Linda K McEvoy
Affiliation: University of California
- Quantitative structural MRI for early detection of Alzheimer's diseaseLinda K McEvoy
Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
Expert Rev Neurother 10:1675-88. 2010....
- Hypertension-related alterations in white matter microstructure detectable in middle ageLinda K McEvoy
From the Departments of Radiology L K M, C F N, D J H, A M D, Psychiatry C F N, L T E, C E F, M S P, W S K, and Neurosciences A M D, University of California, San Diego Mental Illness Research, Education, and Clinical Center L T E and Center of Excellence for Stress and Mental Health W S K, VA San Diego Healthcare System Department of Psychiatry and Brain Sciences, Boston University, Boston, MA M J L and Imaging Genetics Center, Institute for Neuroimaging and Informatics, University of Southern California, Los Angeles D A R
Hypertension 66:317-23. 2015..Although longitudinal studies are needed to confirm these findings, the results suggest that prevention-rather than management-of hypertension may be vital to preserving brain health in aging. ..
- Changes in alcohol intake and their relationship with health status over a 24-year follow-up period in community-dwelling older adultsLinda K McEvoy
Department of Radiology, University of California at San Diego, San Diego, California 92093, USA
J Am Geriatr Soc 61:1303-8. 2013..To determine whether alcohol use changes over time in older adults and whether alcohol intake is associated with common chronic diseases...
- Alzheimer disease: quantitative structural neuroimaging for detection and prediction of clinical and structural changes in mild cognitive impairmentLinda K McEvoy
Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0841, USA
Radiology 251:195-205. 2009....
- Mild cognitive impairment: baseline and longitudinal structural MR imaging measures improve predictive prognosisLinda K McEvoy
Department of Radiology, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
Radiology 259:834-43. 2011..To assess whether single-time-point and longitudinal volumetric magnetic resonance (MR) imaging measures provide predictive prognostic information in patients with amnestic mild cognitive impairment (MCI)...
- Neuroimaging enrichment strategy for secondary prevention trials in Alzheimer diseaseLinda K McEvoy
Department of Radiology, University of California, San Diego, La Jolla, CA 92093 0841, USA
Alzheimer Dis Assoc Disord 24:269-77. 2010..Failure to take into account normal age-related changes risks under-powering trials designed to test disease-modifying properties of potential treatments...
- The role of clusterin in amyloid-β-associated neurodegenerationRahul S Desikan
Department of Radiology, University of California, San Diego, La Jolla
JAMA Neurol 71:180-7. 2014..Converging evidence indicates that clusterin, a chaperone glycoprotein, influences Alzheimer disease neurodegeneration. However, the precise role of clusterin in Alzheimer disease pathogenesis is still not well understood...
- Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer diseaseDavid S Karow
Department of Radiology, University of California, San Diego, La Jolla, CA 92093, USA
Radiology 256:932-42. 2010..To quantify the effect sizes of regional metabolic and morphometric measures in patients with preclinical and mild Alzheimer disease (AD) to aid in the identification of noninvasive biomarkers for the early detection of AD...
- Brain substrates of learning and retention in mild cognitive impairment diagnosis and progression to Alzheimer's diseaseYu Ling Chang
Department of Psychiatry, University of California, San Diego, 8950 Villa La Jolla Drive Suite C101, La Jolla, CA 92037, USA
Neuropsychologia 48:1237-47. 2010..Overall, our results highlight the importance of including learning measures in addition to retention measures when making a diagnosis of MCI and for predicting clinical outcome...
- Metabolic syndrome and 16-year cognitive decline in community-dwelling older adultsLinda K McEvoy
Department of Radiology, University of California, San Diego, La Jolla, CA, USA
Ann Epidemiol 22:310-7. 2012..To determine whether metabolic syndrome is associated with accelerated cognitive decline in community-dwelling older adults...
- Structural MRI biomarkers for preclinical and mild Alzheimer's diseaseChristine Fennema-Notestine
Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0841, USA
Hum Brain Mapp 30:3238-53. 2009..These methods will enable a more complete longitudinal characterization and allow us to identify changes that are predictive of conversion to AD...
- Higher education is not associated with greater cortical thickness in brain areas related to literacy or intelligence in normal aging or mild cognitive impairmentJagan A Pillai
Department of Neurology, VA San Diego Medical Center, San Diego, CA, USA
J Clin Exp Neuropsychol 34:925-35. 2012..Connectivity and synaptic efficiency or other lifestyle factors may more directly reflect cognitive reserve...
- Relationship between regional atrophy rates and cognitive decline in mild cognitive impairmentCarrie R McDonald
Department of Psychiatry, University of California, San Diego, La Jolla, CA, USA
Neurobiol Aging 33:242-53. 2012..MRI measures of regional atrophy can provide valuable information for understanding the neural basis of cognitive impairment in MCI...
- Heart fatty acid binding protein and Aβ-associated Alzheimer's neurodegenerationRahul S Desikan
Department of Radiology, University of California, San Diego, 8950 Villa La Jolla Drive, Suite C101, La Jolla, CA 92037 0841, USA
Mol Neurodegener 8:39. 2013..Epidemiological and molecular findings suggest a relationship between Alzheimer's disease (AD) and dyslipidemia, although the nature of this association is not well understood...
- Sex differences in the association of Framingham Cardiac Risk Score with cognitive decline in community-dwelling elders without clinical heart diseaseGail A Laughlin
Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
Psychosom Med 73:683-9. 2011....
- Age-related changes in the neurophysiology of language in adults: relationship to regional cortical thinning and white matter microstructureNobuko Kemmotsu
Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0603, USA
J Neurosci 32:12204-13. 2012..These neurophysiological changes may reflect an adaptive process that ensues as communication between left perisylvian regions declines...
- Amyloid-β--associated clinical decline occurs only in the presence of elevated P-tauRahul S Desikan
Department of Radiology, University of California San Diego, 8950 Villa La Jolla Dr, Ste C101, La Jolla, CA 92037 0841, USA
Arch Neurol 69:709-13. 2012..To elucidate the relationship between the 2 hallmark proteins of Alzheimer disease (AD), amyloid-(Aβ) and tau, and clinical decline over time among cognitively normal older individuals...
- Cognitive phenotypes, brain morphometry and the detection of cognitive decline in preclinical ADMark W Jacobson
Veterans Affairs San Diego Healthcare System, San Diego, CA 92151, USA
Behav Neurol 21:29-37. 2009..We review several approaches to defining cognitive subgroups, and we consider the possibility that cognitive asymmetry might provide one means of identifying both functional and structural changes associated with aging and dementia...
- Level of executive function influences verbal memory in amnestic mild cognitive impairment and predicts prefrontal and posterior cingulate thicknessYu Ling Chang
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92037, USA
Cereb Cortex 20:1305-13. 2010..Overall, these results demonstrate the importance of evaluating executive function in individuals with MCI to predict involvement of brain areas beyond the mesial temporal lobe...
- Enrichment and stratification for predementia Alzheimer disease clinical trialsDominic Holland
Department of Neurosciences, University of California San Diego, La Jolla, California, USA
PLoS ONE 7:e47739. 2012..Longer natural history studies are needed to inform design of trials aimed at the presymptomatic stage...
- Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer DiseaseRahul S Desikan
From Departments of Radiology R S D, L K M, C H C, D S K, J B B, A M D, Cognitive Science A J S, A M D, Neurosciences Y W, D H, J B B, A M D, and Psychiatry W K T, O A A, University of California, San Diego, La Jolla NORMENT, Institute of Clinical Medicine, University of Oslo, Norway Y W, C H C, A W, O A A, A M D, T F Division of Mental Health and Addiction Y W, C H C, A W, O A A, A M D, Norwegian Centre for Dementia Research, Department of Old Age Psychiatry I D U, andDepartment of Medical Genetics, S D, WA 98104
Circulation 131:2061-9. 2015..We investigated whether this phenotypic association arises from a shared genetic basis...
- Abundant Genetic Overlap between Blood Lipids and Immune-Mediated Diseases Indicates Shared Molecular Genetic MechanismsOle A Andreassen
NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, 0407 Oslo, Norway Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, United States of America
PLoS ONE 10:e0123057. 2015..Our findings provide novel mechanistic insights into dyslipidemia and immune-mediated diseases and may have implications for therapeutic trials involving lipid-lowering and anti-inflammatory agents. ..
- CETP polymorphisms associate with brain structure, atrophy rate, and Alzheimer's disease risk in an APOE-dependent mannerElizabeth A Murphy
Department of Neurosciences, University of California, San Diego, CA, USA
Brain Imaging Behav 6:16-26. 2012..These results suggest CETP may contribute to the genetic variability of brain structure and dementia susceptibility in an APOE-dependent manner...
- Structural neuroimaging in the detection and prognosis of pre-clinical and early ADChristine Fennema-Notestine
Deptartment of Psychiatry, University of California San Diego, San Diego, CA, USA
Behav Neurol 21:3-12. 2009....
- Identifying common genetic variants in blood pressure due to polygenic pleiotropy with associated phenotypesOle A Andreassen
Department of Radiology, University of California, San Diego, 8950 Villa La Jolla Dr, Suite C101, La Jolla, CA 92037 0841 and Ole A Andreassen, NORMENT, KG Jebsen Centre for Psychosis Research, Oslo University Hospital, Ulleval, PO Box 4956 Nydalen, 0424 Oslo, Norway Email
Hypertension 63:819-26. 2014..The new gene loci identified implicate novel genetic mechanisms related to lipid biology and the immune system in SBP. ..
- Unbiased comparison of sample size estimates from longitudinal structural measures in ADNIDominic Holland
Department of Neurosciences, University of California, San Diego, La Jolla, California 92037, USA
Hum Brain Mapp 33:2586-602. 2012..Of all the measures publicly available in ADNI, thinning of the entorhinal cortex quantified with the Quarc methodology provides the most powerful change biomarker...
- Fetuin-A, a new vascular biomarker of cognitive decline in older adultsGail A Laughlin
Division of Epidemiology, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA, USA
Clin Endocrinol (Oxf) 81:134-40. 2014..We evaluated the association of serum fetuin-A levels with cognitive function in community-dwelling older adults...
- White matter tracts associated with set-shifting in healthy agingMichele E Perry
Department of Cognitive Science, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA
Neuropsychologia 47:2835-42. 2009..Automated tractography methods can enhance our understanding of the fiber systems involved in performance of specific cognitive tasks and of the functional consequences of age-related changes in those systems...
- Intracranial EEG reveals a time- and frequency-specific role for the right inferior frontal gyrus and primary motor cortex in stopping initiated responsesNicole Swann
University of California, San Diego, La Jolla, CA 92093 0662, USA
J Neurosci 29:12675-85. 2009..Together with other findings, the results suggest that behavioral stopping is implemented via synchronized activity in the beta frequency band in a right IFG/basal ganglia network, with downstream effects on M1...