Linda K McEvoy

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Quantitative structural MRI for early detection of Alzheimer's disease
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Expert Rev Neurother 10:1675-88. 2010
  2. pmc Changes in alcohol intake and their relationship with health status over a 24-year follow-up period in community-dwelling older adults
    Linda K McEvoy
    Department of Radiology, University of California at San Diego, San Diego, California 92093, USA
    J Am Geriatr Soc 61:1303-8. 2013
  3. pmc Alzheimer disease: quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairment
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0841, USA
    Radiology 251:195-205. 2009
  4. pmc Mild cognitive impairment: baseline and longitudinal structural MR imaging measures improve predictive prognosis
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Radiology 259:834-43. 2011
  5. pmc Neuroimaging enrichment strategy for secondary prevention trials in Alzheimer disease
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, La Jolla, CA 92093 0841, USA
    Alzheimer Dis Assoc Disord 24:269-77. 2010
  6. pmc Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer disease
    David S Karow
    Department of Radiology, University of California, San Diego, La Jolla, CA 92093, USA
    Radiology 256:932-42. 2010
  7. pmc Brain substrates of learning and retention in mild cognitive impairment diagnosis and progression to Alzheimer's disease
    Yu Ling Chang
    Department of Psychiatry, University of California, San Diego, 8950 Villa La Jolla Drive Suite C101, La Jolla, CA 92037, USA
    Neuropsychologia 48:1237-47. 2010
  8. doi request reprint The Role of Clusterin in Amyloid-β-Associated Neurodegeneration
    Rahul S Desikan
    Department of Radiology, University of California, San Diego, La Jolla
    JAMA Neurol 71:180-7. 2014
  9. pmc Metabolic syndrome and 16-year cognitive decline in community-dwelling older adults
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, La Jolla, CA, USA
    Ann Epidemiol 22:310-7. 2012
  10. pmc Structural MRI biomarkers for preclinical and mild Alzheimer's disease
    Christine Fennema-Notestine
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0841, USA
    Hum Brain Mapp 30:3238-53. 2009

Detail Information

Publications24

  1. pmc Quantitative structural MRI for early detection of Alzheimer's disease
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Expert Rev Neurother 10:1675-88. 2010
    ....
  2. pmc Changes in alcohol intake and their relationship with health status over a 24-year follow-up period in community-dwelling older adults
    Linda K McEvoy
    Department of Radiology, University of California at San Diego, San Diego, California 92093, USA
    J Am Geriatr Soc 61:1303-8. 2013
    ..To determine whether alcohol use changes over time in older adults and whether alcohol intake is associated with common chronic diseases...
  3. pmc Alzheimer disease: quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairment
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0841, USA
    Radiology 251:195-205. 2009
    ....
  4. pmc Mild cognitive impairment: baseline and longitudinal structural MR imaging measures improve predictive prognosis
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Radiology 259:834-43. 2011
    ..To assess whether single-time-point and longitudinal volumetric magnetic resonance (MR) imaging measures provide predictive prognostic information in patients with amnestic mild cognitive impairment (MCI)...
  5. pmc Neuroimaging enrichment strategy for secondary prevention trials in Alzheimer disease
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, La Jolla, CA 92093 0841, USA
    Alzheimer Dis Assoc Disord 24:269-77. 2010
    ..Failure to take into account normal age-related changes risks under-powering trials designed to test disease-modifying properties of potential treatments...
  6. pmc Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer disease
    David S Karow
    Department of Radiology, University of California, San Diego, La Jolla, CA 92093, USA
    Radiology 256:932-42. 2010
    ..To quantify the effect sizes of regional metabolic and morphometric measures in patients with preclinical and mild Alzheimer disease (AD) to aid in the identification of noninvasive biomarkers for the early detection of AD...
  7. pmc Brain substrates of learning and retention in mild cognitive impairment diagnosis and progression to Alzheimer's disease
    Yu Ling Chang
    Department of Psychiatry, University of California, San Diego, 8950 Villa La Jolla Drive Suite C101, La Jolla, CA 92037, USA
    Neuropsychologia 48:1237-47. 2010
    ..Overall, our results highlight the importance of including learning measures in addition to retention measures when making a diagnosis of MCI and for predicting clinical outcome...
  8. doi request reprint The Role of Clusterin in Amyloid-β-Associated Neurodegeneration
    Rahul S Desikan
    Department of Radiology, University of California, San Diego, La Jolla
    JAMA Neurol 71:180-7. 2014
    ..These findings implicate a potentially important role for clusterin in the earliest stages of the Alzheimer disease neurodegenerative process and suggest independent effects of clusterin and p-tau on Aβ-associated volume loss. ..
  9. pmc Metabolic syndrome and 16-year cognitive decline in community-dwelling older adults
    Linda K McEvoy
    Department of Radiology, University of California, San Diego, La Jolla, CA, USA
    Ann Epidemiol 22:310-7. 2012
    ..To determine whether metabolic syndrome is associated with accelerated cognitive decline in community-dwelling older adults...
  10. pmc Structural MRI biomarkers for preclinical and mild Alzheimer's disease
    Christine Fennema-Notestine
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0841, USA
    Hum Brain Mapp 30:3238-53. 2009
    ..These methods will enable a more complete longitudinal characterization and allow us to identify changes that are predictive of conversion to AD...
  11. pmc Higher education is not associated with greater cortical thickness in brain areas related to literacy or intelligence in normal aging or mild cognitive impairment
    Jagan A Pillai
    Department of Neurology, VA San Diego Medical Center, San Diego, CA, USA
    J Clin Exp Neuropsychol 34:925-35. 2012
    ..Connectivity and synaptic efficiency or other lifestyle factors may more directly reflect cognitive reserve...
  12. pmc Relationship between regional atrophy rates and cognitive decline in mild cognitive impairment
    Carrie R McDonald
    Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
    Neurobiol Aging 33:242-53. 2012
    ..MRI measures of regional atrophy can provide valuable information for understanding the neural basis of cognitive impairment in MCI...
  13. pmc Sex differences in the association of Framingham Cardiac Risk Score with cognitive decline in community-dwelling elders without clinical heart disease
    Gail A Laughlin
    Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Psychosom Med 73:683-9. 2011
    ....
  14. pmc Age-related changes in the neurophysiology of language in adults: relationship to regional cortical thinning and white matter microstructure
    Nobuko Kemmotsu
    Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0603, USA
    J Neurosci 32:12204-13. 2012
    ..These neurophysiological changes may reflect an adaptive process that ensues as communication between left perisylvian regions declines...
  15. pmc Amyloid-β--associated clinical decline occurs only in the presence of elevated P-tau
    Rahul S Desikan
    Department of Radiology, University of California San Diego, 8950 Villa La Jolla Dr, Ste C101, La Jolla, CA 92037 0841, USA
    Arch Neurol 69:709-13. 2012
    ..To elucidate the relationship between the 2 hallmark proteins of Alzheimer disease (AD), amyloid-(Aβ) and tau, and clinical decline over time among cognitively normal older individuals...
  16. pmc Cognitive phenotypes, brain morphometry and the detection of cognitive decline in preclinical AD
    Mark W Jacobson
    Veterans Affairs San Diego Healthcare System, San Diego, CA 92151, USA
    Behav Neurol 21:29-37. 2009
    ..We review several approaches to defining cognitive subgroups, and we consider the possibility that cognitive asymmetry might provide one means of identifying both functional and structural changes associated with aging and dementia...
  17. pmc Level of executive function influences verbal memory in amnestic mild cognitive impairment and predicts prefrontal and posterior cingulate thickness
    Yu Ling Chang
    Department of Psychiatry, University of California, San Diego, La Jolla, CA 92037, USA
    Cereb Cortex 20:1305-13. 2010
    ..Overall, these results demonstrate the importance of evaluating executive function in individuals with MCI to predict involvement of brain areas beyond the mesial temporal lobe...
  18. pmc Enrichment and stratification for predementia Alzheimer disease clinical trials
    Dominic Holland
    Department of Neurosciences, University of California San Diego, La Jolla, California, USA
    PLoS ONE 7:e47739. 2012
    ..Longer natural history studies are needed to inform design of trials aimed at the presymptomatic stage...
  19. doi request reprint CETP polymorphisms associate with brain structure, atrophy rate, and Alzheimer's disease risk in an APOE-dependent manner
    Elizabeth A Murphy
    Department of Neurosciences, University of California, San Diego, CA, USA
    Brain Imaging Behav 6:16-26. 2012
    ..These results suggest CETP may contribute to the genetic variability of brain structure and dementia susceptibility in an APOE-dependent manner...
  20. pmc Structural neuroimaging in the detection and prognosis of pre-clinical and early AD
    Christine Fennema-Notestine
    Deptartment of Psychiatry, University of California San Diego, San Diego, CA, USA
    Behav Neurol 21:3-12. 2009
    ....
  21. pmc Heart fatty acid binding protein and Aβ-associated Alzheimer's neurodegeneration
    Rahul S Desikan
    Department of Radiology, University of California, San Diego, 8950 Villa La Jolla Drive, Suite C101, La Jolla, CA 92037 0841, USA
    Mol Neurodegener 8:39. 2013
    ..Epidemiological and molecular findings suggest a relationship between Alzheimer's disease (AD) and dyslipidemia, although the nature of this association is not well understood...
  22. pmc Unbiased comparison of sample size estimates from longitudinal structural measures in ADNI
    Dominic Holland
    Department of Neurosciences, University of California, San Diego, La Jolla, California 92037, USA
    Hum Brain Mapp 33:2586-602. 2012
    ..Of all the measures publicly available in ADNI, thinning of the entorhinal cortex quantified with the Quarc methodology provides the most powerful change biomarker...
  23. pmc White matter tracts associated with set-shifting in healthy aging
    Michele E Perry
    Department of Cognitive Science, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
    Neuropsychologia 47:2835-42. 2009
    ..Automated tractography methods can enhance our understanding of the fiber systems involved in performance of specific cognitive tasks and of the functional consequences of age-related changes in those systems...
  24. pmc Intracranial EEG reveals a time- and frequency-specific role for the right inferior frontal gyrus and primary motor cortex in stopping initiated responses
    Nicole Swann
    University of California, San Diego, La Jolla, CA 92093 0662, USA
    J Neurosci 29:12675-85. 2009
    ..Together with other findings, the results suggest that behavioral stopping is implemented via synchronized activity in the beta frequency band in a right IFG/basal ganglia network, with downstream effects on M1...