Susan McElroy

Summary

Affiliation: University of Cincinnati
Country: USA

Publications

  1. ncbi request reprint Comorbidity of bipolar and eating disorders: distinct or related disorders with shared dysregulations?
    Susan L McElroy
    Psychopharmacology Research Program, University of Cincinnati College of Medicine, P O Box 670559, 231 Bethesda Avenue, Cincinnati, OH 45267 0559, USA
    J Affect Disord 86:107-27. 2005
  2. ncbi request reprint Atomoxetine in the treatment of binge-eating disorder: a randomized placebo-controlled trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    J Clin Psychiatry 68:390-8. 2007
  3. ncbi request reprint Topiramate for the treatment of binge eating disorder associated with obesity: a placebo-controlled study
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 61:1039-48. 2007
  4. ncbi request reprint Open-label aripiprazole in the treatment of acute bipolar depression: a prospective pilot trial
    Susan L McElroy
    Psychopharmacology Research Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
    J Affect Disord 101:275-81. 2007
  5. ncbi request reprint Zonisamide in the treatment of binge eating disorder with obesity: a randomized controlled trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    J Clin Psychiatry 67:1897-906. 2006
  6. ncbi request reprint Citalopram in the treatment of binge-eating disorder: a placebo-controlled trial
    Susan L McElroy
    Division of Psychopharmacology Research and Eating Disorders, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 64:807-13. 2003
  7. ncbi request reprint Comorbidity of eating disorders with bipolar disorder and treatment implications
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Bipolar Disord 8:686-95. 2006
  8. ncbi request reprint Zonisamide in the treatment of binge-eating disorder: an open-label, prospective trial
    Susan L McElroy
    Division of Clinical Neuroscience, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Clin Psychiatry 65:50-6. 2004
  9. ncbi request reprint A 52-week, open-label continuation study of lamotrigine in the treatment of bipolar depression
    Susan L McElroy
    Psychopharmacology Research Program, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45267 0559, USA
    J Clin Psychiatry 65:204-10. 2004
  10. ncbi request reprint Antidepressants and suicidal behavior in bipolar disorder
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 8:596-617. 2006

Research Grants

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Comorbidity of bipolar and eating disorders: distinct or related disorders with shared dysregulations?
    Susan L McElroy
    Psychopharmacology Research Program, University of Cincinnati College of Medicine, P O Box 670559, 231 Bethesda Avenue, Cincinnati, OH 45267 0559, USA
    J Affect Disord 86:107-27. 2005
    ..The co-occurrence of bipolar and eating disorders, though of major clinical and public health importance, remains relatively unexamined...
  2. ncbi request reprint Atomoxetine in the treatment of binge-eating disorder: a randomized placebo-controlled trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    J Clin Psychiatry 68:390-8. 2007
    ..Binge-eating disorder (BED) is associated with obesity. Atomoxetine is a highly selective norepinephrine reuptake inhibitor associated with weight loss. The purpose of this study was to evaluate atomoxetine in the treatment of BED...
  3. ncbi request reprint Topiramate for the treatment of binge eating disorder associated with obesity: a placebo-controlled study
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 61:1039-48. 2007
    ..The current investigation evaluated the safety and efficacy of topiramate in a multicenter, placebo-controlled trial...
  4. ncbi request reprint Open-label aripiprazole in the treatment of acute bipolar depression: a prospective pilot trial
    Susan L McElroy
    Psychopharmacology Research Program, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
    J Affect Disord 101:275-81. 2007
    ..Increasing evidence indicates that some second-generation antipsychotics are efficacious in bipolar depression, but there are few data on this illness for the novel agent aripiprazole...
  5. ncbi request reprint Zonisamide in the treatment of binge eating disorder with obesity: a randomized controlled trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    J Clin Psychiatry 67:1897-906. 2006
    ..Binge eating disorder (BED) is associated with obesity. Zonisamide is a novel antiepileptic drug associated with weight loss. The purpose of this study was to evaluate zonisa-mide in the treatment of BED associated with obesity...
  6. ncbi request reprint Citalopram in the treatment of binge-eating disorder: a placebo-controlled trial
    Susan L McElroy
    Division of Psychopharmacology Research and Eating Disorders, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 64:807-13. 2003
    ..Citalopram is a highly selective serotonin reuptake inhibitor antidepressant. The purpose of this study was to assess the efficacy and safety of citalopram in the treatment of binge-eating disorder...
  7. ncbi request reprint Comorbidity of eating disorders with bipolar disorder and treatment implications
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    Bipolar Disord 8:686-95. 2006
    ..To review the scientific evidence examining the comorbidity among eating disorders and bipolar disorder (BD)...
  8. ncbi request reprint Zonisamide in the treatment of binge-eating disorder: an open-label, prospective trial
    Susan L McElroy
    Division of Clinical Neuroscience, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Clin Psychiatry 65:50-6. 2004
    ..It commonly co-occurs with obesity. Zonisamide is a novel antiepileptic drug associated with weight loss. The purpose of this study was to preliminarily assess zonisamide in the treatment of binge-eating disorder...
  9. ncbi request reprint A 52-week, open-label continuation study of lamotrigine in the treatment of bipolar depression
    Susan L McElroy
    Psychopharmacology Research Program, University of Cincinnati College of Medicine, 231 Bethesda Avenue, Cincinnati, OH 45267 0559, USA
    J Clin Psychiatry 65:204-10. 2004
    ..Lamotrigine has demonstrated efficacy for the acute treatment of depression in bipolar I patients in a placebo-controlled, monotherapy study. We describe the results of a 52-week, open-label continuation of that trial...
  10. ncbi request reprint Antidepressants and suicidal behavior in bipolar disorder
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 8:596-617. 2006
    ....
  11. ncbi request reprint Open-label adjunctive zonisamide in the treatment of bipolar disorders: a prospective trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, PO Box 670559, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267, USA
    J Clin Psychiatry 66:617-24. 2005
    ..The response of 62 outpatients with DSM-IV bipolar disorders to open-label adjunctive zonisamide was evaluated in a prospective 8-week acute trial, followed by a 48-week continuation trial, conducted from June 2001 through May 2002...
  12. ncbi request reprint Are mood disorders and obesity related? A review for the mental health professional
    Susan L McElroy
    Psychopharmacology Research and Eating Disorders and Obesity Research and Treatment Programs, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 65:634-51, quiz 730. 2004
    ..We reviewed evidence regarding a possible relationship between mood disorders and obesity to better inform mental health professionals about their overlap...
  13. ncbi request reprint Topiramate in the long-term treatment of binge-eating disorder associated with obesity
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 65:1463-9. 2004
    ..This study assessed the long-term effectiveness and tolerability of topiramate in binge-eating disorder (BED) with obesity...
  14. ncbi request reprint A 24-week, randomized, controlled trial of adjunctive sibutramine versus topiramate in the treatment of weight gain in overweight or obese patients with bipolar disorders
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Bipolar Disord 9:426-34. 2007
    ..The objective of this study was to compare sibutramine and topiramate as adjunctive treatments for psychotropic-associated weight gain in overweight or obese outpatients with BD...
  15. ncbi request reprint Diagnosing and treating comorbid (complicated) bipolar disorder
    Susan L McElroy
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267, USA
    J Clin Psychiatry 65:35-44. 2004
    ....
  16. ncbi request reprint Olanzapine in the treatment of pathological gambling: a negative randomized placebo-controlled trial
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 69:433-40. 2008
    ..Olanzapine is a second-generation antipsychotic with mood-stabilizing properties and antagonistic activity at several dopamine receptors. The purpose of this study was to evaluate olanzapine in the treatment of pathological gambling...
  17. ncbi request reprint Relationship of open acute mania treatment to blinded maintenance outcome in bipolar I disorder
    Susan L McElroy
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    J Affect Disord 107:127-33. 2008
    ..No published studies have statistically evaluated the relationship between the outcomes in maintenance treatment and the principal acute agent...
  18. ncbi request reprint Topiramate in the treatment of binge eating disorder associated with obesity: a randomized, placebo-controlled trial
    Susan L McElroy
    Division of Psychopharmacology Research, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Am J Psychiatry 160:255-61. 2003
    ..Binge eating disorder is associated with obesity. Topiramate is an antiepileptic agent associated with weight loss. The objective of this study was to evaluate topiramate in the treatment of binge eating disorder associated with obesity...
  19. ncbi request reprint Quetiapine for the continuation treatment of bipolar depression: naturalistic prospective case series from the Stanley Bipolar Treatment Network
    Trisha Suppes
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
    Int Clin Psychopharmacol 22:376-81. 2007
    ..No between-group differences in improvement were found. Adjunctive quetiapine may be useful as continuation treatment in bipolar populations with both pure depressive and cycling symptoms. Further controlled studies are warranted...
  20. ncbi request reprint Mixed hypomania in 908 patients with bipolar disorder evaluated prospectively in the Stanley Foundation Bipolar Treatment Network: a sex-specific phenomenon
    Trisha Suppes
    Bipolar Disorder Research Program, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390 9121, USA
    Arch Gen Psychiatry 62:1089-96. 2005
    ..The prevalence of depressive symptoms co-occurring with hypomanic symptoms has not been quantified. Whether there is a greater likelihood for women to experience mixed symptoms has not been resolved...
  21. ncbi request reprint Analyses of treatment-emergent mania with olanzapine/fluoxetine combination in the treatment of bipolar depression
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    J Clin Psychiatry 66:611-6. 2005
    ..These subanalyses compare treatment-emergent mania rates in bipolar I depressed patients treated with olanzapine, placebo, or olanzapine/fluoxetine combination...
  22. ncbi request reprint Maintenance efficacy of divalproex in the prevention of bipolar depression
    Laszlo Gyulai
    Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropsychopharmacology 28:1374-82. 2003
    ....
  23. doi request reprint Lamotrigine in the treatment of binge-eating disorder with obesity: a randomized, placebo-controlled monotherapy trial
    Anna I Guerdjikova
    Department of Psychiatry, University of Cincinnati College of Medicine, Lindner Center of HOPE, Mason, Ohio 45040, USA
    Int Clin Psychopharmacol 24:150-8. 2009
    ..As a result of an exceptionally high placebo response, it is likely that for efficacy measures except for body weight and metabolic indices, the study was incapable of detecting potentially clinically important drug-placebo difference...
  24. ncbi request reprint Venlafaxine treatment of binge-eating disorder associated with obesity: a series of 35 patients
    Shishuka Malhotra
    Department of Psychiatry, University of Cincinnati Medical Center, Ohio 45267 0559, USA
    J Clin Psychiatry 63:802-6. 2002
    ....
  25. ncbi request reprint Subsyndromal depressive symptoms are associated with functional impairment in patients with bipolar disorder: results of a large, multisite study
    Lori L Altshuler
    Department of Psychiatry, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, CA, USA
    J Clin Psychiatry 67:1551-60. 2006
    ..Research examining this relationship in persons with bipolar disorder is rare. This study sought to evaluate the association between subsyndromal depressive symptoms and role functioning in subjects with bipolar disorder...
  26. ncbi request reprint The comorbidity of bipolar and anxiety disorders: prevalence, psychobiology, and treatment issues
    Marlene P Freeman
    University of Cincinnati College of Medicine, Biological Psychiatry Program, Department of Psychiatry, P O Box 670559, 231 Bethesda Avenue, Cincinnati, OH 45267 0559, USA
    J Affect Disord 68:1-23. 2002
    ..Although symptoms of anxiety as well as anxiety disorders commonly occur in patients with bipolar disorder, the pathophysiologic, theoretical, and clinical significance of their co-occurrence has not been well studied...
  27. ncbi request reprint Advances in the pharmacologic treatment of bipolar depression
    Paul E Keck
    Division of Psychopharmacology Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 53:671-9. 2003
    ....
  28. ncbi request reprint Binge eating disorder: a stable syndrome
    Harrison G Pope
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, MA 02478, USA
    Am J Psychiatry 163:2181-3. 2006
    ..This study assessed the stability of binge eating disorder in a community sample...
  29. ncbi request reprint Divalproex in the treatment of impulsive aggression: efficacy in cluster B personality disorders
    Eric Hollander
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Neuropsychopharmacology 28:1186-97. 2003
    ....
  30. doi request reprint Correlates of treatment-emergent mania associated with antidepressant treatment in bipolar depression
    Mark A Frye
    Department of Psychiatry, Mayo Mood Clinic and Research Program, Mayo Clinic, 200 First St, S W, Rochester, MN 55901, USA
    Am J Psychiatry 166:164-72. 2009
    ..This study examined the correlates associated with treatment-emergent mania in patients receiving adjunctive antidepressant treatment for bipolar depression...
  31. ncbi request reprint Correlates of overweight and obesity in 644 patients with bipolar disorder
    Susan L McElroy
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    J Clin Psychiatry 63:207-13. 2002
    ..Overweight and obesity are common clinical problems encountered in the treatment of bipolar disorder. We therefore assessed the prevalence and clinical correlates of overweight, obesity, and extreme obesity in 644 bipolar patients...
  32. ncbi request reprint Relationship of mania symptomatology to maintenance treatment response with divalproex, lithium, or placebo
    Charles L Bowden
    Department of Psychiatry, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Neuropsychopharmacology 30:1932-9. 2005
    ..Dysphoric mania appeared to predispose patients to more side effects when treated with either divalproex or lithium during maintenance therapy...
  33. ncbi request reprint Impact of antidepressant continuation after acute positive or partial treatment response for bipolar depression: a blinded, randomized study
    Lori L Altshuler
    Department of Psychiatry, Veterans Affairs Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, Los Angeles, CA, USA
    J Clin Psychiatry 70:450-7. 2009
    ..To assess long-term outcome in bipolar disorder, subjects were prospectively followed after receiving acute treatment for bipolar depression...
  34. ncbi request reprint Psychiatric and metabolic characteristics of childhood versus adult-onset obesity in patients seeking weight management
    Anna I Guerdjikova
    Psychopharmacology Program, Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
    Eat Behav 8:266-76. 2007
    ..Early recognition and attention to eating and mood dysregulation, including, but not limited to binge eating disorder and bulimia nervosa, in some persons, might help reduce their lifetime risk for obesity...
  35. ncbi request reprint Pharmacologic treatment considerations in co-occurring bipolar and anxiety disorders
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    J Clin Psychiatry 67:8-15. 2006
    ..Anxiety disorders are among the most commonly co-occurring psychiatric syndromes with bipolar disorder. The presence of co-occurring anxiety disorders has important prognostic and treatment implications...
  36. ncbi request reprint Psychopathology in children of bipolar parents
    Manpreet K Singh
    Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    J Affect Disord 102:131-6. 2007
    ..Few studies have examined the psychopathological profiles of child offspring of bipolar parents. Such investigations are useful as a first step to identifying potential prodromal manifestations of bipolar disorder...
  37. ncbi request reprint Double-blind, randomized, placebo-controlled trials of ethyl-eicosapentanoate in the treatment of bipolar depression and rapid cycling bipolar disorder
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and the Mental Health Care Line, Cincinnati, Ohio 45267 0559, USA
    Biol Psychiatry 60:1020-2. 2006
    ..The results of pilot trials suggest that omega-3 fatty acids may have efficacy in the treatment of mood symptoms in bipolar disorder...
  38. ncbi request reprint Lithium augmentation of topiramate for bipolar disorder with comorbid binge eating disorder and obesity
    Renu Kotwal
    Department of Psychiatry, Psychopharmacology Research Program, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Hum Psychopharmacol 21:425-31. 2006
    ..To evaluate the effectiveness of lithium augmentation of topiramate on mood symptoms, binge eating behavior, and body weight in obese bipolar patients with binge eating disorder (BED) seeking weight management...
  39. pmc Characterizing impulsivity in mania
    Stephen M Strakowski
    Division of Bipolar Disorders Research, Universtiy of Cincinnati College of Medicine, Cincinnati, OH, USA
    Bipolar Disord 11:41-51. 2009
    ....
  40. ncbi request reprint High-dose escitalopram in the treatment of binge-eating disorder with obesity: a placebo-controlled monotherapy trial
    Anna I Guerdjikova
    Division of Psychopharmacology Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    Hum Psychopharmacol 23:1-11. 2008
    ..The purpose of this study was to evaluate the efficacy and safety of high-dose escitalopram in the treatment of binge-eating disorder (BED) associated with obesity...
  41. doi request reprint Binge eating disorder pharmacotherapy clinical trails--who is left out?
    Anna I Guerdjikova
    Department of Psychiatry, Lindner Center of HOPE, Mason, OH 45267 0559, USA
    Eur Eat Disord Rev 17:101-8. 2009
    ..This report examined the characteristics of subjects interested in binge eating disorder (BED) pharmacotherapy trails who were ineligible for participation...
  42. ncbi request reprint A placebo-controlled, randomized trial of fluoxetine in the treatment of binge-eating disorder
    Lesley M Arnold
    Women s Health Research Program, Department of Psychiatry, University of Cincinnati Medical Center, Cincinnati, Ohio, USA
    J Clin Psychiatry 63:1028-33. 2002
    ..The purpose of this study was to assess the efficacy and safety of fluoxetine in the treatment of binge-eating disorder...
  43. ncbi request reprint Redefining mood stabilization
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    J Affect Disord 73:163-9. 2003
    ..No available agent meets the criteria for a comprehensive mood-stabilizer, although lithium comes the closest...
  44. ncbi request reprint Bipolar disorder, obesity, and pharmacotherapy-associated weight gain
    Paul E Keck
    Division of Clinical Neuroscience, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 64:1426-35. 2003
    ..This risk may be due to factors associated with the illness itself and/or with medications used to treat bipolar disorder...
  45. ncbi request reprint Bipolar disorders: special diagnostic and treatment considerations in women
    Susan L McElroy
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    CNS Spectr 9:5-18. 2004
    ..Further studies are needed on gestational timing and exposure to mood-stabilizing agents, especially newer agents recently approved or currently being considered for the treatment of bipolar disorder...
  46. ncbi request reprint Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illness
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, OH 45267 0559, USA
    Compr Psychiatry 44:263-9. 2003
    ..The lack of observable prognostic impact may have been, in part, due to the relatively high morbidity and poor functional outcome of a substantial portion of the total cohort...
  47. ncbi request reprint Carbamazepine and valproate in the maintenance treatment of bipolar disorder
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    J Clin Psychiatry 63:13-7. 2002
    ..We reviewed the available data from randomized clinical trials of these agents in bipolar disorder to assess their efficacy and tolerability in the maintenance phase of illness management...
  48. ncbi request reprint Severity of bipolarity in hospitalized manic adolescents with history of stimulant or antidepressant treatment
    Cesar A Soutullo
    University of Cincinnati, Department of Psychiatry, Biological Psychiatry and Psychotic and Bipolar Disorders Research Programs, PO Box 670559, 231 Bethesda Avenue, Cincinnati, OH 45267 0559, USA
    J Affect Disord 70:323-7. 2002
    ..Childhood bipolarity (BP) and ADHD frequently co-occur, these children often receive stimulants...
  49. ncbi request reprint Clinical pharmacodynamics and pharmacokinetics of antimanic and mood-stabilizing medications
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    J Clin Psychiatry 63:3-11. 2002
    ..We reviewed the clinical pharmacodynamics and pharmacokinetics of these agents to provide a summary of these properties relevant to clinical practice...
  50. ncbi request reprint New approaches in managing bipolar depression
    Paul E Keck
    Program Psychopharmacology Research, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267 0559, USA
    J Clin Psychiatry 64:13-8. 2003
    ....
  51. ncbi request reprint Medical management of obesity associated with mental disorders
    Shishuka Malhotra
    Biological Psychiatry Program, University of Cincinnati College of Medicine, Ohio 45267 0559, USA
    J Clin Psychiatry 63:24-32. 2002
    ..In this review, we aim to improve understanding of the relationship between obesity and mental illness and provide practical clinical guidelines for the management of obesity associated with mental disorders...
  52. ncbi request reprint Response of recurrent binge eating and weight gain to topiramate in patients with binge eating disorder after bariatric surgery
    Anna I Guerdjikova
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Obes Surg 15:273-7. 2005
    ..The effectiveness of topiramate was evaluated in the treatment of recurrent binge eating and weight gain in patients with binge eating disorder (BED) and obesity who had undergone initially successful bariatric surgery...
  53. ncbi request reprint Psychiatric and legal features of 113 men convicted of sexual offenses
    Neal W Dunsieth
    Center for the Study of Criminal Behavior, Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267 0559, USA
    J Clin Psychiatry 65:293-300. 2004
    ..To increase understanding of the relationships among sexual violence, paraphilias, and mental illness, the authors assessed the legal and psychiatric features of 113 men convicted of sexual offenses...
  54. ncbi request reprint Divalproex in the treatment of bipolar disorder
    Paul E Keck
    Department of Psychiatry, University of Cincinnati College of Medicine, 231 Albert Sabin Way, PO Box 670559, Cincinnati, OH 45267, USA
    Psychopharmacol Bull 37:67-73. 2003
    ..The results of randomized, controlled trials of valproate in the treatment of bipolar disorder are reviewed along with their implications for clinical practice...
  55. ncbi request reprint Aripiprazole: a partial dopamine D2 receptor agonist antipsychotic
    Paul E Keck
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine and General Clinical Research Center, Mental Health Service Line, Cincinnati Veterans Affairs Medical Center, Cincinnati, Ohio, USA
    Expert Opin Investig Drugs 12:655-62. 2003
    ..In addition, aripiprazole was not associated with significant weight gain or QTc prolongation in both acute and long-term treatment trials...
  56. ncbi request reprint Emotional eating and emotional eating alternatives in subjects undergoing bariatric surgery
    Anna I Guerdjikova
    Psychopharmacology Research Program, Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Obes Surg 17:1091-6. 2007
    ..The purpose of this study was to characterize emotional eating and its alternatives in obese patients undergoing bariatric surgery...
  57. ncbi request reprint Awareness of metabolic concerns and perceived impact of pharmacotherapy in patients with bipolar disorder: a survey of 500 US psychiatrists
    Trisha Suppes
    Department of Psychiatry, Bipolar Disorder Research Program, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9121, USA
    Psychopharmacol Bull 40:22-37; quiz 38-40. 2007
    ....
  58. doi request reprint Are bipolar mood symptoms affected by the phase of the menstrual cycle?
    Geetha Shivakumar
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9086, USA
    J Womens Health (Larchmt) 17:473-8. 2008
    ..We sought to examine the relationship between bipolar disorder and menstrual cycle-related mood changes. To our knowledge, this is one of the largest samples in the literature addressing this issue...
  59. ncbi request reprint Binge-eating disorder as a distinct familial phenotype in obese individuals
    James I Hudson
    Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Mass 02478, USA
    Arch Gen Psychiatry 63:313-9. 2006
    ..However, it remains unclear whether BED represents an etiologically distinct behavioral phenotype of obesity or simply a nonspecific eating pattern sometimes seen in obese individuals...
  60. ncbi request reprint Familiality of temperament in bipolar disorder: support for a genetic spectrum
    Lynn Evans
    Department of Psychiatry, UCSD, School of Medicine, University of California, 9500 Gilman Drive, La Jolla, CA 92093 0603, USA
    J Affect Disord 85:153-68. 2005
    ..We predicted that a gradient of scores would be observed from those with BP to those with major depression to unaffected relatives to controls...
  61. ncbi request reprint Impulsive aggression with irritability and responsive to divalproex: a pediatric bipolar spectrum disorder phenotype?
    Drew H Barzman
    Cincinnati Children s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229 3039, USA
    J Affect Disord 88:279-85. 2005
    ..In addition, we examined whether the symptomatology of this group was consistent with a pediatric divalproex-responsive bipolar spectrum disorder...
  62. ncbi request reprint Impact of bipolar disorder on a U.S. community sample
    Joseph R Calabrese
    Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    J Clin Psychiatry 64:425-32. 2003
    ..Bipolar symptoms have been associated with significant functional impairment. We conducted a study to determine the psychosocial impact of bipolar disorder in a U.S. community sample...
  63. ncbi request reprint Reproductive function and risk for PCOS in women treated for bipolar disorder
    Natalie L Rasgon
    Department of Psychiatry, Stanford School of Medicine, Palo Alto, CA, USA
    Bipolar Disord 7:246-59. 2005
    ..This study examined the reproductive function and prevalence of polycystic ovary syndrome (PCOS) in women with bipolar disorder taking antimanic medications...
  64. ncbi request reprint Screening for bipolar disorder in the community
    Robert M A Hirschfeld
    Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, 77555 188, USA
    J Clin Psychiatry 64:53-9. 2003
    ..Our goal was to estimate the rate of positive screens for bipolar I and bipolar II disorders in the general population of the United States...
  65. ncbi request reprint A placebo-controlled evaluation of adjunctive modafinil in the treatment of bipolar depression
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, Los Angeles, USA
    Am J Psychiatry 164:1242-9. 2007
    ..This study was conducted to evaluate the efficacy and safety of adjunctive modafinil in bipolar depression, which is often characterized by excessive sleepiness and fatigue...
  66. ncbi request reprint Gender differences in prevalence, risk, and clinical correlates of alcoholism comorbidity in bipolar disorder
    Mark A Frye
    Department of Psychiatry and Biobehavioral Sciences, UCLA Bipolar Research Program, University of California Los Angeles School of Medicine, 300 UCLA Medical Plaza, Suite 1544, Los Angeles, CA 90095, USA
    Am J Psychiatry 160:883-9. 2003
    ..This study examined gender-specific relationships between alcoholism and bipolar illness, which have previously received little systematic study...
  67. ncbi request reprint Comparison of rapid-cycling and non-rapid-cycling bipolar disorder based on prospective mood ratings in 539 outpatients
    Ralph W Kupka
    Altrecht Institute for Mental Health Care, Tolsteegsingel 2A, 3582 AC Utrecht, Netherlands
    Am J Psychiatry 162:1273-80. 2005
    ..To detect risk factors for rapid cycling in bipolar disorder, the authors compared characteristics of rapid-cycling and non-rapid-cycling patients both from a categorical and a dimensional perspective...
  68. ncbi request reprint Preliminary observations on the effectiveness of levetiracetam in the open adjunctive treatment of refractory bipolar disorder
    Robert M Post
    Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Clin Psychiatry 66:370-4. 2005
    ..Given the effectiveness of a range of other anticonvulsants in bipolar disorder, we sought to evaluate levetiracetam in patients with treatment-resistant illness...
  69. ncbi request reprint Risk of switch in mood polarity to hypomania or mania in patients with bipolar depression during acute and continuation trials of venlafaxine, sertraline, and bupropion as adjuncts to mood stabilizers
    Gabriele S Leverich
    Biological Psychiatry Branch, National Institutes of Mental Health, Bldg 10 Room 3S239, 10 Center Drive, MSC 1272, Bethesda, MD 20892 1272, USA
    Am J Psychiatry 163:232-9. 2006
    ..The authors examined the comparative risks of switches in mood polarity into hypomania or mania during acute and continuation trials of adjunctive antidepressant treatment of bipolar depression...
  70. ncbi request reprint Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressants
    Lori L Altshuler
    Dept of Psychiatry and Biobehavioral Sciences, University of California Los Angeles, 300 UCLA Medical Plaza, Suite 1544, Box 957057, Los Angeles, CA 90095 7057
    Am J Psychiatry 163:313-5. 2006
    ..The authors compared the switch rate into hypomania/mania in depressed patients treated with second-generation antidepressants who had either bipolar I or bipolar II disorder...
  71. ncbi request reprint A 7-week, randomized, double-blind trial of olanzapine/fluoxetine combination versus lamotrigine in the treatment of bipolar I depression
    Eileen B Brown
    Lilly Research Laboratories, Indianapolis, IN, USA
    J Clin Psychiatry 67:1025-33. 2006
    ..Determine the efficacy and tolerability of olanzapine/fluoxetine combination (OFC) for treatment of acute bipolar I depression compared with lamotrigine...
  72. ncbi request reprint Correlates of 1-year prospective outcome in bipolar disorder: results from the Stanley Foundation Bipolar Network
    Willem A Nolen
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Am J Psychiatry 161:1447-54. 2004
    ..The purpose of the study was to examine potential correlates of outcome in patients treated for bipolar disorder...
  73. ncbi request reprint Pharmacological approaches in the treatment of binge eating disorder
    Jose C Appolinario
    Obesity and Eating Disorders Group Institute of Psychiatry, Federal University of Rio de Janeiro and Institute of Endocrinology and Diabetes of Rio de Janeiro, Brazil
    Curr Drug Targets 5:301-7. 2004
    ..Special issues concerning current pharmacological trials and future research directions in this area are also discussed...
  74. ncbi request reprint An overview of recent findings of the Stanley Foundation Bipolar Network (Part I)
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, NIMH, NIH, DHHS, Bethesda, MD 20892 1272, USA
    Bipolar Disord 5:310-9. 2003
    ..Selected recent findings of the Stanley Foundation Bipolar Network are briefly reviewed and their clinical implications discussed...
  75. ncbi request reprint Olanzapine versus placebo in acute mania: treatment responses in subgroups
    Ross J Baldessarini
    International Consortium for Bipolar Disorder Research, Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    J Clin Psychopharmacol 23:370-6. 2003
    ..5-1.7, all P < 0.01). These well-powered comparisons of subgroups of interest indicate broad efficacy of olanzapine in the treatment of acute mania...
  76. ncbi request reprint Problem gambling in bipolar disorder: results from the Canadian Community Health Survey
    Roger S McIntyre
    Department of Psychiatry, University of Toronto, Toronto, ON, Canada
    J Affect Disord 102:27-34. 2007
    ..This investigation was undertaken to explore the prevalence and associated features of problem gambling amongst individuals with bipolar I disorder...
  77. ncbi request reprint Pharmacologic treatment of binge eating disorder
    William P Carter
    Biological Psychiatry Laboratory, McLean Hospital, Belmont, MA 02478, USA
    Int J Eat Disord 34:S74-88. 2003
    ..To review the findings from pharmacologic trials of binge eating disorder (BED) and to provide guidelines for pharmacologic treatment...
  78. ncbi request reprint Morbidity in 258 bipolar outpatients followed for 1 year with daily prospective ratings on the NIMH life chart method
    Robert M Post
    Stanley Foundation Bipolar Network and Biological Psychiatry Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 12723, USA
    J Clin Psychiatry 64:680-90; quiz 738-9. 2003
    ..The detailed course and pattern of illness emerging despite comprehensive treatment with mood stabilizers and adjunctive agents have previously not been well delineated...
  79. ncbi request reprint Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network
    Gabriele S Leverich
    Stanley Foundation Bipolar Treatment Outcome Network, Department of Health and Human Services, National Institutes of Health, National Institute of Mental Health, Biological Psychiatry Branch, Bethesda, MD 20892 1272, USA
    J Clin Psychiatry 64:506-15. 2003
    ..We investigated demographic and course-of-illness variables to better understand the incidence and potential clinical correlates of serious suicide attempts in 648 outpatients with bipolar disorder...
  80. ncbi request reprint Substance use disorders and overweight/obesity in bipolar I disorder: preliminary evidence for competing addictions
    Roger S McIntyre
    Department of Psychiatry, University of Toronto, Ontario, Canada
    J Clin Psychiatry 68:1352-7. 2007
    ..This investigation was undertaken to explore the relationship between alcohol/illicit drug dependence and overweight/obesity in individuals with bipolar I disorder...

Research Grants5

  1. Bipolar II Depression: Lithium, SSRI or the Combination
    Susan McElroy; Fiscal Year: 2007
    ..We also hypothesize that the frequency of side effects will be significantly less in patients on SSRI monotherapy. Thus, secondary aims include assessment of patient satisfaction, which may affect compliance in the clinical setting. ..
  2. Bipolar II Depression: Lithium, SSRI or the Combination
    Susan L McElroy; Fiscal Year: 2010
    ..We also hypothesize that the frequency of side effects will be significantly less in patients on SSRI monotherapy. Thus, secondary aims include assessment of patient satisfaction, which may affect compliance in the clinical setting. ..