Janet McElhaney

Summary

Affiliation: University of Connecticut Health Center
Country: USA

Publications

  1. ncbi request reprint Overcoming the challenges of immunosenescence in the prevention of acute respiratory illness in older people
    Janet E McElhaney
    Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut Center on Aging, University of Connecticut School of Medicine, Farmington, CT, USA
    Conn Med 67:469-74. 2003
  2. ncbi request reprint Better influenza vaccines for older people: what will it take?
    Janet E McElhaney
    J Infect Dis 198:632-4. 2008
  3. ncbi request reprint Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial
    Janet E McElhaney
    Center for Immunotherapy of Cancer and Infectious Diseases, School of Medicine, University of Connecticut, Farmington, CT, USA
    J Altern Complement Med 12:153-7. 2006
  4. ncbi request reprint T cell responses are better correlates of vaccine protection in the elderly
    Janet E McElhaney
    Center for Immunotherapy of Cancer and Infectious Diseases, MC1601, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1601, USA
    J Immunol 176:6333-9. 2006
  5. pmc Lower GrB+ CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes
    Dongxu Xie
    Center for Immunotherapy of Cancer and Infectious Diseases, MC 1601, Department of Immunology, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030 1601, USA
    Mech Ageing Dev 128:392-400. 2007
  6. ncbi request reprint The unmet need in the elderly: designing new influenza vaccines for older adults
    Janet E McElhaney
    Center for Immunotherapy of Cancer and Infectious Diseases and UConn Center on Aging, University of Connecticut School of Medicine, Farmington, CT 06030 1601, USA
    Vaccine 23:S10-25. 2005
  7. ncbi request reprint Comparison of single versus booster dose of influenza vaccination on humoral and cellular immune responses in older adults
    Janet E McElhaney
    Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, 06030 1601, USA
    Vaccine 23:3294-300. 2005
  8. ncbi request reprint Effect of congestive heart failure on humoral and ex vivo cellular immune responses to influenza vaccination in older adults
    Janet E McElhaney
    Center for Immunotherapy of Cancer and Infectious Diseases, MC 1601, University of Connecticut, School of Medicine, 263 Farmington Avenue, Farmington, CT 06030 1601, USA
    Vaccine 22:681-8. 2004
  9. ncbi request reprint A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults
    Janet E McElhaney
    Eastern Virginia Medical School, Norfolk, Virginia, USA
    J Am Geriatr Soc 52:13-9. 2004
  10. pmc Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults
    Janet E McElhaney
    Center for Immunotherapy of Cancer and Infectious Diseases, Department of Immunology, University of Connecticut School of Medicine, Farmington, 06030, USA
    Vaccine 27:2418-25. 2009

Research Grants

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Overcoming the challenges of immunosenescence in the prevention of acute respiratory illness in older people
    Janet E McElhaney
    Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut Center on Aging, University of Connecticut School of Medicine, Farmington, CT, USA
    Conn Med 67:469-74. 2003
    ..Combining vaccination with antiviral or immunoenhancing agents particularly in high-risk groups could optimize the cost benefit of additional preventive strategies...
  2. ncbi request reprint Better influenza vaccines for older people: what will it take?
    Janet E McElhaney
    J Infect Dis 198:632-4. 2008
  3. ncbi request reprint Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial
    Janet E McElhaney
    Center for Immunotherapy of Cancer and Infectious Diseases, School of Medicine, University of Connecticut, Farmington, CT, USA
    J Altern Complement Med 12:153-7. 2006
    ....
  4. ncbi request reprint T cell responses are better correlates of vaccine protection in the elderly
    Janet E McElhaney
    Center for Immunotherapy of Cancer and Infectious Diseases, MC1601, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1601, USA
    J Immunol 176:6333-9. 2006
    ..Ex vivo measures of the cell-mediated immune response should be incorporated into evaluation of new vaccines for older adults...
  5. pmc Lower GrB+ CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytes
    Dongxu Xie
    Center for Immunotherapy of Cancer and Infectious Diseases, MC 1601, Department of Immunology, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030 1601, USA
    Mech Ageing Dev 128:392-400. 2007
    ..Thus, the increase in CD28(null) CD8 T cells with age may contribute to the limited CTL response to influenza vaccination and diminished protection in older adults...
  6. ncbi request reprint The unmet need in the elderly: designing new influenza vaccines for older adults
    Janet E McElhaney
    Center for Immunotherapy of Cancer and Infectious Diseases and UConn Center on Aging, University of Connecticut School of Medicine, Farmington, CT 06030 1601, USA
    Vaccine 23:S10-25. 2005
    ..A targeted approach will develop vaccines that can reverse these age-related changes in T-cell responses, particularly the functions of cytotoxic T lymphocytes...
  7. ncbi request reprint Comparison of single versus booster dose of influenza vaccination on humoral and cellular immune responses in older adults
    Janet E McElhaney
    Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, 06030 1601, USA
    Vaccine 23:3294-300. 2005
    ..0002). These results suggest that SD influenza vaccine produces Th1 and CTL responses while BD may produce a Th2 response that poorly stimulates the CTL response...
  8. ncbi request reprint Effect of congestive heart failure on humoral and ex vivo cellular immune responses to influenza vaccination in older adults
    Janet E McElhaney
    Center for Immunotherapy of Cancer and Infectious Diseases, MC 1601, University of Connecticut, School of Medicine, 263 Farmington Avenue, Farmington, CT 06030 1601, USA
    Vaccine 22:681-8. 2004
    ..In conclusion, CHF in older adults predicts GrzB responses to influenza vaccination due to cytokine and physical ability differences...
  9. ncbi request reprint A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adults
    Janet E McElhaney
    Eastern Virginia Medical School, Norfolk, Virginia, USA
    J Am Geriatr Soc 52:13-9. 2004
    ..To compare a proprietary extract of American ginseng, CVT-E002, with placebo in preventing acute respiratory illness (ARI) in an institutional setting during the influenza season...
  10. pmc Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adults
    Janet E McElhaney
    Center for Immunotherapy of Cancer and Infectious Diseases, Department of Immunology, University of Connecticut School of Medicine, Farmington, 06030, USA
    Vaccine 27:2418-25. 2009
    ..These results suggest that GrzB levels could be combined with antibody titers to more effectively predict vaccine efficacy in older adults...
  11. ncbi request reprint Inhaled zanamivir versus rimantadine for the control of influenza in a highly vaccinated long-term care population
    Stefan Gravenstein
    Eastern Virginia Medical School, Norfolk, VA 23507, USA
    J Am Med Dir Assoc 6:359-66. 2005
    ..This study evaluated the efficacy and tolerability of zanamivir versus rimantadine for influenza outbreak control in long-term care facilities...
  12. pmc Clinical and immunologic predictors of influenza illness among vaccinated older adults
    Zainab Shahid
    Division of Infectious Diseases, Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA
    Vaccine 28:6145-51. 2010
    ..ILI subjects (p=0.03). The cell-mediated immune response to influenza distinguishes A/H3N2 LCI from other ILI in older adults, and suggests a link between cell-mediated immunity and influenza illness severity in vaccinated older adults...
  13. ncbi request reprint Mood and cytokine response to influenza virus in older adults
    Erin S Costanzo
    University of Iowa, Iowa City, IA 52242, USA
    J Gerontol A Biol Sci Med Sci 59:1328-33. 2004
    ..Associations among mood, optimism, stress, and the in vitro cytokine response to influenza virus and vaccine were evaluated in 18 healthy older adults with low to moderate life stress...
  14. ncbi request reprint A novel cytotoxicity assay to evaluate antigen-specific CTL responses using a colorimetric substrate for Granzyme B
    Catherine Ewen
    Department of Biochemistry, University of Alberta, 463 Medical Sciences Bldg, T6G 2H7, Edmonton, Alberta, Canada
    J Immunol Methods 276:89-101. 2003
    ..The novel cytotoxic assay presented here should give investigators a sensitive, cross-species, nonradioactive alternative to 51Cr-release assays as a means to assess antigen-specific CTL responses in vaccine trials...
  15. ncbi request reprint Efficacy and safety of inhaled zanamivir in the prevention of influenza in community-dwelling, high-risk adult and adolescent subjects: a 28-day, multicenter, randomized, double-blind, placebo-controlled trial
    Craig LaForce
    North Carolina Clinical Research Inc, Raleigh, North Carolina, USA
    Clin Ther 29:1579-90; discussion 1577-8. 2007
    ..Effective prophylaxis can significantly reduce the disease burden in this population. Previous studies conducted primarily in non-high-risk subjects have reported the efficacy of inhaled zanamivir in preventing influenza...
  16. ncbi request reprint Influenza: a preventable lethal disease
    Janet E McElhaney
    J Gerontol A Biol Sci Med Sci 57:M627-8. 2002
  17. ncbi request reprint Nutrition, exercise, and influenza vaccination
    Janet E McElhaney
    J Gerontol A Biol Sci Med Sci 57:M555-6. 2002

Research Grants12

  1. T-Cell Responses Predict Influenza Risk in Older Adults
    Janet E McElhaney; Fiscal Year: 2010
    ..3) Test heat shock proteins (Hsp) as potential vaccine adjuvants to enhance the CTL response to vaccination. ..
  2. Adjuvants and Virosomal Vaccines for the Elderly
    Janet McElhaney; Fiscal Year: 2007
    ..The expected results from these pre-clinical studies is the selection of the most potent virosome and/or other adjuvanted influenza vaccine candidates for clinical trials of interpandemic and pandemic vaccines for older adults. ..
  3. T-Cell Responses Predict Influenza Risk in Older Adults
    Janet McElhaney; Fiscal Year: 2004
    ..The goal is to define an immunologic test that measures influenza risk, a measure critical to future vaccine development and targeted prophylaxis in older adults. ..