Research Topics
| E O McFallsSummaryAffiliation: University of Minnesota Country: USA Publications
Research Grants
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Detail Information
Publications
Coronary-artery revascularization before elective major vascular surgeryEdward O McFalls
Minneapolis Veterans Affairs Medical Center, Department of Medicine, Division of Cardiology, University of Minnesota, Minneapolis 55417, USA
N Engl J Med 351:2795-804. 2004..The benefit of coronary-artery revascularization before elective major vascular surgery is unclear...- Activation of p38 MAPK and increased glucose transport in chronic hibernating swine myocardiumEdward O McFalls
Division of Cardiology, Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
Am J Physiol Heart Circ Physiol 287:H1328-34. 2004..As in preconditioned myocardium, activation of p38 MAPK may play an important role in the metabolic adaptations that characterize chronic hibernating myocardium... - Mitochondrial adaptations within chronically ischemic swine myocardiumEdward O McFalls
Experimental Cardiology, Thoraxcenter, Cardiovascular Research School COEUR, Erasmus MC, Rotterdam, The Netherlands
J Mol Cell Cardiol 41:980-8. 2006..Uncoupling protein 2 expression is enhanced in the mitochondria, providing a potential mechanism for these favorable mitochondrial adaptations... - Myocardial glucose uptake after dobutamine stress in chronic hibernating swine myocardiumEdward O McFalls
Cardiology 111C, VA Medical Center, One Veterans Drive, Minneapolis, MN 55417, USA
J Nucl Cardiol 10:385-94. 2003.... - Repetitive supply-demand ischemia with dobutamine increases glucose uptake in postischemic and remote myocardiumEdward O McFalls
Department of Medicine, VA Medical Center, University of Minnesota, Minneapolis, Minnesota, USA
J Nucl Med 44:85-91. 2003..This would make it difficult to discriminate postischemic from remote myocardium with glucose tracers... - Glucose uptake and glycogen levels are increased in pig heart after repetitive ischemiaEdward O McFalls
Cardiology Dept, 111C, Veterans Affairs Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
Am J Physiol Heart Circ Physiol 282:H205-11. 2002.... - Effect of regional hyperemia on myocardial uptake of 2-deoxy-2-[(18)F]fluoro-D-glucoseE O McFalls
Division of Cardiology, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, Minnesota 55417, USA
Am J Physiol Endocrinol Metab 278:E96-E102. 2000..In conclusion, hyperemia decreased regional myocardial FDG uptake relative to normally perfused regions and this effect on the lumped constant was independent of nitric oxide... - Regional glucose uptake within hypoperfused swine myocardium as measured by positron emission tomographyE O McFalls
Division of Cardiology, Veterans Affairs Medical Center, University of Minnesota, Minneapolis 55417, USA
Am J Physiol 272:H343-9. 1997..In this model of chronic ischemia, hypoperfused dysfunctional regions were characterized by enhanced glucose uptake and preserved bioenergetics. This supports the concept that the myocardium adapts to chronic ischemia... - CON: Preoperative coronary revascularization in high-risk patients undergoing vascular surgerySantiago Garcia
Division of Cardiology, VA Medical Center, University of Minnesota, Minneapolis, MN, USA
Anesth Analg 106:764-6. 2008 - Glucose uptake increases relative to oxygen consumption during short-term hibernationE O McFalls
Cardiology and Cardiovascular Surgery, VA Medical Center, Minneapolis, MN 55417, USA
Basic Res Cardiol 95:39-46. 2000..Although glucose uptake is increased in chronically hypoperfused, viable myocardium, the dynamic changes in glucose uptake relative to oxygen consumption in "short-term" models of hibernation have not been fully explored... - Utility of positron emission tomography in predicting improved left ventricular ejection fraction after coronary artery bypass grafting among patients with ischemic cardiomyopathyE O McFalls
Divisions of Cardiology and Cardiovascular Surgery, VA Medical Center, University of Minnesota, Minneapolis, MN 55417, USA
Cardiology 93:105-12. 2000..PET estimates of relative FDG uptake in the anterior wall help predict those individuals who are likely to have the greatest increment in LVEF... - Clinical factors associated with long-term mortality following vascular surgery: outcomes from the Coronary Artery Revascularization Prophylaxis (CARP) TrialEdward O McFalls
Division of Cardiology, VA Medical Center, Minneapolis, MN 55417, USA
J Vasc Surg 46:694-700. 2007..Using the nonrandomized cohort from the Coronary Artery Revascularization Prophylaxis (CARP) Trial, we analyzed the predictors of outcome based on the presenting vascular problem and prevalence of comorbid conditions and cardiac risks... - Predictors and outcomes of a perioperative myocardial infarction following elective vascular surgery in patients with documented coronary artery disease: results of the CARP trialEdward O McFalls
Division of Cardiology 111C, VA Medical Center, 1 Veterans Drive, Minneapolis, MN 55417, USA
Eur Heart J 29:394-401. 2008.... - Utility of N-acetylcysteine to prevent acute kidney injury after cardiac surgery: a randomized controlled trialA Selcuk Adabag
Division of Cardiology, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, MN 55417, USA
Am Heart J 155:1143-9. 2008..gov identifier NCT00211653)... - Preoperative pulmonary function and mortality after cardiac surgeryA Selcuk Adabag
Division of Cardiology, Veterans Affairs Medical Center and University of Minnesota, Minneapolis, MN, USA
Am Heart J 159:691-7. 2010..The aim of the study was to examine the relationship between preoperative pulmonary function and outcomes after cardiac surgery... - The energetic state within hibernating myocardium is normal during dobutamine despite inhibition of ATP-dependent potassium channel opening with glibenclamideEdward O McFalls
Veterans Affairs Medical Center University of Minnesota, Minneapolis, MN, USA
Am J Physiol Heart Circ Physiol 293:H2945-51. 2007.... - Prognostic significance of elevated cardiac troponin I after heart surgeryA Selcuk Adabag
Division of Cardiology, Veterans Affairs Medical Center and the University of Minnesota, Minneapolis, Minnesota 55417, USA
Ann Thorac Surg 83:1744-50. 2007.... - Mitochondrial function: the heart of myocardial preservationEdward O McFalls
Department of Medicine, Veterans Affairs Medicial Center, University of Minnesota, Minneapolis, 55417, USA
J Lab Clin Med 142:141-8. 2003..It will also provide insight into the mechanisms by which mitochondrial signaling in preconditioning can protect the myocyte during subsequent prolonged ischemic periods... - Disparate opinions regarding indications for coronary artery revascularization before elective vascular surgeryGordon L Pierpont
Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
Am J Cardiol 94:1124-8. 2004..Deviations from published guidelines are common, suggesting that current consensus statements need additional data to support their recommendations... - Culprit coronary lesions requiring percutaneous coronary intervention after vascular surgery often arise from in-stent restenosis of bare metal stentsSantiago Garcia
Division of Cardiology, University of Minnesota and Minneapolis VA Medical Center, Minneapolis, MN 55417, USA
Ann Vasc Surg 24:596-601. 2010.... - Coronary artery bypass grafting is superior to percutaneous coronary intervention in prevention of perioperative myocardial infarctions during subsequent vascular surgeryHerbert B Ward
Department of Surgery, VA Medical Center and University of Minnesota, Minneapolis, Minnesota 55417, USA
Ann Thorac Surg 82:795-800; discussion 800-1. 2006..We hypothesized that more complete revascularization would improve outcomes after vascular surgery... - Prophylactic coronary artery revascularization for elective vascular surgery: study design. Veterans Affairs Cooperative Study Group on Coronary Artery Revascularization Prophylaxis for Elective Vascular SurgeryE O McFalls
Veterans Affairs Medical Center, Minneapolis, Minnesota 55417, USA
Control Clin Trials 20:297-308. 1999..The findings should help determine the best strategy for managing patients with coronary artery disease in need of elective vascular surgery... - Perioperative complications after vascular surgery are predicted by the revised cardiac risk index but are not reduced in high-risk subsets with preoperative revascularizationSantiago Garcia
Division of Cardiology, Minneapolis VA Medical Center and the University of Minnesota, Minneapolis, Minn, USA
Circ Cardiovasc Qual Outcomes 2:73-7. 2009..Among patients with documented coronary artery disease who undergo vascular surgery, it is unclear whether preoperative revascularization reduces postoperative cardiac complications in high-risk subsets defined by the RCRI... - Usefulness of revascularization of patients with multivessel coronary artery disease before elective vascular surgery for abdominal aortic and peripheral occlusive diseaseSantiago Garcia
Cardiology Section, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, Minnesota, USA
Am J Cardiol 102:809-13. 2008..6% of patients who underwent coronary angiography before vascular surgery, and this was the only subset of patients showing a benefit with preoperative coronary artery revascularization... - Diagnostic coronary angiography in patients with peripheral arterial disease: a sub-study of the Coronary Artery Revascularization Prophylaxis TrialSantiago Garcia
Minneapolis Veterans Affairs Medical Center and the University of Minnesota, Minneapolis, MN 55417, USA
J Interv Cardiol 21:369-74. 2008..The goal of this sub-study of the Coronary Artery Revascularization Prophylaxis (CARP) trial was to assess the safety of coronary angiography in patients with peripheral vascular disease... - Functional and structural adaptations of coronary microvessels distal to a chronic coronary artery stenosisOana Sorop
Experimental Cardiology, Thoraxcenter, Cardiovascular Research Institute COEUR, Erasmus University Medical Center, Rotterdam, The Netherlands
Circ Res 102:795-803. 2008..These structural and functional alterations may aggravate flow abnormalities distal to a chronic coronary artery stenosis... - Ischemic preconditioning modulates mitochondrial respiration, irrespective of the employed signal transduction pathwayDavid A Liem
Division of Experimental Cardiology, Thoraxcenter, Department of Clinical Genetics, Mitochondrial Research Unit, Cardiovascular Research Institute COEUR, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands
Transl Res 151:17-26. 2008.... - Nephrotoxicity of iodixanol versus iopamidol in patients with chronic kidney disease and diabetes mellitus undergoing coronary angiographic proceduresWarren Laskey
Department of Medicine, University of New Mexico School of Medicine, Albuquerque, 87131, USA
Am Heart J 158:822-828.e3. 2009..The choice of radiographic contrast media for use in patients at increased risk of contrast-induced nephropathy (CIN) is of ongoing interest... - Dose dependent effect of statins on postoperative atrial fibrillation after cardiac surgery among patients treated with beta blockersSalima Mithani
Department of Internal Medicine, Veterans Affairs Medical Center, Veterans Drive, Minneapolis 55417, USA
J Cardiothorac Surg 4:61. 2009..Whether statins prevent AF in patients treated with postoperative beta blockers and whether the statin-effect is dose related are unknown... - Postoperative outcomes for patients undergoing elective revascularization for critical limb ischemia and intermittent claudication: a subanalysis of the Coronary Artery Revascularization Prophylaxis (CARP) trialAmritha Raghunathan
Vascular Surgery Service, San Francisco VA Medical Center and Univ of California at San Francisco, CA 94121, USA
J Vasc Surg 43:1175-82. 2006..Finally, the better-than-predicted outcomes for these patients with advanced systemic atherosclerosis may be due to aggressive medical management with beta-blockers, statins, and acetylsalicylic acid... - Hibernating myocardium: is the program to survive a pathway to failure?Rosemary F Kelly
Circ Res 102:3-5. 2008
Research Grants
- Mitochondrial Protection Within Chronically Ischemic MyocardiumEdward O McFalls; Fiscal Year: 2010..Using this model, we propose that a class of drugs used in diabetic patients that has been associated with heart failure exacerbations, alters the mitochondrial energy production in a similar way. ..