Affiliation: University of Connecticut Health Center
- Lower GrB+ CD62Lhigh CD8 TCM effector lymphocyte response to influenza virus in older adults is associated with increased CD28null CD8 T lymphocytesDongxu Xie
Center for Immunotherapy of Cancer and Infectious Diseases, MC 1601, Department of Immunology, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT 06030 1601, USA
Mech Ageing Dev 128:392-400. 2007..Thus, the increase in CD28(null) CD8 T cells with age may contribute to the limited CTL response to influenza vaccination and diminished protection in older adults...
- Overcoming the challenges of immunosenescence in the prevention of acute respiratory illness in older peopleJanet E McElhaney
Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut Center on Aging, University of Connecticut School of Medicine, Farmington, CT, USA
Conn Med 67:469-74. 2003..Combining vaccination with antiviral or immunoenhancing agents particularly in high-risk groups could optimize the cost benefit of additional preventive strategies...
- Better influenza vaccines for older people: what will it take?Janet E McElhaney
J Infect Dis 198:632-4. 2008
- Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trialJanet E McElhaney
Center for Immunotherapy of Cancer and Infectious Diseases, School of Medicine, University of Connecticut, Farmington, CT, USA
J Altern Complement Med 12:153-7. 2006..Daily COLD-fX administration can thus be a safe, natural therapeutic means for the prevention of ARI in healthy seniors...
- T cell responses are better correlates of vaccine protection in the elderlyJanet E McElhaney
Center for Immunotherapy of Cancer and Infectious Diseases, MC1601, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1601, USA
J Immunol 176:6333-9. 2006..Ex vivo measures of the cell-mediated immune response should be incorporated into evaluation of new vaccines for older adults...
- The unmet need in the elderly: designing new influenza vaccines for older adultsJanet E McElhaney
Center for Immunotherapy of Cancer and Infectious Diseases and UConn Center on Aging, University of Connecticut School of Medicine, Farmington, CT 06030 1601, USA
Vaccine 23:S10-25. 2005..A targeted approach will develop vaccines that can reverse these age-related changes in T-cell responses, particularly the functions of cytotoxic T lymphocytes...
- Comparison of single versus booster dose of influenza vaccination on humoral and cellular immune responses in older adultsJanet E McElhaney
Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, 06030 1601, USA
Vaccine 23:3294-300. 2005..0002). These results suggest that SD influenza vaccine produces Th1 and CTL responses while BD may produce a Th2 response that poorly stimulates the CTL response...
- Effect of congestive heart failure on humoral and ex vivo cellular immune responses to influenza vaccination in older adultsJanet E McElhaney
Center for Immunotherapy of Cancer and Infectious Diseases, MC 1601, University of Connecticut, School of Medicine, 263 Farmington Avenue, Farmington, CT 06030 1601, USA
Vaccine 22:681-8. 2004..In conclusion, CHF in older adults predicts GrzB responses to influenza vaccination due to cytokine and physical ability differences...
- A placebo-controlled trial of a proprietary extract of North American ginseng (CVT-E002) to prevent acute respiratory illness in institutionalized older adultsJanet E McElhaney
Eastern Virginia Medical School, Norfolk, Virginia, USA
J Am Geriatr Soc 52:13-9. 2004..To compare a proprietary extract of American ginseng, CVT-E002, with placebo in preventing acute respiratory illness (ARI) in an institutional setting during the influenza season...
- Granzyme B: Correlates with protection and enhanced CTL response to influenza vaccination in older adultsJanet E McElhaney
Center for Immunotherapy of Cancer and Infectious Diseases, Department of Immunology, University of Connecticut School of Medicine, Farmington, 06030, USA
Vaccine 27:2418-25. 2009..These results suggest that GrzB levels could be combined with antibody titers to more effectively predict vaccine efficacy in older adults...
- Inhaled zanamivir versus rimantadine for the control of influenza in a highly vaccinated long-term care populationStefan Gravenstein
Eastern Virginia Medical School, Norfolk, VA 23507, USA
J Am Med Dir Assoc 6:359-66. 2005..This study evaluated the efficacy and tolerability of zanamivir versus rimantadine for influenza outbreak control in long-term care facilities...
- Clinical and immunologic predictors of influenza illness among vaccinated older adultsZainab Shahid
Division of Infectious Diseases, Department of Medicine, University of Connecticut Health Center, Farmington, CT, USA
Vaccine 28:6145-51. 2010..ILI subjects (p=0.03). The cell-mediated immune response to influenza distinguishes A/H3N2 LCI from other ILI in older adults, and suggests a link between cell-mediated immunity and influenza illness severity in vaccinated older adults...
- Mood and cytokine response to influenza virus in older adultsErin S Costanzo
University of Iowa, Iowa City, IA 52242, USA
J Gerontol A Biol Sci Med Sci 59:1328-33. 2004..CONCLUSIONS: These findings suggest that among older adults, even mild to moderate mood disturbance is associated with an attenuated cellular immune response to live influenza virus and vaccine...
- A novel cytotoxicity assay to evaluate antigen-specific CTL responses using a colorimetric substrate for Granzyme BCatherine Ewen
Department of Biochemistry, University of Alberta, 463 Medical Sciences Bldg, T6G 2H7, Edmonton, Alberta, Canada
J Immunol Methods 276:89-101. 2003..The novel cytotoxic assay presented here should give investigators a sensitive, cross-species, nonradioactive alternative to 51Cr-release assays as a means to assess antigen-specific CTL responses in vaccine trials...
- Efficacy and safety of inhaled zanamivir in the prevention of influenza in community-dwelling, high-risk adult and adolescent subjects: a 28-day, multicenter, randomized, double-blind, placebo-controlled trialCraig LaForce
North Carolina Clinical Research Inc, Raleigh, North Carolina, USA
Clin Ther 29:1579-90; discussion 1577-8. 2007..Effective prophylaxis can significantly reduce the disease burden in this population. Previous studies conducted primarily in non-high-risk subjects have reported the efficacy of inhaled zanamivir in preventing influenza...
- Influenza: a preventable lethal diseaseJanet E McElhaney
J Gerontol A Biol Sci Med Sci 57:M627-8. 2002
- Nutrition, exercise, and influenza vaccinationJanet E McElhaney
J Gerontol A Biol Sci Med Sci 57:M555-6. 2002
- T-Cell Responses Predict Influenza Risk in Older AdultsJanet E McElhaney; Fiscal Year: 2010..3) Test heat shock proteins (Hsp) as potential vaccine adjuvants to enhance the CTL response to vaccination. ..
- Adjuvants and Virosomal Vaccines for the ElderlyJanet McElhaney; Fiscal Year: 2007..The expected results from these pre-clinical studies is the selection of the most potent virosome and/or other adjuvanted influenza vaccine candidates for clinical trials of interpandemic and pandemic vaccines for older adults. ..
- T-Cell Responses Predict Influenza Risk in Older AdultsJanet McElhaney; Fiscal Year: 2004..The goal is to define an immunologic test that measures influenza risk, a measure critical to future vaccine development and targeted prophylaxis in older adults. ..