Michael F McEntee

Summary

Affiliation: University of Tennessee
Country: USA

Publications

  1. ncbi Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice
    M F McEntee
    Department of Pathology and Nutrition, University of Tennessee, Knoxville 37901, USA
    Carcinogenesis 20:635-40. 1999
  2. ncbi Cyclooxygenase-2 expression in spontaneous intestinal neoplasia of domestic dogs
    M F McEntee
    Department of Pathology, University of Tennessee, Knoxville, USA
    Vet Pathol 39:428-36. 2002
  3. ncbi Dietary polyunsaturated fatty acids and colorectal neoplasia
    M F McEntee
    Department of Pathology, College of Veterinary Medicine, Institute of Agriculture, University of Tennessee, Knoxville 37996 4542, USA
    Biomed Pharmacother 56:380-7. 2002
  4. ncbi Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer
    Michael F McEntee
    Department of Pathobiology, University of Tennessee, 2407 River Dr, Rm A201, Knoxville, TN 37996 4542, USA
    Am J Pathol 173:229-41. 2008
  5. ncbi MCC-555-induced NAG-1 expression is mediated in part by KLF4
    Maria Cekanova
    Department of Pathobiology, College of Veterinary Medicine, The University of Tennessee, Knoxville, Tennessee 37996, USA
    Eur J Pharmacol 637:30-7. 2010
  6. ncbi A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer
    Mugdha Sukhthankar
    Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA
    Gastroenterology 134:1972-80. 2008
  7. ncbi Dietary EPA reduces tumor load in ApcMin/+ mice by altering arachidonic acid metabolism, but conjugated linoleic acid, gamma--and alpha-linolenic acids have no effect
    Jay Whelan
    Department of Nutrition, 229 Jessie Harris Building, University of Tennessee, Knoxville, TN 37996-1900, USA
    Adv Exp Med Biol 507:579-84. 2002
  8. ncbi Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia
    Seung Joon Baek
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA
    Gastroenterology 131:1553-60. 2006
  9. ncbi Dietary resveratrol does not affect intestinal tumorigenesis in Apc(Min/+) mice
    Carol C Ziegler
    Department of Nutrition, University of Tennessee, Knoxville, TN, USA
    J Nutr 134:5-10. 2004
  10. ncbi Dietary (n-6) PUFA and intestinal tumorigenesis
    Jay Whelan
    Department of Nutrition and the Tennessee Agricultural Experiment Station, University of Tennessee, Knoxville, USA
    J Nutr 134:3421S-3426S. 2004

Collaborators

Detail Information

Publications20

  1. ncbi Relationship of beta-catenin and Bcl-2 expression to sulindac-induced regression of intestinal tumors in Min mice
    M F McEntee
    Department of Pathology and Nutrition, University of Tennessee, Knoxville 37901, USA
    Carcinogenesis 20:635-40. 1999
    ..Results suggest that modulation of aberrant beta-catenin expression occurs during NSAID-induced regression of intestinal adenomas and that Bcl-2 may confer resistance to these effects...
  2. ncbi Cyclooxygenase-2 expression in spontaneous intestinal neoplasia of domestic dogs
    M F McEntee
    Department of Pathology, University of Tennessee, Knoxville, USA
    Vet Pathol 39:428-36. 2002
    ..These changes duplicate molecular changes in human intestinal tumorigenesis and substantiate a fundamental role for both beta-catenin and Cox-2 in intestinal neoplasia...
  3. ncbi Dietary polyunsaturated fatty acids and colorectal neoplasia
    M F McEntee
    Department of Pathology, College of Veterinary Medicine, Institute of Agriculture, University of Tennessee, Knoxville 37996 4542, USA
    Biomed Pharmacother 56:380-7. 2002
    ..We will review some of these data and provide a summary of our own work showing that conversion of arachidonate to prostaglandin E2 contributes significantly to tumor growth through the modulation of apoptosis and cellular proliferation...
  4. ncbi Dietary n-3 polyunsaturated fatty acids enhance hormone ablation therapy in androgen-dependent prostate cancer
    Michael F McEntee
    Department of Pathobiology, University of Tennessee, 2407 River Dr, Rm A201, Knoxville, TN 37996 4542, USA
    Am J Pathol 173:229-41. 2008
    ..In conclusion, dietary n-3 PUFA may enhance the response of prostate cancer to ablation therapy and retard progression to androgen-independent growth by altering tumor PUFA content...
  5. ncbi MCC-555-induced NAG-1 expression is mediated in part by KLF4
    Maria Cekanova
    Department of Pathobiology, College of Veterinary Medicine, The University of Tennessee, Knoxville, Tennessee 37996, USA
    Eur J Pharmacol 637:30-7. 2010
    ..This study shows that PPARgamma agonists up-regulate KLF4 expression in receptor-dependent manner, and KLF4 was identified as a novel transcription factor that controls NAG-1 promoter activity in human and mouse colorectal cancers...
  6. ncbi A green tea component suppresses posttranslational expression of basic fibroblast growth factor in colorectal cancer
    Mugdha Sukhthankar
    Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee 37996, USA
    Gastroenterology 134:1972-80. 2008
    ..However, the exact molecular mechanism by which EGCG suppresses bFGF expression is not known. Our objective was to elucidate the molecular mechanisms by which EGCG inhibits bFGF expression in colorectal cancer...
  7. ncbi Dietary EPA reduces tumor load in ApcMin/+ mice by altering arachidonic acid metabolism, but conjugated linoleic acid, gamma--and alpha-linolenic acids have no effect
    Jay Whelan
    Department of Nutrition, 229 Jessie Harris Building, University of Tennessee, Knoxville, TN 37996-1900, USA
    Adv Exp Med Biol 507:579-84. 2002
  8. ncbi Nonsteroidal anti-inflammatory drug-activated gene-1 over expression in transgenic mice suppresses intestinal neoplasia
    Seung Joon Baek
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, Tennessee, USA
    Gastroenterology 131:1553-60. 2006
    ..However, its antitumorigenic activity has not been elucidated in vivo...
  9. ncbi Dietary resveratrol does not affect intestinal tumorigenesis in Apc(Min/+) mice
    Carol C Ziegler
    Department of Nutrition, University of Tennessee, Knoxville, TN, USA
    J Nutr 134:5-10. 2004
    ..However, immunohistochemical staining of intestinal tumors revealed no changes in COX-2 expression. This study demonstrates that resveratrol consumed ad libitum in the diet, does not modify tumorigenesis in Apc(Min/+) mice...
  10. ncbi Dietary (n-6) PUFA and intestinal tumorigenesis
    Jay Whelan
    Department of Nutrition and the Tennessee Agricultural Experiment Station, University of Tennessee, Knoxville, USA
    J Nutr 134:3421S-3426S. 2004
    ..It is the relative contributions of the different dietary PUFA that may determine overall risk for and progression of the disease...
  11. ncbi Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways
    Kiyoshi Yamaguchi
    Department of Pathobiology, College of Veterinary Medicine, The University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Mol Cancer Ther 7:2779-87. 2008
    ..Overall, these results indicate that MCC-555 has a potent tumor suppressor activity in intestinal tumorigenesis, likely involving MUC2 up-regulation by ERK and PPARgamma pathways...
  12. ncbi Zyflamend, a combination of herbal extracts, attenuates tumor growth in murine xenograft models of prostate cancer
    E Chu Huang
    Department of Nutrition, University of Tennessee, Knoxville, Tennessee 37996 192, USA
    Nutr Cancer 64:749-60. 2012
    ....
  13. ncbi Ocular lesions in canine mucopolysaccharidosis I and response to enzyme replacement therapy
    Kim M Newkirk
    Department of Pathobiology, University of Tennessee, College of Veterinary Medicine, Knoxville, Tennessee 37996, USA
    Invest Ophthalmol Vis Sci 52:5130-5. 2011
    ..The purpose of this study was to determine the extent of ocular GAG accumulation and investigate the effectiveness of intravenous enzyme replacement therapy (ERT) on corneal GAG accumulation in dogs...
  14. ncbi Zyflamend reduces the expression of androgen receptor in a model of castrate-resistant prostate cancer
    E Chu Huang
    Department of Nutrition, University of Tennessee, Knoxville, Tennessee 37996 1920, USA
    Nutr Cancer 63:1287-96. 2011
    ..In conclusion, Zyflamend decreased cell proliferation and inhibited IGF-1R and androgen receptor expression in a phosphatidylinositol 3-kinase/pAKT independent manner...
  15. ncbi Prostaglandin E(2) protects intestinal tumors from nonsteroidal anti-inflammatory drug-induced regression in Apc(Min/+) mice
    Melissa B Hansen-Petrik
    Department of Nutrition, University of Tennessee, Knoxville, Tennessee 37996, USA
    Cancer Res 62:403-8. 2002
    ..Overall, our results suggest that NSAIDs exert their antitumorigenic effects, in part, via interference with PGE(2) biosynthesis, and these effects may be mediated through changes in intracellular calcium levels...
  16. ncbi Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells
    Seung Joon Baek
    Laboratory of Environmental Carcinogenesis, Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, 2407 River Drive, Knoxville, TN 37996, USA
    Carcinogenesis 25:2425-32. 2004
    ..The data generated by this study will help elucidate mechanisms of action for components in green tea and this information may lead to the design of more effective anticancer agents and informed clinical trials...
  17. ncbi Arterial pathology in canine mucopolysaccharidosis-I and response to therapy
    Jeremiah A Lyons
    Department of Pathobiology, University of Tennessee, Knoxville, TN, USA
    Lab Invest 91:665-74. 2011
    ....
  18. ncbi Phenotypic characterization of polygenic type 2 diabetes in TALLYHO/JngJ mice
    Jung Han Kim
    Department of Nutrition, The University of Tennesse, Knoxville, Tennesse 37996 1920, USA
    J Endocrinol 191:437-46. 2006
    ..These findings suggest that obesity and insulin resistance are an inherent part of the TH phenotype and glucose intolerance is evident preceding progression to overt diabetes in male TH mice...
  19. ncbi Selective inhibition of Delta-6 desaturase impedes intestinal tumorigenesis
    Melissa B Hansen-Petrik
    Department of Nutrition, University of Tennessee, 229 Jessie Harris Building, 1215 West Cumberland Avenue, Knoxville, TN 37996-1900, USA
    Cancer Lett 175:157-63. 2002
    ....
  20. ncbi Suppression of tumor cell invasion by cyclooxygenase inhibitors is mediated by thrombospondin-1 via the early growth response gene Egr-1
    Yuseok Moon
    Eicosanoid Biochemistry Section, Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Sciences, 111 T.W. Alexander Drive, Research Triangle Park, NC 27709, USA
    Mol Cancer Ther 4:1551-8. 2005
    ..This is the first report suggesting that COX inhibitors suppress tumor cell invasion via TSP-1, which occurs downstream of Egr-1...