Research Topics
Species | D M McDonaldSummaryAffiliation: University of California Country: USA Publications
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Publications
Angiogenesis and remodeling of airway vasculature in chronic inflammationD M McDonald
Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, California 94143 0130, USA
Am J Respir Crit Care Med 164:S39-45. 2001....- Significance of blood vessel leakiness in cancerDonald M McDonald
Comprehensive Cancer Center, Cardiovascular Research Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
Cancer Res 62:5381-5. 2002..New research tools such as intravital measurements of tumor blood flow and vessel leakiness, in vivo phage display, magnetic resonance imaging, and use of selective angiogenesis inhibitors will contribute to this understanding... - Endothelial cells of tumor vessels: abnormal but not absentD M McDonald
Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco 94143 0130, USA
Cancer Metastasis Rev 19:109-20. 2000.... - Imaging of angiogenesis: from microscope to clinicDonald M McDonald
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, California 94143 0452, USA
Nat Med 9:713-25. 2003..The importance of angiogenesis in cancer, chronic inflammatory diseases, age-related macular degeneration and reversal of ischemic heart and limb disease provides incentive for meeting these challenges... - Imaging of angiogenesis in inflamed airways and tumors: newly formed blood vessels are not alike and may be wildly abnormal: Parker B. Francis lectureDonald M McDonald
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, CA 94143-0452, USA
Chest 128:602S-608S. 2005 
Angiogenesis in mice with chronic airway inflammation: strain-dependent differencesG Thurston
Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco 94143 0452, USA
Am J Pathol 153:1099-112. 1998..Endothelial cells proliferate in both cases, but in one case new capillaries form whereas in the other capillaries convert to venules...- Endothelial gaps and adherent leukocytes in allergen-induced early- and late-phase plasma leakage in rat airwaysP Baluk
Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
Am J Pathol 152:1463-76. 1998..We conclude that endothelial gaps contribute to both early and late phases of plasma leakage induced by antigen, but most leakage occurs upstream to sites of leukocyte adhesion... - Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alphaD A Elson
Cancer Genetics Program, UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
Genes Dev 15:2520-32. 2001..Remarkably, blood vessel leakage resistance induced by HIF-1alpha overexpression was not caused by up-regulation of angiopoietin-1 or angiopoietin-2. Hypervascularity induced by HIF-1alpha could improve therapy of tissue ischemia... - Neurogenic plasma leakage in mouse airwaysP Baluk
Cardiovascular Research Institute, Department of Anatomy, University of California, San Francisco 94143 0130, USA
Br J Pharmacol 126:522-8. 1999..Neurogenic inflammation does not involve the pulmonary microvasculature... - Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1G Thurston
Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0452, USA
Science 286:2511-4. 1999..Ang1 therefore may be useful for reducing microvascular leakage in diseases in which the leakage results from chronic inflammation or elevated VEGF and, in combination with VEGF, for promoting growth of nonleaky vessels... - Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in miceG Thurston
Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
J Clin Invest 101:1401-13. 1998..This preferential uptake raises the possibility of using cationic liposomes to target diagnostic or therapeutic agents selectively to angiogenic blood vessels in tumors and sites of chronic inflammation... - Airway vasculature after mycoplasma infection: chronic leakiness and selective hypersensitivity to substance PM L Kwan
Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, California 94143, USA
Am J Physiol Lung Cell Mol Physiol 280:L286-97. 2001..This leakage is accompanied by an abnormal sensitivity to substance P but not to platelet-activating factor or 5-hydroxytryptamine and can be reduced by beta2-agonists... - Distribution of adjuvant MF59 and antigen gD2 after intramuscular injection in miceM Dupuis
Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, CA 94143, USA
Vaccine 18:434-9. 1999..The results indicate that MF59 and gD2 distribute and are cleared independently after i.m. injection. Importantly, MF59 is unlikely to have a repository effect, whereby it slowly releases the antigen... - Microvascular remodelling in chronic airway inflammation in miceG Thurston
Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco 94143 0452, USA
Clin Exp Pharmacol Physiol 27:836-41. 2000.... - Changes in epithelial secretory cells and potentiation of neurogenic inflammation in the trachea of rats with respiratory tract infectionsH T Huang
Cardiovascular Research Institute, University of California, San Francisco 94143
Anat Embryol (Berl) 180:325-41. 1989..They also cause a proliferation of mediator-sensitive blood vessels in the airway mucosa, which is likely to contribute to the potentiation of neurogenic inflammation that accompanies these infections... - Neutral endopeptidase and neurogenic inflammation in rats with respiratory infectionsD B Borson
Cardiovascular Research Institute, University of California, San Francisco 94143 0130
J Appl Physiol 66:2653-8. 1989..Thus decreased NEP activity may exacerbate some of the pathological responses in animals with respiratory tract infections... - Immunization with the adjuvant MF59 induces macrophage trafficking and apoptosisM Dupuis
Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, USA
Eur J Immunol 31:2910-8. 2001..We propose that lymph node-resident dendritic cells can acquire antigen and MF59 after intramuscular immunization by uptake of the apoptotic macrophages... - Rapid vascular regrowth in tumors after reversal of VEGF inhibitionMichael R Mancuso
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143-0452, USA
J Clin Invest 116:2610-21. 2006.... - In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skinKyung Eun Kim
National Research Laboratory of Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
Arterioscler Thromb Vasc Biol 27:564-70. 2007..We analyzed the microvasculature of trachea and ear skin, and compared quiescent skin microvasculature with that during wound healing... 
Markers for microscopic imaging of lymphangiogenesis and angiogenesisPeter Baluk
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143, USA
Ann N Y Acad Sci 1131:1-12. 2008..Other markers, including CD31, junctional proteins, and receptors, such as VEGF-2, are shared by lymphatic and blood vessels...- Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infectionArin B Aurora
Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
J Immunol 175:6319-26. 2005..The results reveal a novel pathway whereby T cell-dependent humoral immunity to a persistent airway infection can induce inflammation-dependent angiogenesis, lymphangiogenesis, and chronic airway pathology... - Uniform overexpression and rapid accessibility of alpha5beta1 integrin on blood vessels in tumorsPatricia Parsons-Wingerter
Department of Anatomy, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
Am J Pathol 167:193-211. 2005..This strategy of injecting antibodies revealed the uniform overexpression and rapid accessibility of alpha5beta1 integrin on tumor vessels and may prove useful in assessing other potential therapeutic targets in cancer... - Rapid access of antibodies to alpha5beta1 integrin overexpressed on the luminal surface of tumor blood vesselsAnette Magnussen
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143-0130, USA
Cancer Res 65:2712-21. 2005..Together, these findings indicate that the rapid accessibility of alpha(5)beta(1) integrin in RIP-Tag2 tumors results from overexpression of the integrin on the luminal surface of tumor vessels... - Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammationPeter Baluk
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143, USA
J Clin Invest 115:247-57. 2005..Correction of defective lymphangiogenesis may benefit the treatment of asthma and other inflammatory airway diseases... - Soluble receptor-mediated selective inhibition of VEGFR and PDGFRbeta signaling during physiologic and tumor angiogenesisFrank Kuhnert
Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 105:10185-90. 2008..These studies using highly specific soluble receptors suggest that additivity between VEGFR and PDGFRbeta inhibition depends on the strength of VEGF blockade and appears minimal under conditions of maximal VEGF antagonism... - Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airwaysPeter Baluk
Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, CA 94143-0130, USA
Am J Pathol 165:1071-85. 2004..Blood vessels can respond to VEGF by sprouting angiogenesis within a few days, but regress more slowly after VEGF withdrawal, and leave a historical record of their previous extent in the form of empty basement membrane sleeves... - Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lungCecile J Favre
Department of Anatomy S1363, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
Am J Physiol Heart Circ Physiol 285:H1917-38. 2003..This approach can readily be used to profile genes expressed in blood vessels in tumors, chronic inflammation, and other sites in which endothelial cells avidly take up cationic liposomes... - Probing the structural and molecular diversity of tumor vasculatureRenata Pasqualini
Dept of Genitourinary Medical Oncology, The University of Texas, M.D. Anderson Cancer Center, Houston 77030, USA
Trends Mol Med 8:563-71. 2002..The combined approach offers a strategy for creating a ligand-receptor map of the human vasculature, and forms a foundation for the development and application of targeted therapies in cancer and other diseases... - Cellular abnormalities of blood vessels as targets in cancerPeter Baluk
Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, CA 94143, USA
Curr Opin Genet Dev 15:102-11. 2005..Rapid vascular regrowth reflects the ongoing drive for angiogenesis and bizarre microenvironment in tumors that promote vascular abnormalities and thereby create therapeutic targets... - Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesisClare R Ozawa
Baxter Laboratory in Genetic Pharmacology, Stanford University School of Medicine, Stanford, California 94305-5175, USA
J Clin Invest 113:516-27. 2004..Long-term continuous delivery of VEGF, when maintained below a threshold microenvironmental level, can lead to normal angiogenesis without other exogenous growth factors... - Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodelingPeter Baluk
Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
Am J Physiol Lung Cell Mol Physiol 287:L307-17. 2004..We conclude that despite major increases in expression, MMP-2 and MMP-9 are not essential for microvascular remodeling in M. pulmonis-induced chronic airway inflammation... - Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghostsTetsuichiro Inai
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy S1363, University of California-San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0452, USA
Am J Pathol 165:35-52. 2004..Early loss of endothelial fenestrations in RIP-Tag2 tumors is a clue that vessel phenotype may be predictive of exceptional sensitivity to these inhibitors... - Magnetic resonance imaging assays for dimethyl sulfoxide effect on cancer vasculatureClemens C Cyran
Center for Pharmaceutical and Molecular Imaging, Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
Invest Radiol 43:298-305. 2008.... - Antiangiogenic therapy decreases integrin expression in normalized tumor blood vesselsVirginia J Yao
Department of Anatomy, University of California, San Francisco, California 91413-0452, USA
Cancer Res 66:2639-49. 2006..Efficacious delivery of drugs may benefit from identification by in vivo phage display of targeting peptides that bind to tumor blood vessels normalized by antiangiogenic agents... - Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lungVineet Bhandari
Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, LCI 401-B, New Haven, CT 06520-8057, USA
Proc Natl Acad Sci U S A 103:11021-6. 2006..Furthermore, they demonstrate that eNOS and iNOS both contribute to these responses. NO/NOS-based interventions may be therapeutic in VEGF-driven inflammation and remodeling... - Rapid changes in shape and number of MHC class II expressing cells in rat airways after Mycoplasma pulmonis infectionEric Y Umemoto
Cardiovascular Research Institute, Department of Anatomy, and Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
Cell Immunol 220:107-15. 2002.... - Report from the society for biological therapy and vascular biology faculty of the NCI workshop on angiogenesis monitoringDonald M McDonald
University of California at San Francisco, San Francisco, CA, USA
J Immunother (1997) 27:161-75. 2004..The third addressed the translation to the clinic and monitoring of antiangiogenic activity of agents in patients and novel trial designs. What follows is a summary of the discussions and findings of each session... - Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102Barbara Sennino
Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, San Francisco, California 94080, USA
Cancer Res 67:7358-67. 2007..Loss of pericytes in tumors is an expected direct consequence of PDGF-B blockade, but reduced tumor vascularity is likely to be secondary to pericyte regression... - Functionally specialized junctions between endothelial cells of lymphatic vesselsPeter Baluk
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 204:2349-62. 2007..Our findings suggest that fluid enters throughout initial lymphatics via openings between buttons, which open and close without disrupting junctional integrity, but most leukocytes enter the proximal half of initial lymphatics... - Disease-specific gene expression profiling in multiple models of lung diseaseChristina C Lewis
Cincinnati Children s Hospital Medical Center Division of Immunobiology, 3333 Burnet Avenue, MLC 7038, Cincinnati, OH 45229, USA
Am J Respir Crit Care Med 177:376-87. 2008..However, analyses of individual diseases or models of diseases frequently yield extensive lists of differentially expressed genes with uncertain relationships to disease pathogenesis... - Vascular permeability during antiangiogenesis treatment: MR imaging assay results as biomarker for subsequent tumor growth in ratsHans Juergen Raatschen
Department of Radiology, Center for Pharmaceutical and Molecular Imaging, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California San Francisco, CA, USA
Radiology 247:391-9. 2008.... - Abnormalities in pericytes on blood vessels and endothelial sprouts in tumorsShunichi Morikawa
Department of Anatomy and Cardiovascular Research Institute and Comprehensive Cancer Center, University of California, San Francisco, California 94143-0130, USA
Am J Pathol 160:985-1000. 2002..The association of pericytes with endothelial sprouts raises the possibility of an involvement in sprout growth or retraction in tumors... - Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lungChun Geun Lee
Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, 441c TAC, New Haven, Connecticut 06520 8057, USA
Nat Med 10:1095-103. 2004..Thus, VEGF is a mediator of vascular and extravascular remodeling and inflammation that enhances antigen sensitization and is crucial in adaptive T(H)2 inflammation. VEGF regulation may be therapeutic in asthma and other T(H)2 disorders... - Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumorsTsutomu Nakahara
Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California-San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0130, USA
Cancer Res 66:1434-45. 2006..Basement membrane sleeves may facilitate this transport. Antibodies preferentially distribute to tumor stroma but also accumulate on tumor cells if binding sites are accessible... - Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumorsPeter Baluk
Cardiovascular Research Institute, Comprehensive Cancer Center, University of California-San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0452, USA
Am J Pathol 163:1801-15. 2003..These findings indicate that basement membrane covers most tumor vessels but has profound structural abnormalities, consistent with the dynamic nature of endothelial cells and pericytes in tumors... - Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1-induced plasticity of adult blood vesselsFabienne Baffert
Department of Anatomy, Cardiovascular Research Institute and Comprehensive Cancer Center, University of California, San Francisco, Calif, USA
Circ Res 94:984-92. 2004..Together, these findings indicate that VEGF and Ang1 participate in blood vessel survival and plasticity in adult life... - Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissectionVirginia J Yao
Departments of Genitourinary Medical Oncology and Cancer Biology, The University of Texas, M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
Am J Pathol 166:625-36. 2005..Our findings show in vivo phage display and laser pressure catapult microdissection can be combined to reveal endothelial cell specialization within focal regions of the microvasculature... - Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental periodGavin Thurston
Regeneron Pharmaceuticals Incorporated, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
Development 132:3317-26. 2005..Finding the key molecular factors that regulate this plasticity may prove crucial to the further development of pro- and anti-angiogenic therapies... - Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flowChung-Hyun Cho
Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
Circ Res 97:86-94. 2005..Sustained overexpression of Tie2 could participate in the maintenance of vascular changes. Together, our findings indicate that sustained treatment with COMP-Ang1 can produce long-lasting vascular enlargement and increased blood flow... - Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markersEmmanuelle di Tomaso
Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
Cancer Res 65:5740-9. 2005..More than 80% of the defects lacked immunoreactivity for multiple basement membrane proteins... - Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venulesFabienne Baffert
Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, San Francisco, CA 94143 0452, USA
Am J Physiol Heart Circ Physiol 290:H107-18. 2006.... - Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signalingFabienne Baffert
Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
Am J Physiol Heart Circ Physiol 290:H547-59. 2006.... - VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculatureTomomi Kamba
Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
Am J Physiol Heart Circ Physiol 290:H560-76. 2006..Our findings of VEGF dependency of normal fenestrated capillaries and rapid regrowth after regression demonstrate the plasticity of the adult microvasculature... - Angiogenesis with pericyte abnormalities in a transgenic model of prostate carcinomaMichael G Ozawa
Department of Anatomy, University of California at San Francisco, San Francisco, California 94143-0130, USA
Cancer 104:2104-15. 2005..CONCLUSIONS: Vascular abnormalities, which begin at the PIN stage and intensify in well differentiated and poorly differentiated tumors, may be useful readouts for early detection and treatment assessment in prostate carcinoma... - Mast cells protect mice from Mycoplasma pneumoniaXiang Xu
Pulmonary and Critical Care Medicine, Mailstop 111-D, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121
Am J Respir Crit Care Med 173:219-25. 2006..CONCLUSIONS: These findings suggest that mast cells are important for innate immune containment of and recovery from respiratory mycoplasma infection... - The biologic basis of in vivo angiogenesis imagingIclal Ocak
Molecular Imaging Program, National Institutes of Health, Bethesda, Maryland 20892 1182, USA
Front Biosci 12:3601-16. 2007..Serial analysis of gene expression or in vivo phage display may help identify new, more selective, markers that can be utilized for the targeted imaging and treatment of angiogenesis...