Research Topics
Genomes and GenesSpecies | Donald McDonaldSummaryAffiliation: University of California Country: USA Publications
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Publications
Dynamics of airway blood vessels and lymphatics: lessons from development and inflammationDonald M McDonald
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California, USA
Proc Am Thorac Soc 8:504-7. 2011..Whatever the mechanisms, the dynamic nature of airway blood vessels and lymphatics during perinatal development foretells the extraordinary vascular plasticity found in many diseases...- Angiopoietin-2-driven vascular remodeling in airway inflammationSebastien P Tabruyn
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143 0425, USA
Am J Pathol 177:3233-43. 2010..pulmonis infection. By blocking such changes, Ang2 inhibitors may prove beneficial in the treatment of sustained inflammation in which vascular remodeling, leakage, and leukocyte influx contribute to its pathophysiology... - TNF-alpha drives remodeling of blood vessels and lymphatics in sustained airway inflammation in micePeter Baluk
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
J Clin Invest 119:2954-64. 2009..We conclude that TNF-alpha is a strong candidate for a mediator that drives blood vessel remodeling and lymphangiogenesis in inflammation... 
Markers for microscopic imaging of lymphangiogenesis and angiogenesisPeter Baluk
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143, USA
Ann N Y Acad Sci 1131:1-12. 2008..Other markers, including CD31, junctional proteins, and receptors, such as VEGF-2, are shared by lymphatic and blood vessels...- Steroid-resistant lymphatic remodeling in chronically inflamed mouse airwaysLi Chin Yao
Department of Anatomy, University of California, 513 Parnassus Ave, Room S1363, San Francisco, CA 94143 0452, USA
Am J Pathol 176:1525-41. 2010..We suggest that lymphatic remodeling that persists after the initial inflammatory response has resolved may influence subsequent inflammatory episodes in clinical situations... 
Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodelingPeter Baluk
Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
Am J Physiol Lung Cell Mol Physiol 287:L307-17. 2004..We conclude that despite major increases in expression, MMP-2 and MMP-9 are not essential for microvascular remodeling in M. pulmonis-induced chronic airway inflammation...- The hepatocyte growth factor/c-Met signaling pathway as a therapeutic target to inhibit angiogenesisWeon Kyoo You
Department of Anatomy, University of California, San Francisco, California, USA
BMB Rep 41:833-9. 2008..The HGF/c-Met signaling pathway is now recognized as a promising target in cancer by inhibiting angiogenesis, tumor growth, invasion, and metastasis... - Cellular source and amount of vascular endothelial growth factor and platelet-derived growth factor in tumors determine response to angiogenesis inhibitorsBarbara Sennino
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
Cancer Res 69:4527-36. 2009..The findings emphasize the interdependence of pericytes and endothelial cells in tumors and the importance of tumor phenotype in determining the cellular effects of VEGF and PDGF inhibitors on tumor vessels... - Imaging of angiogenesis in inflamed airways and tumors: newly formed blood vessels are not alike and may be wildly abnormal: Parker B. Francis lectureDonald M McDonald
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, CA 94143-0452, USA
Chest 128:602S-608S. 2005 - Imaging of angiogenesis: from microscope to clinicDonald M McDonald
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, California 94143 0452, USA
Nat Med 9:713-25. 2003..The importance of angiogenesis in cancer, chronic inflammatory diseases, age-related macular degeneration and reversal of ischemic heart and limb disease provides incentive for meeting these challenges... - Significance of blood vessel leakiness in cancerDonald M McDonald
Comprehensive Cancer Center, Cardiovascular Research Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Cancer Res 62:5381-5. 2002..New research tools such as intravital measurements of tumor blood flow and vessel leakiness, in vivo phage display, magnetic resonance imaging, and use of selective angiogenesis inhibitors will contribute to this understanding... - Ricinus communis agglutinin I leads to rapid down-regulation of VEGFR-2 and endothelial cell apoptosis in tumor blood vesselsWeon Kyoo You
Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
Am J Pathol 176:1927-40. 2010..Together, the results illustrate the selective impact of RCA I on VEGF signaling in tumor blood vessels... - Angiopoietin/Tie2 signaling transforms capillaries into venules primed for leukocyte trafficking in airway inflammationJonas Fuxe
Department of Anatomy, University of California San Francisco, San Francisco, CA 94143 0452, USA
Am J Pathol 176:2009-18. 2010..pulmonis-infected mouse airways. Together, these findings suggest that blockade of the Ang/Tie2 pathway may represent a therapeutic approach in airway inflammation... - Uniform overexpression and rapid accessibility of alpha5beta1 integrin on blood vessels in tumorsPatricia Parsons-Wingerter
Department of Anatomy, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
Am J Pathol 167:193-211. 2005..This strategy of injecting antibodies revealed the uniform overexpression and rapid accessibility of alpha5beta1 integrin on tumor vessels and may prove useful in assessing other potential therapeutic targets in cancer... - Soluble receptor-mediated selective inhibition of VEGFR and PDGFRbeta signaling during physiologic and tumor angiogenesisFrank Kuhnert
Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 105:10185-90. 2008..These studies using highly specific soluble receptors suggest that additivity between VEGFR and PDGFRbeta inhibition depends on the strength of VEGF blockade and appears minimal under conditions of maximal VEGF antagonism... - In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skinKyung Eun Kim
National Research Laboratory of Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
Arterioscler Thromb Vasc Biol 27:564-70. 2007..We analyzed the microvasculature of trachea and ear skin, and compared quiescent skin microvasculature with that during wound healing... - Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infectionArin B Aurora
Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
J Immunol 175:6319-26. 2005..The results reveal a novel pathway whereby T cell-dependent humoral immunity to a persistent airway infection can induce inflammation-dependent angiogenesis, lymphangiogenesis, and chronic airway pathology... - Rapid access of antibodies to alpha5beta1 integrin overexpressed on the luminal surface of tumor blood vesselsAnette Magnussen
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143-0130, USA
Cancer Res 65:2712-21. 2005..Together, these findings indicate that the rapid accessibility of alpha(5)beta(1) integrin in RIP-Tag2 tumors results from overexpression of the integrin on the luminal surface of tumor vessels... - Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghostsTetsuichiro Inai
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy S1363, University of California-San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0452, USA
Am J Pathol 165:35-52. 2004..Early loss of endothelial fenestrations in RIP-Tag2 tumors is a clue that vessel phenotype may be predictive of exceptional sensitivity to these inhibitors... - Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lungCecile J Favre
Department of Anatomy S1363, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
Am J Physiol Heart Circ Physiol 285:H1917-38. 2003..This approach can readily be used to profile genes expressed in blood vessels in tumors, chronic inflammation, and other sites in which endothelial cells avidly take up cationic liposomes... - Probing the structural and molecular diversity of tumor vasculatureRenata Pasqualini
Dept of Genitourinary Medical Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA
Trends Mol Med 8:563-71. 2002..The combined approach offers a strategy for creating a ligand-receptor map of the human vasculature, and forms a foundation for the development and application of targeted therapies in cancer and other diseases... - Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airwaysPeter Baluk
Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, CA 94143-0130, USA
Am J Pathol 165:1071-85. 2004..Blood vessels can respond to VEGF by sprouting angiogenesis within a few days, but regress more slowly after VEGF withdrawal, and leave a historical record of their previous extent in the form of empty basement membrane sleeves... - Cellular abnormalities of blood vessels as targets in cancerPeter Baluk
Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, CA 94143, USA
Curr Opin Genet Dev 15:102-11. 2005..Rapid vascular regrowth reflects the ongoing drive for angiogenesis and bizarre microenvironment in tumors that promote vascular abnormalities and thereby create therapeutic targets... - Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammationPeter Baluk
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143, USA
J Clin Invest 115:247-57. 2005..Correction of defective lymphangiogenesis may benefit the treatment of asthma and other inflammatory airway diseases... - Rapid vascular regrowth in tumors after reversal of VEGF inhibitionMichael R Mancuso
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143-0452, USA
J Clin Invest 116:2610-21. 2006.... - Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesisClare R Ozawa
Baxter Laboratory in Genetic Pharmacology, Stanford University School of Medicine, Stanford, California 94305-5175, USA
J Clin Invest 113:516-27. 2004..Long-term continuous delivery of VEGF, when maintained below a threshold microenvironmental level, can lead to normal angiogenesis without other exogenous growth factors... - The biologic basis of in vivo angiogenesis imagingIclal Ocak
Molecular Imaging Program, National Institutes of Health, Bethesda, Maryland 20892 1182, USA
Front Biosci 12:3601-16. 2007..Serial analysis of gene expression or in vivo phage display may help identify new, more selective, markers that can be utilized for the targeted imaging and treatment of angiogenesis... - Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102Barbara Sennino
Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, San Francisco, California 94080, USA
Cancer Res 67:7358-67. 2007..Loss of pericytes in tumors is an expected direct consequence of PDGF-B blockade, but reduced tumor vascularity is likely to be secondary to pericyte regression... - Functionally specialized junctions between endothelial cells of lymphatic vesselsPeter Baluk
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 204:2349-62. 2007..Our findings suggest that fluid enters throughout initial lymphatics via openings between buttons, which open and close without disrupting junctional integrity, but most leukocytes enter the proximal half of initial lymphatics... - Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumorsPeter Baluk
Cardiovascular Research Institute, Comprehensive Cancer Center, University of California-San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0452, USA
Am J Pathol 163:1801-15. 2003..These findings indicate that basement membrane covers most tumor vessels but has profound structural abnormalities, consistent with the dynamic nature of endothelial cells and pericytes in tumors... - Vascular permeability during antiangiogenesis treatment: MR imaging assay results as biomarker for subsequent tumor growth in ratsHans Juergen Raatschen
Department of Radiology, Center for Pharmaceutical and Molecular Imaging, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California San Francisco, CA, USA
Radiology 247:391-9. 2008.... - Magnetic resonance imaging assays for dimethyl sulfoxide effect on cancer vasculatureClemens C Cyran
Center for Pharmaceutical and Molecular Imaging, Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
Invest Radiol 43:298-305. 2008.... - Disease-specific gene expression profiling in multiple models of lung diseaseChristina C Lewis
Cincinnati Children s Hospital Medical Center Division of Immunobiology, 3333 Burnet Avenue, MLC 7038, Cincinnati, OH 45229, USA
Am J Respir Crit Care Med 177:376-87. 2008..However, analyses of individual diseases or models of diseases frequently yield extensive lists of differentially expressed genes with uncertain relationships to disease pathogenesis... - Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lungVineet Bhandari
Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, LCI 401-B, New Haven, CT 06520-8057, USA
Proc Natl Acad Sci U S A 103:11021-6. 2006..Furthermore, they demonstrate that eNOS and iNOS both contribute to these responses. NO/NOS-based interventions may be therapeutic in VEGF-driven inflammation and remodeling... - Rapid changes in shape and number of MHC class II expressing cells in rat airways after Mycoplasma pulmonis infectionEric Y Umemoto
Cardiovascular Research Institute, Department of Anatomy, and Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
Cell Immunol 220:107-15. 2002.... - Report from the society for biological therapy and vascular biology faculty of the NCI workshop on angiogenesis monitoringDonald M McDonald
University of California at San Francisco, San Francisco, CA, USA
J Immunother (1997) 27:161-75. 2004..The third addressed the translation to the clinic and monitoring of antiangiogenic activity of agents in patients and novel trial designs. What follows is a summary of the discussions and findings of each session... - Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1-induced plasticity of adult blood vesselsFabienne Baffert
Department of Anatomy, Cardiovascular Research Institute and Comprehensive Cancer Center, University of California, San Francisco, Calif, USA
Circ Res 94:984-92. 2004..Together, these findings indicate that VEGF and Ang1 participate in blood vessel survival and plasticity in adult life... - Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lungChun Geun Lee
Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, 441c TAC, New Haven, Connecticut 06520 8057, USA
Nat Med 10:1095-103. 2004..Thus, VEGF is a mediator of vascular and extravascular remodeling and inflammation that enhances antigen sensitization and is crucial in adaptive T(H)2 inflammation. VEGF regulation may be therapeutic in asthma and other T(H)2 disorders... - Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissectionVirginia J Yao
Departments of Genitourinary Medical Oncology and Cancer Biology, The University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Am J Pathol 166:625-36. 2005..Our findings show in vivo phage display and laser pressure catapult microdissection can be combined to reveal endothelial cell specialization within focal regions of the microvasculature... - Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental periodGavin Thurston
Regeneron Pharmaceuticals Incorporated, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
Development 132:3317-26. 2005..Finding the key molecular factors that regulate this plasticity may prove crucial to the further development of pro- and anti-angiogenic therapies... - Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flowChung-Hyun Cho
Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
Circ Res 97:86-94. 2005..Sustained overexpression of Tie2 could participate in the maintenance of vascular changes. Together, our findings indicate that sustained treatment with COMP-Ang1 can produce long-lasting vascular enlargement and increased blood flow... - Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markersEmmanuelle di Tomaso
Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Cancer Res 65:5740-9. 2005..More than 80% of the defects lacked immunoreactivity for multiple basement membrane proteins... - Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venulesFabienne Baffert
Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, San Francisco, CA 94143 0452, USA
Am J Physiol Heart Circ Physiol 290:H107-18. 2006.... - Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signalingFabienne Baffert
Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
Am J Physiol Heart Circ Physiol 290:H547-59. 2006.... - VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculatureTomomi Kamba
Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
Am J Physiol Heart Circ Physiol 290:H560-76. 2006..Our findings of VEGF dependency of normal fenestrated capillaries and rapid regrowth after regression demonstrate the plasticity of the adult microvasculature... - Angiogenesis with pericyte abnormalities in a transgenic model of prostate carcinomaMichael G Ozawa
Department of Anatomy, University of California at San Francisco, San Francisco, California 94143-0130, USA
Cancer 104:2104-15. 2005..CONCLUSIONS: Vascular abnormalities, which begin at the PIN stage and intensify in well differentiated and poorly differentiated tumors, may be useful readouts for early detection and treatment assessment in prostate carcinoma... - Mast cells protect mice from Mycoplasma pneumoniaXiang Xu
Pulmonary and Critical Care Medicine, Mailstop 111-D, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121
Am J Respir Crit Care Med 173:219-25. 2006..CONCLUSIONS: These findings suggest that mast cells are important for innate immune containment of and recovery from respiratory mycoplasma infection... - Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumorsTsutomu Nakahara
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California-San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0130, USA
Cancer Res 66:1434-45. 2006..Basement membrane sleeves may facilitate this transport. Antibodies preferentially distribute to tumor stroma but also accumulate on tumor cells if binding sites are accessible... - Antiangiogenic therapy decreases integrin expression in normalized tumor blood vesselsVirginia J Yao
Department of Anatomy, University of California, San Francisco, California 91413-0452, USA
Cancer Res 66:2639-49. 2006..Efficacious delivery of drugs may benefit from identification by in vivo phage display of targeting peptides that bind to tumor blood vessels normalized by antiangiogenic agents... - Abnormalities in pericytes on blood vessels and endothelial sprouts in tumorsShunichi Morikawa
Department of Anatomy and Cardiovascular Research Institute and Comprehensive Cancer Center, University of California, San Francisco, California 94143-0130, USA
Am J Pathol 160:985-1000. 2002..The association of pericytes with endothelial sprouts raises the possibility of an involvement in sprout growth or retraction in tumors...
Research Grants
- Lymphangiogenesis and Angiogenesis in Airway InflammationDonald McDonald; Fiscal Year: 2009..By elucidating the mechanisms, consequences, and reversibility of these vascular changes, the project will advance the understanding needed to use remodeled lymphatics and blood vessels as therapeutic targets in airway inflammation. ..
- Angiopoietins in airway vascular leak and angiogenesisDonald McDonald; Fiscal Year: 2009....
- Angiopoietins in airway vascular leak and angiogenesisDonald McDonald; Fiscal Year: 2007....
- Angiopoietins in airway vascular leak and angiogenesisDonald McDonald; Fiscal Year: 2005..Furthermore, elucidation of the protective effect of Ang1 on blood vessel leakiness would raise the possibility of a new strategy for reducing airway edema in chronic inflammatory diseases such as bronchitis and asthma. ..
- ENDOTHELIAL PERMEABILITY IN AIRWAY ANGIOGENESISDonald McDonald; Fiscal Year: 2000....
- Angiopoietins in airway vascular leak and angiogenesisDonald M McDonald; Fiscal Year: 2010....