation of p38 MAPK may play an important role in the metabolic adaptations that characterize chronic hibernating myocardium...
  3. ncbi request reprint Mitochondrial adaptations within chronically ischemic swine myocardium
    Edward O McFalls
    Experimental Cardiology, Thoraxcenter, Cardiovascular Research School COEUR, Erasmus MC, Rotterdam, The Netherlands
    J Mol Cell Cardiol 41:980-8. 2006
    ..Uncoupling protein 2 expression is enhanced in the mitochondria, providing a potential mechanism for these favorable mitochondrial adaptations...
  4. ncbi request reprint Myocardial glucose uptake after dobutamine stress in chronic hibernating swine myocardium
    Edward O McFalls
    Cardiology 111C, VA Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
    J Nucl Cardiol 10:385-94. 2003
    ....
  5. ncbi request reprint Repetitive supply-demand ischemia with dobutamine increases glucose uptake in postischemic and remote myocardium
    Edward O McFalls
    Department of Medicine, VA Medical Center, University of Minnesota, Minneapolis, Minnesota, USA
    J Nucl Med 44:85-91. 2003
    ..This would make it difficult to discriminate postischemic from remote myocardium with glucose tracers...
  6. ncbi request reprint Glucose uptake and glycogen levels are increased in pig heart after repetitive ischemia
    Edward O McFalls
    Cardiology Dept, 111C, Veterans Affairs Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
    Am J Physiol Heart Circ Physiol 282:H205-11. 2002
    ....
  7. ncbi request reprint Effect of regional hyperemia on myocardial uptake of 2-deoxy-2-[(18)F]fluoro-D-glucose
    E O McFalls
    Division of Cardiology, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, Minnesota 55417, USA
    Am J Physiol Endocrinol Metab 278:E96-E102. 2000
    ..In conclusion, hyperemia decreased regional myocardial FDG uptake relative to normally perfused regions and this effect on the lumped constant was independent of nitric oxide...
  8. ncbi request reprint Regional glucose uptake within hypoperfused swine myocardium as measured by positron emission tomography
    E O McFalls
    Division of Cardiology, Veterans Affairs Medical Center, University of Minnesota, Minneapolis 55417, USA
    Am J Physiol 272:H343-9. 1997
    ..In this model of chronic ischemia, hypoperfused dysfunctional regions were characterized by enhanced glucose uptake and preserved bioenergetics. This supports the concept that the myocardium adapts to chronic ischemia...
  9. doi request reprint CON: Preoperative coronary revascularization in high-risk patients undergoing vascular surgery
    Santiago Garcia
    Division of Cardiology, VA Medical Center, University of Minnesota, Minneapolis, MN, USA
    Anesth Analg 106:764-6. 2008
  10. ncbi request reprint Glucose uptake increases relative to oxygen consumption during short-term hibernation
    E O McFalls
    Cardiology and Cardiovascular Surgery, VA Medical Center, Minneapolis, MN 55417, USA
    Basic Res Cardiol 95:39-46. 2000
    ..Although glucose uptake is increased in chronically hypoperfused, viable myocardium, the dynamic changes in glucose uptake relative to oxygen consumption in "short-term" models of hibernation have not been fully explored...
  11. ncbi request reprint Utility of positron emission tomography in predicting improved left ventricular ejection fraction after coronary artery bypass grafting among patients with ischemic cardiomyopathy
    E O McFalls
    Divisions of Cardiology and Cardiovascular Surgery, VA Medical Center, University of Minnesota, Minneapolis, MN 55417, USA
    Cardiology 93:105-12. 2000
    ..PET estimates of relative FDG uptake in the anterior wall help predict those individuals who are likely to have the greatest increment in LVEF...
  12. ncbi request reprint Clinical factors associated with long-term mortality following vascular surgery: outcomes from the Coronary Artery Revascularization Prophylaxis (CARP) Trial
    Edward O McFalls
    Division of Cardiology, VA Medical Center, Minneapolis, MN 55417, USA
    J Vasc Surg 46:694-700. 2007
    ..Using the nonrandomized cohort from the Coronary Artery Revascularization Prophylaxis (CARP) Trial, we analyzed the predictors of outcome based on the presenting vascular problem and prevalence of comorbid conditions and cardiac risks...
  13. doi request reprint Predictors and outcomes of a perioperative myocardial infarction following elective vascular surgery in patients with documented coronary artery disease: results of the CARP trial
    Edward O McFalls
    Division of Cardiology 111C, VA Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
    Eur Heart J 29:394-401. 2008
    ....
  14. doi request reprint Utility of N-acetylcysteine to prevent acute kidney injury after cardiac surgery: a randomized controlled trial
    A Selcuk Adabag
    Division of Cardiology, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, MN 55417, USA
    Am Heart J 155:1143-9. 2008
    ..gov identifier NCT00211653)...
  15. doi request reprint Preoperative pulmonary function and mortality after cardiac surgery
    A Selcuk Adabag
    Division of Cardiology, Veterans Affairs Medical Center and University of Minnesota, Minneapolis, MN, USA
    Am Heart J 159:691-7. 2010
    ..The aim of the study was to examine the relationship between preoperative pulmonary function and outcomes after cardiac surgery...
  16. ncbi request reprint The energetic state within hibernating myocardium is normal during dobutamine despite inhibition of ATP-dependent potassium channel opening with glibenclamide
    Edward O McFalls
    Veterans Affairs Medical Center University of Minnesota, Minneapolis, MN, USA
    Am J Physiol Heart Circ Physiol 293:H2945-51. 2007
    ....
  17. ncbi request reprint Prognostic significance of elevated cardiac troponin I after heart surgery
    A Selcuk Adabag
    Division of Cardiology, Veterans Affairs Medical Center and the University of Minnesota, Minneapolis, Minnesota 55417, USA
    Ann Thorac Surg 83:1744-50. 2007
    ....
  18. ncbi request reprint Mitochondrial function: the heart of myocardial preservation
    Edward O McFalls
    Department of Medicine, Veterans Affairs Medicial Center, University of Minnesota, Minneapolis, 55417, USA
    J Lab Clin Med 142:141-8. 2003
    ..It will also provide insight into the mechanisms by which mitochondrial signaling in preconditioning can protect the myocyte during subsequent prolonged ischemic periods...
  19. ncbi request reprint Disparate opinions regarding indications for coronary artery revascularization before elective vascular surgery
    Gordon L Pierpont
    Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    Am J Cardiol 94:1124-8. 2004
    ..Deviations from published guidelines are common, suggesting that current consensus statements need additional data to support their recommendations...
  20. doi request reprint Culprit coronary lesions requiring percutaneous coronary intervention after vascular surgery often arise from in-stent restenosis of bare metal stents
    Santiago Garcia
    Division of Cardiology, University of Minnesota and Minneapolis VA Medical Center, Minneapolis, MN 55417, USA
    Ann Vasc Surg 24:596-601. 2010
    ....
  21. ncbi request reprint Coronary artery bypass grafting is superior to percutaneous coronary intervention in prevention of perioperative myocardial infarctions during subsequent vascular surgery
    Herbert B Ward
    Department of Surgery, VA Medical Center and University of Minnesota, Minneapolis, Minnesota 55417, USA
    Ann Thorac Surg 82:795-800; discussion 800-1. 2006
    ..We hypothesized that more complete revascularization would improve outcomes after vascular surgery...
  22. ncbi request reprint Prophylactic coronary artery revascularization for elective vascular surgery: study design. Veterans Affairs Cooperative Study Group on Coronary Artery Revascularization Prophylaxis for Elective Vascular Surgery
    E O McFalls
    Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
    Control Clin Trials 20:297-308. 1999
    ..The findings should help determine the best strategy for managing patients with coronary artery disease in need of elective vascular surgery...
  23. doi request reprint Perioperative complications after vascular surgery are predicted by the revised cardiac risk index but are not reduced in high-risk subsets with preoperative revascularization
    Santiago Garcia
    Division of Cardiology, Minneapolis VA Medical Center and the University of Minnesota, Minneapolis, Minn, USA
    Circ Cardiovasc Qual Outcomes 2:73-7. 2009
    ..Among patients with documented coronary artery disease who undergo vascular surgery, it is unclear whether preoperative revascularization reduces postoperative cardiac complications in high-risk subsets defined by the RCRI...
  24. doi request reprint Usefulness of revascularization of patients with multivessel coronary artery disease before elective vascular surgery for abdominal aortic and peripheral occlusive disease
    Santiago Garcia
    Cardiology Section, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, Minnesota, USA
    Am J Cardiol 102:809-13. 2008
    ..6% of patients who underwent coronary angiography before vascular surgery, and this was the only subset of patients showing a benefit with preoperative coronary artery revascularization...
  25. doi request reprint Diagnostic coronary angiography in patients with peripheral arterial disease: a sub-study of the Coronary Artery Revascularization Prophylaxis Trial
    Santiago Garcia
    Minneapolis Veterans Affairs Medical Center and the University of Minnesota, Minneapolis, MN 55417, USA
    J Interv Cardiol 21:369-74. 2008
    ..The goal of this sub-study of the Coronary Artery Revascularization Prophylaxis (CARP) trial was to assess the safety of coronary angiography in patients with peripheral vascular disease...
  26. doi request reprint Functional and structural adaptations of coronary microvessels distal to a chronic coronary artery stenosis
    Oana Sorop
    Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands
    Circ Res 102:795-803. 2008
    ..These structural and functional alterations may aggravate flow abnormalities distal to a chronic coronary artery stenosis...
  27. ncbi request reprint Ischemic preconditioning modulates mitochondrial respiration, irrespective of the employed signal transduction pathway
    David A Liem
    Division of Experimental Cardiology, Thoraxcenter, Department of Clinical Genetics, Mitochondrial Research Unit, Cardiovascular Research Institute COEUR, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
    Transl Res 151:17-26. 2008
    ....
  28. doi request reprint Nephrotoxicity of iodixanol versus iopamidol in patients with chronic kidney disease and diabetes mellitus undergoing coronary angiographic procedures
    Warren Laskey
    Department of Medicine, University of New Mexico School of Medicine, Albuquerque, 87131, USA
    Am Heart J 158:822-828.e3. 2009
    ..The choice of radiographic contrast media for use in patients at increased risk of contrast-induced nephropathy (CIN) is of ongoing interest...
  29. pmc Dose dependent effect of statins on postoperative atrial fibrillation after cardiac surgery among patients treated with beta blockers
    Salima Mithani
    Department of Internal Medicine, Veterans Affairs Medical Center, Veterans Drive, Minneapolis 55417, USA
    J Cardiothorac Surg 4:61. 2009
    ..Whether statins prevent AF in patients treated with postoperative beta blockers and whether the statin-effect is dose related are unknown...
  30. ncbi request reprint Postoperative outcomes for patients undergoing elective revascularization for critical limb ischemia and intermittent claudication: a subanalysis of the Coronary Artery Revascularization Prophylaxis (CARP) trial
    Amritha Raghunathan
    Vascular Surgery Service, San Francisco VA Medical Center and Univ of California at San Francisco, CA 94121, USA
    J Vasc Surg 43:1175-82. 2006
    ..This multicenter trial was sponsored by the Cooperative Studies Program of the Department of Veterans Affairs...
  31. ncbi request reprint Hibernating myocardium: is the program to survive a pathway to failure?
    Rosemary F Kelly
    Circ Res 102:3-5. 2008

Research Grants2

  1. Mitochondrial Protection Within Chronically Ischemic Myocardium
    Edward O McFalls; Fiscal Year: 2010
    ..Using this model, we propose that a class of drugs used in diabetic patients that has been associated with heart failure exacerbations, alters the mitochondrial energy production in a similar way. ..