D M McDonald

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Imaging of angiogenesis: from microscope to clinic
    Donald M McDonald
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, California 94143 0452, USA
    Nat Med 9:713-25. 2003
  2. ncbi request reprint Significance of blood vessel leakiness in cancer
    Donald M McDonald
    Comprehensive Cancer Center, Cardiovascular Research Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cancer Res 62:5381-5. 2002
  3. ncbi request reprint Angiogenesis and remodeling of airway vasculature in chronic inflammation
    D M McDonald
    Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, California 94143 0130, USA
    Am J Respir Crit Care Med 164:S39-45. 2001
  4. ncbi request reprint Imaging of angiogenesis in inflamed airways and tumors: newly formed blood vessels are not alike and may be wildly abnormal: Parker B. Francis lecture
    Donald M McDonald
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Chest 128:602S-608S. 2005
  5. ncbi request reprint Endothelial cells of tumor vessels: abnormal but not absent
    D M McDonald
    Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco 94143 0130, USA
    Cancer Metastasis Rev 19:109-20. 2000
  6. pmc Angiogenesis in mice with chronic airway inflammation: strain-dependent differences
    G Thurston
    Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco 94143 0452, USA
    Am J Pathol 153:1099-112. 1998
  7. pmc Endothelial gaps and adherent leukocytes in allergen-induced early- and late-phase plasma leakage in rat airways
    P Baluk
    Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
    Am J Pathol 152:1463-76. 1998
  8. pmc Neurogenic plasma leakage in mouse airways
    P Baluk
    Cardiovascular Research Institute, Department of Anatomy, University of California, San Francisco 94143 0130, USA
    Br J Pharmacol 126:522-8. 1999
  9. pmc Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha
    D A Elson
    Cancer Genetics Program, UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
    Genes Dev 15:2520-32. 2001
  10. ncbi request reprint Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
    G Thurston
    Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0452, USA
    Science 286:2511-4. 1999

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Imaging of angiogenesis: from microscope to clinic
    Donald M McDonald
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, 513 Parnassus Avenue, San Francisco, California 94143 0452, USA
    Nat Med 9:713-25. 2003
    ..The importance of angiogenesis in cancer, chronic inflammatory diseases, age-related macular degeneration and reversal of ischemic heart and limb disease provides incentive for meeting these challenges...
  2. ncbi request reprint Significance of blood vessel leakiness in cancer
    Donald M McDonald
    Comprehensive Cancer Center, Cardiovascular Research Institute, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Cancer Res 62:5381-5. 2002
    ..New research tools such as intravital measurements of tumor blood flow and vessel leakiness, in vivo phage display, magnetic resonance imaging, and use of selective angiogenesis inhibitors will contribute to this understanding...
  3. ncbi request reprint Angiogenesis and remodeling of airway vasculature in chronic inflammation
    D M McDonald
    Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, California 94143 0130, USA
    Am J Respir Crit Care Med 164:S39-45. 2001
    ....
  4. ncbi request reprint Imaging of angiogenesis in inflamed airways and tumors: newly formed blood vessels are not alike and may be wildly abnormal: Parker B. Francis lecture
    Donald M McDonald
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Chest 128:602S-608S. 2005
  5. ncbi request reprint Endothelial cells of tumor vessels: abnormal but not absent
    D M McDonald
    Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco 94143 0130, USA
    Cancer Metastasis Rev 19:109-20. 2000
    ....
  6. pmc Angiogenesis in mice with chronic airway inflammation: strain-dependent differences
    G Thurston
    Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco 94143 0452, USA
    Am J Pathol 153:1099-112. 1998
    ..Endothelial cells proliferate in both cases, but in one case new capillaries form whereas in the other capillaries convert to venules...
  7. pmc Endothelial gaps and adherent leukocytes in allergen-induced early- and late-phase plasma leakage in rat airways
    P Baluk
    Cardiovascular Research Institute, University of California, San Francisco 94143 0130, USA
    Am J Pathol 152:1463-76. 1998
    ..We conclude that endothelial gaps contribute to both early and late phases of plasma leakage induced by antigen, but most leakage occurs upstream to sites of leukocyte adhesion...
  8. pmc Neurogenic plasma leakage in mouse airways
    P Baluk
    Cardiovascular Research Institute, Department of Anatomy, University of California, San Francisco 94143 0130, USA
    Br J Pharmacol 126:522-8. 1999
    ..Neurogenic inflammation does not involve the pulmonary microvasculature...
  9. pmc Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1alpha
    D A Elson
    Cancer Genetics Program, UCSF Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
    Genes Dev 15:2520-32. 2001
    ..Remarkably, blood vessel leakage resistance induced by HIF-1alpha overexpression was not caused by up-regulation of angiopoietin-1 or angiopoietin-2. Hypervascularity induced by HIF-1alpha could improve therapy of tissue ischemia...
  10. ncbi request reprint Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1
    G Thurston
    Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0452, USA
    Science 286:2511-4. 1999
    ..Ang1 therefore may be useful for reducing microvascular leakage in diseases in which the leakage results from chronic inflammation or elevated VEGF and, in combination with VEGF, for promoting growth of nonleaky vessels...
  11. pmc Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice
    G Thurston
    Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco, California 94143, USA
    J Clin Invest 101:1401-13. 1998
    ..This preferential uptake raises the possibility of using cationic liposomes to target diagnostic or therapeutic agents selectively to angiogenic blood vessels in tumors and sites of chronic inflammation...
  12. ncbi request reprint Airway vasculature after mycoplasma infection: chronic leakiness and selective hypersensitivity to substance P
    M L Kwan
    Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, California 94143, USA
    Am J Physiol Lung Cell Mol Physiol 280:L286-97. 2001
    ..This leakage is accompanied by an abnormal sensitivity to substance P but not to platelet-activating factor or 5-hydroxytryptamine and can be reduced by beta2-agonists...
  13. ncbi request reprint Distribution of adjuvant MF59 and antigen gD2 after intramuscular injection in mice
    M Dupuis
    Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Vaccine 18:434-9. 1999
    ..The results indicate that MF59 and gD2 distribute and are cleared independently after i.m. injection. Importantly, MF59 is unlikely to have a repository effect, whereby it slowly releases the antigen...
  14. ncbi request reprint Microvascular remodelling in chronic airway inflammation in mice
    G Thurston
    Department of Anatomy and Cardiovascular Research Institute, University of California, San Francisco 94143 0452, USA
    Clin Exp Pharmacol Physiol 27:836-41. 2000
    ....
  15. ncbi request reprint Neutral endopeptidase and neurogenic inflammation in rats with respiratory infections
    D B Borson
    Cardiovascular Research Institute, University of California, San Francisco 94143 0130
    J Appl Physiol (1985) 66:2653-8. 1989
    ..Thus decreased NEP activity may exacerbate some of the pathological responses in animals with respiratory tract infections...
  16. ncbi request reprint Changes in epithelial secretory cells and potentiation of neurogenic inflammation in the trachea of rats with respiratory tract infections
    H T Huang
    Cardiovascular Research Institute, University of California, San Francisco 94143
    Anat Embryol (Berl) 180:325-41. 1989
    ..They also cause a proliferation of mediator-sensitive blood vessels in the airway mucosa, which is likely to contribute to the potentiation of neurogenic inflammation that accompanies these infections...
  17. pmc Identification of pY654-β-catenin as a critical co-factor in hypoxia-inducible factor-1α signaling and tumor responses to hypoxia
    Y Xi
    Pulmonary and Critical Care Division, Department of Medicine, University of California San Francisco, San Francisco, CA, USA
    Oncogene 32:5048-57. 2013
    ..The findings also suggest that targeting ROS-dependent aspects of the pY654-β-catenin/ HIF1α pathway may attenuate untoward biological effects of anti-angiogenic agents and tumor hypoxia. ..
  18. ncbi request reprint Immunization with the adjuvant MF59 induces macrophage trafficking and apoptosis
    M Dupuis
    Cardiovascular Research Institute and Department of Anatomy, University of California, San Francisco, USA
    Eur J Immunol 31:2910-8. 2001
    ..We propose that lymph node-resident dendritic cells can acquire antigen and MF59 after intramuscular immunization by uptake of the apoptotic macrophages...
  19. pmc Uniform overexpression and rapid accessibility of alpha5beta1 integrin on blood vessels in tumors
    Patricia Parsons-Wingerter
    Department of Anatomy, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
    Am J Pathol 167:193-211. 2005
    ..This strategy of injecting antibodies revealed the uniform overexpression and rapid accessibility of alpha5beta1 integrin on tumor vessels and may prove useful in assessing other potential therapeutic targets in cancer...
  20. pmc Rapid vascular regrowth in tumors after reversal of VEGF inhibition
    Michael R Mancuso
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143 0452, USA
    J Clin Invest 116:2610-21. 2006
    ....
  21. ncbi request reprint Rapid access of antibodies to alpha5beta1 integrin overexpressed on the luminal surface of tumor blood vessels
    Anette Magnussen
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143 0130, USA
    Cancer Res 65:2712-21. 2005
    ..Together, these findings indicate that the rapid accessibility of alpha(5)beta(1) integrin in RIP-Tag2 tumors results from overexpression of the integrin on the luminal surface of tumor vessels...
  22. pmc Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, UCSF, San Francisco, California 94143, USA
    J Clin Invest 115:247-57. 2005
    ..Correction of defective lymphangiogenesis may benefit the treatment of asthma and other inflammatory airway diseases...
  23. pmc Regulated angiogenesis and vascular regression in mice overexpressing vascular endothelial growth factor in airways
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, CA 94143 0130, USA
    Am J Pathol 165:1071-85. 2004
    ..Blood vessels can respond to VEGF by sprouting angiogenesis within a few days, but regress more slowly after VEGF withdrawal, and leave a historical record of their previous extent in the form of empty basement membrane sleeves...
  24. ncbi request reprint Immune complex-dependent remodeling of the airway vasculature in response to a chronic bacterial infection
    Arin B Aurora
    Department of Microbiology and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 175:6319-26. 2005
    ..The results reveal a novel pathway whereby T cell-dependent humoral immunity to a persistent airway infection can induce inflammation-dependent angiogenesis, lymphangiogenesis, and chronic airway pathology...
  25. pmc Inhibition of vascular endothelial growth factor (VEGF) signaling in cancer causes loss of endothelial fenestrations, regression of tumor vessels, and appearance of basement membrane ghosts
    Tetsuichiro Inai
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy S1363, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    Am J Pathol 165:35-52. 2004
    ..Early loss of endothelial fenestrations in RIP-Tag2 tumors is a clue that vessel phenotype may be predictive of exceptional sensitivity to these inhibitors...
  26. ncbi request reprint Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodeling
    Peter Baluk
    Cardiovascular Research Institute, University of California, San Francisco, CA 94143 0130, USA
    Am J Physiol Lung Cell Mol Physiol 287:L307-17. 2004
    ..We conclude that despite major increases in expression, MMP-2 and MMP-9 are not essential for microvascular remodeling in M. pulmonis-induced chronic airway inflammation...
  27. ncbi request reprint Probing the structural and molecular diversity of tumor vasculature
    Renata Pasqualini
    Dept of Genitourinary Medical Oncology, The University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Trends Mol Med 8:563-71. 2002
    ..The combined approach offers a strategy for creating a ligand-receptor map of the human vasculature, and forms a foundation for the development and application of targeted therapies in cancer and other diseases...
  28. ncbi request reprint Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung
    Cecile J Favre
    Department of Anatomy S1363, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    Am J Physiol Heart Circ Physiol 285:H1917-38. 2003
    ..This approach can readily be used to profile genes expressed in blood vessels in tumors, chronic inflammation, and other sites in which endothelial cells avidly take up cationic liposomes...
  29. pmc Soluble receptor-mediated selective inhibition of VEGFR and PDGFRbeta signaling during physiologic and tumor angiogenesis
    Frank Kuhnert
    Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 105:10185-90. 2008
    ..These studies using highly specific soluble receptors suggest that additivity between VEGFR and PDGFRbeta inhibition depends on the strength of VEGF blockade and appears minimal under conditions of maximal VEGF antagonism...
  30. ncbi request reprint In vivo actions of angiopoietins on quiescent and remodeling blood and lymphatic vessels in mouse airways and skin
    Kyung Eun Kim
    National Research Laboratory of Vascular Biology and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    Arterioscler Thromb Vasc Biol 27:564-70. 2007
    ..We analyzed the microvasculature of trachea and ear skin, and compared quiescent skin microvasculature with that during wound healing...
  31. ncbi request reprint Cellular abnormalities of blood vessels as targets in cancer
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, Department of Anatomy, University of California, San Francisco, CA 94143, USA
    Curr Opin Genet Dev 15:102-11. 2005
    ..Rapid vascular regrowth reflects the ongoing drive for angiogenesis and bizarre microenvironment in tumors that promote vascular abnormalities and thereby create therapeutic targets...
  32. pmc Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis
    Clare R Ozawa
    Baxter Laboratory in Genetic Pharmacology, Stanford University School of Medicine, Stanford, California 94305 5175, USA
    J Clin Invest 113:516-27. 2004
    ..Long-term continuous delivery of VEGF, when maintained below a threshold microenvironmental level, can lead to normal angiogenesis without other exogenous growth factors...
  33. doi request reprint Markers for microscopic imaging of lymphangiogenesis and angiogenesis
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California, San Francisco, California 94143, USA
    Ann N Y Acad Sci 1131:1-12. 2008
    ..Other markers, including CD31, junctional proteins, and receptors, such as VEGF-2, are shared by lymphatic and blood vessels...
  34. ncbi request reprint Effect of inhibition of vascular endothelial growth factor signaling on distribution of extravasated antibodies in tumors
    Tsutomu Nakahara
    Cardiovascular Research Institute, Comprehensive Cancer Center, and Department of Anatomy, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0130, USA
    Cancer Res 66:1434-45. 2006
    ..Basement membrane sleeves may facilitate this transport. Antibodies preferentially distribute to tumor stroma but also accumulate on tumor cells if binding sites are accessible...
  35. pmc Essential role of nitric oxide in VEGF-induced, asthma-like angiogenic, inflammatory, mucus, and physiologic responses in the lung
    Vineet Bhandari
    Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, LCI 401 B, New Haven, CT 06520 8057, USA
    Proc Natl Acad Sci U S A 103:11021-6. 2006
    ..Furthermore, they demonstrate that eNOS and iNOS both contribute to these responses. NO/NOS-based interventions may be therapeutic in VEGF-driven inflammation and remodeling...
  36. ncbi request reprint Antiangiogenic therapy decreases integrin expression in normalized tumor blood vessels
    Virginia J Yao
    Department of Anatomy, University of California, San Francisco, California 91413 0452, USA
    Cancer Res 66:2639-49. 2006
    ..Efficacious delivery of drugs may benefit from identification by in vivo phage display of targeting peptides that bind to tumor blood vessels normalized by antiangiogenic agents...
  37. ncbi request reprint The biologic basis of in vivo angiogenesis imaging
    Iclal Ocak
    Molecular Imaging Program, National Institutes of Health, Bethesda, Maryland 20892 1182, USA
    Front Biosci 12:3601-16. 2007
    ..Serial analysis of gene expression or in vivo phage display may help identify new, more selective, markers that can be utilized for the targeted imaging and treatment of angiogenesis...
  38. ncbi request reprint Report from the society for biological therapy and vascular biology faculty of the NCI workshop on angiogenesis monitoring
    Donald M McDonald
    University of California at San Francisco, San Francisco, CA, USA
    J Immunother 27:161-75. 2004
    ..The third addressed the translation to the clinic and monitoring of antiangiogenic activity of agents in patients and novel trial designs. What follows is a summary of the discussions and findings of each session...
  39. pmc Functionally specialized junctions between endothelial cells of lymphatic vessels
    Peter Baluk
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 204:2349-62. 2007
    ..Our findings suggest that fluid enters throughout initial lymphatics via openings between buttons, which open and close without disrupting junctional integrity, but most leukocytes enter the proximal half of initial lymphatics...
  40. pmc Disease-specific gene expression profiling in multiple models of lung disease
    Christina C Lewis
    Cincinnati Children s Hospital Medical Center Division of Immunobiology, 3333 Burnet Avenue, MLC 7038, Cincinnati, OH 45229, USA
    Am J Respir Crit Care Med 177:376-87. 2008
    ..However, analyses of individual diseases or models of diseases frequently yield extensive lists of differentially expressed genes with uncertain relationships to disease pathogenesis...
  41. doi request reprint Vascular permeability during antiangiogenesis treatment: MR imaging assay results as biomarker for subsequent tumor growth in rats
    Hans Juergen Raatschen
    Department of Radiology, Center for Pharmaceutical and Molecular Imaging, Cardiovascular Research Institute, Comprehensive Cancer Center, University of California San Francisco, CA, USA
    Radiology 247:391-9. 2008
    ....
  42. doi request reprint Magnetic resonance imaging assays for dimethyl sulfoxide effect on cancer vasculature
    Clemens C Cyran
    Center for Pharmaceutical and Molecular Imaging, Department of Radiology, University of California San Francisco, San Francisco, CA 94143 0628, USA
    Invest Radiol 43:298-305. 2008
    ....
  43. ncbi request reprint Rapid changes in shape and number of MHC class II expressing cells in rat airways after Mycoplasma pulmonis infection
    Eric Y Umemoto
    Cardiovascular Research Institute, Department of Anatomy, and Comprehensive Cancer Center, University of California, San Francisco, CA 94143, USA
    Cell Immunol 220:107-15. 2002
    ....
  44. pmc Mast cells protect mice from Mycoplasma pneumonia
    Xiang Xu
    Pulmonary and Critical Care Medicine, Mailstop 111 D, Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 94121
    Am J Respir Crit Care Med 173:219-25. 2006
    ..Mice infected with Mycoplasma pulmonis can develop localized, life-long airway infection accompanied by persistent inflammation and remodeling...
  45. pmc Abnormalities of basement membrane on blood vessels and endothelial sprouts in tumors
    Peter Baluk
    Cardiovascular Research Institute, Comprehensive Cancer Center, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0452, USA
    Am J Pathol 163:1801-15. 2003
    ..These findings indicate that basement membrane covers most tumor vessels but has profound structural abnormalities, consistent with the dynamic nature of endothelial cells and pericytes in tumors...
  46. ncbi request reprint Age-related changes in vascular endothelial growth factor dependency and angiopoietin-1-induced plasticity of adult blood vessels
    Fabienne Baffert
    Department of Anatomy, Cardiovascular Research Institute and Comprehensive Cancer Center, University of California, San Francisco, Calif, USA
    Circ Res 94:984-92. 2004
    ..Together, these findings indicate that VEGF and Ang1 participate in blood vessel survival and plasticity in adult life...
  47. pmc Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung
    Chun Geun Lee
    Section of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, 441c TAC, New Haven, Connecticut 06520 8057, USA
    Nat Med 10:1095-103. 2004
    ..Thus, VEGF is a mediator of vascular and extravascular remodeling and inflammation that enhances antigen sensitization and is crucial in adaptive T(H)2 inflammation. VEGF regulation may be therapeutic in asthma and other T(H)2 disorders...
  48. pmc Abnormalities in pericytes on blood vessels and endothelial sprouts in tumors
    Shunichi Morikawa
    Department of Anatomy and Cardiovascular Research Institute and Comprehensive Cancer Center, University of California, San Francisco, California 94143 0130, USA
    Am J Pathol 160:985-1000. 2002
    ..The association of pericytes with endothelial sprouts raises the possibility of an involvement in sprout growth or retraction in tumors...
  49. pmc Targeting pancreatic islets with phage display assisted by laser pressure catapult microdissection
    Virginia J Yao
    Departments of Genitourinary Medical Oncology and Cancer Biology, The University of Texas, M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    Am J Pathol 166:625-36. 2005
    ..Our findings show in vivo phage display and laser pressure catapult microdissection can be combined to reveal endothelial cell specialization within focal regions of the microvasculature...
  50. ncbi request reprint Angiopoietin 1 causes vessel enlargement, without angiogenic sprouting, during a critical developmental period
    Gavin Thurston
    Regeneron Pharmaceuticals Incorporated, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA
    Development 132:3317-26. 2005
    ..Finding the key molecular factors that regulate this plasticity may prove crucial to the further development of pro- and anti-angiogenic therapies...
  51. ncbi request reprint Long-term and sustained COMP-Ang1 induces long-lasting vascular enlargement and enhanced blood flow
    Chung Hyun Cho
    Biomedical Research Center and Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Korea
    Circ Res 97:86-94. 2005
    ..Sustained overexpression of Tie2 could participate in the maintenance of vascular changes. Together, our findings indicate that sustained treatment with COMP-Ang1 can produce long-lasting vascular enlargement and increased blood flow...
  52. ncbi request reprint Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers
    Emmanuelle di Tomaso
    Steele Laboratory for Tumor Biology, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Cancer Res 65:5740-9. 2005
    ..More than 80% of the defects lacked immunoreactivity for multiple basement membrane proteins...
  53. ncbi request reprint Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules
    Fabienne Baffert
    Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, San Francisco, CA 94143 0452, USA
    Am J Physiol Heart Circ Physiol 290:H107-18. 2006
    ....
  54. ncbi request reprint Cellular changes in normal blood capillaries undergoing regression after inhibition of VEGF signaling
    Fabienne Baffert
    Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
    Am J Physiol Heart Circ Physiol 290:H547-59. 2006
    ....
  55. ncbi request reprint VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature
    Tomomi Kamba
    Cardiovascular Research Institute, and Dept of Anatomy, Univ of California, 513 Parnassus Ave, San Francisco, CA 94143 0452, USA
    Am J Physiol Heart Circ Physiol 290:H560-76. 2006
    ..Our findings of VEGF dependency of normal fenestrated capillaries and rapid regrowth after regression demonstrate the plasticity of the adult microvasculature...
  56. ncbi request reprint Angiogenesis with pericyte abnormalities in a transgenic model of prostate carcinoma
    Michael G Ozawa
    Department of Anatomy, University of California at San Francisco, San Francisco, California 94143 0130, USA
    Cancer 104:2104-15. 2005
    ..The authors used a new approach to characterize morphologic and architectural changes of blood vessels and pericytes during tumor development in TRAMP mice...
  57. ncbi request reprint Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102
    Barbara Sennino
    Cardiovascular Research Institute, Comprehensive Cancer Center, University of California, San Francisco, California 94080, USA
    Cancer Res 67:7358-67. 2007
    ..Loss of pericytes in tumors is an expected direct consequence of PDGF-B blockade, but reduced tumor vascularity is likely to be secondary to pericyte regression...