Donald McDonald

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Mechanisms of adverse effects of anti-VEGF therapy for cancer
    T Kamba
    Department of Urology, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Br J Cancer 96:1788-95. 2007
  2. pmc Dynamics of airway blood vessels and lymphatics: lessons from development and inflammation
    Donald M McDonald
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California, USA
    Proc Am Thorac Soc 8:504-7. 2011
  3. pmc Angiopoietin-2-driven vascular remodeling in airway inflammation
    Sebastien P Tabruyn
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143 0425, USA
    Am J Pathol 177:3233-43. 2010
  4. ncbi request reprint The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis
    Weon Kyoo You
    Department of Anatomy, University of California, San Francisco, California, USA
    BMB Rep 41:833-9. 2008
  5. ncbi request reprint Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodeling
    Peter Baluk
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 287:L307-17. 2004
  6. ncbi request reprint Imaging of angiogenesis in inflamed airways and tumors: newly formed blood vessels are not alike and may be wildly abnormal: Parker B. Francis lecture
    Donald M McDonald
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Chest 128:602S-608S. 2005
  7. doi request reprint Markers for microscopic imaging of lymphangiogenesis and angiogenesis
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143, USA
    Ann N Y Acad Sci 1131:1-12. 2008
  8. pmc Cellular source and amount of vascular endothelial growth factor and platelet-derived growth factor in tumors determine response to angiogenesis inhibitors
    Barbara Sennino
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Cancer Res 69:4527-36. 2009
  9. ncbi request reprint Imaging of angiogenesis: from microscope to clinic
    Donald M McDonald
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, California 94143 0452, USA
    Nat Med 9:713-25. 2003
  10. pmc TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    J Clin Invest 119:2954-64. 2009

Collaborators

Detail Information

Publications51

  1. pmc Mechanisms of adverse effects of anti-VEGF therapy for cancer
    T Kamba
    Department of Urology, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Br J Cancer 96:1788-95. 2007
    ..These changes are generally manageable and pose less risk than the tumours being treated, but they highlight the properties shared by tumour vessels and the vasculature of normal organs...
  2. pmc Dynamics of airway blood vessels and lymphatics: lessons from development and inflammation
    Donald M McDonald
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California, USA
    Proc Am Thorac Soc 8:504-7. 2011
    ..Whatever the mechanisms, the dynamic nature of airway blood vessels and lymphatics during perinatal development foretells the extraordinary vascular plasticity found in many diseases...
  3. pmc Angiopoietin-2-driven vascular remodeling in airway inflammation
    Sebastien P Tabruyn
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143 0425, USA
    Am J Pathol 177:3233-43. 2010
    ..pulmonis infection. By blocking such changes, Ang2 inhibitors may prove beneficial in the treatment of sustained inflammation in which vascular remodeling, leakage, and leukocyte influx contribute to its pathophysiology...
  4. ncbi request reprint The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesis
    Weon Kyoo You
    Department of Anatomy, University of California, San Francisco, California, USA
    BMB Rep 41:833-9. 2008
    ..The HGF/c-Met signaling pathway is now recognized as a promising target in cancer by inhibiting angiogenesis, tumor growth, invasion, and metastasis...
  5. ncbi request reprint Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodeling
    Peter Baluk
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 287:L307-17. 2004
    ..We conclude that despite major increases in expression, MMP-2 and MMP-9 are not essential for microvascular remodeling in M. pulmonis-induced chronic airway inflammation...
  6. ncbi request reprint Imaging of angiogenesis in inflamed airways and tumors: newly formed blood vessels are not alike and may be wildly abnormal: Parker B. Francis lecture
    Donald M McDonald
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Chest 128:602S-608S. 2005
  7. doi request reprint Markers for microscopic imaging of lymphangiogenesis and angiogenesis
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143, USA
    Ann N Y Acad Sci 1131:1-12. 2008
    ..Other markers, including CD31, junctional proteins, and receptors, such as VEGF-2, are shared by lymphatic and blood vessels...
  8. pmc Cellular source and amount of vascular endothelial growth factor and platelet-derived growth factor in tumors determine response to angiogenesis inhibitors
    Barbara Sennino
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Cancer Res 69:4527-36. 2009
    ..The findings emphasize the interdependence of pericytes and endothelial cells in tumors and the importance of tumor phenotype in determining the cellular effects of VEGF and PDGF inhibitors on tumor vessels...
  9. ncbi request reprint Imaging of angiogenesis: from microscope to clinic
    Donald M McDonald
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, California 94143 0452, USA
    Nat Med 9:713-25. 2003
    ..The importance of angiogenesis in cancer, chronic inflammatory diseases, age-related macular degeneration and reversal of ischemic heart and limb disease provides incentive for meeting these challenges...
  10. pmc TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in mice
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    J Clin Invest 119:2954-64. 2009
    ..We conclude that TNF-alpha is a strong candidate for a mediator that drives blood vessel remodeling and lymphangiogenesis in inflammation...
  11. ncbi request reprint Significance of blood vessel leakiness in cancer
    Donald M McDonald
    Comprehensive Cancer Center, Cardiovascular Research Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cancer Res 62:5381-5. 2002
    ..New research tools such as intravital measurements of tumor blood flow and vessel leakiness, in vivo phage display, magnetic resonance imaging, and use of selective angiogenesis inhibitors will contribute to this understanding...
  12. pmc Steroid-resistant lymphatic remodeling in chronically inflamed mouse airways
    Li Chin Yao
    Department of Anatomy, University of California, 513 Parnassus Ave, Room S1363, San Francisco, CA 94143 0452, USA
    Am J Pathol 176:1525-41. 2010
    ..We suggest that lymphatic remodeling that persists after the initial inflammatory response has resolved may influence subsequent inflammatory episodes in clinical situations...
  13. pmc Angiopoietin/Tie2 signaling transforms capillaries into venules primed for leukocyte trafficking in airway inflammation
    Jonas Fuxe
    Department of Anatomy, University of California San Francisco, San Francisco, CA 94143 0452, USA
    Am J Pathol 176:2009-18. 2010
    ..pulmonis-infected mouse airways. Together, these findings suggest that blockade of the Ang/Tie2 pathway may represent a therapeutic approach in airway inflammation...
  14. pmc Ricinus communis agglutinin I leads to rapid down-regulation of VEGFR-2 and endothelial cell apoptosis in tumor blood vessels
    Weon Kyoo You
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Am J Pathol 176:1927-40. 2010
    ..Together, the results illustrate the selective impact of RCA I on VEGF signaling in tumor blood vessels...
  15. ncbi request reprint Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection
    Arin B Aurora
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 175:6319-26. 2005
    ..The results reveal a novel pathway whereby T cell-dependent humoral immunity to a persistent airway infection can induce inflammation-dependent angiogenesis, lymphangiogenesis, and chronic airway pathology...
  16. pmc Soluble receptor-mediated selective inhibition of VEGFR and PDGFRbeta signaling during physiologic and tumor angiogenesis
    Frank Kuhnert
    Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:10185-90. 2008
    ..These studies using highly specific soluble receptors suggest that additivity between VEGFR and PDGFRbeta inhibition depends on the strength of VEGF blockade and appears minimal under conditions of maximal VEGF antagonism...
  17. pmc Rapid vascular regrowth in tumors after reversal of VEGF inhibition
    Michael R Mancuso
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143 0452, USA
    J Clin Invest 116:2610-21. 2006
    ....
  18. pmc Uniform overexpression and rapid accessibility of alpha5beta1 integrin on blood vessels in tumors
    Patricia Parsons-Wingerter
    Department of Anatomy, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
    Am J Pathol 167:193-211. 2005
    ..This strategy of injecting antibodies revealed the uniform overexpression and rapid accessibility of alpha5beta1 integrin on tumor vessels and may prove useful in assessing other potential therapeutic targets in cancer...
  19. ncbi request reprint In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skin
    Kyung Eun Kim
    National Research Laboratory of Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    Arterioscler Thromb Vasc Biol 27:564-70. 2007
    ..We analyzed the microvasculature of trachea and ear skin, and compared quiescent skin microvasculature with that during wound healing...
  20. pmc Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis
    Clare R Ozawa
    Baxter Laboratory in Genetic Pharmacology, Stanford University School of Medicine, Stanford, California 94305 5175, USA
    J Clin Invest 113:516-27. 2004
    ..Long-term continuous delivery of VEGF, when maintained below a threshold microenvironmental level, can lead to normal angiogenesis without other exogenous growth factors...
  21. ncbi request reprint Rapid access of antibodies to alpha5beta1 integrin overexpressed on the luminal surface of tumor blood vessels
    Anette Magnussen
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143 0130, USA
    Cancer Res 65:2712-21. 2005
    ..Together, these findings indicate that the rapid accessibility of alpha(5)beta(1) integrin in RIP-Tag2 tumors results from overexpression of the integrin on the luminal surface of tumor vessels...
  22. pmc Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143, USA
    J Clin Invest 115:247-57. 2005
    ..Correction of defective lymphangiogenesis may benefit the treatment of asthma and other inflammatory airway diseases...
  23. ncbi request reprint Cellular abnormalities of blood vessels as targets in cancer
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Curr Opin Genet Dev 15:102-11. 2005
    ..Rapid vascular regrowth reflects the ongoing drive for angiogenesis and bizarre microenvironment in tumors that promote vascular abnormalities and thereby create therapeutic targets...
  24. ncbi request reprint Probing the structural and molecular diversity of tumor vasculature
    Renata Pasqualini
    Dept of Genitourinary Medical Oncology, The University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Trends Mol Med 8:563-71. 2002
    ..The combined approach offers a strategy for creating a ligand-receptor map of the human vasculature, and forms a foundation for the development and application of targeted therapies in cancer and other diseases...
  25. pmc Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
    Tetsuichiro Inai
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy S1363, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    Am J Pathol 165:35-52. 2004
    ..Early loss of endothelial fenestrations in RIP-Tag2 tumors is a clue that vessel phenotype may be predictive of exceptional sensitivity to these inhibitors...
  26. pmc Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airways
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, CA 94143 0130, USA
    Am J Pathol 165:1071-85. 2004
    ..Blood vessels can respond to VEGF by sprouting angiogenesis within a few days, but regress more slowly after VEGF withdrawal, and leave a historical record of their previous extent in the form of empty basement membrane sleeves...
  27. ncbi request reprint Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung
    Cecile J Favre
    Department of Anatomy S1363, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    Am J Physiol Heart Circ Physiol 285:H1917-38. 2003
    ..This approach can readily be used to profile genes expressed in blood vessels in tumors, chronic inflammation, and other sites in which endothelial cells avidly take up cationic liposomes...
  28. ncbi request reprint The biologic basis of in vivo angiogenesis imaging
    Iclal Ocak
    Molecular Imaging Program, National Institutes of Health, Bethesda, Maryland 20892 1182, USA
    Front Biosci 12:3601-16. 2007
    ..Serial analysis of gene expression or in vivo phage display may help identify new, more selective, markers that can be utilized for the targeted imaging and treatment of angiogenesis...
  29. pmc Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    Am J Pathol 163:1801-15. 2003
    ..These findings indicate that basement membrane covers most tumor vessels but has profound structural abnormalities, consistent with the dynamic nature of endothelial cells and pericytes in tumors...
  30. ncbi request reprint Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102
    Barbara Sennino
    Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, San Francisco, California 94080, USA
    Cancer Res 67:7358-67. 2007
    ..Loss of pericytes in tumors is an expected direct consequence of PDGF-B blockade, but reduced tumor vascularity is likely to be secondary to pericyte regression...
  31. pmc Functionally specialized junctions between endothelial cells of lymphatic vessels
    Peter Baluk
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 204:2349-62. 2007
    ..Our findings suggest that fluid enters throughout initial lymphatics via openings between buttons, which open and close without disrupting junctional integrity, but most leukocytes enter the proximal half of initial lymphatics...
  32. doi request reprint Vascular permeability during antiangiogenesis treatment: MR imaging assay results as biomarker for subsequent tumor growth in rats
    Hans Juergen Raatschen
    Department of Radiology, Center for Pharmaceutical and Molecular Imaging, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California San Francisco, CA, USA
    Radiology 247:391-9. 2008
    ....
  33. doi request reprint Magnetic resonance imaging assays for dimethyl sulfoxide effect on cancer vasculature
    Clemens C Cyran
    Center for Pharmaceutical and Molecular Imaging, Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
    Invest Radiol 43:298-305. 2008
    ....
  34. pmc Disease-specific gene expression profiling in multiple models of lung disease
    Christina C Lewis
    Cincinnati Children s Hospital Medical Center Division of Immunobiology, 3333 Burnet Avenue, MLC 7038, Cincinnati, OH 45229, USA
    Am J Respir Crit Care Med 177:376-87. 2008
    ..However, analyses of individual diseases or models of diseases frequently yield extensive lists of differentially expressed genes with uncertain relationships to disease pathogenesis...
  35. pmc Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung
    Vineet Bhandari
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, LCI 401 B, New Haven, CT 06520 8057, USA
    Proc Natl Acad Sci U S A 103:11021-6. 2006
    ..Furthermore, they demonstrate that eNOS and iNOS both contribute to these responses. NO/NOS-based interventions may be therapeutic in VEGF-driven inflammation and remodeling...
  36. ncbi request reprint Rapid changes in shape and number of MHC class II expressing cells in rat airways after Mycoplasma pulmonis infection
    Eric Y Umemoto
    Cardiovascular Research Institute, Department of Anatomy, and Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    Cell Immunol 220:107-15. 2002
    ....
  37. ncbi request reprint Report from the society for biological therapy and vascular biology faculty of the NCI workshop on angiogenesis monitoring
    Donald M McDonald
    University of California at San Francisco, San Francisco, CA, USA
    J Immunother 27:161-75. 2004
    ..The third addressed the translation to the clinic and monitoring of antiangiogenic activity of agents in patients and novel trial designs. What follows is a summary of the discussions and findings of each session...
  38. ncbi request reprint Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1-induced plasticity of adult blood vessels
    Fabienne Baffert
    Department of Anatomy, Cardiovascular Research Institute and Comprehensive Cancer Center, University of California, San Francisco, Calif, USA
    Circ Res 94:984-92. 2004
    ..Together, these findings indicate that VEGF and Ang1 participate in blood vessel survival and plasticity in adult life...
  39. pmc Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, 441c TAC, New Haven, Connecticut 06520 8057, USA
    Nat Med 10:1095-103. 2004
    ..Thus, VEGF is a mediator of vascular and extravascular remodeling and inflammation that enhances antigen sensitization and is crucial in adaptive T(H)2 inflammation. VEGF regulation may be therapeutic in asthma and other T(H)2 disorders...
  40. pmc Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissection
    Virginia J Yao
    Departments of Genitourinary Medical Oncology and Cancer Biology, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Pathol 166:625-36. 2005
    ..Our findings show in vivo phage display and laser pressure catapult microdissection can be combined to reveal endothelial cell specialization within focal regions of the microvasculature...
  41. ncbi request reprint Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period
    Gavin Thurston
    Regeneron Pharmaceuticals Incorporated, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Development 132:3317-26. 2005
    ..Finding the key molecular factors that regulate this plasticity may prove crucial to the further development of pro- and anti-angiogenic therapies...
  42. ncbi request reprint Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow
    Chung Hyun Cho
    Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    Circ Res 97:86-94. 2005
    ..Sustained overexpression of Tie2 could participate in the maintenance of vascular changes. Together, our findings indicate that sustained treatment with COMP-Ang1 can produce long-lasting vascular enlargement and increased blood flow...
  43. ncbi request reprint Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers
    Emmanuelle di Tomaso
    Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer Res 65:5740-9. 2005
    ..More than 80% of the defects lacked immunoreactivity for multiple basement membrane proteins...
  44. ncbi request reprint Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules
    Fabienne Baffert
    Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, San Francisco, CA 94143 0452, USA
    Am J Physiol Heart Circ Physiol 290:H107-18. 2006
    ....
  45. ncbi request reprint Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling
    Fabienne Baffert
    Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
    Am J Physiol Heart Circ Physiol 290:H547-59. 2006
    ....
  46. ncbi request reprint VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
    Tomomi Kamba
    Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
    Am J Physiol Heart Circ Physiol 290:H560-76. 2006
    ..Our findings of VEGF dependency of normal fenestrated capillaries and rapid regrowth after regression demonstrate the plasticity of the adult microvasculature...
  47. ncbi request reprint Angiogenesis with pericyte abnormalities in a transgenic model of prostate carcinoma
    Michael G Ozawa
    Department of Anatomy, University of California at San Francisco, San Francisco, California 94143 0130, USA
    Cancer 104:2104-15. 2005
    ..The authors used a new approach to characterize morphologic and architectural changes of blood vessels and pericytes during tumor development in TRAMP mice...
  48. pmc Mast cells protect mice from Mycoplasma pneumonia
    Xiang Xu
    Pulmonary and Critical Care Medicine, Mailstop 111 D, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121
    Am J Respir Crit Care Med 173:219-25. 2006
    ..Mice infected with Mycoplasma pulmonis can develop localized, life-long airway infection accompanied by persistent inflammation and remodeling...
  49. ncbi request reprint Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors
    Tsutomu Nakahara
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0130, USA
    Cancer Res 66:1434-45. 2006
    ..Basement membrane sleeves may facilitate this transport. Antibodies preferentially distribute to tumor stroma but also accumulate on tumor cells if binding sites are accessible...
  50. ncbi request reprint Antiangiogenic therapy decreases integrin expression in normalized tumor blood vessels
    Virginia J Yao
    Department of Anatomy, University of California, San Francisco, California 91413 0452, USA
    Cancer Res 66:2639-49. 2006
    ..Efficacious delivery of drugs may benefit from identification by in vivo phage display of targeting peptides that bind to tumor blood vessels normalized by antiangiogenic agents...
  51. pmc Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors
    Shunichi Morikawa
    Department of Anatomy and Cardiovascular Research Institute and Comprehensive Cancer Center, University of California, San Francisco, California 94143 0130, USA
    Am J Pathol 160:985-1000. 2002
    ..The association of pericytes with endothelial sprouts raises the possibility of an involvement in sprout growth or retraction in tumors...

Research Grants13

  1. Lymphangiogenesis and Angiogenesis in Airway Inflammation
    Donald McDonald; Fiscal Year: 2009
    ..By elucidating the mechanisms, consequences, and reversibility of these vascular changes, the project will advance the understanding needed to use remodeled lymphatics and blood vessels as therapeutic targets in airway inflammation. ..
  2. ENDOTHELIAL PERMEABILITY IN AIRWAY ANGIOGENESIS
    Donald McDonald; Fiscal Year: 1999
    ....
  3. Angiopoietins in airway vascular leak and angiogenesis
    Donald McDonald; Fiscal Year: 2009
    ....
  4. Angiopoietins in airway vascular leak and angiogenesis
    Donald McDonald; Fiscal Year: 2007
    ....
  5. Angiopoietins in airway vascular leak and angiogenesis
    Donald McDonald; Fiscal Year: 2006
    ....
  6. Angiopoietins in airway vascular leak and angiogenesis
    Donald McDonald; Fiscal Year: 2005
    ..Furthermore, elucidation of the protective effect of Ang1 on blood vessel leakiness would raise the possibility of a new strategy for reducing airway edema in chronic inflammatory diseases such as bronchitis and asthma. ..
  7. Angiopoietins in airway vascular leak and angiogenesis
    Donald McDonald; Fiscal Year: 2004
    ..Furthermore, elucidation of the protective effect of Ang1 on blood vessel leakiness would raise the possibility of a new strategy for reducing airway edema in chronic inflammatory diseases such as bronchitis and asthma. ..
  8. Angiopoietins in airway vascular leak and angiogenesis
    Donald McDonald; Fiscal Year: 2003
    ..Furthermore, elucidation of the protective effect of Ang1 on blood vessel leakiness would raise the possibility of a new strategy for reducing airway edema in chronic inflammatory diseases such as bronchitis and asthma. ..
  9. Angiopoietins in airway vascular leak and angiogenesis
    Donald McDonald; Fiscal Year: 2002
    ..Furthermore, elucidation of the protective effect of Ang1 on blood vessel leakiness would raise the possibility of a new strategy for reducing airway edema in chronic inflammatory diseases such as bronchitis and asthma. ..
  10. Angiopoietins in airway vascular leak and angiogenesis
    Donald McDonald; Fiscal Year: 2001
    ..Furthermore, elucidation of the protective effect of Ang1 on blood vessel leakiness would raise the possibility of a new strategy for reducing airway edema in chronic inflammatory diseases such as bronchitis and asthma. ..
  11. ENDOTHELIAL PERMEABILITY IN AIRWAY ANGIOGENESIS
    Donald McDonald; Fiscal Year: 2000
    ....
  12. Angiopoietins in airway vascular leak and angiogenesis
    Donald M McDonald; Fiscal Year: 2010
    ....